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Items: 15


HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.

Efimova EV, Ricco N, Labay E, Mauceri HJ, Flor AC, Ramamurthy A, Sutton HG, Weichselbaum RR, Kron SJ.

Mol Cancer Ther. 2018 Feb;17(2):407-418. doi: 10.1158/1535-7163.MCT-17-0288. Epub 2017 Oct 13.


Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers.

Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR.

Oncotarget. 2016 Jun 7;7(23):33919-33. doi: 10.18632/oncotarget.8984.


Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.

Efimova EV, Takahashi S, Shamsi NA, Wu D, Labay E, Ulanovskaya OA, Weichselbaum RR, Kozmin SA, Kron SJ.

Mol Cancer Res. 2016 Feb;14(2):173-84. doi: 10.1158/1541-7786.MCR-15-0263. Epub 2015 Nov 4.


Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.

Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR.

PLoS One. 2012;7(10):e46104. doi: 10.1371/journal.pone.0046104. Epub 2012 Oct 4.


Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.

Labay E, Efimova EV, Quarshie BK, Golden DW, Weichselbaum RR, Kron SJ.

Int J High Throughput Screen. 2011 Mar;2:1-13.


Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.

Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR.

Cancer Res. 2010 Aug 1;70(15):6277-82. doi: 10.1158/0008-5472.CAN-09-4224. Epub 2010 Jul 7.


Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.

Efimova EV, Liang H, Pitroda SP, Labay E, Darga TE, Levina V, Lokshin A, Roizman B, Weichselbaum RR, Khodarev NN.

Int J Radiat Biol. 2009 May;85(5):421-31. doi: 10.1080/09553000902838566. Erratum in: Int J Radiat Biol. 2009 Jul;85(7):642.


Extraction and assembly of tissue-derived gels for cell culture and tissue engineering.

Uriel S, Labay E, Francis-Sedlak M, Moya ML, Weichselbaum RR, Ervin N, Cankova Z, Brey EM.

Tissue Eng Part C Methods. 2009 Sep;15(3):309-21. doi: 10.1089/ten.tec.2008.0309.


Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB.

Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE, Garofalo M, Nakamura S, Kufe DW, Posner MC, Weichselbaum RR.

Int J Oncol. 2007 Dec;31(6):1519-28.


Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.

Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR.

Cancer Res. 2007 Oct 1;67(19):9214-20.


Characterization of the theorectical radiation dose enhancement from nanoparticles.

Roeske JC, Nunez L, Hoggarth M, Labay E, Weichselbaum RR.

Technol Cancer Res Treat. 2007 Oct;6(5):395-401.


Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.

Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ.

FEBS Lett. 2004 May 7;565(1-3):167-70.


STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.

Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1714-9. Epub 2004 Jan 30.


Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis.

Khodarev NN, Labay E, Darga T, Yu J, Mauceri H, Gupta N, Kataoka Y, Weichselbaum RR.

Int J Cancer. 2004 Mar 20;109(2):214-9.


Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.

Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR.

J Cell Sci. 2003 Mar 15;116(Pt 6):1013-22.

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