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Items: 1 to 50 of 81

1.

Glucocorticoid resistance of allogeneic T cells alters the gene expression profile in the inflamed small intestine of mice suffering from acute graft-versus-host disease.

Li H, Kaiser TK, Borschiwer M, Bohnenberger H, Reichardt SD, Lühder F, Walter L, Dressel R, Meijsing SH, Reichardt HM.

J Steroid Biochem Mol Biol. 2019 Sep 24;195:105485. doi: 10.1016/j.jsbmb.2019.105485. [Epub ahead of print]

PMID:
31561002
2.

Glucocorticoid Therapy of Multiple Sclerosis Patients Induces Anti-inflammatory Polarization and Increased Chemotaxis of Monocytes.

Fischer HJ, Finck TLK, Pellkofer HL, Reichardt HM, Lühder F.

Front Immunol. 2019 May 29;10:1200. doi: 10.3389/fimmu.2019.01200. eCollection 2019.

3.

Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.

Hoepner R, Bagnoud M, Pistor M, Salmen A, Briner M, Synn H, Schrewe L, Guse K, Ahmadi F, Demir S, Laverick L, Gresle M, Worley P, Reichardt HM, Butzkueven H, Gold R, Metz I, Lühder F, Chan A.

Acta Neuropathol. 2019 Sep;138(3):443-456. doi: 10.1007/s00401-019-02018-8. Epub 2019 Apr 27.

4.

During acute graft versus host disease CD28 deletion in donor CD8+ , but not CD4+ , T cells maintain antileukemia responses in mice.

Uri A, Lühder F, Kerkau T, Beyersdorf N.

Eur J Immunol. 2018 Dec;48(12):2055-2067. doi: 10.1002/eji.201847669. Epub 2018 Nov 14.

PMID:
30320878
5.

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo.

Langenhorst D, Haack S, Göb S, Uri A, Lühder F, Vanhove B, Hünig T, Beyersdorf N.

Front Immunol. 2018 May 16;9:1060. doi: 10.3389/fimmu.2018.01060. eCollection 2018.

6.

Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.

Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H.

Mol Psychiatry. 2019 Oct;24(10):1489-1501. doi: 10.1038/s41380-017-0011-3. Epub 2018 Feb 9.

7.

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells.

Meers GK, Bohnenberger H, Reichardt HM, Lühder F, Reichardt SD.

PLoS One. 2018 Jan 11;13(1):e0190846. doi: 10.1371/journal.pone.0190846. eCollection 2018.

8.

Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity.

Montes-Cobos E, Schweingruber N, Li X, Fischer HJ, Reichardt HM, Lühder F.

Front Immunol. 2017 Oct 13;8:1319. doi: 10.3389/fimmu.2017.01319. eCollection 2017.

9.

Novel Drug Delivery Systems Tailored for Improved Administration of Glucocorticoids.

Lühder F, Reichardt HM.

Int J Mol Sci. 2017 Aug 24;18(9). pii: E1836. doi: 10.3390/ijms18091836. Review.

10.

Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells.

Uri A, Werner S, Lühder F, Hünig T, Kerkau T, Beyersdorf N.

Front Immunol. 2017 Jun 23;8:721. doi: 10.3389/fimmu.2017.00721. eCollection 2017.

11.

Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma.

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.

J Immunol. 2017 Jul 1;199(1):48-61. doi: 10.4049/jimmunol.1601691. Epub 2017 May 17.

12.

Laquinimod enhances central nervous system barrier functions.

Lühder F, Kebir H, Odoardi F, Litke T, Sonneck M, Alvarez JI, Winchenbach J, Eckert N, Hayardeny L, Sorani E, Lodygin D, Flügel A, Prat A.

Neurobiol Dis. 2017 Jun;102:60-69. doi: 10.1016/j.nbd.2017.02.002. Epub 2017 Feb 22.

PMID:
28235673
13.

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.

Engler JB, Kursawe N, Solano ME, Patas K, Wehrmann S, Heckmann N, Lühder F, Reichardt HM, Arck PC, Gold SM, Friese MA.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E181-E190. doi: 10.1073/pnas.1617115114. Epub 2017 Jan 3.

14.

Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles.

Montes-Cobos E, Ring S, Fischer HJ, Heck J, Strauß J, Schwaninger M, Reichardt SD, Feldmann C, Lühder F, Reichardt HM.

J Control Release. 2017 Jan 10;245:157-169. doi: 10.1016/j.jconrel.2016.12.003. Epub 2016 Dec 3.

PMID:
27919626
15.

Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.

Fröhlich M, Gogishvili T, Langenhorst D, Lühder F, Hünig T.

Eur J Immunol. 2016 Jul;46(7):1644-55. doi: 10.1002/eji.201546232. Epub 2016 May 17.

16.

Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.

Flach AC, Litke T, Strauss J, Haberl M, Gómez CC, Reindl M, Saiz A, Fehling HJ, Wienands J, Odoardi F, Lühder F, Flügel A.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3323-8. doi: 10.1073/pnas.1519608113. Epub 2016 Mar 8.

17.

Evaluation of the Therapeutic Potential of Anti-TLR4-Antibody MTS510 in Experimental Stroke and Significance of Different Routes of Application.

Andresen L, Theodorou K, Grünewald S, Czech-Zechmeister B, Könnecke B, Lühder F, Trendelenburg G.

PLoS One. 2016 Feb 5;11(2):e0148428. doi: 10.1371/journal.pone.0148428. eCollection 2016.

18.

Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.

Krey L, Lühder F, Kusch K, Czech-Zechmeister B, Könnecke B, Fleming Outeiro T, Trendelenburg G.

J Cereb Blood Flow Metab. 2015 Dec;35(12):2080-8. doi: 10.1038/jcbfm.2015.178. Epub 2015 Jul 29.

19.

Neurotoxocarosis alters myelin protein gene transcription and expression.

Heuer L, Beyerbach M, Lühder F, Beineke A, Strube C.

Parasitol Res. 2015 Jun;114(6):2175-86. doi: 10.1007/s00436-015-4407-1. Epub 2015 Mar 17.

PMID:
25773181
20.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
21.

Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage.

Linker RA, Lee DH, Flach AC, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.

Eur J Immunol. 2015 May;45(5):1326-38. doi: 10.1002/eji.201444985. Epub 2015 Feb 19.

22.

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.

Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U.

Cell Commun Signal. 2014 Dec 5;12:75. doi: 10.1186/s12964-014-0075-5.

23.

Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells.

Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM.

J Pathol. 2015 Mar;235(4):646-55. doi: 10.1002/path.4475. Epub 2015 Jan 7.

PMID:
25358639
24.

Glucocorticoids induce gastroparesis in mice through depletion of l-arginine.

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM.

Endocrinology. 2014 Oct;155(10):3899-908. doi: 10.1210/en.2014-1246. Epub 2014 Jul 24.

PMID:
25057793
25.

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.

Uhmann A, Heß I, Frommhold A, König S, Zabel S, Nitzki F, Dittmann K, Lühder F, Christiansen H, Reifenberger J, Schulz-Schaeffer W, Hahn H.

J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24.

26.

Trial and error in clinical studies: lessons from ATAMS.

Lühder F, Gold R.

Lancet Neurol. 2014 Apr;13(4):340-1. doi: 10.1016/S1474-4422(14)70050-X. Epub 2014 Mar 6. No abstract available.

PMID:
24613348
27.

Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses.

Ndlovu H, Darby M, Froelich M, Horsnell W, Lühder F, Hünig T, Brombacher F.

PLoS Pathog. 2014 Feb 6;10(2):e1003906. doi: 10.1371/journal.ppat.1003906. eCollection 2014 Feb.

28.

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM.

Acta Neuropathol. 2014 May;127(5):713-29. doi: 10.1007/s00401-014-1248-4. Epub 2014 Feb 1.

29.

Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H.

Mol Psychiatry. 2014 Oct;19(10):1143-9. doi: 10.1038/mp.2013.110. Epub 2013 Sep 3.

PMID:
23999527
30.

The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis.

Fischer HJ, Schweingruber N, Lühder F, Reichardt HM.

Mol Cell Endocrinol. 2013 Nov 5;380(1-2):99-107. doi: 10.1016/j.mce.2013.04.001. Epub 2013 Apr 8. Review.

PMID:
23578583
31.

Brain-derived neurotrophic factor in neuroimmunology: lessons learned from multiple sclerosis patients and experimental autoimmune encephalomyelitis models.

Lühder F, Gold R, Flügel A, Linker RA.

Arch Immunol Ther Exp (Warsz). 2013 Apr;61(2):95-105. doi: 10.1007/s00005-012-0211-0. Epub 2013 Jan 3. Review.

PMID:
23283517
32.

Preventive treatment with methylprednisolone paradoxically exacerbates experimental autoimmune encephalomyelitis.

Wüst S, van den Brandt J, Reichardt HM, Lühder F.

Int J Endocrinol. 2012;2012:417017. doi: 10.1155/2012/417017. Epub 2012 Nov 29.

33.

Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.

Gogishvili T, Lühder F, Kirstein F, Nieuwenhuizen NE, Goebbels S, Beer-Hammer S, Pfeffer K, Reuter S, Taube C, Brombacher F, Hünig T.

J Allergy Clin Immunol. 2012 Dec;130(6):1394-403.e4. doi: 10.1016/j.jaci.2012.08.049. Epub 2012 Oct 24.

PMID:
23102920
34.

Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.

Gogishvili T, Lühder F, Goebbels S, Beer-Hammer S, Pfeffer K, Hünig T.

Eur J Immunol. 2013 Jan;43(1):188-93. doi: 10.1002/eji.201242824. Epub 2012 Nov 17.

35.

The ambivalent role of apoptosis in experimental autoimmune encephalomyelitis and multiple sclerosis.

Reichardt HM, Lühder F.

Curr Pharm Des. 2012;18(29):4453-64. Review.

PMID:
22612741
36.

Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1β-induced accumulation of β-amyloid and cell death.

Schmidt J, Barthel K, Zschüntzsch J, Muth IE, Swindle EJ, Hombach A, Sehmisch S, Wrede A, Lühder F, Gold R, Dalakas MC.

Brain. 2012 Apr;135(Pt 4):1102-14. doi: 10.1093/brain/aws046. Epub 2012 Mar 21.

PMID:
22436237
37.

Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease.

Frank T, Klinker F, Falkenburger BH, Laage R, Lühder F, Göricke B, Schneider A, Neurath H, Desel H, Liebetanz D, Bähr M, Weishaupt JH.

Brain. 2012 Jun;135(Pt 6):1914-25. doi: 10.1093/brain/aws054. Epub 2012 Mar 16.

PMID:
22427327
38.

Autoimmune disease in the brain--how to spot the culprits and how to keep them in check.

Flügel A, Schläger C, Lühder F, Odoardi F.

J Neurol Sci. 2011 Dec;311 Suppl 1:S3-11.

PMID:
22206764
39.

Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination.

Lee DH, Geyer E, Flach AC, Jung K, Gold R, Flügel A, Linker RA, Lühder F.

Acta Neuropathol. 2012 Feb;123(2):247-58. doi: 10.1007/s00401-011-0890-3. Epub 2011 Oct 19.

40.

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death.

Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM.

J Immunol. 2011 Nov 1;187(9):4509-16. doi: 10.4049/jimmunol.1100911. Epub 2011 Sep 23.

41.

Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.

Schweingruber N, Haine A, Tiede K, Karabinskaya A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F.

J Immunol. 2011 Oct 15;187(8):4310-8. doi: 10.4049/jimmunol.1101604. Epub 2011 Sep 14.

42.

Mechanisms of glucocorticoids in the control of neuroinflammation.

Schweingruber N, Reichardt SD, Lühder F, Reichardt HM.

J Neuroendocrinol. 2012 Jan;24(1):174-82. doi: 10.1111/j.1365-2826.2011.02161.x. Review.

PMID:
21615563
43.

T cell development critically depends on prethymic stromal patched expression.

Uhmann A, van den Brandt J, Dittmann K, Hess I, Dressel R, Binder C, Lühder F, Christiansen H, Fassnacht M, Bhandoola A, Wienands J, Reichardt HM, Hahn H.

J Immunol. 2011 Mar 15;186(6):3383-91. doi: 10.4049/jimmunol.1001939. Epub 2011 Feb 11.

44.

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.

Linker RA, Lee DH, Demir S, Wiese S, Kruse N, Siglienti I, Gerhardt E, Neumann H, Sendtner M, Lühder F, Gold R.

Brain. 2010 Aug;133(Pt 8):2248-63. doi: 10.1093/brain/awq179.

PMID:
20826430
45.

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.

Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A.

Brain. 2010 Jul;133(Pt 7):1930-43. doi: 10.1093/brain/awq135. Epub 2010 Jun 2.

46.

CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.

Shevtsova Z, Garrido M, Weishaupt J, Saftig P, Bähr M, Lühder F, Kügler S.

Am J Pathol. 2010 Jul;177(1):271-9. doi: 10.2353/ajpath.2010.091267. Epub 2010 May 20.

47.

CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.

Hünig T, Lühder F, Elflein K, Gogishvili T, Fröhlich M, Guler R, Cutler A, Brombacher F.

Med Microbiol Immunol. 2010 Aug;199(3):239-46. doi: 10.1007/s00430-010-0156-z. Review.

48.

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.

Wüst S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Lühder F, Reichardt HM.

PLoS One. 2009 Dec 7;4(12):e8202. doi: 10.1371/journal.pone.0008202.

49.

Small but powerful: short peptide hormones and their role in autoimmune inflammation.

Lühder F, Lee DH, Gold R, Stegbauer J, Linker RA.

J Neuroimmunol. 2009 Dec 10;217(1-2):1-7. doi: 10.1016/j.jneuroim.2009.08.008. Epub 2009 Sep 12. Review.

PMID:
19748684
50.

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease.

Tischner D, van den Brandt J, Weishaupt A, Lühder F, Herold MJ, Reichardt HM.

Eur J Immunol. 2009 Sep;39(9):2361-70. doi: 10.1002/eji.200939490.

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