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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy.

Dohmen M, Krieg S, Agalaridis G, Zhu X, Shehata SN, Pfeiffenberger E, Amelang J, Bütepage M, Buerova E, Pfaff CM, Chanda D, Geley S, Preisinger C, Sakamoto K, Lüscher B, Neumann D, Vervoorts J.

Nat Commun. 2020 Feb 25;11(1):1032. doi: 10.1038/s41467-020-14812-0.


Cl- as a bona fide signaling ion.

Lüscher BP, Vachel L, Ohana E, Muallem S.

Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C125-C136. doi: 10.1152/ajpcell.00354.2019. Epub 2019 Nov 6.


Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia.

Lüscher BP, Surbek DV, Clémençon B, Huang X, Albrecht C, Marini C, Hediger MA, Baumann MU.

Cell Physiol Biochem. 2019;53(3):508-517. doi: 10.33594/000000154.


Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience.

Lüscher B, Möhler H.

F1000Res. 2019 May 29;8. pii: F1000 Faculty Rev-751. doi: 10.12688/f1000research.18758.1. eCollection 2019. Review.


PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1.

Guo H, Treude F, Krämer OH, Lüscher B, Hartkamp J.

Sci Rep. 2019 Jun 19;9(1):8755. doi: 10.1038/s41598-019-45209-9.


Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l.

Lüscher-Firzlaff J, Chatain N, Kuo CC, Braunschweig T, Bochyńska A, Ullius A, Denecke B, Costa IG, Koschmieder S, Lüscher B.

Sci Rep. 2019 Jun 4;9(1):8262. doi: 10.1038/s41598-019-44720-3.


Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels.

Wu Z, Huo Q, Ren L, Dong F, Feng M, Wang Y, Bai Y, Lüscher B, Li ST, Wang GL, Long C, Wang Y, Wu G, Chen G.

Mol Brain. 2019 May 15;12(1):50. doi: 10.1186/s13041-019-0465-0.


Correction: SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310 (doi:10.1242/jcs.073783).

Rothgiesser KM, Erener S, Waibel S, Lüscher B, Hottiger MO.

J Cell Sci. 2019 Apr 24;132(8). pii: jcs232801. doi: 10.1242/jcs.232801. No abstract available.


Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine.

Feng M, Crowley NA, Patel A, Guo Y, Bugni SE, Luscher B.

Neuroscience. 2019 May 15;406:109-125. doi: 10.1016/j.neuroscience.2019.03.003. Epub 2019 Mar 8.


Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice.

Crowley NA, Magee SN, Feng M, Jefferson SJ, Morris CJ, Dao NC, Brockway DF, Luscher B.

Neuropharmacology. 2019 May 1;149:35-44. doi: 10.1016/j.neuropharm.2019.02.003. Epub 2019 Feb 4.


JAK1/3 inhibition preserves epidermal morphology in full-thickness 3D skin models of atopic dermatitis and psoriasis.

Clarysse K, Pfaff CM, Marquardt Y, Huth L, Kortekaas Krohn I, Kluwig D, Lüscher B, Gutermuth J, Baron J.

J Eur Acad Dermatol Venereol. 2019 Feb;33(2):367-375. doi: 10.1111/jdv.15301. Epub 2019 Jan 1.


Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8.

Bütepage M, Krieg S, Eckei L, Li J, Rossetti G, Verheugd P, Lüscher B.

Methods Mol Biol. 2018;1813:41-63. doi: 10.1007/978-1-4939-8588-3_4.


4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10.

Murthy S, Desantis J, Verheugd P, Maksimainen MM, Venkannagari H, Massari S, Ashok Y, Obaji E, Nkizinkinko Y, Lüscher B, Tabarrini O, Lehtiö L.

Eur J Med Chem. 2018 Aug 5;156:93-102. doi: 10.1016/j.ejmech.2018.06.047. Epub 2018 Jun 20.


Effects of a ceramide-containing water-in-oil ointment on skin barrier function and allergen penetration in an IL-31 treated 3D model of the disrupted skin barrier.

Huth S, Schmitt L, Marquardt Y, Heise R, Lüscher B, Amann PM, Baron JM.

Exp Dermatol. 2018 Sep;27(9):1009-1014. doi: 10.1111/exd.13697. Epub 2018 Jul 20.


Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

Bütepage M, Preisinger C, von Kriegsheim A, Scheufen A, Lausberg E, Li J, Kappes F, Feederle R, Ernst S, Eckei L, Krieg S, Müller-Newen G, Rossetti G, Feijs KLH, Verheugd P, Lüscher B.

Sci Rep. 2018 Apr 30;8(1):6748. doi: 10.1038/s41598-018-25137-w.


Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system.

Clémençon B, Lüscher BP, Hediger MA.

J Pharmacol Toxicol Methods. 2018 Jul - Aug;92:67-76. doi: 10.1016/j.vascn.2018.03.004. Epub 2018 Mar 23.


Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.

Bochyńska A, Lüscher-Firzlaff J, Lüscher B.

Cells. 2018 Mar 2;7(3). pii: E17. doi: 10.3390/cells7030017. Review.


Studying the Role of AMPK in Autophagy.

Krieg S, Lüscher B, Vervoorts J, Dohmen M.

Methods Mol Biol. 2018;1732:373-391. doi: 10.1007/978-1-4939-7598-3_24.


The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis.

Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, Smith K, Nelson K, Bergeson R, McKee R, Harrod C, Ratner L, Lüscher B, Martinez E, Harrod R.

Virology. 2018 May;518:103-115. doi: 10.1016/j.virol.2018.02.010. Epub 2018 Feb 20.


Adolescent Social Stress Increases Anxiety-like Behavior and Alters Synaptic Transmission, Without Influencing Nicotine Responses, in a Sex-Dependent Manner.

Caruso MJ, Crowley NA, Reiss DE, Caulfield JI, Luscher B, Cavigelli SA, Kamens HM.

Neuroscience. 2018 Mar 1;373:182-198. doi: 10.1016/j.neuroscience.2018.01.006. Epub 2018 Jan 16.


PARP10 (ARTD10) modulates mitochondrial function.

Márton J, Fodor T, Nagy L, Vida A, Kis G, Brunyánszki A, Antal M, Lüscher B, Bai P.

PLoS One. 2018 Jan 2;13(1):e0187789. doi: 10.1371/journal.pone.0187789. eCollection 2018.


The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection.

Wang S, Mott KR, Cilluffo M, Kilpatrick CL, Murakami S, Ljubimov AV, Kousoulas KG, Awasthi S, Luscher B, Ghiasi H.

J Virol. 2018 Jan 30;92(4). pii: e01599-17. doi: 10.1128/JVI.01599-17. Print 2018 Feb 15.


ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease.

Lüscher B, Bütepage M, Eckei L, Krieg S, Verheugd P, Shilton BH.

Chem Rev. 2018 Feb 14;118(3):1092-1136. doi: 10.1021/acs.chemrev.7b00122. Epub 2017 Nov 27. Review.


The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function.

Pfaff CM, Marquardt Y, Fietkau K, Baron JM, Lüscher B.

Sci Rep. 2017 Nov 15;7(1):15631. doi: 10.1038/s41598-017-15892-7.


Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.

Wang S, Mott KR, Wawrowsky K, Kousoulas KG, Luscher B, Ghiasi H.

J Virol. 2017 Sep 12;91(19). pii: e00945-17. doi: 10.1128/JVI.00945-17. Print 2017 Oct 1.


Endotoxin tolerance in mast cells, its consequences for IgE-mediated signalling, and the effects of BCL3 deficiency.

Poplutz M, Levikova M, Lüscher-Firzlaff J, Lesina M, Algül H, Lüscher B, Huber M.

Sci Rep. 2017 Jul 3;7(1):4534. doi: 10.1038/s41598-017-04890-4.


Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia.

Lüscher BP, Marini C, Joerger-Messerli MS, Huang X, Hediger MA, Albrecht C, Baumann MU, Surbek DV.

Placenta. 2017 Jul;55:94-99. doi: 10.1016/j.placenta.2017.04.023. Epub 2017 Apr 27.


Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors.

Fuchs T, Jefferson SJ, Hooper A, Yee PP, Maguire J, Luscher B.

Mol Psychiatry. 2017 Jun;22(6):787. doi: 10.1038/mp.2017.110. No abstract available.


Sulfoximines as ATR inhibitors: Analogs of VE-821.

Hendriks CMM, Hartkamp J, Wiezorek S, Steinkamp AD, Rossetti G, Lüscher B, Bolm C.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2659-2662. doi: 10.1016/j.bmcl.2017.04.026. Epub 2017 Apr 8.


The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases.

Eckei L, Krieg S, Bütepage M, Lehmann A, Gross A, Lippok B, Grimm AR, Kümmerer BM, Rossetti G, Lüscher B, Verheugd P.

Sci Rep. 2017 Feb 2;7:41746. doi: 10.1038/srep41746.


DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation.

Du K, Murakami S, Sun Y, Kilpatrick CL, Luscher B.

J Biol Chem. 2017 Feb 17;292(7):2979-2991. doi: 10.1074/jbc.M116.747139. Epub 2017 Jan 5.


Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant.

Li J, Vervoorts J, Carloni P, Rossetti G, Lüscher B.

BMC Bioinformatics. 2017 Jan 5;18(1):15. doi: 10.1186/s12859-016-1411-0.


Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice.

Kilpatrick CL, Murakami S, Feng M, Wu X, Lal R, Chen G, Du K, Luscher B.

J Biol Chem. 2016 Dec 30;291(53):27371-27386. doi: 10.1074/jbc.M116.732768. Epub 2016 Nov 14.


Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABAA Receptor γ2 Subunit in the Cerebellum.

Leppä E, Linden AM, Aller MI, Wulff P, Vekovischeva O, Luscher B, Lüddens H, Wisden W, Korpi ER.

Front Pharmacol. 2016 Oct 27;7:403. eCollection 2016.


Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state.

Fuchs T, Jefferson SJ, Hooper A, Yee PH, Maguire J, Luscher B.

Mol Psychiatry. 2017 Jun;22(6):920-930. doi: 10.1038/mp.2016.188. Epub 2016 Nov 8.


Players in ADP-ribosylation: Readers and Erasers.

Verheugd P, Bütepage M, Eckei L, Lüscher B.

Curr Protein Pept Sci. 2016;17(7):654-667. Review.


Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.

Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Ashok Y, Narwal M, Pihlajaniemi T, Lüscher B, Lehtiö L.

Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. doi: 10.1016/j.chembiol.2016.08.012. Epub 2016 Sep 22.


Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization.

Fahrenkamp D, Li J, Ernst S, Schmitz-Van de Leur H, Chatain N, Küster A, Koschmieder S, Lüscher B, Rossetti G, Müller-Newen G.

Sci Rep. 2016 Oct 18;6:35454. doi: 10.1038/srep35454.


Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice.

Deisl C, Anderegg M, Albano G, Lüscher BP, Cerny D, Soria R, Bouillet E, Rimoldi S, Scherrer U, Fuster DG.

PLoS One. 2016 Sep 29;11(9):e0163568. doi: 10.1371/journal.pone.0163568. eCollection 2016.


IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T.

Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11.


Inhibition of SIRT2 suppresses hepatic fibrosis.

Arteaga M, Shang N, Ding X, Yong S, Cotler SJ, Denning MF, Shimamura T, Breslin P, Lüscher B, Qiu W.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1155-68. doi: 10.1152/ajpgi.00271.2015. Epub 2016 Apr 28.


Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.

Ren Z, Pribiag H, Jefferson SJ, Shorey M, Fuchs T, Stellwagen D, Luscher B.

Biol Psychiatry. 2016 Sep 15;80(6):457-468. doi: 10.1016/j.biopsych.2016.02.009. Epub 2016 Feb 13.


Control of the Physical and Antimicrobial Skin Barrier by an IL-31-IL-1 Signaling Network.

Hänel KH, Pfaff CM, Cornelissen C, Amann PM, Marquardt Y, Czaja K, Kim A, Lüscher B, Baron JM.

J Immunol. 2016 Apr 15;196(8):3233-44. doi: 10.4049/jimmunol.1402943. Epub 2016 Mar 4.


Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation.

Bahram F, Hydbring P, Tronnersjö S, Zakaria SM, Frings O, Fahlén S, Nilsson H, Goodwin J, von der Lehr N, Su Y, Lüscher B, Castell A, Larsson LG.

Oncotarget. 2016 Jan 19;7(3):2837-54. doi: 10.18632/oncotarget.6693.


GAR22β regulates cell migration, sperm motility, and axoneme structure.

Gamper I, Fleck D, Barlin M, Spehr M, El Sayad S, Kleine H, Maxeiner S, Schalla C, Aydin G, Hoss M, Litchfield DW, Lüscher B, Zenke M, Sechi A.

Mol Biol Cell. 2016 Jan 15;27(2):277-94. doi: 10.1091/mbc.E15-06-0426. Epub 2015 Nov 12.


Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.

Ebersole B, Petko J, Woll M, Murakami S, Sokolina K, Wong V, Stagljar I, Lüscher B, Levenson R.

PLoS One. 2015 Nov 4;10(11):e0140661. doi: 10.1371/journal.pone.0140661. eCollection 2015.


Intracellular Mono-ADP-Ribosylation in Signaling and Disease.

Bütepage M, Eckei L, Verheugd P, Lüscher B.

Cells. 2015 Sep 25;4(4):569-95. doi: 10.3390/cells4040569. Review.


Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).

Li J, Flick F, Verheugd P, Carloni P, Lüscher B, Rossetti G.

PLoS One. 2015 Sep 25;10(9):e0139095. doi: 10.1371/journal.pone.0139095. eCollection 2015.


Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria.

Dhayat N, Simonin A, Anderegg M, Pathare G, Lüscher BP, Deisl C, Albano G, Mordasini D, Hediger MA, Surbek DV, Vogt B, Sass JO, Kloeckener-Gruissem B, Fuster DG.

J Am Soc Nephrol. 2016 May;27(5):1426-36. doi: 10.1681/ASN.2015040411. Epub 2015 Sep 16.


ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53.

Linzen U, Lilischkis R, Pandithage R, Schilling B, Ullius A, Lüscher-Firzlaff J, Kremmer E, Lüscher B, Vervoorts J.

PLoS One. 2015 Apr 10;10(4):e0123736. doi: 10.1371/journal.pone.0123736. eCollection 2015.

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