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Items: 20

1.

A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish.

Varshney GK, Carrington B, Pei W, Bishop K, Chen Z, Fan C, Xu L, Jones M, LaFave MC, Ledin J, Sood R, Burgess SM.

Nat Protoc. 2016 Dec;11(12):2357-2375. doi: 10.1038/nprot.2016.141. Epub 2016 Oct 27.

2.

Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?

Chandler RJ, LaFave MC, Varshney GK, Burgess SM, Venditti CP.

Mol Ther. 2016 Feb;24(2):198-201. doi: 10.1038/mt.2016.17. No abstract available.

3.

Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility.

Vrljicak P, Tao S, Varshney GK, Quach HN, Joshi A, LaFave MC, Burgess SM, Sampath K.

G3 (Bethesda). 2016 Apr 7;6(4):805-17. doi: 10.1534/g3.115.026849.

4.

A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies.

Marquart GD, Tabor KM, Brown M, Strykowski JL, Varshney GK, LaFave MC, Mueller T, Burgess SM, Higashijima S, Burgess HA.

Front Neural Circuits. 2015 Nov 24;9:78. doi: 10.3389/fncir.2015.00078. eCollection 2015.

5.

Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa.

van Belkum A, Soriaga LB, LaFave MC, Akella S, Veyrieras JB, Barbu EM, Shortridge D, Blanc B, Hannum G, Zambardi G, Miller K, Enright MC, Mugnier N, Brami D, Schicklin S, Felderman M, Schwartz AS, Richardson TH, Peterson TC, Hubby B, Cady KC.

MBio. 2015 Nov 24;6(6):e01796-15. doi: 10.1128/mBio.01796-15.

6.

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J.

PLoS One. 2015 Jul 10;10(7):e0131908. doi: 10.1371/journal.pone.0131908. eCollection 2015.

7.

GeIST: a pipeline for mapping integrated DNA elements.

LaFave MC, Varshney GK, Burgess SM.

Bioinformatics. 2015 Oct 1;31(19):3219-21. doi: 10.1093/bioinformatics/btv350. Epub 2015 Jun 6.

8.

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.

Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM.

Genome Res. 2015 Jul;25(7):1030-42. doi: 10.1101/gr.186379.114. Epub 2015 Jun 5.

9.

Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs.

Yin L, Maddison LA, Li M, Kara N, LaFave MC, Varshney GK, Burgess SM, Patton JG, Chen W.

Genetics. 2015 Jun;200(2):431-41. doi: 10.1534/genetics.115.176917. Epub 2015 Apr 8.

10.

A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish.

Quach HN, Tao S, Vrljicak P, Joshi A, Ruan H, Sukumaran R, Varshney GK, LaFave MC; Ds Screen Team, Burgess SM, Winkler C, Emelyanov A, Parinov S, Sampath K.

G3 (Bethesda). 2015 Apr 2;5(6):1283-99. doi: 10.1534/g3.114.015842.

11.

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.

Chandler RJ, LaFave MC, Varshney GK, Trivedi NS, Carrillo-Carrasco N, Senac JS, Wu W, Hoffmann V, Elkahloun AG, Burgess SM, Venditti CP.

J Clin Invest. 2015 Feb;125(2):870-80. doi: 10.1172/JCI79213. Epub 2015 Jan 20.

12.

Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates.

Walia JS, Altaleb N, Bello A, Kruck C, LaFave MC, Varshney GK, Burgess SM, Chowdhury B, Hurlbut D, Hemming R, Kobinger GP, Triggs-Raine B.

Mol Ther. 2015 Mar;23(3):414-22. doi: 10.1038/mt.2014.240. Epub 2014 Dec 17.

13.

trieFinder: an efficient program for annotating Digital Gene Expression (DGE) tags.

Renaud G, LaFave MC, Liang J, Wolfsberg TG, Burgess SM.

BMC Bioinformatics. 2014 Oct 13;15:329. doi: 10.1186/1471-2105-15-329.

14.

A defined zebrafish line for high-throughput genetics and genomics: NHGRI-1.

LaFave MC, Varshney GK, Vemulapalli M, Mullikin JC, Burgess SM.

Genetics. 2014 Sep;198(1):167-70. doi: 10.1534/genetics.114.166769. Epub 2014 Jul 9.

15.

MLV integration site selection is driven by strong enhancers and active promoters.

LaFave MC, Varshney GK, Gildea DE, Wolfsberg TG, Baxevanis AD, Burgess SM.

Nucleic Acids Res. 2014 Apr;42(7):4257-69. doi: 10.1093/nar/gkt1399. Epub 2014 Jan 23.

16.

Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila.

LaFave MC, Andersen SL, Stoffregen EP, Holsclaw JK, Kohl KP, Overton LJ, Sekelsky J.

Genetics. 2014 Jan;196(1):107-18. doi: 10.1534/genetics.113.158618. Epub 2013 Oct 30.

17.

Transcription initiation from within P elements generates hypomorphic mutations in Drosophila melanogaster.

LaFave MC, Sekelsky J.

Genetics. 2011 Jul;188(3):749-52. doi: 10.1534/genetics.111.129825. Epub 2011 Apr 28.

18.

DNA damage responses in Drosophila nbs mutants with reduced or altered NBS function.

Mukherjee S, LaFave MC, Sekelsky J.

DNA Repair (Amst). 2009 Jul 4;8(7):803-12. doi: 10.1016/j.dnarep.2009.03.004. Epub 2009 Apr 22.

19.

Mitotic recombination: why? when? how? where?

LaFave MC, Sekelsky J.

PLoS Genet. 2009 Mar;5(3):e1000411. doi: 10.1371/journal.pgen.1000411. Epub 2009 Mar 13. Review. No abstract available.

20.

Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters.

Burket CT, Montgomery JE, Thummel R, Kassen SC, LaFave MC, Langenau DM, Zon LI, Hyde DR.

Transgenic Res. 2008 Apr;17(2):265-79. Epub 2007 Oct 30.

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