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Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex.

Vogel Ciernia A, Laufer BI, Hwang H, Dunaway KW, Mordaunt CE, Coulson RL, Yasui DH, LaSalle JM.

Cereb Cortex. 2019 Jun 26. pii: bhz115. doi: 10.1093/cercor/bhz115. [Epub ahead of print]


Genetics and epigenetic factors of Wilson disease.

Medici V, LaSalle JM.

Ann Transl Med. 2019 Apr;7(Suppl 2):S58. doi: 10.21037/atm.2019.01.67. Review.


Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights.

Laufer BI, Hwang H, Vogel Ciernia A, Mordaunt CE, LaSalle JM.

Epigenetics. 2019 Jul;14(7):672-684. doi: 10.1080/15592294.2019.1609867. Epub 2019 May 6.


Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Zhu Y, Mordaunt CE, Yasui DH, Marathe R, Coulson RL, Dunaway KW, Jianu JM, Walker CK, Ozonoff S, Hertz-Picciotto I, Schmidt RJ, LaSalle JM.

Hum Mol Genet. 2019 Apr 22. pii: ddz084. doi: 10.1093/hmg/ddz084. [Epub ahead of print]


Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.

Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V.

Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z.


UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease.

Lopez SJ, Segal DJ, LaSalle JM.

Front Mol Neurosci. 2019 Jan 4;11:476. doi: 10.3389/fnmol.2018.00476. eCollection 2018. Review.


A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study.

Hertz-Picciotto I, Schmidt RJ, Walker CK, Bennett DH, Oliver M, Shedd-Wise KM, LaSalle JM, Giulivi C, Puschner B, Thomas J, Roa DL, Pessah IN, Van de Water J, Tancredi DJ, Ozonoff S.

Environ Health Perspect. 2018 Nov;126(11):117004. doi: 10.1289/EHP535.


MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome.

Vogel Ciernia A, Yasui DH, Pride MC, Durbin-Johnson B, Noronha AB, Chang A, Knotts TA, Rutkowsky JR, Ramsey JJ, Crawley JN, LaSalle JM.

Hum Mol Genet. 2018 Dec 1;27(23):4077-4093. doi: 10.1093/hmg/ddy301.


Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.

Coulson RL, Powell WT, Yasui DH, Dileep G, Resnick J, LaSalle JM.

Hum Mol Genet. 2018 Dec 1;27(23):4051-4060. doi: 10.1093/hmg/ddy296.


Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease.

Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V.

Hum Mol Genet. 2018 Nov 15;27(22):3854-3869. doi: 10.1093/hmg/ddy262.


Epigenetics of Circadian Rhythms in Imprinted Neurodevelopmental Disorders.

Coulson RL, LaSalle JM.

Prog Mol Biol Transl Sci. 2018;157:67-92. doi: 10.1016/bs.pmbts.2017.11.023. Epub 2018 Apr 12. Review.


Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome.

Adhikari A, Copping NA, Onaga B, Pride MC, Coulson RL, Yang M, Yasui DH, LaSalle JM, Silverman JL.

Neurobiol Learn Mem. 2018 May 23. pii: S1074-7427(18)30119-9. doi: 10.1016/j.nlm.2018.05.011. [Epub ahead of print] Review.


Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex.

Coulson RL, Yasui DH, Dunaway KW, Laufer BI, Vogel Ciernia A, Zhu Y, Mordaunt CE, Totah TS, LaSalle JM.

Nat Commun. 2018 Apr 24;9(1):1616. doi: 10.1038/s41467-018-03676-0.


Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches.

Vogel Ciernia A, Laufer BI, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH.

Epigenetics. 2018;13(3):318-330. doi: 10.1080/15592294.2018.1451720. Epub 2018 May 10.


Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation.

Dou J, Schmidt RJ, Benke KS, Newschaffer C, Hertz-Picciotto I, Croen LA, Iosif AM, LaSalle JM, Fallin MD, Bakulski KM.

Epigenetics. 2018;13(1):108-116. doi: 10.1080/15592294.2017.1417710. Epub 2018 Feb 16.


Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism.

Vogel Ciernia A, Careaga M, LaSalle JM, Ashwood P.

Glia. 2018 Mar;66(3):505-521. doi: 10.1002/glia.23261. Epub 2017 Nov 14.


Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.

Copping NA, Christian SGB, Ritter DJ, Islam MS, Buscher N, Zolkowska D, Pride MC, Berg EL, LaSalle JM, Ellegood J, Lerch JP, Reiter LT, Silverman JL, Dindot SV.

Hum Mol Genet. 2017 Oct 15;26(20):3995-4010. doi: 10.1093/hmg/ddx289.


UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons.

Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal DJ, LaSalle JM.

Epigenetics. 2017;12(11):982-990. doi: 10.1080/15592294.2017.1376151. Epub 2017 Nov 6.


Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.

Schmidt RJ, Schroeder DI, Crary-Dooley FK, Barkoski JM, Tancredi DJ, Walker CK, Ozonoff S, Hertz-Picciotto I, LaSalle JM.

Environ Epigenet. 2016 Dec;2(4). pii: dvw024. doi: 10.1093/eep/dvw024. Epub 2016 Dec 1.


Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.

Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK.

Environ Health Perspect. 2017 Apr;125(4):511-526. doi: 10.1289/EHP595. Epub 2017 Mar 31.


Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.

Vogel Ciernia A, Pride MC, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM.

Hum Mol Genet. 2017 May 15;26(10):1839-1854. doi: 10.1093/hmg/ddx087.


A comparison of existing global DNA methylation assays to low-coverage whole-genome bisulfite sequencing for epidemiological studies.

Crary-Dooley FK, Tam ME, Dunaway KW, Hertz-Picciotto I, Schmidt RJ, LaSalle JM.

Epigenetics. 2017 Mar 4;12(3):206-214. doi: 10.1080/15592294.2016.1276680. Epub 2017 Jan 5.


Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns.

Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM.

Stem Cells. 2017 Apr;35(4):981-988. doi: 10.1002/stem.2563. Epub 2017 Jan 19.


Placental methylome analysis from a prospective autism study.

Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM.

Mol Autism. 2016 Dec 15;7:51. doi: 10.1186/s13229-016-0114-8. eCollection 2016.


Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.

Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM.

Cell Rep. 2016 Dec 13;17(11):3035-3048. doi: 10.1016/j.celrep.2016.11.058.


Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.

Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM.

Epigenetics. 2016 Nov;11(11):804-818. Epub 2016 Sep 9.


Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.

Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC.

Hum Mol Genet. 2016 Aug 1;25(15):3284-3302. doi: 10.1093/hmg/ddw178. Epub 2016 Jun 30.


15q Duplication Syndrome and Related Disorders.

Finucane BM, Lusk L, Arkilo D, Chamberlain S, Devinsky O, Dindot S, Jeste SS, LaSalle JM, Reiter LT, Schanen NC, Spence SJ, Thibert RL, Calvert G, Luchsinger K, Cook EH.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2016 Jun 16.


Sequence features accurately predict genome-wide MeCP2 binding in vivo.

Rube HT, Lee W, Hejna M, Chen H, Yasui DH, Hess JF, LaSalle JM, Song JS, Gong Q.

Nat Commun. 2016 Mar 24;7:11025. doi: 10.1038/ncomms11025.


Autism and Cancer Share Risk Genes, Pathways, and Drug Targets.

Crawley JN, Heyer WD, LaSalle JM.

Trends Genet. 2016 Mar;32(3):139-146. doi: 10.1016/j.tig.2016.01.001. Epub 2016 Jan 29. Review.


Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders.

LaSalle JM, Reiter LT, Chamberlain SJ.

Epigenomics. 2015 Oct;7(7):1213-28. doi: 10.2217/epi.15.70. Epub 2015 Nov 20. Review.


Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas.

Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM.

PLoS Genet. 2015 Aug 4;11(8):e1005442. doi: 10.1371/journal.pgen.1005442. eCollection 2015 Aug.


Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment.

Powell WT, LaSalle JM.

Hum Mol Genet. 2015 Oct 15;24(R1):R1-9. doi: 10.1093/hmg/ddv234. Epub 2015 Jun 23. Review.


Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity.

Li MM, Addepalli B, Tu MJ, Chen QX, Wang WP, Limbach PA, LaSalle JM, Zeng S, Huang M, Yu AM.

Drug Metab Dispos. 2015 Jul;43(7):1129-36. doi: 10.1124/dmd.115.064493. Epub 2015 May 1.


MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons.

Lee W, Yun JM, Woods R, Dunaway K, Yasui DH, Lasalle JM, Gong Q.

Hum Mol Genet. 2014 Dec 1;23(23):6366-74. doi: 10.1093/hmg/ddu358. Epub 2014 Jul 9.


Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease.

Le A, Shibata NM, French SW, Kim K, Kharbanda KK, Islam MS, LaSalle JM, Halsted CH, Keen CL, Medici V.

Int J Mol Sci. 2014 May 7;15(5):8004-23. doi: 10.3390/ijms15058004.


Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.

Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME.

Front Immunol. 2014 Mar 28;5:128. doi: 10.3389/fimmu.2014.00128. eCollection 2014. Erratum in: Front Immunol. 2014;5:371. Seldin, Michael F [added].


Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.

Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH.

Alcohol Clin Exp Res. 2014 Jun;38(6):1540-9. doi: 10.1111/acer.12405. Epub 2014 Apr 14.


Autism genes keep turning up chromatin.

Lasalle JM.

OA Autism. 2013 Jun 19;1(2):14.


Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.

Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Carolyn Schanen N, Olson CO, Rastegar M, Lasalle JM.

Hum Mol Genet. 2014 May 1;23(9):2447-58. doi: 10.1093/hmg/ddt640. Epub 2013 Dec 18. Erratum in: Hum Mol Genet. 2014 Dec 15;23(24):6695.


How has the study of the human placenta aided our understanding of partially methylated genes?

Schroeder DI, LaSalle JM.

Epigenomics. 2013 Dec;5(6):645-54. doi: 10.2217/epi.13.62.


Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease.

Medici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JM.

Epigenetics. 2014 Feb;9(2):286-96. doi: 10.4161/epi.27110. Epub 2013 Nov 12.


R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.

Powell WT, Coulson RL, Gonzales ML, Crary FK, Wong SS, Adams S, Ach RA, Tsang P, Yamada NA, Yasui DH, Chédin F, LaSalle JM.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13938-43. doi: 10.1073/pnas.1305426110. Epub 2013 Aug 5.


A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure.

Powell WT, Coulson RL, Crary FK, Wong SS, Ach RA, Tsang P, Alice Yamada N, Yasui DH, Lasalle JM.

Hum Mol Genet. 2013 Nov 1;22(21):4318-28. doi: 10.1093/hmg/ddt281. Epub 2013 Jun 13.


Epigenetic layers and players underlying neurodevelopment.

LaSalle JM, Powell WT, Yasui DH.

Trends Neurosci. 2013 Aug;36(8):460-70. doi: 10.1016/j.tins.2013.05.001. Epub 2013 May 31. Review.


Epigenomic strategies at the interface of genetic and environmental risk factors for autism.

LaSalle JM.

J Hum Genet. 2013 Jul;58(7):396-401. doi: 10.1038/jhg.2013.49. Epub 2013 May 16. Review.


The human placenta methylome.

Schroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, LaSalle JM.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6037-42. doi: 10.1073/pnas.1215145110. Epub 2013 Mar 25.


MeCP2 modulates gene expression pathways in astrocytes.

Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I.

Mol Autism. 2013 Jan 25;4(1):3. doi: 10.1186/2040-2392-4-3.


Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.

Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH.

Hepatology. 2013 Feb;57(2):555-65. doi: 10.1002/hep.26047. Epub 2013 Jan 10.


Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder.

Mitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM.

Environ Mol Mutagen. 2012 Oct;53(8):589-98. doi: 10.1002/em.21722. Epub 2012 Aug 29.

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