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Items: 1 to 50 of 90

1.

A monofunctional derivative of melphalan: preparation, DNA alkylation products, and determination of the specificity of monoclonal antibodies that recognize melphalan-DNA adducts.

Tilby MJ, McCartney H, Gould KA, O'Hare CC, Hartley JA, Hall AG, Golding BT, Lawley PD.

Chem Res Toxicol. 1998 Oct;11(10):1162-8.

PMID:
9778312
2.

DNA adducts from chemotherapeutic agents.

Lawley PD, Phillips DH.

Mutat Res. 1996 Aug 17;355(1-2):13-40. Review.

PMID:
8781575
3.

Products from alkylation of DNA in cells by melphalan: human soft tissue sarcoma cell line RD and Escherichia coli WP2.

Osborne MR, Lawley PD, Crofton-Sleigh C, Warren W.

Chem Biol Interact. 1995 Aug 18;97(3):287-96.

PMID:
7545551
4.

Alkylation of DNA and its aftermath.

Lawley PD.

Bioessays. 1995 Jun;17(6):561-8. Review.

PMID:
7575500
5.

Alkylation of DNA by the nitrogen mustard bis(2-chloroethyl)methylamine.

Osborne MR, Wilman DE, Lawley PD.

Chem Res Toxicol. 1995 Mar;8(2):316-20.

PMID:
7766817
6.
7.

Historical origins of current concepts of carcinogenesis.

Lawley PD.

Adv Cancer Res. 1994;65:17-111. Review.

PMID:
7879666
8.
9.
10.

The reaction of melphalan with deoxyguanosine and deoxyguanylic acid.

Osborne MR, Lawley PD.

Chem Biol Interact. 1992 Sep 28;84(2):189-98.

PMID:
1394623
15.

Mutagens as carcinogens: development of current concepts.

Lawley PD.

Mutat Res. 1989 Jul;213(1):3-25. Review.

PMID:
2664491
16.
17.

Deficient repair of O6-methylguanine in lymphocytes from rheumatoid arthritis families may be an acquired defect.

Colaço CB, Harris G, Lawley PD, Lydyard PM, Roitt IM.

Clin Exp Immunol. 1988 Apr;72(1):15-9.

18.
19.

Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses.

Warren W, Lawley PD, Gardner E, Harris G, Ball JK, Cooper CS.

Carcinogenesis. 1987 Jan;8(1):163-72.

PMID:
3026678
20.

Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine.

Lawley PD, Harris G, Phillips E, Irving W, Colaço CB, Lydyard PM, Roitt IM.

Chem Biol Interact. 1986 Jan;57(1):107-21.

PMID:
3948282
22.

Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.

Harris G, Lawley PD, Asbery LJ, Chandler PM, Jones MG.

Immunology. 1983 Jul;49(3):439-49.

23.

Defective repair of 0(6)-methylguanine in autoimmune diseases.

Harris G, Asbery L, Lawley PD, Denman AM, Hylton W.

Lancet. 1982 Oct 30;2(8305):952-6.

PMID:
6127461
24.

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treated human fibroblasts.

Medcalf AS, Lawley PD.

Nature. 1981 Feb 26;289(5800):796-8. No abstract available.

PMID:
7464943
25.

Mode of action of methylating carcinogens: comparative studies of murine and human cells.

Harris G, Lawley PD, Olsen I.

Carcinogenesis. 1981;2(5):403-11.

PMID:
7273321
27.

Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.

Frei JV, Lawley PD.

J Natl Cancer Inst. 1980 Apr;64(4):845-56.

PMID:
6928996
29.

DNA as a target of alkylating carcinogens.

Lawley PD.

Br Med Bull. 1980 Jan;36(1):19-24. Review. No abstract available.

PMID:
7020825
30.
31.

Rapid screening of carcinogens -- end of the beginning?

Lawley PD.

Nature. 1979 Nov 8;282(5735):134-5. No abstract available.

PMID:
492333
37.

Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea.

Lawley PD, Warren W.

Chem Biol Interact. 1975 Jul;11(1):55-7. No abstract available.

PMID:
1095240
40.
41.
43.
44.

Some chemical aspects of dose-response relationships in alkylation mutagenesis.

Lawley PD.

Mutat Res. 1974 Jun;23(3):283-95. Review. No abstract available.

PMID:
4366872
45.

Methylation of nucleic acids by 2,2-dichlorovinyl dimethyl phosphate (dichlorvos, DDVP).

Lawley PD, Shah SA, Orr DJ.

Chem Biol Interact. 1974 Mar;8(3):171-82. No abstract available.

PMID:
4595853
46.

Increased urinary excretion of pyrimidine and nicotinamide derivatives in rats treated with methyl methanesulphonate.

Chu BC, Lawley PD.

Chem Biol Interact. 1974 Feb;8(2):65-73. No abstract available.

PMID:
4374319
48.

Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.

Miller CT, Lawley PD, Shah SA.

Biochem J. 1973 Oct;136(2):387-93.

50.

Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group.

Lawley PD, Shah SA.

Chem Biol Interact. 1973 Aug;7(2):115-20. No abstract available.

PMID:
4797441

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