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Items: 6

1.

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.

Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, Mairet-Coello G, Cardenas A, Vanclef F, Laaniste L, Niespodziany I, Keaney J, Gasser J, Gillet G, Shkura K, Chong SA, Behmoaras J, Kadiu I, Petretto E, Kaminski RM, Johnson MR.

Nat Commun. 2018 Sep 3;9(1):3561. doi: 10.1038/s41467-018-06008-4.

2.

A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma.

Yu K, Youshani AS, Wilkinson FL, O'Leary C, Cook P, Laaniste L, Liao A, Mosses D, Waugh C, Shorrock H, Pathmanaban O, Macdonald A, Kamaly-Asl I, Roncaroli F, Bigger BW.

Neuropathol Appl Neurobiol. 2019 Feb;45(2):119-140. doi: 10.1111/nan.12489. Epub 2018 May 17.

PMID:
29679380
3.

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.

Delahaye-Duriez A, Srivastava P, Shkura K, Langley SR, Laaniste L, Moreno-Moral A, Danis B, Mazzuferi M, Foerch P, Gazina EV, Richards K, Petrou S, Kaminski RM, Petretto E, Johnson MR.

Genome Biol. 2016 Dec 13;17(1):245.

4.

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.

Zhang L, Laaniste L, Jiang Y, Alafuzoff I, Uhrbom L, Dimberg A.

Oncotarget. 2016 Dec 6;7(49):80382-80390. doi: 10.18632/oncotarget.12983.

5.

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang L, Kundu S, Feenstra T, Li X, Jin C, Laaniste L, El Hassan TE, Ohlin KE, Yu D, Olofsson T, Olsson AK, Pontén F, Magnusson PU, Nilsson KF, Essand M, Smits A, Dieterich LC, Dimberg A.

Sci Signal. 2015 Dec 8;8(406):ra125. doi: 10.1126/scisignal.aaa1690.

PMID:
26645582
6.

Alterations of bronchial epithelial metabolome by cigarette smoke are reversible by an antioxidant, O-methyl-L-tyrosinyl-γ-L-glutamyl-L-cysteinylglycine.

Aug A, Altraja A, Altraja S, Laaniste L, Mahlapuu R, Soomets U, Kilk K.

Am J Respir Cell Mol Biol. 2014 Oct;51(4):586-94. doi: 10.1165/rcmb.2013-0377OC.

PMID:
24810251

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