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Items: 1 to 50 of 346

1.

Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds.

Schepers M, Martens N, Tiane A, Vanbrabant K, Liu HB, Lütjohann D, Mulder M, Vanmierlo T.

Neural Regen Res. 2020 May;15(5):790-795. doi: 10.4103/1673-5374.268894. Review.

PMID:
31719238
2.

Interaction of chylomicron remnants and VLDLs during ultracentrifuge separation based on the Svedberg flotation rate.

Stellaard F, Lütjohann D.

J Intern Med. 2019 Oct 21. doi: 10.1111/joim.13000. [Epub ahead of print] No abstract available.

PMID:
31709626
3.

Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses.

Pecks U, Bornemann V, Klein A, Segger L, Maass N, Alkatout I, Eckmann-Scholz C, Elessawy M, Lütjohann D.

Lipids Health Dis. 2019 Oct 25;18(1):185. doi: 10.1186/s12944-019-1117-1.

4.

Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement.

Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, Calabresi L, Chapman MJ, Cuchel M, von Eckardstein A, Frikke-Schmidt R, Gaudet D, Hovingh GK, Kronenberg F, Lütjohann D, Parhofer KG, Raal FJ, Ray KK, Remaley AT, Stock JK, Stroes ES, Tokgözoğlu L, Catapano AL.

Lancet Diabetes Endocrinol. 2019 Sep 30. pii: S2213-8587(19)30264-5. doi: 10.1016/S2213-8587(19)30264-5. [Epub ahead of print] Review.

PMID:
31582260
5.

Serum Concentration of Plant Sterol Oxidation Products (POP) Compared to Cholesterol Oxidation Products (COP) after Intake of Oxidized Plant Sterols: A Randomised, Placebo-Controlled, Double-Blind Dose‒Response Pilot Study.

Lin Y, Koppenol WP, Knol D, Vermeer MA, Hiemstra H, Friedrichs S, Lütjohann D, Trautwein EA.

Nutrients. 2019 Sep 30;11(10). pii: E2319. doi: 10.3390/nu11102319.

6.

Need to individualise cholesterol-lowering therapy.

Lütjohann D, Weingärtner O.

Heart. 2019 Aug;105(16):1291-1292. doi: 10.1136/heartjnl-2019-315376. No abstract available.

PMID:
31350368
7.

In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes.

Nascimento EBM, Konings M, Schaart G, Groen AK, Lütjohann D, van Marken Lichtenbelt WD, Schrauwen P, Plat J.

Eur J Nutr. 2019 Jul 17. doi: 10.1007/s00394-019-02052-y. [Epub ahead of print]

PMID:
31317217
8.

[Sitosterolemia (phytosterolemia)].

Lütjohann D.

Internist (Berl). 2019 Aug;60(8):871-877. doi: 10.1007/s00108-019-0635-2. Review. German.

PMID:
31254003
9.

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells.

Silva LMR, Lütjohann D, Hamid P, Velasquez ZD, Kerner K, Larrazabal C, Failing K, Hermosilla C, Taubert A.

Sci Rep. 2019 Apr 30;9(1):6650. doi: 10.1038/s41598-019-43153-2.

10.

Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study.

Weingärtner O, Lütjohann D, Meyer S, Fuhrmann A, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada A, Laufs U, Schulze PC, Scheller B, Fliser D, Böhm M, Sijbrands E, Heine GH.

Clin Res Cardiol. 2019 Apr 4. doi: 10.1007/s00392-019-01474-2. [Epub ahead of print]

PMID:
30949753
11.

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods.

Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, Caccia C, Ceglarek U, Cenarro A, Crick PJ, Fauler G, Garcia-Llatas G, Gray R, Griffiths WJ, Gylling H, Harding S, Helmschrodt C, Iuliano L, Janssen HG, Jones P, Kaipiainen L, Kannenberg F, Lagarda MJ, Leoni V, Lottenberg AM, MacKay DS, Matysik S, McDonald J, Menendez-Carreño M, Myrie SB, Sutti Nunes V, Ostlund RE, Polisecki E, Ramos F, Rideout TC, Schaefer EJ, Schmitz G, Wang Y, Zerbinati C, Diczfalusy U, Schött HF.

J Steroid Biochem Mol Biol. 2019 Jun;190:115-125. doi: 10.1016/j.jsbmb.2019.03.025. Epub 2019 Mar 30.

12.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.

Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, Mulder M.

Sci Rep. 2019 Mar 20;9(1):4908. doi: 10.1038/s41598-019-41399-4.

13.

The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats.

Šošić-Jurjević B, Lütjohann D, Renko K, Filipović B, Radulović N, Ajdžanović V, Trifunović S, Nestorović N, Živanović J, Manojlović Stojanoski M, Kӧhrle J, Milošević V.

J Steroid Biochem Mol Biol. 2019 Jun;190:1-10. doi: 10.1016/j.jsbmb.2019.03.009. Epub 2019 Mar 15.

PMID:
30885834
14.

The emerging concept of "individualized cholesterol-lowering therapy": A change in paradigm.

Lütjohann D, Stellaard F, Mulder MT, Sijbrands EJG, Weingärtner O.

Pharmacol Ther. 2019 Jul;199:111-116. doi: 10.1016/j.pharmthera.2019.03.004. Epub 2019 Mar 12. Review.

PMID:
30877023
15.

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?"

Plat J, Baumgartner S, Vanmierlo T, Lütjohann D, Calkins KL, Burrin DG, Guthrie G, Thijs C, Te Velde AA, Vreugdenhil ACE, Sverdlov R, Garssen J, Wouters K, Trautwein EA, Wolfs TG, van Gorp C, Mulder MT, Riksen NP, Groen AK, Mensink RP.

Prog Lipid Res. 2019 Apr;74:87-102. doi: 10.1016/j.plipres.2019.02.003. Epub 2019 Feb 26. Review.

16.

Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation.

Matassoli FL, Leão IC, Bezerra BB, Pollard RB, Lütjohann D, Hildreth JEK, Arruda LB.

mSphere. 2018 Nov 7;3(6). pii: e00497-18. doi: 10.1128/mSphere.00497-18.

17.

Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex.

Romano MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmüller J, Nürnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lütjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC.

Am J Hum Genet. 2018 Nov 1;103(5):777-785. doi: 10.1016/j.ajhg.2018.09.011. Epub 2018 Oct 25.

18.

Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events.

Fuhrmann A, Weingärtner O, Meyer S, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada AM, Laufs U, Scheller B, Fliser D, Schulze PC, Böhm M, Heine GH, Lütjohann D.

Atherosclerosis. 2018 Dec;279:17-22. doi: 10.1016/j.atherosclerosis.2018.10.010. Epub 2018 Oct 17.

PMID:
30366187
19.

Comment on Tauriainen et al.: Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD.

Plat J, Baumgartner S, Houben T, Vreugdenhil ACE, Mensink RP, Lütjohann D, Shiri-Sverdlov R.

Biosci Rep. 2018 Oct 31;38(5). pii: BSR20180505. doi: 10.1042/BSR20180505. Print 2018 Oct 31.

20.

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.

Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, Brüne B.

Front Immunol. 2018 Aug 24;9:1906. doi: 10.3389/fimmu.2018.01906. eCollection 2018.

21.

Call for an ezetimibe effectiveness test.

Lütjohann D, Laufs U, Schulze PC, Weingärtner O.

Atherosclerosis. 2018 Nov;278:334. doi: 10.1016/j.atherosclerosis.2018.08.028. Epub 2018 Aug 26. No abstract available.

PMID:
30193821
22.

Progress and perspectives in plant sterol and plant stanol research.

Jones PJH, Shamloo M, MacKay DS, Rideout TC, Myrie SB, Plat J, Roullet JB, Baer DJ, Calkins KL, Davis HR, Barton Duell P, Ginsberg H, Gylling H, Jenkins D, Lütjohann D, Moghadasian M, Moreau RA, Mymin D, Ostlund RE Jr, Ras RT, Ochoa Reparaz J, Trautwein EA, Turley S, Vanmierlo T, Weingärtner O.

Nutr Rev. 2018 Oct 1;76(10):725-746. doi: 10.1093/nutrit/nuy032. Review.

23.

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods.

Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Geilenkeuser WJ, Lövgren-Sandblom A, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Bretillon L, Browne RW, Caccia C, Cenarro A, Crick PJ, Fauler G, García-Llatas G, Griffiths WJ, Iuliano L, Lagarda MJ, Leoni V, Lottenberg AM, Matysik S, McDonald J, Rideout TC, Schmitz G, Nunes VS, Wang Y, Zerbinati C, Diczfalusy U, Schött HF.

Biochimie. 2018 Oct;153:26-32. doi: 10.1016/j.biochi.2018.07.016. Epub 2018 Jul 29.

PMID:
30063945
24.

Modulation of cholesterol-related sterols during Eimeria bovis macromeront formation and impact of selected oxysterols on parasite development.

Taubert A, Silva LMR, Velásquez ZD, Larrazabal C, Lütjohann D, Hermosilla C.

Mol Biochem Parasitol. 2018 Jul;223:1-12. doi: 10.1016/j.molbiopara.2018.06.002. Epub 2018 Jun 15.

PMID:
29909067
25.

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.

Jehle J, Schöne B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G.

PLoS One. 2018 May 29;13(5):e0197751. doi: 10.1371/journal.pone.0197751. eCollection 2018.

26.

Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2tm1.1Bird Mouse, a Model for Rett Syndrome.

Lütjohann D, Lopez AM, Chuang JC, Kerksiek A, Turley SD.

Lipids. 2018 Apr;53(4):363-373. doi: 10.1002/lipd.12041. Epub 2018 May 17.

PMID:
29770459
27.

Cholesterol Absorption and Synthesis in Vegetarians and Omnivores.

Lütjohann D, Meyer S, von Bergmann K, Stellaard F.

Mol Nutr Food Res. 2018 Mar;62(6):e1700689. doi: 10.1002/mnfr.201700689. Epub 2018 Feb 23.

PMID:
29427539
28.

Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage-refractory itch.

Holz R, Kremer AE, Lütjohann D, Wasmuth HE, Lammert F, Krawczyk M.

Hepatol Commun. 2018 Jan 10;2(2):152-154. doi: 10.1002/hep4.1144. eCollection 2018 Feb.

29.

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging.

Smiljanic K, Todorovic S, Mladenovic Djordjevic A, Vanmierlo T, Lütjohann D, Ivkovic S, Kanazir S.

Biogerontology. 2018 Apr;19(2):121-132. doi: 10.1007/s10522-018-9743-y. Epub 2018 Jan 16.

PMID:
29340834
30.

Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects.

Lütjohann D, Marinova M, Wolter K, Willinek W, Bitterlich N, Coenen M, Coch C, Stellaard F.

Nutrients. 2018 Jan 11;10(1). pii: E72. doi: 10.3390/nu10010072.

31.

Defective cholesterol clearance limits remyelination in the aged central nervous system.

Cantuti-Castelvetri L, Fitzner D, Bosch-Queralt M, Weil MT, Su M, Sen P, Ruhwedel T, Mitkovski M, Trendelenburg G, Lütjohann D, Möbius W, Simons M.

Science. 2018 Feb 9;359(6376):684-688. doi: 10.1126/science.aan4183. Epub 2018 Jan 4.

PMID:
29301957
32.

The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial.

Baumgartner S, Mensink RP, Haenen GR, Bast A, Binder CJ, Bekers O, Husche C, Lütjohann D, Plat J.

Sci Rep. 2017 Nov 10;7(1):15288. doi: 10.1038/s41598-017-15615-y.

33.

Chemotion ELN: an Open Source electronic lab notebook for chemists in academia.

Tremouilhac P, Nguyen A, Huang YC, Kotov S, Lütjohann DS, Hübsch F, Jung N, Bräse S.

J Cheminform. 2017 Sep 25;9(1):54. doi: 10.1186/s13321-017-0240-0.

34.

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation.

Houben T, Oligschlaeger Y, Bitorina AV, Hendrikx T, Walenbergh SMA, Lenders MH, Gijbels MJJ, Verheyen F, Lütjohann D, Hofker MH, Binder CJ, Shiri-Sverdlov R.

Sci Rep. 2017 Oct 2;7(1):12550. doi: 10.1038/s41598-017-13058-z.

35.

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.

Monzel JV, Budde T, Meyer Zu Schwabedissen HE, Schwebe M, Bien-Möller S, Lütjohann D, Kroemer HK, Jedlitschky G, Grube M.

Biochem Pharmacol. 2017 Nov 15;144:108-119. doi: 10.1016/j.bcp.2017.08.008. Epub 2017 Aug 12.

PMID:
28807695
36.

Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia.

Berbée JFP, Mol IM, Milne GL, Pollock E, Hoeke G, Lütjohann D, Monaco C, Rensen PCN, van der Ploeg LHT, Shchepinov MS.

Atherosclerosis. 2017 Sep;264:100-107. doi: 10.1016/j.atherosclerosis.2017.06.916. Epub 2017 Jun 21.

PMID:
28655430
37.

The effects of amoxicillin and vancomycin on parameters reflecting cholesterol metabolism.

Baumgartner S, Reijnders D, Konings MCJM, Groen AK, Lütjohann D, Goossens GH, Blaak EE, Plat J.

Chem Phys Lipids. 2017 Oct;207(Pt B):239-245. doi: 10.1016/j.chemphyslip.2017.06.006. Epub 2017 Jun 21.

PMID:
28647339
38.

Cathepsin D regulates lipid metabolism in murine steatohepatitis.

Houben T, Oligschlaeger Y, Hendrikx T, Bitorina AV, Walenbergh SMA, van Gorp PJ, Gijbels MJJ, Friedrichs S, Plat J, Schaap FG, Lütjohann D, Hofker MH, Shiri-Sverdlov R.

Sci Rep. 2017 Jun 14;7(1):3494. doi: 10.1038/s41598-017-03796-5.

39.

Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice.

Wiesmann M, Zerbi V, Jansen D, Lütjohann D, Veltien A, Heerschap A, Kiliaan AJ.

Theranostics. 2017 Mar 6;7(5):1277-1289. doi: 10.7150/thno.18509. eCollection 2017.

40.

Effects of age and soybean isoflavones on hepatic cholesterol metabolism and thyroid hormone availability in acyclic female rats.

Šošić-Jurjević B, Lütjohann D, Jarić I, Miler M, Vojnović Milutinović D, Filipović B, Ajdžanović V, Renko K, Wirth EK, Janković S, Kӧhrle J, Milošević V.

Exp Gerontol. 2017 Jun;92:74-81. doi: 10.1016/j.exger.2017.03.016. Epub 2017 Mar 21.

PMID:
28336316
41.
42.

Oxysterols: Players in different metabolic leagues.

Lütjohann D, Lizard G, Iuliano L.

J Steroid Biochem Mol Biol. 2017 May;169:1-3. doi: 10.1016/j.jsbmb.2017.03.011. Epub 2017 Mar 16. No abstract available.

PMID:
28315792
43.

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions.

Mailleux J, Vanmierlo T, Bogie JF, Wouters E, Lütjohann D, Hendriks JJ, van Horssen J.

Mult Scler. 2018 Mar;24(3):279-289. doi: 10.1177/1352458517696595. Epub 2017 Feb 1.

PMID:
28273782
44.

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.

Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, Meyer Zu Heringdorf D.

Sci Rep. 2017 Mar 6;7:43575. doi: 10.1038/srep43575.

45.

Thermal stability of plant sterols and formation of their oxidation products in vegetable oils and margarines upon controlled heating.

Lin Y, Knol D, Valk I, van Andel V, Friedrichs S, Lütjohann D, Hrncirik K, Trautwein EA.

Chem Phys Lipids. 2017 Oct;207(Pt B):99-107. doi: 10.1016/j.chemphyslip.2017.01.007. Epub 2017 Feb 2.

PMID:
28163064
46.

Variations in dietary intake and plasma concentrations of plant sterols across plant-based diets among North American adults.

Jaceldo-Siegl K, Lütjohann D, Sirirat R, Mashchak A, Fraser GE, Haddad E.

Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600828. Epub 2017 Mar 20.

47.

Bioactive Compound Screen for Pharmacological Enhancers of Apolipoprotein E in Primary Human Astrocytes.

Finan GM, Realubit R, Chung S, Lütjohann D, Wang N, Cirrito JR, Karan C, Kim TW.

Cell Chem Biol. 2016 Dec 22;23(12):1526-1538. doi: 10.1016/j.chembiol.2016.10.015. Epub 2016 Nov 23.

48.

Statins improve NASH via inhibition of RhoA and Ras.

Schierwagen R, Maybüchen L, Hittatiya K, Klein S, Uschner FE, Braga TT, Franklin BS, Nickenig G, Strassburg CP, Plat J, Sauerbruch T, Latz E, Lütjohann D, Zimmer S, Trebicka J.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G724-G733. doi: 10.1152/ajpgi.00063.2016. Epub 2016 Sep 15.

49.

Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.

Weingärtner O, Bogeski I, Kummerow C, Schirmer SH, Husche C, Vanmierlo T, Wagenpfeil G, Hoth M, Böhm M, Lütjohann D, Laufs U.

J Steroid Biochem Mol Biol. 2017 May;169:219-225. doi: 10.1016/j.jsbmb.2016.07.016. Epub 2016 Jul 27.

PMID:
27473562
50.

Personalize and Optimize Lipid-Lowering Therapies.

Weingärtner O, Lütjohann D, Elsässer A.

J Am Coll Cardiol. 2016 Jul 19;68(3):325-326. doi: 10.1016/j.jacc.2016.02.086. No abstract available.

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