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Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase.

Heo J, Larner JM, Brautigan DL.

Biochem J. 2020 Jan 6. pii: BCJ20190740. doi: 10.1042/BCJ20190740. [Epub ahead of print]


Aurora B kinase promotes CHIP-dependent degradation of HIF1a in prostate cancer cells.

Biswas K, Sarkar S, Said N, Brautigan DL, Larner JM.

Mol Cancer Ther. 2019 Dec 17. pii: molcanther.0777.2019. doi: 10.1158/1535-7163.MCT-19-0777. [Epub ahead of print]


Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.

Dziegielewski J, Bońkowska MA, Poniecka EA, Heo J, Du K, Crittenden RB, Bender TP, Brautigan DL, Larner JM.

DNA Repair (Amst). 2020 Jan;85:102737. doi: 10.1016/j.dnarep.2019.102737. Epub 2019 Nov 9.


Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study.

Alonso CE, Bunevicius A, Trifiletti DM, Larner J, Lee CC, Pai FY, Liscak R, Kosak M, Kano H, Sisterson ND, Mathieu D, Lunsford LD, Sheehan JP.

J Neurooncol. 2019 Nov;145(2):301-307. doi: 10.1007/s11060-019-03296-8. Epub 2019 Sep 20.


Rapid Response to Pembrolizumab in a Critically Ill Mechanically Ventilated Patient with New Diagnosis of NSCLC.

McLoughlin EM, Larner JM, Bergman MP, Stelow EB, Brady K, Lynch AC, Abraham RS, Gentzler RD.

J Thorac Oncol. 2019 Sep;14(9):e193-e195. doi: 10.1016/j.jtho.2019.04.010. No abstract available.


Stereotactic radiosurgery with and without checkpoint inhibition for patients with metastatic non-small cell lung cancer to the brain: a matched cohort study.

Shepard MJ, Xu Z, Donahue J, Eluvathingal Muttikkal TJ, Cordeiro D, Hansen L, Mohammed N, Gentzler RD, Larner J, Fadul CE, Sheehan JP.

J Neurosurg. 2019 Jul 26:1-8. doi: 10.3171/2019.4.JNS19822. [Epub ahead of print]


In reply: UK's initial operational response and specialist operational response to CBRN and HazMat incidents: a primer on decontamination protocols for healthcare professionals.

Chilcott RP, Larner J, Matar H.

Emerg Med J. 2019 Aug;36(8):515-516. doi: 10.1136/emermed-2019-208798. Epub 2019 Jul 4. No abstract available.


Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders.

Larner J, Durrant A, Hughes P, Mahalingam D, Rivers S, Matar H, Thomas E, Barrett M, Pinhal A, Amer N, Hall C, Jackson T, Catalani V, Chilcott RP.

Prehosp Emerg Care. 2019 Jul 19:1-14. doi: 10.1080/10903127.2019.1636912. [Epub ahead of print]


Decontamination and management of contaminated hair following a CBRN incident.

Matar H, Pinhal A, Amer N, Barrett M, Thomas E, Hughes P, Larner J, Chilcott RP.

Toxicol Sci. 2019 Jun 26. pii: kfz145. doi: 10.1093/toxsci/kfz145. [Epub ahead of print]


Spatial shifts in frame-based Gamma Knife radiosurgery: A case for cone beam CT imaging as quality assurance using the Gamma Knife® Icon™.

Peach MS, Trifiletti DM, Dutta SW, Larner JM, Schlesinger DJ, Sheehan JP.

J Radiosurg SBRT. 2018;5(4):315-322.


UK's initial operational response and specialist operational response to CBRN and HazMat incidents: a primer on decontamination protocols for healthcare professionals.

Chilcott RP, Larner J, Matar H.

Emerg Med J. 2019 Feb;36(2):117-123. doi: 10.1136/emermed-2018-207562. Epub 2018 Dec 1.


Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants.

Matar H, Amer N, Kansagra S, Pinhal A, Thomas E, Townend S, Larner J, Chilcott RP.

Sci Rep. 2018 Nov 15;8(1):16906. doi: 10.1038/s41598-018-35105-z.


Stereotactic Shifts During Frame-Based Image-Guided Stereotactic Radiosurgery: Clinical Measurements.

Dutta SW, Kowalchuk RO, Trifiletti DM, Peach MS, Sheehan JP, Larner JM, Schlesinger D.

Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):895-902. doi: 10.1016/j.ijrobp.2018.05.042. Epub 2018 May 24.


Evaluation of US Federal Guidelines (Primary Response Incident Scene Management [PRISM]) for Mass Decontamination of Casualties During the Initial Operational Response to a Chemical Incident.

Chilcott RP, Larner J, Durrant A, Hughes P, Mahalingam D, Rivers S, Thomas E, Amer N, Barrett M, Matar H, Pinhal A, Jackson T, McCarthy-Barnett K, Reppucci J.

Ann Emerg Med. 2019 Jun;73(6):671-684. doi: 10.1016/j.annemergmed.2018.06.042. Epub 2018 Aug 23.


Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid.

Frosini SM, Bond R, Loeffler A, Larner J.

BMC Vet Res. 2017 Nov 21;13(1):345. doi: 10.1186/s12917-017-1270-6.


Volunteer trials of a novel improvised dry decontamination protocol for use during mass casualty incidents as part of the UK'S Initial Operational Response (IOR).

Amlôt R, Carter H, Riddle L, Larner J, Chilcott RP.

PLoS One. 2017 Jun 16;12(6):e0179309. doi: 10.1371/journal.pone.0179309. eCollection 2017.


Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.

Ziembik MA, Bender TP, Larner JM, Brautigan DL.

Biochem Soc Trans. 2017 Jun 15;45(3):693-701. doi: 10.1042/BST20160169. Review.


Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.

Sarkar S, Brautigan DL, Larner JM.

Mol Cancer Res. 2017 Aug;15(8):1063-1072. doi: 10.1158/1541-7786.MCR-17-0062. Epub 2017 May 23.


The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.

Biswas K, Sarkar S, Du K, Brautigan DL, Abbas T, Larner JM.

Mol Cancer Res. 2017 Jun;15(6):651-659. doi: 10.1158/1541-7786.MCR-16-0466. Epub 2017 Feb 23.


Evaluation of absorbent materials for use as ad hoc dry decontaminants during mass casualty incidents as part of the UK's Initial Operational Response (IOR).

Kassouf N, Syed S, Larner J, Amlôt R, Chilcott RP.

PLoS One. 2017 Feb 2;12(2):e0170966. doi: 10.1371/journal.pone.0170966. eCollection 2017.


Equivalence of cell survival data for radiation dose and thermal dose in ablative treatments: analysis applied to essential tremor thalamotomy by focused ultrasound and gamma knife.

Schlesinger D, Lee M, Ter Haar G, Sela B, Eames M, Snell J, Kassell N, Sheehan J, Larner JM, Aubry JF.

Int J Hyperthermia. 2017 Jun;33(4):401-410. doi: 10.1080/02656736.2016.1278281. Epub 2017 Jan 31.


Choosing a Prescription Isodose in Stereotactic Radiosurgery for Brain Metastases: Implications for Local Control.

Romano KD, Trifiletti DM, Garda A, Xu Z, Schlesinger D, Watkins WT, Neal B, Larner JM, Sheehan JP.

World Neurosurg. 2017 Feb;98:761-767.e1. doi: 10.1016/j.wneu.2016.11.038. Epub 2016 Nov 17.


Evaluation of a new topical skin protectant (RD1433) for the prevention and treatment of incontinence-associated dermatitis.

Matar H, Larner J, Viegas V, Kansagra S, Atkinson KL, Shetage S, Skamarauskas JT, Theivendran B, Goldman VS, Chilcott RP.

Cutan Ocul Toxicol. 2017 Sep;36(3):211-219. doi: 10.1080/15569527.2016.1257637. Epub 2016 Nov 23.


Mass Casualty Decontamination in the United States: An Online Survey of Current Practice.

Power S, Symons C, Carter H, Jones E, Amlôt R, Larner J, Matar H, Chilcott RP.

Health Secur. 2016 Jul-Aug;14(4):226-36. doi: 10.1089/hs.2016.0047. Epub 2016 Jul 21.


Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer.

Chen L, Li J, Farah E, Sarkar S, Ahmad N, Gupta S, Larner J, Liu X.

Mol Cancer Ther. 2016 Sep;15(9):2107-18. doi: 10.1158/1535-7163.MCT-16-0241. Epub 2016 Jul 7.


Trans sodium crocetinate with temozolomide and radiation therapy for glioblastoma multiforme.

Gainer JL, Sheehan JP, Larner JM, Jones DR.

J Neurosurg. 2017 Feb;126(2):460-466. doi: 10.3171/2016.3.JNS152693. Epub 2016 May 13.


When should patients with brain metastases receive whole brain irradiation?

Trifiletti DM, Larner JM, Sheehan JP.

J Radiosurg SBRT. 2016;4(1):1-3. No abstract available.


Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.

Ta HQ, Ivey ML, Frierson HF Jr, Conaway MR, Dziegielewski J, Larner JM, Gioeli D.

Cancer Res. 2015 Dec 1;75(23):5093-105. doi: 10.1158/0008-5472.CAN-15-0224. Epub 2015 Nov 16.


Leukoencephalopathy After Stereotactic Radiosurgery for Brain Metastases.

Trifiletti DM, Lee CC, Schlesinger D, Larner JM, Xu Z, Sheehan JP.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):870-8. doi: 10.1016/j.ijrobp.2015.07.2280. Epub 2015 Jul 29.


Brainstem metastases treated with stereotactic radiosurgery: safety, efficacy, and dose response.

Trifiletti DM, Lee CC, Winardi W, Patel NV, Yen CP, Larner JM, Sheehan JP.

J Neurooncol. 2015 Nov;125(2):385-92. doi: 10.1007/s11060-015-1927-6. Epub 2015 Sep 4.


Optimisation of a dosing regime for a topical skin protectant (barrier cream).

Chilcott RP, Larner J, Matar H, Kansagra S, Theivendran B, Viegas VA, Goldman VS.

Cutan Ocul Toxicol. 2015;34(4):327-34. doi: 10.3109/15569527.2014.994124. Epub 2015 Jan 19.


Development of a cumulative irritation model for incontinence-associated dermatitis.

Larner J, Matar H, Goldman VS, Chilcott RP.

Arch Dermatol Res. 2015 Jan;307(1):39-48. doi: 10.1007/s00403-014-1526-y. Epub 2014 Nov 22.


Pulmonary toxicity in a rabbit model of stereotactic lung radiation therapy: efficacy of a radioprotector.

Mata J, Sheng K, Hagspiel K, Ruppert K, Sylvester P, Mugler J 3rd, Fernandes C, Guan S, Larner J, Read P.

Exp Lung Res. 2014 Aug;40(6):308-16. doi: 10.3109/01902148.2014.918213. Epub 2014 Jun 13.


Magnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results.

Hurwitz MD, Ghanouni P, Kanaev SV, Iozeffi D, Gianfelice D, Fennessy FM, Kuten A, Meyer JE, LeBlang SD, Roberts A, Choi J, Larner JM, Napoli A, Turkevich VG, Inbar Y, Tempany CM, Pfeffer RM.

J Natl Cancer Inst. 2014 Apr 23;106(5). pii: dju082. doi: 10.1093/jnci/dju082.


D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells.

Lazarenko R, Geisler J, Bayliss D, Larner J, Li C.

Mol Cell Endocrinol. 2014 Apr 25;387(1-2):1-7. doi: 10.1016/j.mce.2014.02.004. Epub 2014 Feb 14.


Design and characterisation of a novel in vitro skin diffusion cell system for assessing mass casualty decontamination systems.

Matar H, Larner J, Kansagra S, Atkinson KL, Skamarauskas JT, Amlot R, Chilcott RP.

Toxicol In Vitro. 2014 Jun;28(4):492-501. doi: 10.1016/j.tiv.2014.01.001. Epub 2014 Jan 8.


Pilot Study of iPad Incorporation Into Graduate Medical Education.

Lobo MJ, Crandley EF, Rumph JS, Kirk SE, Dunlap NE, Rahimi AS, Turner AB Jr, Larner JM, Read PW.

J Grad Med Educ. 2013 Mar;5(1):142-4. doi: 10.4300/JGME-D-12-00007.1.


T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.

Dziegielewska B, Brautigan DL, Larner JM, Dziegielewski J.

Mol Cancer Res. 2014 Mar;12(3):348-58. doi: 10.1158/1541-7786.MCR-13-0485. Epub 2013 Dec 20.


microRNA-34a promotes DNA damage and mitotic catastrophe.

Kofman AV, Kim J, Park SY, Dupart E, Letson C, Bao Y, Ding K, Chen Q, Schiff D, Larner J, Abounader R.

Cell Cycle. 2013 Nov 15;12(22):3500-11. doi: 10.4161/cc.26459. Epub 2013 Sep 19.


MR-guided focused ultrasound surgery, present and future.

Schlesinger D, Benedict S, Diederich C, Gedroyc W, Klibanov A, Larner J.

Med Phys. 2013 Aug;40(8):080901. doi: 10.1118/1.4811136. Review.


MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation.

Li Q, Zhang D, Wang Y, Sun P, Hou X, Larner J, Xiong W, Mi J.

Sci Rep. 2013;3:2038. doi: 10.1038/srep02038.


Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

Jiang N, Shen Y, Fei X, Sheng K, Sun P, Qiu Y, Larner J, Cao L, Kong X, Mi J.

Cell Death Dis. 2013 May 30;4:e647. doi: 10.1038/cddis.2013.171.


Gamma Knife surgery for large vestibular schwannomas: a single-center retrospective case-matched comparison assessing the effect of lesion size.

Williams BJ, Xu Z, Salvetti DJ, McNeill IT, Larner J, Sheehan JP.

J Neurosurg. 2013 Aug;119(2):463-71. doi: 10.3171/2013.4.JNS122195. Epub 2013 May 24.


Inositol, glycogen, insulin, and six nobelists.

Larner J.

J Biol Chem. 2013 Apr 26;288(17):12313-24. doi: 10.1074/jbc.X113.471177. Epub 2013 Mar 20. No abstract available.


Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.

Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J.

Biochem Pharmacol. 2013 Apr 1;85(7):888-97. doi: 10.1016/j.bcp.2012.12.017. Epub 2013 Jan 1.


Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells.

Sarkar S, Brautigan DL, Parsons SJ, Larner JM.

Oncogene. 2014 Jan 2;33(1):26-33. doi: 10.1038/onc.2012.561. Epub 2012 Dec 17.


Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols.

Pitt J, Thorner M, Brautigan D, Larner J, Klein WL.

FASEB J. 2013 Jan;27(1):199-207. doi: 10.1096/fj.12-211896. Epub 2012 Oct 16.


Computed tomography-based anatomic assessment overestimates local tumor recurrence in patients with mass-like consolidation after stereotactic body radiotherapy for early-stage non-small cell lung cancer.

Dunlap NE, Yang W, McIntosh A, Sheng K, Benedict SH, Read PW, Larner JM.

Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):1071-7. doi: 10.1016/j.ijrobp.2012.01.088. Epub 2012 Aug 14.


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