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Mendelian randomization with multiple exposures: the importance of thinking about time.

Labrecque JA, Swanson SA.

Int J Epidemiol. 2019 Dec 4. pii: dyz234. doi: 10.1093/ije/dyz234. [Epub ahead of print] No abstract available.


Application of the Instrumental Inequalities to a Mendelian Randomization Study With Multiple Proposed Instruments.

Diemer EW, Labrecque J, Tiemeier H, Swanson SA.

Epidemiology. 2020 Jan;31(1):65-74. doi: 10.1097/EDE.0000000000001126.


Application of the instrumental inequalities to a Mendelian randomization study with multiple proposed instruments.

Diemer EW, Labrecque J, Tiemeier H, Swanson SA.

Epidemiology. 2019 Oct 17. doi: 10.1097/EDE.0000000000001126. [Epub ahead of print]


Application of the instrumental inequalities to a Mendelian randomization study with multiple proposed instruments.

Diemer EW, Labrecque J, Tiemeier H, Swanson SA.

Epidemiology. 2019 Oct 17. doi: 10.1097/EDE.0000000000001126. [Epub ahead of print]


Associations of physical activity and screen time with white matter microstructure in children from the general population.

Rodriguez-Ayllon M, Derks IPM, van den Dries MA, Esteban-Cornejo I, Labrecque JA, Yang-Huang J, Raat H, Vernooij MW, White T, Ortega FB, Tiemeier H, Muetzel RL.

Neuroimage. 2019 Oct 9;205:116258. doi: 10.1016/j.neuroimage.2019.116258. [Epub ahead of print]


Health profile differences between recipients and non-recipients of the Brazilian Income Transfer Program in a low-income population.

Labrecque JA, Kaufman JS.

Cad Saude Publica. 2019 Jul 4;35(6):e00141218. doi: 10.1590/0102-311X00141218.


Saving Mothers, Giving Life: It Takes a System to Save a Mother (Republication).

Conlon CM, Serbanescu F, Marum L, Healey J, LaBrecque J, Hobson R, Levitt M, Kekitiinwa A, Picho B, Soud F, Spigel L, Steffen M, Velasco J, Cohen R, Weiss W.

Glob Health Sci Pract. 2019 Mar 29;7(1):20-40. doi: 10.9745/GHSP-D-19-00092. Print 2019 Mar 22.


Addressing the Third Delay in Saving Mothers, Giving Life Districts in Uganda and Zambia: Ensuring Adequate and Appropriate Facility-Based Maternal and Perinatal Health Care.

Morof D, Serbanescu F, Goodwin MM, Hamer DH, Asiimwe AR, Hamomba L, Musumali M, Binzen S, Kekitiinwa A, Picho B, Kaharuza F, Namukanja PM, Murokora D, Kamara V, Dynes M, Blanton C, Nalutaaya A, Luwaga F, Schmitz MM, LaBrecque J, Conlon CM, McCarthy B, Kroelinger C, Clark T.

Glob Health Sci Pract. 2019 Mar 13;7(Suppl 1):S85-S103. doi: 10.9745/GHSP-D-18-00272. Print 2019 Mar 11.


Saving Mothers, Giving Life: It Takes a System to Save a Mother.

Conlon CM, Serbanescu F, Marum L, Healey J, LaBrecque J, Hobson R, Levitt M, Kekitiinwa A, Picho B, Soud F, Spigel L, Steffen M, Velasco J, Cohen R, Weiss W.

Glob Health Sci Pract. 2019 Mar 13;7(Suppl 1):S6-S26. doi: 10.9745/GHSP-D-18-00427. Print 2019 Mar 11.


Interleukin-1β and prostaglandin-synthesizing enzymes as modulators of human omental and subcutaneous adipose tissue function.

Labrecque J, Michaud A, Gauthier MF, Pelletier M, Julien F, Bouvet-Bouchard L, Tchernof A.

Prostaglandins Leukot Essent Fatty Acids. 2019 Feb;141:9-16. doi: 10.1016/j.plefa.2018.11.015. Epub 2018 Nov 29.


The Impact of Parental and Medical Leave Policies on Socioeconomic and Health Outcomes in OECD Countries: A Systematic Review of the Empirical Literature.

Nandi A, Jahagirdar D, Dimitris MC, Labrecque JA, Strumpf EC, Kaufman JS, Vincent I, Atabay E, Harper S, Earle A, Heymann SJ.

Milbank Q. 2018 Sep;96(3):434-471. doi: 10.1111/1468-0009.12340. Review.


Validation of two Amanita species from eastern North America: A.rhacopus sp. nov. and A.variicolor sp. nov.

Lambert H, Fortin G, Labbé R, Labrecque J, Bérubé JA, Landry J, Ilyukhin E, Margaritescu S, Moncalvo JM, Lamoureux Y.

MycoKeys. 2018 Aug 14;(38):47-57. doi: 10.3897/mycokeys.38.27041. eCollection 2018.


Interpretation and Potential Biases of Mendelian Randomization Estimates With Time-Varying Exposures.

Labrecque JA, Swanson SA.

Am J Epidemiol. 2019 Jan 1;188(1):231-238. doi: 10.1093/aje/kwy204.


Understanding the Assumptions Underlying Instrumental Variable Analyses: a Brief Review of Falsification Strategies and Related Tools.

Labrecque J, Swanson SA.

Curr Epidemiol Rep. 2018;5(3):214-220. doi: 10.1007/s40471-018-0152-1. Epub 2018 Jun 22. Review.


Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates.

Burgess S, Labrecque JA.

Eur J Epidemiol. 2018 Oct;33(10):947-952. doi: 10.1007/s10654-018-0424-6. Epub 2018 Jul 23.


Effect of a conditional cash transfer program on length-for-age and weight-for-age in Brazilian infants at 24 months using doubly-robust, targeted estimation.

Labrecque JA, Kaufman JS, Balzer LB, Maclehose RF, Strumpf EC, Matijasevich A, Santos IS, Schmidt KH, Barros AJD.

Soc Sci Med. 2018 Aug;211:9-15. doi: 10.1016/j.socscimed.2018.05.040. Epub 2018 May 24.


Causal null hypotheses of sustained treatment strategies: What can be tested with an instrumental variable?

Swanson SA, Labrecque J, Hernán MA.

Eur J Epidemiol. 2018 Aug;33(8):723-728. doi: 10.1007/s10654-018-0396-6. Epub 2018 May 2. Review.


Crystal and electronic structure of a hexacarbonyldiiron cluster tethered to naphthalene-2-thiolate ligands.

Mebi C, Gerasimchuk N, Labrecque J.

Acta Crystallogr C Struct Chem. 2018 Feb 1;74(Pt 2):224-228. doi: 10.1107/S2053229618000712. Epub 2018 Jan 23.


Target trial emulation: teaching epidemiology and beyond.

Labrecque JA, Swanson SA.

Eur J Epidemiol. 2017 Jun;32(6):473-475. doi: 10.1007/s10654-017-0293-4. Epub 2017 Aug 2. No abstract available.


Malignancy in Pediatric-onset Systemic Lupus Erythematosus.

Bernatsky S, Clarke AE, Zahedi Niaki O, Labrecque J, Schanberg LE, Silverman ED, Hayward K, Imundo L, Brunner HI, Haines KA, Cron RQ, Oen K, Wagner-Weiner L, Rosenberg AM, O'Neil KM, Duffy CM, von Scheven E, Joseph L, Lee JL, Ramsey-Goldman R.

J Rheumatol. 2017 Oct;44(10):1484-1486. doi: 10.3899/jrheum.170179. Epub 2017 Aug 1.


Reduction in Costs after Treating Comorbid Panic Disorder with Agoraphobia and Generalized Anxiety Disorder.

Ikic V, Belanger C, Bouchard S, Gosselin P, Langlois F, Labrecque J, Dugas MJ, Marchand A.

J Ment Health Policy Econ. 2017 Mar 1;20(1):11-20.


Focus and coverage of Bolsa Família Program in the Pelotas 2004 birth cohort.

Schmidt KH, Labrecque J, Santos IS, Matijasevich A, Barros FC, Barros AJ.

Rev Saude Publica. 2017 Mar 30;51(0):22. doi: 10.1590/S1518-8787.2017051006792. English, Portuguese.


Impact of Bariatric Surgery on White Adipose Tissue Inflammation.

Labrecque J, Laforest S, Michaud A, Biertho L, Tchernof A.

Can J Diabetes. 2017 Aug;41(4):407-417. doi: 10.1016/j.jcjd.2016.12.003. Epub 2017 Mar 29. Review.


Health-selective migration among patients with rheumatoid arthritis in Québec: a cohort study using administrative data.

Labrecque JA, Kyle RP, Joseph L, Bernatsky S.

Rheumatol Int. 2016 Sep;36(9):1275-9. doi: 10.1007/s00296-016-3540-1. Epub 2016 Jul 26.


Malignancy incidence in 5294 patients with juvenile arthritis.

Zahedi Niaki O, Clarke AE, Ramsey-Goldman R, Yeung R, Hayward K, Oen K, Duffy CM, Rosenberg A, O'Neil KM, von Scheven E, Schanberg L, Labrecque J, Tse SM, Hasija R, Lee JL, Bernatsky S.

RMD Open. 2016 May 2;2(1):e000212. doi: 10.1136/rmdopen-2015-000212. eCollection 2016.


Commentary: Can a Quasi-experimental Design Be a Better Idea than an Experimental One?

Labrecque JA, Kaufman JS.

Epidemiology. 2016 Jul;27(4):500-2. doi: 10.1097/EDE.0000000000000485. No abstract available.


Insomnia Symptoms Following Treatment for Comorbid Panic Disorder With Agoraphobia and Generalized Anxiety Disorder.

Cousineau H, Marchand A, Bouchard S, Bélanger C, Gosselin P, Langlois F, Labrecque J, Dugas MJ, Belleville G.

J Nerv Ment Dis. 2016 Apr;204(4):267-73. doi: 10.1097/NMD.0000000000000466.


Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction.

Laforest S, Labrecque J, Michaud A, Cianflone K, Tchernof A.

Crit Rev Clin Lab Sci. 2015;52(6):301-13. doi: 10.3109/10408363.2015.1041582. Epub 2015 Aug 17. Review.


Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue: ROLE OF ILE198.

Lau G, Labrecque J, Metz M, Vaz R, Fricker SP.

J Biol Chem. 2015 Apr 24;290(17):11041-51. doi: 10.1074/jbc.M115.640169. Epub 2015 Mar 12.


What measures of habit strength to use? Comment on Gardner (2015).

Labrecque JS, Wood W.

Health Psychol Rev. 2015;9(3):303-10. doi: 10.1080/17437199.2014.992030. Epub 2015 Apr 17. No abstract available.


Multiple paternity is a shared reproductive strategy in the live-bearing surfperches (Embiotocidae) that may be associated with female fitness.

LaBrecque JR, Alva-Campbell YR, Archambeault S, Crow KD.

Ecol Evol. 2014 Jun;4(12):2316-29. doi: 10.1002/ece3.1071. Epub 2014 May 12.


Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists.

Laliberté S, Vallée F, Fournier PA, Bedard L, Labrecque J, Albert JS.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3204-6. doi: 10.1016/j.bmcl.2014.05.013. Epub 2014 May 16.


Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists.

Hu YJ, St-Onge M, Laliberté S, Vallée F, Jin S, Bedard L, Labrecque J, Albert JS.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3199-203. doi: 10.1016/j.bmcl.2014.04.045. Epub 2014 Apr 19.


Cancer risk in childhood-onset systemic lupus.

Bernatsky S, Clarke AE, Labrecque J, von Scheven E, Schanberg LE, Silverman ED, Brunner HI, Haines KA, Cron RQ, O'Neil KM, Oen K, Rosenberg AM, Duffy CM, Joseph L, Lee JL, Kale M, Turnbull EM, Ramsey-Goldman R.

Arthritis Res Ther. 2013;15(6):R198.


The effect of a combined versus a conventional cognitive-behavioral therapy on quality of life for comorbid panic disorder with agoraphobia and generalized anxiety disorder: preliminary results.

Primiano S, Marchand A, Gosselin P, Langlois F, Bouchard S, Bélanger C, Labrecque J, Dugas M, Dupuis G.

Behav Modif. 2014 Jan;38(1):3-24. doi: 10.1177/0145445513504430. Epub 2013 Sep 24.


RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.

Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang T.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13522-7. doi: 10.1073/pnas.1310067110. Epub 2013 Jul 29.


Breast cancer in systemic lupus erythematosus.

Tessier Cloutier B, Clarke AE, Ramsey-Goldman R, Wang Y, Foulkes W, Gordon C, Hansen JE, Yelin E, Urowitz MB, Gladman D, Fortin PR, Wallace DJ, Petri M, Manzi S, Ginzler EM, Labrecque J, Edworthy S, Dooley MA, Senécal JL, Peschken CA, Bae SC, Isenberg D, Rahman A, Ruiz-Irastorza G, Hanly JG, Jacobsen S, Nived O, Witte T, Criswell LA, Barr SG, Dreyer L, Sturfelt G, Bernatsky S.

Oncology. 2013;85(2):117-21. doi: 10.1159/000353138. Epub 2013 Jul 25.


Efficacy of two cognitive-behavioral treatment modalities for panic disorder with nocturnal panic attacks.

Marchand L, Marchand A, Landry P, Letarte A, Labrecque J.

Behav Modif. 2013 Sep;37(5):680-704. doi: 10.1177/0145445513492792. Epub 2013 Jul 2.


Systematic review and critical appraisal of validation studies to identify rheumatic diseases in health administrative databases.

Widdifield J, Labrecque J, Lix L, Paterson JM, Bernatsky S, Tu K, Ivers N, Bombardier C.

Arthritis Care Res (Hoboken). 2013 Sep;65(9):1490-503. doi: 10.1002/acr.21993. Review.


Cancer risk in systemic lupus: an updated international multi-centre cohort study.

Bernatsky S, Ramsey-Goldman R, Labrecque J, Joseph L, Boivin JF, Petri M, Zoma A, Manzi S, Urowitz MB, Gladman D, Fortin PR, Ginzler E, Yelin E, Bae SC, Wallace DJ, Edworthy S, Jacobsen S, Gordon C, Dooley MA, Peschken CA, Hanly JG, Alarcón GS, Nived O, Ruiz-Irastorza G, Isenberg D, Rahman A, Witte T, Aranow C, Kamen DL, Steinsson K, Askanase A, Barr S, Criswell LA, Sturfelt G, Patel NM, Senécal JL, Zummer M, Pope JE, Ensworth S, El-Gabalawy H, McCarthy T, Dreyer L, Sibley J, St Pierre Y, Clarke AE.

J Autoimmun. 2013 May;42:130-5. doi: 10.1016/j.jaut.2012.12.009. Epub 2013 Feb 12.


Novel methodology to identify TRPV1 antagonists independent of capsaicin activation.

Zicha S, Radresa O, Laplante P, Morton M, Jones K, Main M, Trivedi S, Julien RP, Griffin A, Labrecque J, Ahmad S, Brown W.

J Biomol Screen. 2013 Jun;18(5):544-55. doi: 10.1177/1087057112470563. Epub 2012 Dec 20.


Prevalence of autoimmune inflammatory myopathy in the first nations population of Alberta, Canada.

Barnabe C, Joseph L, Bélisle P, Labrecque J, Barr SG, Fritzler MJ, Svenson LW, Peschken CA, Hemmelgarn B, Bernatsky S.

Arthritis Care Res (Hoboken). 2012 Nov;64(11):1715-9. doi: 10.1002/acr.21743.


Discovery of P2X3 selective antagonists for the treatment of chronic pain.

Cantin LD, Bayrakdarian M, Buon C, Grazzini E, Hu YJ, Labrecque J, Leung C, Luo X, Martino G, Paré M, Payza K, Popovic N, Projean D, Santhakumar V, Walpole C, Yu XH, Tomaszewski MJ.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2565-71. doi: 10.1016/j.bmcl.2012.01.124. Epub 2012 Feb 9.


The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.

Mosi RM, Anastassova V, Cox J, Darkes MC, Idzan SR, Labrecque J, Lau G, Nelson KL, Patel K, Santucci Z, Wong RS, Skerlj RT, Bridger GJ, Huskens D, Schols D, Fricker SP.

Biochem Pharmacol. 2012 Feb 15;83(4):472-9. doi: 10.1016/j.bcp.2011.11.020. Epub 2011 Nov 28.


A population-based assessment of live births in women with systemic lupus erythematosus.

Vinet E, Labrecque J, Pineau CA, Clarke AE, St-Pierre Y, Platt R, Bernatsky S.

Ann Rheum Dis. 2012 Apr;71(4):557-9. doi: 10.1136/annrheumdis-2011-200276. Epub 2011 Nov 14.


Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada.

Barnabe C, Joseph L, Belisle P, Labrecque J, Edworthy S, Barr SG, Fritzler M, Svenson LW, Hemmelgarn B, Bernatsky S.

Arthritis Care Res (Hoboken). 2012 Jan;64(1):138-43. doi: 10.1002/acr.20656.


Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.

Metz M, Bourque E, Labrecque J, Danthi SJ, Langille J, Harwig C, Yang W, Darkes MC, Lau G, Santucci Z, Bridger GJ, Schols D, Fricker SP, Skerlj RT.

J Am Chem Soc. 2011 Oct 19;133(41):16477-85. doi: 10.1021/ja2043722. Epub 2011 Sep 23.


Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.

Skerlj R, Bridger G, Zhou Y, Bourque E, Langille J, Di Fluri M, Bogucki D, Yang W, Li T, Wang L, Nan S, Baird I, Metz M, Darkes M, Labrecque J, Lau G, Fricker S, Huskens D, Schols D.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2450-5. doi: 10.1016/j.bmcl.2011.02.058. Epub 2011 Feb 23.


HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay.

Labrecque J, Metz M, Lau G, Darkes MC, Wong RS, Bogucki D, Carpenter B, Chen G, Li T, Nan S, Schols D, Bridger GJ, Fricker SP, Skerlj RT.

Virology. 2011 May 10;413(2):231-43. doi: 10.1016/j.virol.2011.02.016. Epub 2011 Mar 9.


Malignancies in juvenile idiopathic arthritis: a preliminary report.

Bernatsky S, Rosenberg AM, Oen KG, Duffy CM, Ramsey-Goldman R, Labrecque J, St Pierre Y, Clarke AE.

J Rheumatol. 2011 Apr;38(4):760-3. doi: 10.3899/jrheum.100711. Epub 2011 Jan 15.


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