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Items: 1 to 50 of 350

1.

Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer.

Diquigiovanni C, Bergamini C, Evangelisti C, Isidori F, Vettori A, Tiso N, Argenton F, Costanzini A, Iommarini L, Anbunathan H, Pagotto U, Repaci A, Babbi G, Casadio R, Lenaz G, Rhoden KJ, Porcelli AM, Fato R, Bowcock A, Seri M, Romeo G, Bonora E.

Int J Cancer. 2018 Apr 19. doi: 10.1002/ijc.31548. [Epub ahead of print]

2.

Complex I function in mitochondrial supercomplexes.

Lenaz G, Tioli G, Falasca AI, Genova ML.

Biochim Biophys Acta. 2016 Jul;1857(7):991-1000. doi: 10.1016/j.bbabio.2016.01.013. Epub 2016 Jan 25. Review.

3.

The Interplay Between Respiratory Supercomplexes and ROS in Aging.

Genova ML, Lenaz G.

Antioxid Redox Signal. 2015 Jul 20;23(3):208-38. doi: 10.1089/ars.2014.6214. Epub 2015 Mar 25. Review.

PMID:
25711676
4.

Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity.

Canistro D, Boccia C, Falconi R, Bonamassa B, Valgimigli L, Vivarelli F, Soleti A, Genova ML, Lenaz G, Sapone A, Zaccanti F, Abdel-Rahman SZ, Paolini M.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):936-43. doi: 10.1093/gerona/glu160. Epub 2014 Sep 4.

PMID:
25190068
5.

Coenzyme q and the respiratory chain: coenzyme q pool and mitochondrial supercomplexes.

Enriquez JA, Lenaz G.

Mol Syndromol. 2014 Jul;5(3-4):119-40. doi: 10.1159/000363364.

6.

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians.

Sgarbi G, Matarrese P, Pinti M, Lanzarini C, Ascione B, Gibellini L, Dika E, Patrizi A, Tommasino C, Capri M, Cossarizza A, Baracca A, Lenaz G, Solaini G, Franceschi C, Malorni W, Salvioli S.

Aging (Albany NY). 2014 Apr;6(4):296-310.

7.

Preface for dynamic and ultrastructure of bioenergetic membranes and their components.

Lenaz G, Nevo R, Reich Z.

Biochim Biophys Acta. 2014 Apr;1837(4):407. doi: 10.1016/j.bbabio.2014.01.007. Epub 2014 Jan 19. No abstract available.

8.

Functional role of mitochondrial respiratory supercomplexes.

Genova ML, Lenaz G.

Biochim Biophys Acta. 2014 Apr;1837(4):427-43. doi: 10.1016/j.bbabio.2013.11.002. Epub 2013 Nov 15. Review.

9.

Mitochondrial respiratory supercomplex association limits production of reactive oxygen species from complex I.

Maranzana E, Barbero G, Falasca AI, Lenaz G, Genova ML.

Antioxid Redox Signal. 2013 Nov 1;19(13):1469-80. doi: 10.1089/ars.2012.4845. Epub 2013 Jun 28.

10.

A critical appraisal of the role of respiratory supercomplexes in mitochondria.

Genova ML, Lenaz G.

Biol Chem. 2013 May;394(5):631-9. doi: 10.1515/hsz-2012-0317. Review.

PMID:
23449521
11.

Relevance of mitochondrial genetics and metabolism in cancer development.

Gasparre G, Porcelli AM, Lenaz G, Romeo G.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a011411. doi: 10.1101/cshperspect.a011411. Review.

12.

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A.

PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17.

13.

Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation.

Lenaz G, Genova ML.

Adv Exp Med Biol. 2012;748:107-44. doi: 10.1007/978-1-4614-3573-0_5. Review.

PMID:
22729856
14.

A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells.

Bergamini C, Moruzzi N, Sblendido A, Lenaz G, Fato R.

PLoS One. 2012;7(3):e33712. doi: 10.1371/journal.pone.0033712. Epub 2012 Mar 14.

15.

Mitochondria and reactive oxygen species. Which role in physiology and pathology?

Lenaz G.

Adv Exp Med Biol. 2012;942:93-136. doi: 10.1007/978-94-007-2869-1_5. Review.

PMID:
22399420
16.

The effects of idebenone on mitochondrial bioenergetics.

Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, Bernardi P.

Biochim Biophys Acta. 2012 Feb;1817(2):363-9. doi: 10.1016/j.bbabio.2011.10.012. Epub 2011 Nov 4.

17.

Hyperoxia fully protects mitochondria of explanted livers.

Sgarbi G, Giannone F, Casalena GA, Baracca A, Baldassare M, Longobardi P, Caraceni P, Derenzini M, Lenaz G, Trerè D, Solaini G.

J Bioenerg Biomembr. 2011 Dec;43(6):673-82. doi: 10.1007/s10863-011-9390-3. Epub 2011 Oct 21.

PMID:
22015484
18.

New developments on the functions of coenzyme Q in mitochondria.

Genova ML, Lenaz G.

Biofactors. 2011 Sep-Oct;37(5):330-54. doi: 10.1002/biof.168. Epub 2011 Oct 11. Review.

PMID:
21989973
19.

An open-label, dose-escalating phase I study of elsamitrucin (SPI 28090) in treatment of malignant solid tumors in dogs.

Fiocchi SC, Selting KA, Rosenberg MP, Kolli P, Lenaz G, Henry C.

J Vet Intern Med. 2011 Jul-Aug;25(4):897-902. doi: 10.1111/j.1939-1676.2011.0752.x. Epub 2011 Jul 7.

20.

Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach.

Di Domenico F, Casalena G, Sultana R, Cai J, Pierce WM, Perluigi M, Cini C, Baracca A, Solaini G, Lenaz G, Jia J, Dziennis S, Murphy SJ, Alkayed NJ, Butterfield DA.

Brain Res. 2010 Nov 29;1362:1-12. doi: 10.1016/j.brainres.2010.09.074. Epub 2010 Sep 25.

21.

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents.

Simoni E, Bergamini C, Fato R, Tarozzi A, Bains S, Motterlini R, Cavalli A, Bolognesi ML, Minarini A, Hrelia P, Lenaz G, Rosini M, Melchiorre C.

J Med Chem. 2010 Oct 14;53(19):7264-8. doi: 10.1021/jm100637k.

PMID:
20831222
22.

The primary role of glutathione against nuclear DNA damage of striatum induced by permethrin in rats.

Falcioni ML, Nasuti C, Bergamini C, Fato R, Lenaz G, Gabbianelli R.

Neuroscience. 2010 Jun 16;168(1):2-10. doi: 10.1016/j.neuroscience.2010.03.053. Epub 2010 Mar 29.

PMID:
20359525
23.

Oxidative stress in the denervated muscle.

Abruzzo PM, di Tullio S, Marchionni C, Belia S, Fanó G, Zampieri S, Carraro U, Kern H, Sgarbi G, Lenaz G, Marini M.

Free Radic Res. 2010 May;44(5):563-76. doi: 10.3109/10715761003692487.

PMID:
20298122
24.

Hypoxia and mitochondrial oxidative metabolism.

Solaini G, Baracca A, Lenaz G, Sgarbi G.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1171-7. doi: 10.1016/j.bbabio.2010.02.011. Epub 2010 Feb 11. Review.

25.

Mitochondrial respiratory chain super-complex I-III in physiology and pathology.

Lenaz G, Baracca A, Barbero G, Bergamini C, Dalmonte ME, Del Sole M, Faccioli M, Falasca A, Fato R, Genova ML, Sgarbi G, Solaini G.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):633-40. doi: 10.1016/j.bbabio.2010.01.025. Epub 2010 Jan 30. Review.

26.

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells.

Baracca A, Chiaradonna F, Sgarbi G, Solaini G, Alberghina L, Lenaz G.

Biochim Biophys Acta. 2010 Feb;1797(2):314-23. doi: 10.1016/j.bbabio.2009.11.006. Epub 2009 Nov 18.

27.

Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

Bolognesi ML, Cavalli A, Bergamini C, Fato R, Lenaz G, Rosini M, Bartolini M, Andrisano V, Melchiorre C.

J Med Chem. 2009 Dec 10;52(23):7883-6. doi: 10.1021/jm901123n.

PMID:
19813747
28.

Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy.

Fato R, Bergamini C, Leoni S, Pinna A, Carta F, Cardascia N, Ferrari TM, Sborgia C, Lenaz G.

Acta Ophthalmol. 2010 Jun;88(4):e150-1. doi: 10.1111/j.1755-3768.2009.01632.x. Epub 2009 Oct 3. No abstract available.

29.

Control of respiration by cytochrome c oxidase in intact cells: role of the membrane potential.

Dalmonte ME, Forte E, Genova ML, Giuffrè A, Sarti P, Lenaz G.

J Biol Chem. 2009 Nov 20;284(47):32331-5. doi: 10.1074/jbc.M109.050146. Epub 2009 Sep 23.

30.

Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject.

Lenaz G, Genova ML.

Antioxid Redox Signal. 2010 Apr 15;12(8):961-1008. doi: 10.1089/ars.2009.2704. Review.

PMID:
19739941
31.

Structural and functional organization of the mitochondrial respiratory chain: a dynamic super-assembly.

Lenaz G, Genova ML.

Int J Biochem Cell Biol. 2009 Oct;41(10):1750-1772. Review.

PMID:
19711505
32.

Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.

Sgarbi G, Casalena GA, Baracca A, Lenaz G, DiMauro S, Solaini G.

Arch Neurol. 2009 Aug;66(8):951-7. doi: 10.1001/archneurol.2009.134.

PMID:
19667215
33.

Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis.

Cavalieri E, Bergamini C, Mariotto S, Leoni S, Perbellini L, Darra E, Suzuki H, Fato R, Lenaz G.

FEBS J. 2009 Aug;276(15):3990-4000. doi: 10.1111/j.1742-4658.2009.07108.x. Epub 2009 Jun 29.

34.

Mobility and function of coenzyme Q (ubiquinone) in the mitochondrial respiratory chain.

Lenaz G, Genova ML.

Biochim Biophys Acta. 2009 Jun;1787(6):563-73. doi: 10.1016/j.bbabio.2009.02.019. Epub 2009 Mar 4. Review.

35.

Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates.

Jain A, Phillips RM, Scally AJ, Lenaz G, Beer M, Puri R.

Urology. 2009 May;73(5):1083-6. doi: 10.1016/j.urology.2007.12.062. Epub 2009 Feb 20.

PMID:
19232688
36.

Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues.

Fato R, Bergamini C, Leoni S, Lenaz G.

Biofactors. 2008;32(1-4):31-9.

PMID:
19096098
37.

Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species.

Fato R, Bergamini C, Bortolus M, Maniero AL, Leoni S, Ohnishi T, Lenaz G.

Biochim Biophys Acta. 2009 May;1787(5):384-92. doi: 10.1016/j.bbabio.2008.11.003. Epub 2008 Nov 14.

38.

Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration.

Fato R, Bergamini C, Leoni S, Strocchi P, Lenaz G.

Neurochem Res. 2008 Dec;33(12):2487-501. doi: 10.1007/s11064-008-9747-0. Epub 2008 Jun 6. Review.

PMID:
18535905
39.

The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics.

Solaini G, Harris DA, Lenaz G, Sgarbi G, Baracca A.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):941-5. doi: 10.1016/j.bbabio.2008.04.034. Epub 2008 Apr 30.

40.

Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

Genova ML, Baracca A, Biondi A, Casalena G, Faccioli M, Falasca AI, Formiggini G, Sgarbi G, Solaini G, Lenaz G.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):740-6. doi: 10.1016/j.bbabio.2008.04.007. Epub 2008 Apr 11. Review.

41.

Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone).

Rauchová H, Drahota Z, Bergamini C, Fato R, Lenaz G.

J Bioenerg Biomembr. 2008 Apr;40(2):85-93. doi: 10.1007/s10863-008-9134-1. Epub 2008 Mar 27.

PMID:
18368470
42.

Alpha-bisabolol: unexpected plant-derived weapon in the struggle against tumour survival?

Darra E, Lenaz G, Cavalieri E, Fato R, Mariotto S, Bergamini C, Carcereri de Prati A, Perbellini L, Leoni S, Suzuki H.

Ital J Biochem. 2007 Dec;56(4):323-8. Review.

PMID:
19192636
43.

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.

Bolognesi ML, Banzi R, Bartolini M, Cavalli A, Tarozzi A, Andrisano V, Minarini A, Rosini M, Tumiatti V, Bergamini C, Fato R, Lenaz G, Hrelia P, Cattaneo A, Recanatini M, Melchiorre C.

J Med Chem. 2007 Oct 4;50(20):4882-97. Epub 2007 Sep 13.

PMID:
17850125
44.

Mitochondrial changes induced by natural and synthetic asbestos fibers: studies on isolated mitochondria.

Bergamini C, Fato R, Biagini G, Pugnaloni A, Giantomassi F, Foresti E, Lesci GI, Roveri N, Lenaz G.

Cell Mol Biol (Noisy-le-grand). 2007 Jan 21;52 Suppl:OL905-13.

PMID:
17543227
45.

Biochemical phenotypes associated with the mitochondrial ATP6 gene mutations at nt8993.

Baracca A, Sgarbi G, Mattiazzi M, Casalena G, Pagnotta E, Valentino ML, Moggio M, Lenaz G, Carelli V, Solaini G.

Biochim Biophys Acta. 2007 Jul;1767(7):913-9. Epub 2007 May 18.

46.

Evaluating mitochondrial membrane potential in cells.

Solaini G, Sgarbi G, Lenaz G, Baracca A.

Biosci Rep. 2007 Jun;27(1-3):11-21. Review.

PMID:
17497220
47.

The role of Coenzyme Q in mitochondrial electron transport.

Lenaz G, Fato R, Formiggini G, Genova ML.

Mitochondrion. 2007 Jun;7 Suppl:S8-33. Epub 2007 Mar 31. Review.

PMID:
17485246
48.

Isolation and subfractionation of mitochondria from animal cells and tissue culture lines.

Pallotti F, Lenaz G.

Methods Cell Biol. 2007;80:3-44. Review. No abstract available.

PMID:
17445687
49.

Mitochondrial Complex I: structure, function, and implications in neurodegeneration.

Lenaz G, Baracca A, Fato R, Genova ML, Solaini G.

Ital J Biochem. 2006 Sep-Dec;55(3-4):232-53. Review.

PMID:
17274529
50.

Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling.

Lenaz G, Genova ML.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1221-39. Epub 2006 Oct 11. Review.

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