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The lysosomal disease caused by mutant VPS33A.

Pavlova EV, Shatunov A, Wartosch L, Moskvina AI, Nikolaeva LE, Bright NA, Tylee KL, Church HJ, Ballabio A, Luzio JP, Cox TM.

Hum Mol Genet. 2019 Apr 10. pii: ddz077. doi: 10.1093/hmg/ddz077. [Epub ahead of print]


CLN8 safeguards lysosome biogenesis.

Luzio JP.

Nat Cell Biol. 2018 Dec;20(12):1333-1335. doi: 10.1038/s41556-018-0240-y. No abstract available.


The Lysosome and Intracellular Signalling.

Hesketh GG, Wartosch L, Davis LJ, Bright NA, Luzio JP.

Prog Mol Subcell Biol. 2018;57:151-180. doi: 10.1007/978-3-319-96704-2_6. Review.


Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity.

Bright NA, Davis LJ, Luzio JP.

Curr Biol. 2016 Sep 12;26(17):2233-45. doi: 10.1016/j.cub.2016.06.046. Epub 2016 Aug 4.


BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers.

Dennis MK, Delevoye C, Acosta-Ruiz A, Hurbain I, Romao M, Hesketh GG, Goff PS, Sviderskaya EV, Bennett DC, Luzio JP, Galli T, Owen DJ, Raposo G, Marks MS.

J Cell Biol. 2016 Aug 1;214(3):293-308. doi: 10.1083/jcb.201605090.


A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

Parkinson MD, Piper SC, Bright NA, Evans JL, Boname JM, Bowers K, Lehner PJ, Luzio JP.

Biochem J. 2015 Oct 1;471(1):79-88. doi: 10.1042/BJ20150336. Epub 2015 Jul 28.



Wartosch L, Bright NA, Luzio JP.

Curr Biol. 2015 Apr 20;25(8):R315-6. doi: 10.1016/j.cub.2015.02.027. No abstract available.


Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

Wartosch L, Günesdogan U, Graham SC, Luzio JP.

Traffic. 2015 Jul;16(7):727-42. doi: 10.1111/tra.12283. Epub 2015 Apr 30.


Lysosome fusion in cultured mammalian cells.

Bright NA, Wartosch L, Luzio JP.

Methods Cell Biol. 2015;126:101-18. doi: 10.1016/bs.mcb.2014.10.029. Epub 2015 Jan 14.


The biogenesis of lysosomes and lysosome-related organelles.

Luzio JP, Hackmann Y, Dieckmann NM, Griffiths GM.

Cold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a016840. doi: 10.1101/cshperspect.a016840. Review.


VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.

Hesketh GG, Pérez-Dorado I, Jackson LP, Wartosch L, Schäfer IB, Gray SR, McCoy AJ, Zeldin OB, Garman EF, Harbour ME, Evans PR, Seaman MNJ, Luzio JP, Owen DJ.

Dev Cell. 2014 Jun 9;29(5):591-606. doi: 10.1016/j.devcel.2014.04.010. Epub 2014 May 22.


Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

Graham SC, Wartosch L, Gray SR, Scourfield EJ, Deane JE, Luzio JP, Owen DJ.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13345-50. doi: 10.1073/pnas.1307074110. Epub 2013 Jul 30.


Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli.

Birchenough GM, Johansson ME, Stabler RA, Dalgakiran F, Hansson GC, Wren BW, Luzio JP, Taylor PW.

Infect Immun. 2013 Sep;81(9):3264-75. doi: 10.1128/IAI.00268-13. Epub 2013 Jun 24.


The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation.

Schäfer IB, Hesketh GG, Bright NA, Gray SR, Pryor PR, Evans PR, Luzio JP, Owen DJ.

Nat Struct Mol Biol. 2012 Dec;19(12):1300-9. doi: 10.1038/nsmb.2414. Epub 2012 Oct 28.


Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex.

Kent HM, Evans PR, Schäfer IB, Gray SR, Sanderson CM, Luzio JP, Peden AA, Owen DJ.

Dev Cell. 2012 May 15;22(5):979-88. doi: 10.1016/j.devcel.2012.01.018. Epub 2012 Apr 19.


Endosome-lysosome fusion.

Luzio JP, Gray SR, Bright NA.

Biochem Soc Trans. 2010 Dec;38(6):1413-6. doi: 10.1042/BST0381413.


The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.

Lawrence SP, Bright NA, Luzio JP, Bowers K.

Mol Biol Cell. 2010 Oct 15;21(20):3540-51. doi: 10.1091/mbc.E09-12-1053. Epub 2010 Aug 18.


Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1.

Zelmer A, Martin MJ, Gundogdu O, Birchenough G, Lever R, Wren BW, Luzio JP, Taylor PW.

Microbiology. 2010 Jul;156(Pt 7):2205-15. doi: 10.1099/mic.0.036145-0. Epub 2010 Apr 15.


Mistargeting of SH3TC2 away from the recycling endosome causes Charcot-Marie-Tooth disease type 4C.

Roberts RC, Peden AA, Buss F, Bright NA, Latouche M, Reilly MM, Kendrick-Jones J, Luzio JP.

Hum Mol Genet. 2010 Mar 15;19(6):1009-18. doi: 10.1093/hmg/ddp565. Epub 2009 Dec 22.


The delivery of endocytosed cargo to lysosomes.

Luzio JP, Parkinson MD, Gray SR, Bright NA.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1019-21. doi: 10.1042/BST0371019. Review.


The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.

Tsang HT, Edwards TL, Wang X, Connell JW, Davies RJ, Durrington HJ, O'Kane CJ, Luzio JP, Reid E.

Hum Mol Genet. 2009 Oct 15;18(20):3805-21. doi: 10.1093/hmg/ddp324. Epub 2009 Jul 20.


Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.

Edwards TL, Clowes VE, Tsang HT, Connell JW, Sanderson CM, Luzio JP, Reid E.

Biochem J. 2009 Sep 14;423(1):31-9. doi: 10.1042/BJ20082398. Erratum in: Biochem J. 2009 Nov 1;423(3):442.


Delivery of endocytosed membrane proteins to the lysosome.

Pryor PR, Luzio JP.

Biochim Biophys Acta. 2009 Apr;1793(4):615-24. doi: 10.1016/j.bbamcr.2008.12.022. Epub 2009 Jan 8. Review.


ESCRT proteins and the regulation of endocytic delivery to lysosomes.

Luzio JP, Piper SC, Bowers K, Parkinson MD, Lehner PJ, Bright NA.

Biochem Soc Trans. 2009 Feb;37(Pt 1):178-80. doi: 10.1042/BST0370178.


Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.

Connell JW, Lindon C, Luzio JP, Reid E.

Traffic. 2009 Jan;10(1):42-56. doi: 10.1111/j.1600-0854.2008.00847.x. Epub 2008 Oct 29.


Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.

Pryor PR, Jackson L, Gray SR, Edeling MA, Thompson A, Sanderson CM, Evans PR, Owen DJ, Luzio JP.

Cell. 2008 Sep 5;134(5):817-27. doi: 10.1016/j.cell.2008.07.023.


Differential expression of the polysialyl capsule during blood-to-brain transit of neuropathogenic Escherichia coli K1.

Zelmer A, Bowen M, Jokilammi A, Finne J, Luzio JP, Taylor PW.

Microbiology. 2008 Aug;154(Pt 8):2522-32. doi: 10.1099/mic.0.2008/017988-0.


The role of calcium and other ions in sorting and delivery in the late endocytic pathway.

Luzio JP, Bright NA, Pryor PR.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1088-91. Review.


Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes.

Piper RC, Luzio JP.

Curr Opin Cell Biol. 2007 Aug;19(4):459-65. Epub 2007 Aug 3. Review.


Lysosomes: fusion and function.

Luzio JP, Pryor PR, Bright NA.

Nat Rev Mol Cell Biol. 2007 Aug;8(8):622-32. Review.


Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic.

Pryor PR, Reimann F, Gribble FM, Luzio JP.

Traffic. 2006 Oct;7(10):1388-98.


Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules.

Duncan LM, Piper S, Dodd RB, Saville MK, Sanderson CM, Luzio JP, Lehner PJ.

EMBO J. 2006 Apr 19;25(8):1635-45. Epub 2006 Apr 6.


Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.

Bowers K, Piper SC, Edeling MA, Gray SR, Owen DJ, Lehner PJ, Luzio JP.

J Biol Chem. 2006 Feb 24;281(8):5094-105. Epub 2005 Dec 20.


Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners.

Sanderson CM, Connell JW, Edwards TL, Bright NA, Duley S, Thompson A, Luzio JP, Reid E.

Hum Mol Genet. 2006 Jan 15;15(2):307-18. Epub 2005 Dec 8.


Treatment of experimental Escherichia coli infection with recombinant bacteriophage-derived capsule depolymerase.

Mushtaq N, Redpath MB, Luzio JP, Taylor PW.

J Antimicrob Chemother. 2005 Jul;56(1):160-5. Epub 2005 May 24.


Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.

Sahlender DA, Roberts RC, Arden SD, Spudich G, Taylor MJ, Luzio JP, Kendrick-Jones J, Buss F.

J Cell Biol. 2005 Apr 25;169(2):285-95. Epub 2005 Apr 18.


Membrane traffic to and from lysosomes.

Luzio JP, Pryor PR, Gray SR, Gratian MJ, Piper RC, Bright NA.

Biochem Soc Symp. 2005;(72):77-86. Review.


AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.

Kyttälä A, Yliannala K, Schu P, Jalanko A, Luzio JP.

J Biol Chem. 2005 Mar 18;280(11):10277-83. Epub 2004 Dec 13.


Differential use of two AP-3-mediated pathways by lysosomal membrane proteins.

Ihrke G, Kyttälä A, Russell MR, Rous BA, Luzio JP.

Traffic. 2004 Dec;5(12):946-62.


CUPpling calcium to lysosomal biogenesis.

Piper RC, Luzio JP.

Trends Cell Biol. 2004 Sep;14(9):471-3. Review.


Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

Pryor PR, Mullock BM, Bright NA, Lindsay MR, Gray SR, Richardson SC, Stewart A, James DE, Piper RC, Luzio JP.

EMBO Rep. 2004 Jun;5(6):590-5. Epub 2004 May 7.


Prevention and cure of systemic Escherichia coli K1 infection by modification of the bacterial phenotype.

Mushtaq N, Redpath MB, Luzio JP, Taylor PW.

Antimicrob Agents Chemother. 2004 May;48(5):1503-8.


Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Bowers K, Lottridge J, Helliwell SB, Goldthwaite LM, Luzio JP, Stevens TH.

Traffic. 2004 Mar;5(3):194-210.


Two motifs target Batten disease protein CLN3 to lysosomes in transfected nonneuronal and neuronal cells.

Kyttälä A, Ihrke G, Vesa J, Schell MJ, Luzio JP.

Mol Biol Cell. 2004 Mar;15(3):1313-23. Epub 2003 Dec 29.


Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.

Richardson SC, Winistorfer SC, Poupon V, Luzio JP, Piper RC.

Mol Biol Cell. 2004 Mar;15(3):1197-210. Epub 2003 Dec 10.


The role of mVps18p in clustering, fusion, and intracellular localization of late endocytic organelles.

Poupon V, Stewart A, Gray SR, Piper RC, Luzio JP.

Mol Biol Cell. 2003 Oct;14(10):4015-27. Epub 2003 Jul 11.


Membrane dynamics and the biogenesis of lysosomes.

Luzio JP, Poupon V, Lindsay MR, Mullock BM, Piper RC, Pryor PR.

Mol Membr Biol. 2003 Apr-Jun;20(2):141-54. Review.


Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice.

Warner CL, Stewart A, Luzio JP, Steel KP, Libby RT, Kendrick-Jones J, Buss F.

EMBO J. 2003 Feb 3;22(3):569-79.


Myosin VI, an actin motor for membrane traffic and cell migration.

Buss F, Luzio JP, Kendrick-Jones J.

Traffic. 2002 Dec;3(12):851-8. Review.

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