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Items: 1 to 50 of 72

1.

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease.

Hardy MY, Russell AK, Pizzey C, Jones CM, Watson KA, La Gruta NL, Cameron DJ, Tye-Din JA.

Gut. 2019 Aug 28. pii: gutjnl-2019-319093. doi: 10.1136/gutjnl-2019-319093. [Epub ahead of print]

PMID:
31462555
2.

Modified Vaccinia Virus Ankara Can Induce Optimal CD8+ T Cell Responses to Directly Primed Antigens Depending on Vaccine Design.

Wong YC, Croft S, Smith SA, Lin LCW, Cukalac T, La Gruta NL, Drexler I, Tscharke DC.

J Virol. 2019 Oct 15;93(21). pii: e01154-19. doi: 10.1128/JVI.01154-19. Print 2019 Nov 1.

3.

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses.

Wu T, Guan J, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP, Purcell AW, La Gruta NL.

Nat Commun. 2019 Jun 28;10(1):2846. doi: 10.1038/s41467-019-10661-8.

4.

CD4+ T help promotes influenza virus-specific CD8+ T cell memory by limiting metabolic dysfunction.

Cullen JG, McQuilten HA, Quinn KM, Olshansky M, Russ BE, Morey A, Wei S, Prier JE, La Gruta NL, Doherty PC, Turner SJ.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4481-4488. doi: 10.1073/pnas.1808849116. Epub 2019 Feb 20.

5.

Most viral peptides displayed by class I MHC on infected cells are immunogenic.

Croft NP, Smith SA, Pickering J, Sidney J, Peters B, Faridi P, Witney MJ, Sebastian P, Flesch IEA, Heading SL, Sette A, La Gruta NL, Purcell AW, Tscharke DC.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3112-3117. doi: 10.1073/pnas.1815239116. Epub 2019 Feb 4.

6.

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells.

Quinn KM, Fox A, Harland KL, Russ BE, Li J, Nguyen THO, Loh L, Olshanksy M, Naeem H, Tsyganov K, Wiede F, Webster R, Blyth C, Sng XYX, Tiganis T, Powell D, Doherty PC, Turner SJ, Kedzierska K, La Gruta NL.

Cell Rep. 2018 Jun 19;23(12):3512-3524. doi: 10.1016/j.celrep.2018.05.057.

7.

Understanding the drivers of MHC restriction of T cell receptors.

La Gruta NL, Gras S, Daley SR, Thomas PG, Rossjohn J.

Nat Rev Immunol. 2018 Jul;18(7):467-478. doi: 10.1038/s41577-018-0007-5. Review.

PMID:
29636542
8.

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.

Wang Z, Zhu L, Nguyen THO, Wan Y, Sant S, Quiñones-Parra SM, Crawford JC, Eltahla AA, Rizzetto S, Bull RA, Qiu C, Koutsakos M, Clemens EB, Loh L, Chen T, Liu L, Cao P, Ren Y, Kedzierski L, Kotsimbos T, McCaw JM, La Gruta NL, Turner SJ, Cheng AC, Luciani F, Zhang X, Doherty PC, Thomas PG, Xu J, Kedzierska K.

Nat Commun. 2018 Feb 26;9(1):824. doi: 10.1038/s41467-018-03243-7.

9.

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude.

Quinn KM, Kan WT, Watson KA, Liddicoat BJ, Swan NG, McQuilten H, Denton AE, Li J, Chen W, Brown LE, Jackson DC, Reading PC, Doherty PC, Kedzierska K, Kedzierski L, Turner SJ, La Gruta NL.

PLoS One. 2017 Sep 8;12(9):e0184732. doi: 10.1371/journal.pone.0184732. eCollection 2017.

10.

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin.

Overgaard NH, Cruz JL, Bridge JA, Nel HJ, Frazer IH, La Gruta NL, Blumenthal A, Steptoe RJ, Wells JW.

J Leukoc Biol. 2017 Sep;102(3):837-844. doi: 10.1189/jlb.1AB0217-065R. Epub 2017 Jun 21.

PMID:
28637895
11.

Quantifiable predictive features define epitope-specific T cell receptor repertoires.

Dash P, Fiore-Gartland AJ, Hertz T, Wang GC, Sharma S, Souquette A, Crawford JC, Clemens EB, Nguyen THO, Kedzierska K, La Gruta NL, Bradley P, Thomas PG.

Nature. 2017 Jul 6;547(7661):89-93. doi: 10.1038/nature22383. Epub 2017 Jun 21.

12.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR.

Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.

13.

Corrigendum to ''Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host'' [J.Theor. Biol. 413 (2017) 34-49].

Yan AWC, Cao P, Heffernan JM, McVernon J, Quinn KM, La Gruta NL, Laurie KL, McCaw JM.

J Theor Biol. 2017 Apr 21;419:394. doi: 10.1016/j.jtbi.2017.03.015. No abstract available.

PMID:
28363398
14.

Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.

Villanueva JE, Walters SN, Saito M, Malle EK, Zammit NW, Watson KA, Brink R, La Gruta NL, Alexander SI, Grey ST.

Diabetologia. 2017 Apr;60(4):679-689. doi: 10.1007/s00125-016-4198-7. Epub 2017 Jan 6.

PMID:
28062921
15.

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host.

Yan AW, Cao P, Heffernan JM, McVernon J, Quinn KM, La Gruta NL, Laurie KL, McCaw JM.

J Theor Biol. 2017 Jan 21;413:34-49. doi: 10.1016/j.jtbi.2016.11.008. Epub 2016 Nov 15. Erratum in: J Theor Biol. 2017 Apr 21;419:394.

PMID:
27856216
16.

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Gras S, Chadderton J, Del Campo CM, Farenc C, Wiede F, Josephs TM, Sng XYX, Mirams M, Watson KA, Tiganis T, Quinn KM, Rossjohn J, La Gruta NL.

Immunity. 2016 Oct 18;45(4):749-760. doi: 10.1016/j.immuni.2016.09.007. Epub 2016 Oct 4.

17.

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection.

Liu H, Jain R, Guan J, Vuong V, Ishido S, La Gruta NL, Gray DH, Villadangos JA, Mintern JD.

J Exp Med. 2016 Aug 22;213(9):1695-703. doi: 10.1084/jem.20160312. Epub 2016 Aug 8.

18.

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.

Quinn KM, Zaloumis SG, Cukalac T, Kan WT, Sng XY, Mirams M, Watson KA, McCaw JM, Doherty PC, Thomas PG, Handel A, La Gruta NL.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1333-8. doi: 10.1073/pnas.1525167113. Epub 2016 Jan 19.

19.

Sizing up the key determinants of the CD8(+) T cell response.

Tscharke DC, Croft NP, Doherty PC, La Gruta NL.

Nat Rev Immunol. 2015 Nov;15(11):705-16. doi: 10.1038/nri3905. Epub 2015 Oct 9. Review.

PMID:
26449178
20.

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.

Cameron G, Pellicci DG, Uldrich AP, Besra GS, Illarionov P, Williams SJ, La Gruta NL, Rossjohn J, Godfrey DI.

J Immunol. 2015 Nov 15;195(10):4604-14. doi: 10.4049/jimmunol.1501222. Epub 2015 Sep 30.

21.

Consistency in polyclonal T-cell responses to gluten between children and adults with celiac disease.

Hardy MY, Girardin A, Pizzey C, Cameron DJ, Watson KA, Picascia S, Auricchio R, Greco L, Gianfrani C, La Gruta NL, Anderson RP, Tye-Din JA.

Gastroenterology. 2015 Nov;149(6):1541-1552.e2. doi: 10.1053/j.gastro.2015.07.013. Epub 2015 Jul 29.

PMID:
26226573
22.

Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire.

Cukalac T, Kan WT, Dash P, Guan J, Quinn KM, Gras S, Thomas PG, La Gruta NL.

Immunol Cell Biol. 2015 Oct;93(9):804-14. doi: 10.1038/icb.2015.44. Epub 2015 Mar 25.

23.

T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

Zanker D, Quinn K, Waithman J, Lata R, Murphy R, La Gruta NL, Chen W.

Immunol Cell Biol. 2015 May-Jun;93(5):500-7. doi: 10.1038/icb.2014.113. Epub 2015 Jan 6.

PMID:
25559620
24.

Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity.

Clemens EB, Doherty PC, La Gruta NL, Turner SJ.

J Immunol. 2015 Feb 1;194(3):898-910. doi: 10.4049/jimmunol.1401792. Epub 2014 Dec 22.

25.

T cell mediated immunity to influenza: mechanisms of viral control.

La Gruta NL, Turner SJ.

Trends Immunol. 2014 Aug;35(8):396-402. doi: 10.1016/j.it.2014.06.004. Epub 2014 Jul 16. Review.

PMID:
25043801
26.

T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.

Petersen J, Montserrat V, Mujico JR, Loh KL, Beringer DX, van Lummel M, Thompson A, Mearin ML, Schweizer J, Kooy-Winkelaar Y, van Bergen J, Drijfhout JW, Kan WT, La Gruta NL, Anderson RP, Reid HH, Koning F, Rossjohn J.

Nat Struct Mol Biol. 2014 May;21(5):480-8. doi: 10.1038/nsmb.2817. Epub 2014 Apr 28.

PMID:
24777060
27.

The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells.

Cukalac T, Chadderton J, Zeng W, Cullen JG, Kan WT, Doherty PC, Jackson DC, Turner SJ, La Gruta NL.

J Immunol. 2014 May 1;192(9):4061-8. doi: 10.4049/jimmunol.1301403. Epub 2014 Apr 2.

28.

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection.

Cukalac T, Chadderton J, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1485-90. doi: 10.1073/pnas.1323736111. Epub 2014 Jan 13.

29.

PTPN2 attenuates T-cell lymphopenia-induced proliferation.

Wiede F, La Gruta NL, Tiganis T.

Nat Commun. 2014;5:3073. doi: 10.1038/ncomms4073.

PMID:
24445916
30.

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.

Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL, Wijeyewickrema LC, Eckle SB, van Heemst J, Pike RN, McCluskey J, Toes RE, La Gruta NL, Purcell AW, Reid HH, Thomas R, Rossjohn J.

J Exp Med. 2013 Nov 18;210(12):2569-82. doi: 10.1084/jem.20131241. Epub 2013 Nov 4.

31.

Interrogating the relationship between naïve and immune antiviral T cell repertoires.

La Gruta NL, Thomas PG.

Curr Opin Virol. 2013 Aug;3(4):447-51. doi: 10.1016/j.coviro.2013.06.011. Epub 2013 Jul 10. Review.

32.

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations.

Thomas PG, Handel A, Doherty PC, La Gruta NL.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1839-44. doi: 10.1073/pnas.1222149110. Epub 2013 Jan 14.

33.

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response.

Seah SG, Brady JL, Carrington EM, Ng WC, Sutherland RM, Hancock MS, La Gruta NL, Brown LE, Turner SJ, Lew AM, Zhan Y.

J Leukoc Biol. 2013 Jan;93(1):145-54. doi: 10.1189/jlb.0612266. Epub 2012 Oct 29.

PMID:
23108101
34.

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity.

Seah SG, Carrington EM, Ng WC, Belz GT, Brady JL, Sutherland RM, Hancock MS, La Gruta NL, Brown LE, Turner SJ, Zhan Y, Lew AM.

Eur J Immunol. 2012 Jul;42(7):1744-54. doi: 10.1002/eji.201142211. Epub 2012 Jun 14.

35.

Precursor frequency and competition dictate the HLA-A2-restricted CD8+ T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic mice.

Tan AC, La Gruta NL, Zeng W, Jackson DC.

J Immunol. 2011 Aug 15;187(4):1895-902. doi: 10.4049/jimmunol.1100664. Epub 2011 Jul 15.

36.

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses.

Day EB, Guillonneau C, Gras S, La Gruta NL, Vignali DA, Doherty PC, Purcell AW, Rossjohn J, Turner SJ.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9536-41. doi: 10.1073/pnas.1106851108. Epub 2011 May 23.

37.

Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function.

Day EB, Charlton KL, La Gruta NL, Doherty PC, Turner SJ.

J Immunol. 2011 Jun 1;186(11):6319-28. doi: 10.4049/jimmunol.1000883. Epub 2011 May 2.

38.

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses.

Seah SG, Sutherland RM, La Gruta NL, Brown LE, Carrington EM, Belz GT, Brady JL, Turner SJ, Zhan Y, Lew AM.

Eur J Immunol. 2011 May;41(5):1499-500. doi: 10.1002/eji.201141399. Epub 2011 Apr 11. No abstract available.

39.

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by TCRβ clonotype.

Moffat JM, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL.

J Immunol. 2010 Dec 1;185(11):6850-6. doi: 10.4049/jimmunol.1002025. Epub 2010 Nov 1.

40.

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.

Pang SS, Berry R, Chen Z, Kjer-Nielsen L, Perugini MA, King GF, Wang C, Chew SH, La Gruta NL, Williams NK, Beddoe T, Tiganis T, Cowieson NP, Godfrey DI, Purcell AW, Wilce MC, McCluskey J, Rossjohn J.

Nature. 2010 Oct 14;467(7317):844-8. doi: 10.1038/nature09448.

PMID:
20944746
41.

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.

Valkenburg SA, Gras S, Guillonneau C, La Gruta NL, Thomas PG, Purcell AW, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K.

PLoS Pathog. 2010 Aug 12;6(8):e1001039. doi: 10.1371/journal.ppat.1001039.

42.

Multiplexed combinatorial tetramer staining in a mouse model of virus infection.

Cukalac T, Valkenburg SA, La Gruta NL, Turner SJ, Doherty PC, Kedzierska K.

J Immunol Methods. 2010 Aug 31;360(1-2):157-61. doi: 10.1016/j.jim.2010.06.003. Epub 2010 Jun 15.

PMID:
20558170
43.

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion.

La Gruta NL, Rothwell WT, Cukalac T, Swan NG, Valkenburg SA, Kedzierska K, Thomas PG, Doherty PC, Turner SJ.

J Clin Invest. 2010 Jun;120(6):1885-94. doi: 10.1172/JCI41538. Epub 2010 May 3.

44.

Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

Flesch IE, Woo WP, Wang Y, Panchanathan V, Wong YC, La Gruta NL, Cukalac T, Tscharke DC.

J Immunol. 2010 Jan 1;184(1):45-55. doi: 10.4049/jimmunol.0900999. Epub 2009 Nov 30.

45.

Functional implications of T cell receptor diversity.

Turner SJ, La Gruta NL, Kedzierska K, Thomas PG, Doherty PC.

Curr Opin Immunol. 2009 Jun;21(3):286-90. doi: 10.1016/j.coi.2009.05.004. Epub 2009 Jun 11. Review.

46.

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

Jenkins MR, La Gruta NL, Doherty PC, Trapani JA, Turner SJ, Waterhouse NJ.

Cell Death Differ. 2009 Apr;16(4):537-42. doi: 10.1038/cdd.2008.176. Epub 2009 Jan 9.

47.

Killer T cells in influenza.

Stambas J, Guillonneau C, Kedzierska K, Mintern JD, Doherty PC, La Gruta NL.

Pharmacol Ther. 2008 Nov;120(2):186-96. doi: 10.1016/j.pharmthera.2008.08.007. Epub 2008 Aug 28. Review.

PMID:
18801385
48.

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells.

Jenkins MR, Mintern J, La Gruta NL, Kedzierska K, Doherty PC, Turner SJ.

J Immunol. 2008 Sep 15;181(6):3818-22.

49.

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses.

Kedzierska K, Thomas PG, Venturi V, Davenport MP, Doherty PC, Turner SJ, La Gruta NL.

J Immunol. 2008 Aug 15;181(4):2556-62.

50.

A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.

Lieu ZZ, Lock JG, Hammond LA, La Gruta NL, Stow JL, Gleeson PA.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3351-6. doi: 10.1073/pnas.0800137105. Epub 2008 Feb 28.

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