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Items: 1 to 50 of 283

1.

Interplay between intracellular loop 1 and helix VIII of the angiotensin II type 2 receptor controls its activation.

Connolly A, Holleran BJ, Simard É, Baillargeon JP, Lavigne P, Leduc R.

Biochem Pharmacol. 2019 Jul 23;168:330-338. doi: 10.1016/j.bcp.2019.07.018. [Epub ahead of print]

PMID:
31348898
2.

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD.

J Biol Chem. 2019 Aug 16;294(33):12459-12471. doi: 10.1074/jbc.RA118.006159. Epub 2019 Jun 27.

PMID:
31248990
3.

Identification and Quantification of Proteoforms by Mass Spectrometry.

Schaffer LV, Millikin RJ, Miller RM, Anderson LC, Fellers RT, Ge Y, Kelleher NL, LeDuc RD, Liu X, Payne SH, Sun L, Thomas PM, Tucholski T, Wang Z, Wu S, Wu Z, Yu D, Shortreed MR, Smith LM.

Proteomics. 2019 May;19(10):e1800361. doi: 10.1002/pmic.201800361. Review.

PMID:
31050378
4.

A Group Randomized Intervention Trial Increases Participation in the School Breakfast Program in 16 Rural High Schools in Minnesota.

Nanney MS, Leduc R, Hearst M, Shanafelt A, Wang Q, Schroeder M, Grannon KY, Kubik MY, Caspi C, Harnack LJ.

J Acad Nutr Diet. 2019 Jun;119(6):915-922. doi: 10.1016/j.jand.2018.12.007. Epub 2019 Feb 14.

PMID:
30772298
5.

Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics.

LeDuc RD, Fellers RT, Early BP, Greer JB, Shams DP, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2019 Apr;18(4):796-805. doi: 10.1074/mcp.RA118.000993. Epub 2019 Jan 15.

PMID:
30647073
6.

Long-term follow-up of the DeKAF cross-sectional cohort study.

Matas AJ, Fieberg A, Mannon RB, Leduc R, Grande J, Kasiske BL, Cecka M, Gaston R, Hunsicker L, Connett J, Cosio F, Gourishankar S, Rush D.

Am J Transplant. 2019 May;19(5):1432-1443. doi: 10.1111/ajt.15204. Epub 2019 Jan 24.

PMID:
30506642
7.

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.

Sci Signal. 2018 Dec 4;11(559). pii: eaat1631. doi: 10.1126/scisignal.aat1631.

PMID:
30514808
8.

Morphologic variations of the second cervical vertebra in Down syndrome compared with age-matched peers.

Hofler RC, Heiferman DM, Molefe A, LeDuc R, Johans SJ, Rosenblum JD, Nockels RP, Jones GA.

J Neurosurg Spine. 2018 Nov 23;30(2):175-181. doi: 10.3171/2018.8.SPINE18750.

PMID:
30497148
9.

Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines.

Dion SP, Béliveau F, Morency LP, Désilets A, Najmanovich R, Leduc R.

Sci Rep. 2018 Aug 22;8(1):12562. doi: 10.1038/s41598-018-30618-z.

10.

GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.

Tutunea-Fatan E, Abd-Elrahman KS, Thibodeau JF, Holterman CE, Holleran BJ, Leduc R, Kennedy CRJ, Gros R, Ferguson SSG.

Sci Rep. 2018 Jul 30;8(1):11415. doi: 10.1038/s41598-018-29876-8.

11.

Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).

Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É.

J Med Chem. 2018 Aug 23;61(16):7103-7115. doi: 10.1021/acs.jmedchem.8b00175. Epub 2018 Aug 13.

PMID:
30035538
12.

Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses.

Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M.

Pharmacol Res. 2018 Oct;136:108-120. doi: 10.1016/j.phrs.2018.06.027. Epub 2018 Jun 28.

PMID:
29959993
13.

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins.

Riley NM, Sikora JW, Seckler HS, Greer JB, Fellers RT, LeDuc RD, Westphall MS, Thomas PM, Kelleher NL, Coon JJ.

Anal Chem. 2018 Jul 17;90(14):8553-8560. doi: 10.1021/acs.analchem.8b01638. Epub 2018 Jul 5.

14.

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms.

St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R.

Biochem Pharmacol. 2018 Aug;154:104-117. doi: 10.1016/j.bcp.2018.04.021. Epub 2018 Apr 20.

PMID:
29684376
15.

Evaluation of PM surface concentrations simulated by Version 1 of NASA's MERRA Aerosol Reanalysis over Europe.

Provençal S, Buchard V, da Silva AM, Leduc R, Barrette N.

Atmos Pollut Res. 2017 Mar 2;8(2):374-382. doi: 10.1016/j.apr.2016.10.009. Epub 2016 Nov 3.

16.

Sirolimus in Refractory Cronkhite-Canada Syndrome and Focus on Standard Treatment.

Langevin C, Chapdelaine H, Picard JM, Poitras P, Leduc R.

J Investig Med High Impact Case Rep. 2018 Mar 22;6:2324709618765893. doi: 10.1177/2324709618765893. eCollection 2018 Jan-Dec.

17.

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4140-4145. doi: 10.1073/pnas.1716122115. Epub 2018 Apr 2.

18.

In Search of the Optimal Macrocyclization Site for Neurotensin.

Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É.

ACS Med Chem Lett. 2018 Jan 29;9(3):227-232. doi: 10.1021/acsmedchemlett.7b00500. eCollection 2018 Mar 8.

19.

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.

Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.

Pharmacol Res. 2018 May;131:7-16. doi: 10.1016/j.phrs.2018.02.032. Epub 2018 Mar 9.

PMID:
29530600
20.

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

Davis RG, Park HM, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, Sweedler JV, Rhodes JS, Kelleher NL.

Anal Chem. 2018 Mar 20;90(6):3802-3810. doi: 10.1021/acs.analchem.7b04108. Epub 2018 Feb 26.

21.

Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities.

Dion SP, Béliveau F, Désilets A, Ghinet MG, Leduc R.

J Cell Mol Med. 2018 Apr;22(4):2498-2509. doi: 10.1111/jcmm.13562. Epub 2018 Feb 14.

22.

ProForma: A Standard Proteoform Notation.

LeDuc RD, Schwämmle V, Shortreed MR, Cesnik AJ, Solntsev SK, Shaw JB, Martin MJ, Vizcaino JA, Alpi E, Danis P, Kelleher NL, Smith LM, Ge Y, Agar JN, Chamot-Rooke J, Loo JA, Pasa-Tolic L, Tsybin YO.

J Proteome Res. 2018 Mar 2;17(3):1321-1325. doi: 10.1021/acs.jproteome.7b00851. Epub 2018 Feb 14.

23.

Altering the School Breakfast Environment Reduces Barriers to School Breakfast Participation Among Diverse Rural Youth.

Hearst MO, Shanafelt A, Wang Q, Leduc R, Nanney MS.

J Sch Health. 2018 Jan;88(1):3-8. doi: 10.1111/josh.12575.

24.

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover.

Wilkinson DJ, Desilets A, Lin H, Charlton S, Del Carmen Arques M, Falconer A, Bullock C, Hsu YC, Birchall K, Hawkins A, Thompson P, Ferrell WR, Lockhart J, Plevin R, Zhang Y, Blain E, Lin SW, Leduc R, Milner JM, Rowan AD.

Sci Rep. 2017 Dec 1;7(1):16693. doi: 10.1038/s41598-017-17028-3.

25.

s protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.

Li X, Létourneau D, Holleran B, Leduc R, Lavigne P, Lavoie C.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13477-13482. doi: 10.1073/pnas.1708215114. Epub 2017 Nov 30.

26.

Late graft failure after kidney transplantation as the consequence of late versus early events.

Gaston RS, Fieberg A, Hunsicker L, Kasiske BL, Leduc R, Cosio FG, Gourishankar S, Grande J, Mannon RB, Rush D, Cecka JM, Connett J, Matas AJ.

Am J Transplant. 2018 May;18(5):1158-1167. doi: 10.1111/ajt.14590. Epub 2017 Dec 5.

27.

The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide.

Lanchec E, Désilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, Gris D, Leduc R, Lavoie C.

J Biol Chem. 2017 Dec 15;292(50):20669-20682. doi: 10.1074/jbc.M117.792911. Epub 2017 Oct 20.

28.

Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.

Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL.

Sci Rep. 2017 Aug 25;7(1):9520. doi: 10.1038/s41598-017-10422-x.

29.

Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.

Lahey KA, Ronaghan NJ, Shang J, Dion SP, Désilets A, Leduc R, MacNaughton WK.

PLoS One. 2017 Jul 3;12(7):e0180259. doi: 10.1371/journal.pone.0180259. eCollection 2017.

30.

Increasing Social Support for Breakfast: Project BreakFAST.

Mumm J, Hearst MO, Shanafelt A, Wang Q, Leduc R, Nanney MS.

Health Promot Pract. 2017 Nov;18(6):862-868. doi: 10.1177/1524839917711123. Epub 2017 Jun 4.

31.

Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients.

Toby TK, Abecassis M, Kim K, Thomas PM, Fellers RT, LeDuc RD, Kelleher NL, Demetris J, Levitsky J.

Am J Transplant. 2017 Sep;17(9):2458-2467. doi: 10.1111/ajt.14359. Epub 2017 Jun 27.

32.

Simple screening protocol for identification of potential mycoremediation tools for the elimination of polycyclic aromatic hydrocarbons and phenols from hyperalkalophile industrial effluents.

Batista-García RA, Kumar VV, Ariste A, Tovar-Herrera OE, Savary O, Peidro-Guzmán H, González-Abradelo D, Jackson SA, Dobson ADW, Sánchez-Carbente MDR, Folch-Mallol JL, Leduc R, Cabana H.

J Environ Manage. 2017 Aug 1;198(Pt 2):1-11. doi: 10.1016/j.jenvman.2017.05.010. Epub 2017 May 9.

PMID:
28499155
33.

Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms.

Wilkinson DJ, Wang H, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD.

Arthritis Rheumatol. 2017 Aug;69(8):1601-1611. doi: 10.1002/art.40133. Epub 2017 Jul 5. Erratum in: Arthritis Rheumatol. 2018 Oct;70(10):1596.

34.

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer.

Cleland TP, DeHart CJ, Fellers RT, VanNispen AJ, Greer JB, LeDuc RD, Parker WR, Thomas PM, Kelleher NL, Brodbelt JS.

J Proteome Res. 2017 May 5;16(5):2072-2079. doi: 10.1021/acs.jproteome.7b00043. Epub 2017 Apr 19.

35.

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry.

Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL.

J Am Soc Mass Spectrom. 2017 Jun;28(6):1203-1215. doi: 10.1007/s13361-017-1635-x. Epub 2017 Apr 3.

36.

Synthesis and Evaluation of a 64Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent.

Pirisedigh A, Blais V, Ait-Mohand S, Abdallah K, Holleran BJ, Leduc R, Dory YL, Gendron L, Guérin B.

Org Lett. 2017 Apr 21;19(8):2018-2021. doi: 10.1021/acs.orglett.7b00575. Epub 2017 Apr 3.

PMID:
28368122
37.

The signaling signature of the neurotensin type 1 receptor with endogenous ligands.

Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R.

Eur J Pharmacol. 2017 Jun 15;805:1-13. doi: 10.1016/j.ejphar.2017.03.046. Epub 2017 Mar 22.

PMID:
28341345
38.

What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels for Environmental Enrichment.

Leduc RY, Rauw G, Baker GB, McDermid HE.

J Am Assoc Lab Anim Sci. 2017 Mar 1;56(2):194-201.

39.

Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.

St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É.

Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11.

PMID:
28219045
40.

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.

Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL.

J Proteome Res. 2017 Feb 3;16(2):609-618. doi: 10.1021/acs.jproteome.6b00698. Epub 2016 Dec 2.

41.

Evaluation of PM2.5 surface concentration simulated by Version 1 of the NASA's MERRA Aerosol Reanalysis over Israel and Taiwan.

Provençal S, Buchard V, da Silva AM, Leduc R, Barrette N, Elhacham E, Wang SH.

Aerosol Air Qual Res. 2017 Jan;17(1):253-261. doi: 10.4209/aaqr.2016.04.0145. Epub 2017 Jan 1.

42.

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry.

Anderson LC, DeHart CJ, Kaiser NK, Fellers RT, Smith DF, Greer JB, LeDuc RD, Blakney GT, Thomas PM, Kelleher NL, Hendrickson CL.

J Proteome Res. 2017 Feb 3;16(2):1087-1096. doi: 10.1021/acs.jproteome.6b00696. Epub 2016 Dec 12.

43.

Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.

Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.

Org Biomol Chem. 2017 Jan 4;15(2):449-458. doi: 10.1039/c6ob02247b.

PMID:
27924341
44.

Genetic variation in blue whales in the eastern pacific: implication for taxonomy and use of common wintering grounds.

Leduc RG, Archer FI, Lang AR, Martien KK, Hancock-Hanser B, Torres-Florez JP, Hucke-Gaete R, Rosenbaum HC, van Waerebeek K, Brownell RL Jr, Taylor BL.

Mol Ecol. 2017 Feb;26(3):740-751. doi: 10.1111/mec.13940. Epub 2016 Dec 25.

PMID:
27891694
45.

Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality.

Perreault S, de Denus S, White M, White-Guay B, Bouvier M, Dorais M, Dubé MP, Rouleau JL, Tardif JC, Jenna S, Haibe-Kains B, Leduc R, Deblois D.

Pharmacoepidemiol Drug Saf. 2017 Jan;26(1):81-90. doi: 10.1002/pds.4132. Epub 2016 Nov 16.

PMID:
27859924
46.

Design, synthesis, and biological evaluation of CXCR4 ligands.

Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.

Org Biomol Chem. 2016 Nov 2;14(43):10298-10311.

PMID:
27752700
47.

Genetic backgrounds and modifier genes of NTD mouse models: An opportunity for greater understanding of the multifactorial etiology of neural tube defects.

Leduc RY, Singh P, McDermid HE.

Birth Defects Res. 2017 Jan 30;109(2):140-152. doi: 10.1002/bdra.23554. Review.

PMID:
27768235
48.

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer.

Zoratti GL, Tanabe LM, Hyland TE, Duhaime MJ, Colombo É, Leduc R, Marsault E, Johnson MD, Lin CY, Boerner J, Lang JE, List K.

Oncotarget. 2016 Sep 6;7(36):58162-58173. doi: 10.18632/oncotarget.11262.

49.

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.

Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G466-79. doi: 10.1152/ajpgi.00441.2015. Epub 2016 Aug 4. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G776.

50.

Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists.

Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.

J Med Chem. 2016 Aug 25;59(16):7512-24. doi: 10.1021/acs.jmedchem.6b00566. Epub 2016 Aug 11.

PMID:
27434274

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