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Items: 1 to 50 of 85

1.

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans.

Hong Y, Velkova M, Silva N, Jagut M, Scheidt V, Labib K, Jantsch V, Gartner A.

PLoS Genet. 2018 Jun 7;14(6):e1007453. doi: 10.1371/journal.pgen.1007453. eCollection 2018 Jun.

2.

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis.

Hong Y, Sonneville R, Wang B, Scheidt V, Meier B, Woglar A, Demetriou S, Labib K, Jantsch V, Gartner A.

Nat Commun. 2018 Feb 20;9(1):728. doi: 10.1038/s41467-018-03135-w.

3.

Pregabalin Did Not Improve Pain Management After Spinal Fusions.

Urban MK, Labib KM, Reid SC, Goon AK, Rotundo V, Cammisa FP Jr, Girardi FP.

HSS J. 2018 Feb;14(1):41-46. doi: 10.1007/s11420-017-9584-2. Epub 2017 Nov 6.

PMID:
29398993
4.

Plasticity of Human Meniscus Fibrochondrocytes: A Study on Effects of Mitotic Divisions and Oxygen Tension.

Liang Y, Idrees E, Andrews SHJ, Labib K, Szojka A, Kunze M, Burbank AD, Mulet-Sierra A, Jomha NM, Adesida AB.

Sci Rep. 2017 Sep 22;7(1):12148. doi: 10.1038/s41598-017-12096-x.

5.

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.

Wu Y, Villa F, Maman J, Lau YH, Dobnikar L, Simon AC, Labib K, Spring DR, Pellegrini L.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):12866-12872. doi: 10.1002/anie.201705611. Epub 2017 Sep 7.

PMID:
28815832
6.

Assessment of hysteroscopic role in management of women with recurrent pregnancy loss.

Elsokkary M, Elshourbagy M, Labib K, Mamdouh A, El-Shahawy Y, Nossair WS, Abd El Fattah O, Hemeda H, Sallam S, Khalaf WM, Ali M, Elsayed M, Kotb A, Abdelhadi R, Etman M, Abd El Aleem M, Samy M, Salama A, Abdelhaleem M, Abdelshafy A.

J Matern Fetal Neonatal Med. 2018 Jun;31(11):1494-1504. doi: 10.1080/14767058.2017.1319925. Epub 2017 May 2.

PMID:
28412850
7.

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.

Sonneville R, Moreno SP, Knebel A, Johnson C, Hastie CJ, Gartner A, Gambus A, Labib K.

Nat Cell Biol. 2017 May;19(5):468-479. doi: 10.1038/ncb3500. Epub 2017 Apr 3.

8.

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication.

Maric M, Mukherjee P, Tatham MH, Hay R, Labib K.

Cell Rep. 2017 Mar 28;18(13):3033-3042. doi: 10.1016/j.celrep.2017.03.020.

9.

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.

Villa F, Simon AC, Ortiz Bazan MA, Kilkenny ML, Wirthensohn D, Wightman M, Matak-Vinkovíc D, Pellegrini L, Labib K.

Mol Cell. 2016 Aug 4;63(3):385-96. doi: 10.1016/j.molcel.2016.06.009. Epub 2016 Jul 7.

10.

Chromosome Duplication in Saccharomyces cerevisiae.

Bell SP, Labib K.

Genetics. 2016 Jul;203(3):1027-67. doi: 10.1534/genetics.115.186452. Review.

11.

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.

Abdul Rehman SA, Kristariyanto YA, Choi SY, Nkosi PJ, Weidlich S, Labib K, Hofmann K, Kulathu Y.

Mol Cell. 2016 Jul 7;63(1):146-55. doi: 10.1016/j.molcel.2016.05.009. Epub 2016 Jun 9.

12.

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.

Buser R, Kellner V, Melnik A, Wilson-Zbinden C, Schellhaas R, Kastner L, Piwko W, Dees M, Picotti P, Maric M, Labib K, Luke B, Peter M.

PLoS Genet. 2016 Feb 5;12(2):e1005843. doi: 10.1371/journal.pgen.1005843. eCollection 2016 Feb.

13.

Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase.

Maculins T, Nkosi PJ, Nishikawa H, Labib K.

Curr Biol. 2015 Aug 31;25(17):2254-9. doi: 10.1016/j.cub.2015.07.012. Epub 2015 Aug 6.

14.

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.

García-Rodríguez LJ, De Piccoli G, Marchesi V, Jones RC, Edmondson RD, Labib K.

Nucleic Acids Res. 2015 Oct 15;43(18):8830-8. doi: 10.1093/nar/gkv799. Epub 2015 Aug 6.

15.

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos.

Sonneville R, Craig G, Labib K, Gartner A, Blow JJ.

Cell Rep. 2015 Jul 21;12(3):405-17. doi: 10.1016/j.celrep.2015.06.046. Epub 2015 Jul 9.

16.

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication.

Maric M, Maculins T, De Piccoli G, Labib K.

Science. 2014 Oct 24;346(6208):1253596. doi: 10.1126/science.1253596.

17.

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.

Simon AC, Zhou JC, Perera RL, van Deursen F, Evrin C, Ivanova ME, Kilkenny ML, Renault L, Kjaer S, Matak-Vinković D, Labib K, Costa A, Pellegrini L.

Nature. 2014 Jun 12;510(7504):293-297. doi: 10.1038/nature13234. Epub 2014 May 4.

18.

Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.

Sengupta S, van Deursen F, de Piccoli G, Labib K.

Curr Biol. 2013 Apr 8;23(7):543-52. doi: 10.1016/j.cub.2013.02.011. Epub 2013 Mar 14.

19.

Eukaryotic replisome components cooperate to process histones during chromosome replication.

Foltman M, Evrin C, De Piccoli G, Jones RC, Edmondson RD, Katou Y, Nakato R, Shirahige K, Labib K.

Cell Rep. 2013 Mar 28;3(3):892-904. doi: 10.1016/j.celrep.2013.02.028. Epub 2013 Mar 14.

20.

Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.

Nkosi PJ, Targosz BS, Labib K, Sanchez-Diaz A.

PLoS One. 2013;8(2):e57846. doi: 10.1371/journal.pone.0057846. Epub 2013 Feb 28.

21.

Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts.

Devrekanli A, Foltman M, Roncero C, Sanchez-Diaz A, Labib K.

J Cell Sci. 2012 Nov 15;125(Pt 22):5453-66. doi: 10.1242/jcs.109157. Epub 2012 Sep 6.

22.

The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Sanchez-Diaz A, Nkosi PJ, Murray S, Labib K.

EMBO J. 2012 Aug 29;31(17):3620-34. doi: 10.1038/emboj.2012.224. Epub 2012 Aug 7.

23.

A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.

Kilkenny ML, De Piccoli G, Perera RL, Labib K, Pellegrini L.

J Biol Chem. 2012 Jul 6;287(28):23740-7. doi: 10.1074/jbc.M112.368951. Epub 2012 May 16.

24.

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.

van Deursen F, Sengupta S, De Piccoli G, Sanchez-Diaz A, Labib K.

EMBO J. 2012 May 2;31(9):2195-206. doi: 10.1038/emboj.2012.69. Epub 2012 Mar 20.

25.

Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases.

De Piccoli G, Katou Y, Itoh T, Nakato R, Shirahige K, Labib K.

Mol Cell. 2012 Mar 9;45(5):696-704. doi: 10.1016/j.molcel.2012.01.007. Epub 2012 Feb 9.

26.

Building a double hexamer of DNA helicase at eukaryotic replication origins.

Labib K.

EMBO J. 2011 Dec 14;30(24):4853-5. doi: 10.1038/emboj.2011.437. No abstract available.

27.

Surviving chromosome replication: the many roles of the S-phase checkpoint pathway.

Labib K, De Piccoli G.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3554-61. doi: 10.1098/rstb.2011.0071. Review.

28.

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

Labib K.

Genes Dev. 2010 Jun 15;24(12):1208-19. doi: 10.1101/gad.1933010. Review.

29.

The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex.

Morohashi H, Maculins T, Labib K.

Curr Biol. 2009 Dec 1;19(22):1943-9. doi: 10.1016/j.cub.2009.09.062. Epub 2009 Nov 12.

30.

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.

Gambus A, van Deursen F, Polychronopoulos D, Foltman M, Jones RC, Edmondson RD, Calzada A, Labib K.

EMBO J. 2009 Oct 7;28(19):2992-3004. doi: 10.1038/emboj.2009.226. Epub 2009 Aug 6.

31.

New insights into the chromosome cycle. Conference on the Replication & Segregation of Chromosomes.

de la Cueva-Mendez G, Labib K.

EMBO Rep. 2008 Dec;9(12):1177-81. doi: 10.1038/embor.2008.203. Epub 2008 Oct 31. No abstract available.

32.

Making connections at DNA replication forks: Mrc1 takes the lead.

Labib K.

Mol Cell. 2008 Oct 24;32(2):166-8. doi: 10.1016/j.molcel.2008.10.005.

33.

Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.

Sanchez-Diaz A, Marchesi V, Murray S, Jones R, Pereira G, Edmondson R, Allen T, Labib K.

Nat Cell Biol. 2008 Apr;10(4):395-406. doi: 10.1038/ncb1701. Epub 2008 Mar 16.

PMID:
18344988
34.

Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase.

Hodgson B, Calzada A, Labib K.

Mol Biol Cell. 2007 Oct;18(10):3894-902. Epub 2007 Jul 25.

35.

A key role for the GINS complex at DNA replication forks.

Labib K, Gambus A.

Trends Cell Biol. 2007 Jun;17(6):271-8. Epub 2007 Apr 30. Review.

PMID:
17467990
36.

Highlights of the 23rd Genes and Cancer meeting University of Warwick 11-13 December 2006.

Labib K.

Oncogene. 2007 Apr 26;26(19):2675-7. No abstract available.

PMID:
17460715
37.

Replication fork barriers: pausing for a break or stalling for time?

Labib K, Hodgson B.

EMBO Rep. 2007 Apr;8(4):346-53. Review.

38.
39.

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

Gambus A, Jones RC, Sanchez-Diaz A, Kanemaki M, van Deursen F, Edmondson RD, Labib K.

Nat Cell Biol. 2006 Apr;8(4):358-66. Epub 2006 Mar 12.

PMID:
16531994
40.

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

Calzada A, Hodgson B, Kanemaki M, Bueno A, Labib K.

Genes Dev. 2005 Aug 15;19(16):1905-19.

41.

Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron.

Sanchez-Diaz A, Kanemaki M, Marchesi V, Labib K.

Sci STKE. 2004 Mar 2;2004(223):PL8.

PMID:
15010550
42.

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

Kanemaki M, Sanchez-Diaz A, Gambus A, Labib K.

Nature. 2003 Jun 12;423(6941):720-4. Epub 2003 May 25.

PMID:
12768207
43.

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.

Diffley JF, Bousset K, Labib K, Noton EA, Santocanale C, Tercero JA.

Cold Spring Harb Symp Quant Biol. 2000;65:333-42. Review. No abstract available.

PMID:
12760047
44.

The chromosome replication cycle.

Diffley JF, Labib K.

J Cell Sci. 2002 Mar 1;115(Pt 5):869-72. Review. No abstract available.

46.

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Labib K, Diffley JF.

Curr Opin Genet Dev. 2001 Feb;11(1):64-70. Review.

PMID:
11163153
47.

Uninterrupted MCM2-7 function required for DNA replication fork progression.

Labib K, Tercero JA, Diffley JF.

Science. 2000 Jun 2;288(5471):1643-7. Erratum in: Science 2000 Sep 22;289(5487):2052.

48.
49.
50.

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls.

Grallert B, Kearsey SE, Lenhard M, Carlson CR, Nurse P, Boye E, Labib K.

J Cell Sci. 2000 Apr;113 ( Pt 8):1447-58.

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