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Items: 1 to 50 of 140

1.

Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis.

Coutts AS, Munro S, La Thangue NB.

Cell Death Dis. 2018 May 1;9(5):577. doi: 10.1038/s41419-018-0529-6.

2.

Linking H1 with chromatin and growth control.

Munro S, La Thangue NB.

Mol Cell Oncol. 2017 Sep 21;4(6):e1360977. doi: 10.1080/23723556.2017.1360977. eCollection 2017.

3.

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.

Carr SM, Munro S, Sagum CA, Fedorov O, Bedford MT, La Thangue NB.

Cell Death Differ. 2017 Dec;24(12):2139-2149. doi: 10.1038/cdd.2017.135. Epub 2017 Aug 25.

4.

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.

Munro S, Hookway ES, Floderer M, Carr SM, Konietzny R, Kessler BM, Oppermann U, La Thangue NB.

Cell Rep. 2017 Jun 13;19(11):2193-2201. doi: 10.1016/j.celrep.2017.05.053.

5.

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, Fedorov O, Munro S, England KS, Nowak RP, Schofield CJ, La Thangue NB, Pawlyn C, Davies F, Morgan G, Athanasou N, Müller S, Oppermann U, Brennan PE.

Cell Chem Biol. 2017 Mar 16;24(3):371-380. doi: 10.1016/j.chembiol.2017.02.006. Epub 2017 Mar 2.

6.

CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.

Olzscha H, Fedorov O, Kessler BM, Knapp S, La Thangue NB.

Cell Chem Biol. 2017 Jan 19;24(1):9-23. doi: 10.1016/j.chembiol.2016.11.009. Epub 2016 Dec 15.

7.

TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism.

New M, Sheikh S, Bekheet M, Olzscha H, Thezenas ML, Care MA, Fotheringham S, Tooze RM, Kessler B, La Thangue NB.

Cancer Res. 2016 Dec 1;76(23):6975-6987. Epub 2016 Oct 12.

8.

HDAC Inhibitors.

Olzscha H, Bekheet ME, Sheikh S, La Thangue NB.

Methods Mol Biol. 2016;1436:281-303. doi: 10.1007/978-1-4939-3667-0_19.

PMID:
27246222
9.

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Kawalkowska J, Quirke AM, Ghari F, Davis S, Subramanian V, Thompson PR, Williams RO, Fischer R, La Thangue NB, Venables PJ.

Sci Rep. 2016 May 23;6:26430. doi: 10.1038/srep26430.

10.

Regulation of actin nucleation and autophagosome formation.

Coutts AS, La Thangue NB.

Cell Mol Life Sci. 2016 Sep;73(17):3249-63. doi: 10.1007/s00018-016-2224-z. Epub 2016 May 4. Review.

11.

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB.

Sci Adv. 2016 Feb 5;2(2):e1501257. doi: 10.1126/sciadv.1501257. eCollection 2016 Feb.

12.

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC.

Cancer Cell. 2015 Nov 9;28(5):557-568. doi: 10.1016/j.ccell.2015.09.015.

13.

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S.

Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9.

14.

Post-translational control of transcription factors: methylation ranks highly.

Carr SM, Poppy Roworth A, Chan C, La Thangue NB.

FEBS J. 2015 Dec;282(23):4450-65. doi: 10.1111/febs.13524. Epub 2015 Oct 16. Review.

15.

Actin nucleation by WH2 domains at the autophagosome.

Coutts AS, La Thangue NB.

Nat Commun. 2015 Jul 30;6:7888. doi: 10.1038/ncomms8888.

16.

Deacetylation of chromatin and gene expression regulation: a new target for epigenetic therapy.

Olzscha H, Sheikh S, La Thangue NB.

Crit Rev Oncog. 2015;20(1-2):1-17. Review.

PMID:
25746101
17.

To live or let die - complexity within the E2F1 pathway.

Poppy Roworth A, Ghari F, La Thangue NB.

Mol Cell Oncol. 2015 Jan 30;2(1):e970480. doi: 10.4161/23723548.2014.970480. eCollection 2015 Jan-Mar. Review.

18.

Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

Maniam S, Coutts AS, Stratford MR, McGouran J, Kessler B, La Thangue NB.

Cell Death Differ. 2015 Jan;22(1):156-63. doi: 10.1038/cdd.2014.135. Epub 2014 Aug 29.

19.

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

Carr SM, Munro S, Zalmas LP, Fedorov O, Johansson C, Krojer T, Sagum CA, Bedford MT, Oppermann U, La Thangue NB.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11341-6. doi: 10.1073/pnas.1403737111. Epub 2014 Jul 21.

20.

SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability.

Pfister SX, Ahrabi S, Zalmas LP, Sarkar S, Aymard F, Bachrati CZ, Helleday T, Legube G, La Thangue NB, Porter AC, Humphrey TC.

Cell Rep. 2014 Jun 26;7(6):2006-18. doi: 10.1016/j.celrep.2014.05.026. Epub 2014 Jun 12.

21.

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.

Zheng S, Moehlenbrink J, Lu YC, Zalmas LP, Sagum CA, Carr S, McGouran JF, Alexander L, Fedorov O, Munro S, Kessler B, Bedford MT, Yu Q, La Thangue NB.

Mol Cell. 2013 Oct 10;52(1):37-51. doi: 10.1016/j.molcel.2013.08.039. Epub 2013 Sep 26.

22.

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.

Zalmas LP, Coutts AS, Helleday T, La Thangue NB.

Cell Cycle. 2013 Sep 15;12(18):3037-51. doi: 10.4161/cc.26078. Epub 2013 Aug 20.

23.

Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.

Munro S, Oppermann U, La Thangue NB.

Oncogene. 2014 Jul 3;33(27):3594-603. doi: 10.1038/onc.2013.316. Epub 2013 Aug 12.

PMID:
23934193
24.

A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.

New M, Olzscha H, Liu G, Khan O, Stimson L, McGouran J, Kerr D, Coutts A, Kessler B, Middleton M, La Thangue NB.

Cell Death Differ. 2013 Oct;20(10):1306-16. doi: 10.1038/cdd.2013.47. Epub 2013 May 24.

25.

HDAC inhibitor-based therapies: can we interpret the code?

New M, Olzscha H, La Thangue NB.

Mol Oncol. 2012 Dec;6(6):637-56. doi: 10.1016/j.molonc.2012.09.003. Epub 2012 Oct 23. Review.

26.

Actin nucleators in the nucleus: an emerging theme.

Weston L, Coutts AS, La Thangue NB.

J Cell Sci. 2012 Aug 1;125(Pt 15):3519-27. Epub 2012 Aug 30. Review.

27.

T-ARG-eting E2F-1 growth control.

Moehlenbrink J, La Thangue NB.

Cell Cycle. 2012 Aug 15;11(16):2973-4. doi: 10.4161/cc.21467. Epub 2012 Aug 8. No abstract available.

28.

NEDDylation regulates E2F-1-dependent transcription.

Loftus SJ, Liu G, Carr SM, Munro S, La Thangue NB.

EMBO Rep. 2012 Sep;13(9):811-8. doi: 10.1038/embor.2012.113. Epub 2012 Jul 27.

29.

Lysine methylation and the regulation of p53.

Carr SM, Munro S, La Thangue NB.

Essays Biochem. 2012;52:79-92. doi: 10.1042/bse0520079. Review.

PMID:
22708565
30.

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.

Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. doi: 10.1073/pnas.1113731109. Epub 2012 Feb 23.

31.

Diversity within the pRb pathway: is there a code of conduct?

Munro S, Carr SM, La Thangue NB.

Oncogene. 2012 Oct 4;31(40):4343-52. doi: 10.1038/onc.2011.603. Epub 2012 Jan 16. Review.

PMID:
22249267
32.

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications.

Khan O, La Thangue NB.

Immunol Cell Biol. 2012 Jan;90(1):85-94. doi: 10.1038/icb.2011.100. Epub 2011 Nov 29. Review.

PMID:
22124371
33.

Predictive biomarkers: a paradigm shift towards personalized cancer medicine.

La Thangue NB, Kerr DJ.

Nat Rev Clin Oncol. 2011 Aug 23;8(10):587-96. doi: 10.1038/nrclinonc.2011.121. Review.

PMID:
21862978
34.

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.

Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li JL, Harris AL, Hammond EM, La Thangue NB.

Oncogene. 2011 Dec 1;30(48):4835-42. doi: 10.1038/onc.2011.188. Epub 2011 May 30.

PMID:
21625218
35.

Cell cycle control by a methylation-phosphorylation switch.

Carr SM, La Thangue NB.

Cell Cycle. 2011 Mar 1;10(5):733-4. Epub 2011 Mar 1. No abstract available.

36.

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.

Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB.

EMBO J. 2011 Jan 19;30(2):317-27. doi: 10.1038/emboj.2010.311. Epub 2010 Nov 30.

37.

E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

Ingram L, Munro S, Coutts AS, La Thangue NB.

Cell Death Differ. 2011 Jan;18(1):122-32. doi: 10.1038/cdd.2010.70. Epub 2010 Jun 18.

38.

Actin nucleation by a transcription co-factor that links cytoskeletal events with the p53 response.

Coutts AS, Weston L, La Thangue NB.

Cell Cycle. 2010 Apr 15;9(8):1511-5. Epub 2010 Apr 15.

PMID:
20372063
39.

HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy.

Khan O, Fotheringham S, Wood V, Stimson L, Zhang C, Pezzella F, Duvic M, Kerr DJ, La Thangue NB.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6532-7. doi: 10.1073/pnas.0913912107. Epub 2010 Mar 22.

40.

Lysine methylation regulates the pRb tumour suppressor protein.

Munro S, Khaire N, Inche A, Carr S, La Thangue NB.

Oncogene. 2010 Apr 22;29(16):2357-67. doi: 10.1038/onc.2009.511. Epub 2010 Feb 8.

PMID:
20140018
41.

A transcription co-factor integrates cell adhesion and motility with the p53 response.

Coutts AS, Weston L, La Thangue NB.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19872-7. doi: 10.1073/pnas.0906785106. Epub 2009 Nov 6.

42.

HDAC inhibitor-based therapies and haematological malignancy.

Stimson L, Wood V, Khan O, Fotheringham S, La Thangue NB.

Ann Oncol. 2009 Aug;20(8):1293-302. doi: 10.1093/annonc/mdn792. Epub 2009 Jun 10. Review.

PMID:
19515748
43.

Biomarkers for predicting clinical responses to HDAC inhibitors.

Stimson L, La Thangue NB.

Cancer Lett. 2009 Aug 8;280(2):177-83. doi: 10.1016/j.canlet.2009.03.016. Epub 2009 Apr 10. Review.

PMID:
19362413
44.

p53 methylation--the Arg-ument is clear.

Durant ST, Cho EC, La Thangue NB.

Cell Cycle. 2009 Mar 15;8(6):801-2. Epub 2009 Mar 14.

PMID:
19221494
45.

p53 ubiquitination by Mdm2: a never ending tail?

Coutts AS, Adams CJ, La Thangue NB.

DNA Repair (Amst). 2009 Apr 5;8(4):483-90. doi: 10.1016/j.dnarep.2009.01.008. Epub 2009 Feb 12. Review.

PMID:
19217357
46.

Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis.

Fotheringham S, Epping MT, Stimson L, Khan O, Wood V, Pezzella F, Bernards R, La Thangue NB.

Cancer Cell. 2009 Jan 6;15(1):57-66. doi: 10.1016/j.ccr.2008.12.001.

47.

Arginine methylation regulates the p53 response.

Jansson M, Durant ST, Cho EC, Sheahan S, Edelmann M, Kessler B, La Thangue NB.

Nat Cell Biol. 2008 Dec;10(12):1431-9. doi: 10.1038/ncb1802. Epub 2008 Nov 16.

PMID:
19011621
48.

Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas.

Khan O, La Thangue NB.

Nat Clin Pract Oncol. 2008 Dec;5(12):714-26. doi: 10.1038/ncponc1238. Epub 2008 Oct 7. Review.

PMID:
18839006
49.

ATM and Chk2 kinase target the p53 cofactor Strap.

Adams CJ, Graham AL, Jansson M, Coutts AS, Edelmann M, Smith L, Kessler B, La Thangue NB.

EMBO Rep. 2008 Dec;9(12):1222-9. doi: 10.1038/embor.2008.186. Epub 2008 Oct 3.

50.

Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset.

Lammens T, Boudolf V, Kheibarshekan L, Zalmas LP, Gaamouche T, Maes S, Vanstraelen M, Kondorosi E, La Thangue NB, Govaerts W, Inzé D, De Veylder L.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14721-6. doi: 10.1073/pnas.0806510105. Epub 2008 Sep 11.

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