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Items: 1 to 50 of 341

1.

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes.

Kastner B, Will CL, Stark H, Lührmann R.

Cold Spring Harb Perspect Biol. 2019 Feb 14. pii: a032417. doi: 10.1101/cshperspect.a032417. [Epub ahead of print]

PMID:
30765414
2.

Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome.

Bao P, Boon KL, Will CL, Hartmuth K, Lührmann R.

Nucleic Acids Res. 2018 Dec 14;46(22):12126-12138. doi: 10.1093/nar/gky966.

3.

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M.

Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y.

4.

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

Cretu C, Agrawal AA, Cook A, Will CL, Fekkes P, Smith PG, Lührmann R, Larsen N, Buonamici S, Pena V.

Mol Cell. 2018 Apr 19;70(2):265-273.e8. doi: 10.1016/j.molcel.2018.03.011. Epub 2018 Apr 12.

5.

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, Kachala M, Svergun D, Urlaub H, Lührmann R, Pena V.

Mol Cell. 2018 Mar 15;69(6):979-992.e6. doi: 10.1016/j.molcel.2018.02.022.

6.

The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation.

Roithová A, Klimešová K, Pánek J, Will CL, Lührmann R, Stanek D, Girard C.

Nucleic Acids Res. 2018 Apr 20;46(7):3774-3790. doi: 10.1093/nar/gky070.

7.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2018 Jan 25;172(3):454-464.e11. doi: 10.1016/j.cell.2018.01.010. Epub 2018 Jan 17.

8.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex.

Bao P, Will CL, Urlaub H, Boon KL, Lührmann R.

Genes Dev. 2017 Dec 1;31(23-24):2416-2429. doi: 10.1101/gad.308163.117. Epub 2018 Jan 12.

9.

Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.

Bao P, Höbartner C, Hartmuth K, Lührmann R.

RNA. 2017 Dec;23(12):1770-1779. doi: 10.1261/rna.063115.117. Epub 2017 Sep 1.

10.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2017 Aug 10;170(4):701-713.e11. doi: 10.1016/j.cell.2017.07.011. Epub 2017 Aug 3.

11.

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.

Pozzi B, Bragado L, Will CL, Mammi P, Risso G, Urlaub H, Lührmann R, Srebrow A.

Nucleic Acids Res. 2017 Jun 20;45(11):6729-6745. doi: 10.1093/nar/gkx213.

12.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Sidarovich A, Will CL, Anokhina MM, Ceballos J, Sievers S, Agafonov DE, Samatov T, Bao P, Kastner B, Urlaub H, Waldmann H, Lührmann R.

Elife. 2017 Mar 16;6. pii: e23533. doi: 10.7554/eLife.23533.

13.

Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.

Tauchert MJ, Fourmann JB, Lührmann R, Ficner R.

Elife. 2017 Jan 16;6. pii: e21510. doi: 10.7554/eLife.21510.

14.

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Lührmann R.

Nature. 2017 Feb 16;542(7641):318-323. doi: 10.1038/nature21079. Epub 2017 Jan 11.

PMID:
28076346
15.

Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2.

Fourmann JB, Tauchert MJ, Ficner R, Fabrizio P, Lührmann R.

Nucleic Acids Res. 2017 Apr 20;45(7):4068-4080. doi: 10.1093/nar/gkw1225.

16.

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.

Cretu C, Schmitzová J, Ponce-Salvatierra A, Dybkov O, De Laurentiis EI, Sharma K, Will CL, Urlaub H, Lührmann R, Pena V.

Mol Cell. 2016 Oct 20;64(2):307-319. doi: 10.1016/j.molcel.2016.08.036. Epub 2016 Oct 6.

17.

Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing.

Jagtap PK, Garg D, Kapp TG, Will CL, Demmer O, Lührmann R, Kessler H, Sattler M.

J Med Chem. 2016 Nov 23;59(22):10190-10197. Epub 2016 Nov 4.

PMID:
27753493
18.

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome.

Rauhut R, Fabrizio P, Dybkov O, Hartmuth K, Pena V, Chari A, Kumar V, Lee CT, Urlaub H, Kastner B, Stark H, Lührmann R.

Science. 2016 Sep 23;353(6306):1399-1405. Epub 2016 Aug 25.

19.

ATPγS stalls splicing after B complex formation but prior to spliceosome activation.

Agafonov DE, van Santen M, Kastner B, Dube P, Will CL, Urlaub H, Lührmann R.

RNA. 2016 Sep;22(9):1329-37. doi: 10.1261/rna.057810.116. Epub 2016 Jul 13.

20.

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity.

Boesler C, Rigo N, Anokhina MM, Tauchert MJ, Agafonov DE, Kastner B, Urlaub H, Ficner R, Will CL, Lührmann R.

Nat Commun. 2016 Jul 5;7:11997. doi: 10.1038/ncomms11997.

21.

A protein map of the yeast activated spliceosome as obtained by electron microscopy.

Sun C, Rigo N, Fabrizio P, Kastner B, Lührmann R.

RNA. 2016 Sep;22(9):1427-40. doi: 10.1261/rna.057778.116. Epub 2016 Jul 1.

22.

The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction.

Fourmann JB, Dybkov O, Agafonov DE, Tauchert MJ, Urlaub H, Ficner R, Fabrizio P, Lührmann R.

Elife. 2016 Apr 26;5. pii: e15564. doi: 10.7554/eLife.15564.

23.

Molecular architecture of the human U4/U6.U5 tri-snRNP.

Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, Lührmann R, Stark H.

Science. 2016 Mar 25;351(6280):1416-20. doi: 10.1126/science.aad2085. Epub 2016 Feb 18.

24.

Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum.

Tauchert MJ, Fourmann JB, Christian H, Lührmann R, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2016 Feb;72(Pt 2):112-20. doi: 10.1107/S2053230X15024498. Epub 2016 Jan 22.

25.

Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways.

Heininger AU, Hackert P, Andreou AZ, Boon KL, Memet I, Prior M, Clancy A, Schmidt B, Urlaub H, Schleiff E, Sloan KE, Deckers M, Lührmann R, Enderlein J, Klostermeier D, Rehling P, Bohnsack MT.

RNA Biol. 2016;13(3):320-30. doi: 10.1080/15476286.2016.1142038. Epub 2016 Jan 29.

26.

Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.

Schütze T, Ulrich AK, Apelt L, Will CL, Bartlick N, Seeger M, Weber G, Lührmann R, Stelzl U, Wahl MC.

RNA. 2016 Feb;22(2):265-77. doi: 10.1261/rna.054296.115. Epub 2015 Dec 16.

27.

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.

Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Lührmann R, Santos KF, Wahl MC.

Genes Dev. 2015 Dec 15;29(24):2576-87. doi: 10.1101/gad.271528.115. Epub 2015 Dec 4.

28.

Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex.

Rigo N, Sun C, Fabrizio P, Kastner B, Lührmann R.

EMBO J. 2015 Dec 14;34(24):3059-73. doi: 10.15252/embj.201592022. Epub 2015 Nov 18.

29.

Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.

Schneider C, Agafonov DE, Schmitzová J, Hartmuth K, Fabrizio P, Lührmann R.

PLoS Genet. 2015 Sep 22;11(9):e1005539. doi: 10.1371/journal.pgen.1005539. eCollection 2015.

30.

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.

Boesler C, Rigo N, Agafonov DE, Kastner B, Urlaub H, Will CL, Lührmann R.

RNA. 2015 Nov;21(11):1993-2005. doi: 10.1261/rna.053991.115. Epub 2015 Sep 18.

31.

HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.

Benito E, Urbanke H, Ramachandran B, Barth J, Halder R, Awasthi A, Jain G, Capece V, Burkhardt S, Navarro-Sala M, Nagarajan S, Schütz AL, Johnsen SA, Bonn S, Lührmann R, Dean C, Fischer A.

J Clin Invest. 2015 Sep;125(9):3572-84. doi: 10.1172/JCI79942. Epub 2015 Aug 17.

32.

SnapShot: Spliceosome Dynamics III.

Wahl MC, Lührmann R.

Cell. 2015 Jul 30;162(3):690-690.e1. doi: 10.1016/j.cell.2015.07.033.

33.

SnapShot: Spliceosome Dynamics II.

Wahl MC, Lührmann R.

Cell. 2015 Jul 16;162(2):456-456.e1. doi: 10.1016/j.cell.2015.06.061.

34.

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.

Liu S, Mozaffari-Jovin S, Wollenhaupt J, Santos KF, Theuser M, Dunin-Horkawicz S, Fabrizio P, Bujnicki JM, Lührmann R, Wahl MC.

Elife. 2015 Jul 10;4:e07320. doi: 10.7554/eLife.07320.

35.

SnapShot: Spliceosome Dynamics I.

Wahl MC, Lührmann R.

Cell. 2015 Jun 4;161(6):1474-e1. doi: 10.1016/j.cell.2015.05.050.

36.

Identification of small molecule inhibitors of pre-mRNA splicing.

Pawallek A, McElroy S, Samatov T, Mitchell L, Woodland A, Ryder U, Gray D, Lührmann R, Lamond AI.

J Biol Chem. 2015 Mar 6;290(10):6005. doi: 10.1074/jbc.A114.590976. No abstract available.

37.

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.

De I, Bessonov S, Hofele R, dos Santos K, Will CL, Urlaub H, Lührmann R, Pena V.

Nat Struct Mol Biol. 2015 Feb;22(2):138-44. doi: 10.1038/nsmb.2951. Epub 2015 Jan 19.

PMID:
25599396
38.

The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome.

Warkocki Z, Schneider C, Mozaffari-Jovin S, Schmitzová J, Höbartner C, Fabrizio P, Lührmann R.

Genes Dev. 2015 Jan 1;29(1):94-107. doi: 10.1101/gad.253070.114.

39.

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells.

Alló M, Agirre E, Bessonov S, Bertucci P, Gómez Acuña L, Buggiano V, Bellora N, Singh B, Petrillo E, Blaustein M, Miñana B, Dujardin G, Pozzi B, Pelisch F, Bechara E, Agafonov DE, Srebrow A, Lührmann R, Valcárcel J, Eyras E, Kornblihtt AR.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15622-9. doi: 10.1073/pnas.1416858111. Epub 2014 Oct 13.

40.

Identification of small molecule inhibitors of pre-mRNA splicing.

Pawellek A, McElroy S, Samatov T, Mitchell L, Woodland A, Ryder U, Gray D, Lührmann R, Lamond AI.

J Biol Chem. 2014 Dec 12;289(50):34683-98. doi: 10.1074/jbc.M114.590976. Epub 2014 Oct 3. Erratum in: J Biol Chem. 2015 Mar 6;290(10):6005.

41.

Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex.

Wysoczański P, Schneider C, Xiang S, Munari F, Trowitzsch S, Wahl MC, Lührmann R, Becker S, Zweckstetter M.

Nat Struct Mol Biol. 2014 Oct;21(10):911-8. doi: 10.1038/nsmb.2889. Epub 2014 Sep 14.

PMID:
25218446
42.

Analyzing the protein assembly and dynamics of the human spliceosome with SILAC.

Schmidt C, Raabe M, Lührmann R, Urlaub H.

Methods Mol Biol. 2014;1188:227-44. doi: 10.1007/978-1-4939-1142-4_16.

PMID:
25059615
43.

Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28.

Möhlmann S, Mathew R, Neumann P, Schmitt A, Lührmann R, Ficner R.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1622-30. doi: 10.1107/S1399004714006439. Epub 2014 May 24.

44.

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.

Mozaffari-Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC.

RNA Biol. 2014;11(4):298-312. doi: 10.4161/rna.28353. Epub 2014 Mar 5. Review.

45.

Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count.

Schmidt C, Grønborg M, Deckert J, Bessonov S, Conrad T, Lührmann R, Urlaub H.

RNA. 2014 Mar;20(3):406-20. doi: 10.1261/rna.041244.113. Epub 2014 Jan 21.

46.

Phosphorylation drives a dynamic switch in serine/arginine-rich proteins.

Xiang S, Gapsys V, Kim HY, Bessonov S, Hsiao HH, Möhlmann S, Klaukien V, Ficner R, Becker S, Urlaub H, Lührmann R, de Groot B, Zweckstetter M.

Structure. 2013 Dec 3;21(12):2162-74. doi: 10.1016/j.str.2013.09.014. Epub 2013 Oct 31.

47.

The Prp19 complex directly functions in mitotic spindle assembly.

Hofmann JC, Tegha-Dunghu J, Dräger S, Will CL, Lührmann R, Gruss OJ.

PLoS One. 2013 Sep 19;8(9):e74851. doi: 10.1371/journal.pone.0074851. eCollection 2013.

48.

RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.

Anokhina M, Bessonov S, Miao Z, Westhof E, Hartmuth K, Lührmann R.

EMBO J. 2013 Oct 30;32(21):2804-18. doi: 10.1038/emboj.2013.198. Epub 2013 Sep 3.

49.

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.

Mozaffari-Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC.

Science. 2013 Jul 5;341(6141):80-4. doi: 10.1126/science.1237515. Epub 2013 May 23.

50.

Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.

Ohrt T, Odenwälder P, Dannenberg J, Prior M, Warkocki Z, Schmitzová J, Karaduman R, Gregor I, Enderlein J, Fabrizio P, Lührmann R.

RNA. 2013 Jul;19(7):902-15. doi: 10.1261/rna.039024.113. Epub 2013 May 17.

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