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Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency.

Gao MH, Giamouridis D, Lai NC, Guo T, Xia B, Kim YC, Huu VAN, Skowronska-Krawczyk D, Lantier L, Bhargava R, Hammond HK.

Mol Ther Methods Clin Dev. 2019 Dec 14;17:220-233. doi: 10.1016/j.omtm.2019.12.002. eCollection 2020 Jun 12.


Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance.

Kim YC, Truax AD, Giamouridis D, Lai NC, Guo T, Hammond HK, Gao MH.

PLoS One. 2019 Dec 2;14(12):e0224428. doi: 10.1371/journal.pone.0224428. eCollection 2019.


Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice.

Giamouridis D, Gao MH, Lai NC, Guo T, Miyanohara A, Blankesteijn WM, Biessen EAL, Hammond HK.

Mol Ther. 2020 Jan 8;28(1):180-188. doi: 10.1016/j.ymthe.2019.10.003. Epub 2019 Oct 29.


Increase Trichomonas vaginalis detection based on urine routine analysis through a machine learning approach.

Wang HY, Hung CC, Chen CH, Lee TY, Huang KY, Ning HC, Lai NC, Tsai MH, Lu LC, Tseng YJ, Lu JJ.

Sci Rep. 2019 Aug 19;9(1):11074. doi: 10.1038/s41598-019-47361-8.


Chiral Cyclometalated Oxazoline Gold(III) Complex-Catalyzed Asymmetric Carboalkoxylation of Alkynes.

Jiang JJ, Cui JF, Yang B, Ning Y, Lai NC, Wong MK.

Org Lett. 2019 Aug 16;21(16):6289-6294. doi: 10.1021/acs.orglett.9b02171. Epub 2019 Aug 6.


Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.

Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA.

PLoS One. 2019 Jun 7;14(6):e0218110. doi: 10.1371/journal.pone.0218110. eCollection 2019.


A high-rate and long-life organic-oxygen battery.

Cong G, Wang W, Lai NC, Liang Z, Lu YC.

Nat Mater. 2019 Apr;18(4):390-396. doi: 10.1038/s41563-019-0286-7. Epub 2019 Feb 11.


Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice.

Kim YC, Giamouridis D, Lai NC, Guo T, Xia B, Fu Z, Gao MH, Hammond HK.

Hum Gene Ther. 2019 Jun;30(6):693-701. doi: 10.1089/hum.2018.150. Epub 2019 Mar 11.


Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (C1C2) Attenuates Deleterious Effects of Pressure Overload.

Tan Z, Giamouridis D, Lai NC, Kim YC, Guo T, Xia B, Gao MH, Hammond HK.

Hum Gene Ther. 2019 Jun;30(6):682-692. doi: 10.1089/hum.2018.176. Epub 2019 Mar 8.


Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal.

Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn WM, Biessen E, Hammond HK.

JACC Basic Transl Sci. 2018 May 30;3(2):249-264. doi: 10.1016/j.jacbts.2017.12.004. eCollection 2018 Apr.


Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart.

Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn MW, Biessen EAL, Hammond HK.

Hum Gene Ther. 2019 Jan;30(1):10-20. doi: 10.1089/hum.2018.103. Epub 2018 Oct 2.


Superoxide Stabilization and a Universal KO2 Growth Mechanism in Potassium-Oxygen Batteries.

Wang W, Lai NC, Liang Z, Wang Y, Lu YC.

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):5042-5046. doi: 10.1002/anie.201801344. Epub 2018 Mar 23.


Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation.

Gao MH, Lai NC, Giamouridis D, Kim YC, Guo T, Hammond HK.

PLoS One. 2017 Aug 2;12(8):e0181282. doi: 10.1371/journal.pone.0181282. eCollection 2017.


Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation.

Gao MH, Lai NC, Giamouridis D, Kim YC, Tan Z, Guo T, Dillmann WH, Suarez J, Hammond HK.

JACC Basic Transl Sci. 2016 Dec;1(7):617-629. doi: 10.1016/j.jacbts.2016.08.004.


C,O-Chelated BINOL/Gold(III) Complexes: Synthesis and Catalysis with Tunable Product Profiles.

Cui JF, Ko HM, Shing KP, Deng JR, Lai NC, Wong MK.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):3074-3079. doi: 10.1002/anie.201612243. Epub 2017 Feb 6.


Functional magnetic resonance imaging for in vivo quantification of pulmonary hypertension in the Sugen 5416/hypoxia mouse.

Breen EC, Scadeng M, Lai NC, Murray F, Bigby TD.

Exp Physiol. 2017 Mar 1;102(3):347-353. doi: 10.1113/EP086067. Epub 2017 Feb 14.


One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance.

Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK.

JCI Insight. 2016 Sep 22;1(15):e88322. doi: 10.1172/jci.insight.88322.


Clinical Evaluation of Heart Failure: Agreement among Tests.

Pandey AK, Penny WF, Bhargava V, Lai NC, Xu R, Hammond HK.

PLoS One. 2016 Aug 18;11(8):e0161536. doi: 10.1371/journal.pone.0161536. eCollection 2016.


Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial.

Hammond HK, Penny WF, Traverse JH, Henry TD, Watkins MW, Yancy CW, Sweis RN, Adler ED, Patel AN, Murray DR, Ross RS, Bhargava V, Maisel A, Barnard DD, Lai NC, Dalton ND, Lee ML, Narayan SM, Blanchard DG, Gao MH.

JAMA Cardiol. 2016 May 1;1(2):163-71. doi: 10.1001/jamacardio.2016.0008.


Synthesis of sub-nanosized Pt particles on mesoporous SBA-15 material and its application to the CO oxidation reaction.

Wu HC, Chen TC, Lai NC, Yang CM, Wu JH, Chen YC, Lee JF, Chen CS.

Nanoscale. 2015 Oct 28;7(40):16848-59. doi: 10.1039/c5nr04943a.


Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice.

Lai NC, Gao MH, Giamouridis D, Suarez J, Miyanohara A, Parikh J, Hightower S, Guo T, Dillmann W, Kim YC, Diaz-Juarez J, Hammond HK.

Hum Gene Ther. 2015 Jun;26(6):347-56. doi: 10.1089/hum.2014.157. Epub 2015 Apr 9.


Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: a new strategy for cancer therapy.

Lu HY, Chang YJ, Fan NC, Wang LS, Lai NC, Yang CM, Wu LC, Ho JA.

Biomaterials. 2015 Feb;42:30-41. doi: 10.1016/j.biomaterials.2014.11.029. Epub 2014 Dec 12.


Spiracular air breathing in polypterid fishes and its implications for aerial respiration in stem tetrapods.

Graham JB, Wegner NC, Miller LA, Jew CJ, Lai NC, Berquist RM, Frank LR, Long JA.

Nat Commun. 2014;5:3022. doi: 10.1038/ncomms4022.


Preserved cardiac function despite marked impairment of cAMP generation.

Gao MH, Lai NC, Tang T, Guo T, Tang R, Chun BJ, Wang H, Dalton NN, Suarez J, Dillmann WH, Hammond HK.

PLoS One. 2013 Sep 16;8(9):e72151. doi: 10.1371/journal.pone.0072151. eCollection 2013.


Integrins protect cardiomyocytes from ischemia/reperfusion injury.

Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS.

J Clin Invest. 2013 Oct;123(10):4294-308. doi: 10.1172/JCI64216. Epub 2013 Sep 16.


Trivalent galactosyl-functionalized mesoporous silica nanoparticles as a target-specific delivery system for boron neutron capture therapy.

Lai CH, Lai NC, Chuang YJ, Chou FI, Yang CM, Lin CC.

Nanoscale. 2013 Oct 7;5(19):9412-8. doi: 10.1039/c3nr02594b. Epub 2013 Aug 20.


Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice.

Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth DM, Dalton ND, Hammond HK.

Hum Gene Ther. 2013 Sep;24(9):777-85. doi: 10.1089/hum.2013.088.


Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation.

Tang T, Lai NC, Wright AT, Gao MH, Lee P, Guo T, Tang R, McCulloch AD, Hammond HK.

J Mol Cell Cardiol. 2013 Jul;60:60-7. doi: 10.1016/j.yjmcc.2013.04.005. Epub 2013 Apr 12.


Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice.

Lew WY, Bayna E, Molle ED, Dalton ND, Lai NC, Bhargava V, Mendiola V, Clopton P, Tang T.

PLoS One. 2013 Apr 9;8(4):e61057. doi: 10.1371/journal.pone.0061057. Print 2013.


Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer.

Fang H, Lai NC, Gao MH, Miyanohara A, Roth DM, Tang T, Hammond HK.

Hum Gene Ther Methods. 2012 Aug;23(4):234-41. doi: 10.1089/hgtb.2012.105.


Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice.

Lai NC, Gao MH, Tang E, Tang R, Guo T, Dalton ND, Deng A, Tang T.

Lab Invest. 2012 Nov;92(11):1518-26. doi: 10.1038/labinvest.2012.97. Epub 2012 Jul 23.


Improved function of the failing rat heart by regulated expression of insulin-like growth factor I via intramuscular gene transfer.

Lai NC, Tang T, Gao MH, Saito M, Miyanohara A, Hammond HK.

Hum Gene Ther. 2012 Mar;23(3):255-61. doi: 10.1089/hum.2011.094. Epub 2012 Jan 12.


Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression.

Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL.

J Am Coll Cardiol. 2011 Oct 11;58(16):1715-27. doi: 10.1016/j.jacc.2011.07.017.


Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts.

Tang T, Hammond HK, Firth A, Yang Y, Gao MH, Yuan JX, Lai NC.

J Am Coll Cardiol. 2011 May 3;57(18):1846-55. doi: 10.1016/j.jacc.2010.11.052.


Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.

Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):349-55. doi: 10.1016/j.bbrc.2010.12.113. Epub 2010 Dec 30.


Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.

Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK.

Mol Pharmacol. 2011 Mar;79(3):381-8. doi: 10.1124/mol.110.067298. Epub 2010 Dec 2.


Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.

Tang T, Lai NC, Hammond HK, Roth DM, Yang Y, Guo T, Gao MH.

J Am Coll Cardiol. 2010 Apr 6;55(14):1476-86. doi: 10.1016/j.jacc.2009.11.066.


The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals.

Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6386-91. doi: 10.1073/pnas.0801490105. Epub 2008 Apr 23. Erratum in: Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8160.


Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice.

Lai NC, Tang T, Gao MH, Saito M, Takahashi T, Roth DM, Hammond HK.

J Am Coll Cardiol. 2008 Apr 15;51(15):1490-7. doi: 10.1016/j.jacc.2008.01.015.


Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.

Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK.

Circulation. 2008 Jan 1;117(1):61-9. Epub 2007 Dec 10.


Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction.

Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3216-20. Epub 2007 Sep 14.


Adenylylcyclase gene transfer increases function of the failing heart.

Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth DM, Baird SM, Hammond HK.

Hum Gene Ther. 2006 Oct;17(10):1043-8.


Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction.

Sastry A, Arnold E, Gurji H, Iwasa A, Bui H, Hassankhani A, Patel HH, Feramisco JR, Roth DM, Lai NC, Hammond HK, Narayan SM.

J Am Coll Cardiol. 2006 Aug 1;48(3):559-65. Epub 2006 Jul 12.


Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction.

Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK.

Circulation. 2006 Aug 1;114(5):388-96. Epub 2006 Jul 24. Erratum in: Circulation. 2006 Sep 12;114(11):e497.


Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice.

Tsutsumi YM, Patel HH, Lai NC, Takahashi T, Head BP, Roth DM.

Anesthesiology. 2006 Mar;104(3):495-502.


Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus.

Roth DA, McKirnan MD, Canestrelli I, Gao MH, Dalton N, Lai NC, Roth DM, Hammond HK.

Hum Gene Ther. 2006 Feb;17(2):230-8.


Adenylyl cyclase type V deletion increases basal left ventricular function and reduces left ventricular contractile responsiveness to beta-adrenergic stimulation.

Tang T, Lai NC, Roth DM, Drumm J, Guo T, Lee KW, Han PL, Dalton N, Gao MH.

Basic Res Cardiol. 2006 Mar;101(2):117-26. Epub 2005 Nov 11.


Signal peptide increases the efficacy of angiogenic gene transfer for treatment of myocardial ischemia.

Gao MH, Lai NC, Hammond HK.

Hum Gene Ther. 2005 Sep;16(9):1058-64.


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