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Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence-structure-function analysis.

Fleury C, Gracy J, Gautier MF, Pons JL, Dufayard JF, Labesse G, Ruiz M, de Lamotte F.

PeerJ. 2019 Aug 14;7:e7504. doi: 10.7717/peerj.7504. eCollection 2019.


Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity.

Schneider M, Pons JL, Bourguet W, Labesse G.

Bioinformatics. 2019 Jul 26. pii: btz538. doi: 10.1093/bioinformatics/btz538. [Epub ahead of print]


In silico predictions of endocrine disruptors properties.

Schneider M, Pons JL, Labesse G, Bourguet W.

Endocrinology. 2019 Jul 2. pii: en.2019-00382. doi: 10.1210/en.2019-00382. [Epub ahead of print]


A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor.

Loeuillet C, Touquet B, Guichou JF, Labesse G, Sereno D.

Int J Mol Sci. 2019 Jun 18;20(12). pii: E2973. doi: 10.3390/ijms20122973.


Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor.

Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prézeau L.

Mol Pharmacol. 2019 Aug;96(2):233-246. doi: 10.1124/mol.118.113019. Epub 2019 Jun 12.


Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification.

López-Sánchez U, Nicolas G, Richard AC, Maltête D, Charif M, Ayrignac X, Goizet C, Touhami J, Labesse G, Battini JL, Sitbon M.

Sci Rep. 2019 May 1;9(1):6776. doi: 10.1038/s41598-019-43255-x.


Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2A Receptor by a Mini-G Protein.

Renault P, Louet M, Marie J, Labesse G, Floquet N.

Sci Rep. 2019 Apr 2;9(1):5495. doi: 10.1038/s41598-019-41980-x.


SHEDding light on the role of Pragmin pseudo-kinases in cancer.

Roche S, Lecointre C, Simon V, Labesse G.

Am J Cancer Res. 2019 Feb 1;9(2):449-454. eCollection 2019.


First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H.

Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2.


Structural basis for chemically-induced homodimerization of a single domain antibody.

Lesne J, Chang HJ, De Visch A, Paloni M, Barthe P, Guichou JF, Mayonove P, Barducci A, Labesse G, Bonnet J, Cohen-Gonsaud M.

Sci Rep. 2019 Feb 12;9(1):1840. doi: 10.1038/s41598-019-38752-y.


Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.

Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S.

Structure. 2018 Nov 6;26(11):1563. doi: 10.1016/j.str.2018.10.020. No abstract available.


Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.

Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S.

Structure. 2018 Apr 3;26(4):545-554.e4. doi: 10.1016/j.str.2018.01.017. Epub 2018 Mar 1. Erratum in: Structure. 2018 Nov 6;26(11):1563.


Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity.

Loeuillet C, Touquet B, Oury B, Eddaikra N, Pons JL, Guichou JF, Labesse G, Sereno D.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):59-66. doi: 10.1016/j.ijpddr.2018.01.002. Epub 2018 Jan 31.


Correction for Vigneron et al., "Characterization of the Mechanisms Controlling Greatwall Activity".

Vigneron S, Gharbi-Ayachi A, Raymond AA, Burgess A, Labbé JC, Labesse G, Monsarrat B, Lorca T, Castro A.

Mol Cell Biol. 2017 Jun 29;37(14). pii: e00231-17. doi: 10.1128/MCB.00231-17. Print 2017 Jul 15. No abstract available.


8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.

Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S.

Eur J Med Chem. 2016 Nov 29;124:1041-1056. doi: 10.1016/j.ejmech.2016.10.033. Epub 2016 Oct 18.


A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene.

Meunier I, Bocquet B, Labesse G, Zeitz C, Defoort-Dhellemmes S, Lacroux A, Mauget-Faysse M, Drumare I, Gamez AS, Mathieu C, Marquette V, Sagot L, Dhaenens CM, Arndt C, Carroll P, Remy-Jardin M, Cohen SY, Sahel JA, Puech B, Audo I, Mrejen S, Hamel CP.

Sci Rep. 2016 Sep 7;6:32544. doi: 10.1038/srep32544.


A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.

Meunier I, Lenaers G, Bocquet B, Baudoin C, Piro-Megy C, Cubizolle A, Quilès M, Jean-Charles A, Cohen SY, Merle H, Gaudric A, Labesse G, Manes G, Péquignot M, Cazevieille C, Dhaenens CM, Fichard A, Ronkina N, Arthur SJ, Gaestel M, Hamel CP.

Hum Mol Genet. 2016 Mar 1;25(5):916-26. doi: 10.1093/hmg/ddv624. Epub 2016 Jan 6.


Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.

Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1890-9. doi: 10.1107/S1399004715013115. Epub 2015 Aug 25.


Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.

Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1777-87. doi: 10.1107/S1399004715010342. Epub 2015 Jul 31.


Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome.

Vogelmann J, Le Gall A, Dejardin S, Allemand F, Gamot A, Labesse G, Cuvier O, Nègre N, Cohen-Gonsaud M, Margeat E, Nöllmann M.

PLoS Genet. 2014 Aug 28;10(8):e1004544. doi: 10.1371/journal.pgen.1004544. eCollection 2014 Aug.


6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.

Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S.

Eur J Med Chem. 2014 Oct 6;85:418-37. doi: 10.1016/j.ejmech.2014.07.110. Epub 2014 Aug 1.


Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.

Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P.

Nucleic Acids Res. 2014 Sep;42(15):10173-84. doi: 10.1093/nar/gku692. Epub 2014 Jul 26.


Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV.

J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 Jul 10.


The stoichiometry of scaffold complexes in living neurons - DLC2 functions as a dimerization engine for GKAP.

Moutin E, Compan V, Raynaud F, Clerté C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J.

J Cell Sci. 2014 Aug 15;127(Pt 16):3451-62. doi: 10.1242/jcs.145748. Epub 2014 Jun 17.


Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV.

Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. Epub 2014 Mar 3.


N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.

Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA.

PLoS One. 2013 Nov 19;8(11):e80755. doi: 10.1371/journal.pone.0080755. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/c529909c-9d88-4c03-9262-ff5c61b96a36.


Mutations in IMPG1 cause vitelliform macular dystrophies.

Manes G, Meunier I, Avila-Fernández A, Banfi S, Le Meur G, Zanlonghi X, Corton M, Simonelli F, Brabet P, Labesse G, Audo I, Mohand-Said S, Zeitz C, Sahel JA, Weber M, Dollfus H, Dhaenens CM, Allorge D, De Baere E, Koenekoop RK, Kohl S, Cremers FP, Hollyfield JG, Sénéchal A, Hebrard M, Bocquet B, Ayuso García C, Hamel CP.

Am J Hum Genet. 2013 Sep 5;93(3):571-8. doi: 10.1016/j.ajhg.2013.07.018. Epub 2013 Aug 29.


MgATP regulates allostery and fiber formation in IMPDHs.

Labesse G, Alexandre T, Vaupré L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H.

Structure. 2013 Jun 4;21(6):975-85. doi: 10.1016/j.str.2013.03.011. Epub 2013 May 2.


Structure of the oncoprotein Rcl bound to three nucleotide analogues.

Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G.

Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):247-55. doi: 10.1107/S0907444912045039. Epub 2013 Jan 19.


Phosphodeoxyribosyltransferases, designed enzymes for deoxyribonucleotides synthesis.

Kaminski PA, Labesse G.

J Biol Chem. 2013 Mar 1;288(9):6534-41. doi: 10.1074/jbc.M112.446492. Epub 2013 Jan 16.


Fragment and conquer: from structure to complexes to function.

Guichou JF, Labesse G.

Structure. 2012 Oct 10;20(10):1617-9. doi: 10.1016/j.str.2012.09.008.


The C-terminal domain of the virulence factor MgtC is a divergent ACT domain.

Yang Y, Labesse G, Carrère-Kremer S, Esteves K, Kremer L, Cohen-Gonsaud M, Blanc-Potard AB.

J Bacteriol. 2012 Nov;194(22):6255-63. doi: 10.1128/JB.01424-12. Epub 2012 Sep 14.


Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.

Delfosse V, Grimaldi M, Pons JL, Boulahtouf A, le Maire A, Cavailles V, Labesse G, Bourguet W, Balaguer P.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14930-5. doi: 10.1073/pnas.1203574109. Epub 2012 Aug 27.


Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.

Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugué L, Dussurget O, Pochet S, Labesse G.

Structure. 2012 Jun 6;20(6):1107-17. doi: 10.1016/j.str.2012.03.024. Epub 2012 May 17.


In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.

le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G.

Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):747-55. doi: 10.1107/S0907444911023249. Epub 2011 Aug 9.


Interdomain movements in metabotropic glutamate receptor activation.

Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15480-5. doi: 10.1073/pnas.1107775108. Epub 2011 Sep 6.


The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation.

Gazanion E, Garcia D, Silvestre R, Gérard C, Guichou JF, Labesse G, Seveno M, Cordeiro-Da-Silva A, Ouaissi A, Sereno D, Vergnes B.

Mol Microbiol. 2011 Oct;82(1):21-38. doi: 10.1111/j.1365-2958.2011.07799.x. Epub 2011 Sep 1.


Montpellier infectious diseases (MID): 1st annual meeting (2011).

Sitbon M, Biard-Piechaczyk M, Robert V, Briant L, Köhler S, Labesse G, Devaux C.

Infect Genet Evol. 2011 Oct;11(7):1493-8. doi: 10.1016/j.meegid.2011.07.001. Epub 2011 Jul 13. No abstract available.


Characterization of the mechanisms controlling Greatwall activity.

Vigneron S, Gharbi-Ayachi A, Raymond AA, Burgess A, Labbé JC, Labesse G, Monsarrat B, Lorca T, Castro A.

Mol Cell Biol. 2011 Jun;31(11):2262-75. doi: 10.1128/MCB.00753-10. Epub 2011 Mar 28. Erratum in: Mol Cell Biol. 2017 Jun 29;37(14 ):.


Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.

Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H.

Nucleic Acids Res. 2011 Apr;39(8):3458-72. doi: 10.1093/nar/gkq1250. Epub 2010 Dec 10.


Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors.

Yang Y, Padilla A, Zhang C, Labesse G, Kaminski PA.

J Mol Biol. 2009 Dec 4;394(3):435-47. doi: 10.1016/j.jmb.2009.10.004. Epub 2009 Oct 12.


@TOME-2: a new pipeline for comparative modeling of protein-ligand complexes.

Pons JL, Labesse G.

Nucleic Acids Res. 2009 Jul;37(Web Server issue):W485-91. doi: 10.1093/nar/gkp368. Epub 2009 May 13.


A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts.

Diouf B, Collazos A, Labesse G, Macari F, Choquet A, Clair P, Gauthier-Rouvière C, Guérineau NC, Jay P, Hollande F, Joubert D.

J Biol Chem. 2009 Jul 10;284(28):18808-15. doi: 10.1074/jbc.M109.004614. Epub 2009 May 8.


Inhibition of 7,8-diaminopelargonic acid aminotransferase from Mycobacterium tuberculosis by chiral and achiral anologs of its substrate: biological implications.

Mann S, Colliandre L, Labesse G, Ploux O.

Biochimie. 2009 Jul;91(7):826-34. doi: 10.1016/j.biochi.2009.03.019. Epub 2009 Apr 2.


ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.

Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF.

Structure. 2009 Jan 14;17(1):139-46. doi: 10.1016/j.str.2008.11.005.


PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity.

Monnier C, Dodé C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, Rondard P.

Hum Mol Genet. 2009 Jan 1;18(1):75-81. doi: 10.1093/hmg/ddn318. Epub 2008 Sep 29.


Comprehensive 3D-modeling of allergenic proteins and amino acid composition of potential conformational IgE epitopes.

Oezguen N, Zhou B, Negi SS, Ivanciuc O, Schein CH, Labesse G, Braun W.

Mol Immunol. 2008 Aug;45(14):3740-7. doi: 10.1016/j.molimm.2008.05.026. Epub 2008 Jul 14.


Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.

Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu J.

EMBO J. 2008 May 7;27(9):1321-32. doi: 10.1038/emboj.2008.64. Epub 2008 Apr 3.


A phospho-sugar binding domain homologous to NagB enzymes regulates the activity of the central glycolytic genes repressor.

Doan T, Martin L, Zorrilla S, Chaix D, Aymerich S, Labesse G, Declerck N.

Proteins. 2008 Jun;71(4):2038-50. doi: 10.1002/prot.21883.


NAD kinases use substrate-assisted catalysis for specific recognition of NAD.

Poncet-Montange G, Assairi L, Arold S, Pochet S, Labesse G.

J Biol Chem. 2007 Nov 23;282(47):33925-34. Epub 2007 Aug 8.

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