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Items: 1 to 50 of 69

1.

Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease.

Konki M, Malonzo M, Karlsson IK, Lindgren N, Ghimire B, Smolander J, Scheinin NM, Ollikainen M, Laiho A, Elo LL, Lönnberg T, Röyttä M, Pedersen NL, Kaprio J, Lähdesmäki H, Rinne JO, Lund RJ.

Clin Epigenetics. 2019 Sep 2;11(1):130. doi: 10.1186/s13148-019-0729-7.

2.

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.

Takeda A, Hollmén M, Dermadi D, Pan J, Brulois KF, Kaukonen R, Lönnberg T, Boström P, Koskivuo I, Irjala H, Miyasaka M, Salmi M, Butcher EC, Jalkanen S.

Immunity. 2019 Sep 17;51(3):561-572.e5. doi: 10.1016/j.immuni.2019.06.027. Epub 2019 Aug 8.

PMID:
31402260
3.

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age.

Kallionpää H, Somani J, Tuomela S, Ullah U, de Albuquerque R, Lönnberg T, Komsi E, Siljander H, Honkanen J, Härkönen T, Peet A, Tillmann V, Chandra V, Anagandula MK, Frisk G, Otonkoski T, Rasool O, Lund R, Lähdesmäki H, Knip M, Lahesmaa R.

Diabetes. 2019 Oct;68(10):2024-2034. doi: 10.2337/db19-0287. Epub 2019 Jul 16.

PMID:
31311800
4.

3-Fluoro-2-mercuri-6-methylaniline Nucleotide as a High-Affinity Nucleobase-Specific Hybridization Probe.

Aro-Heinilä A, Lönnberg T, Virta P.

Bioconjug Chem. 2019 Aug 21;30(8):2183-2190. doi: 10.1021/acs.bioconjchem.9b00405. Epub 2019 Jul 15.

PMID:
31246432
5.

Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.

Hande M, Saher O, Lundin KE, Smith CIE, Zain R, Lönnberg T.

Molecules. 2019 Mar 26;24(6). pii: E1180. doi: 10.3390/molecules24061180.

6.

Single-cell immune profiling reveals new insights into colorectal cancer.

Lönnberg T, Stubbington MJ.

Immunol Cell Biol. 2019 Mar;97(3):241-243. doi: 10.1111/imcb.12240. Epub 2019 Feb 21. No abstract available.

PMID:
30791147
7.

Covalently Palladated Oligonucleotides Through Oxidative Addition of Pd0.

Räisälä H, Lönnberg T.

Chemistry. 2019 Mar 27;25(18):4751-4756. doi: 10.1002/chem.201806022. Epub 2019 Feb 27.

PMID:
30666718
8.

2,6-Dimercuriphenol as a Bifacial Dinuclear Organometallic Nucleobase.

Ukale DU, Lönnberg T.

Angew Chem Int Ed Engl. 2018 Dec 3;57(49):16171-16175. doi: 10.1002/anie.201809398. Epub 2018 Nov 11.

PMID:
30358071
9.

Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides.

Hande M, Maity S, Lönnberg T.

Int J Mol Sci. 2018 May 28;19(6). pii: E1588. doi: 10.3390/ijms19061588.

10.

Phosphodiester models for cleavage of nucleic acids.

Mikkola S, Lönnberg T, Lönnberg H.

Beilstein J Org Chem. 2018 Apr 10;14:803-837. doi: 10.3762/bjoc.14.68. eCollection 2018. Review.

11.

Triplex Formation by Oligonucleotides Containing Organomercurated Base Moieties.

Ukale DU, Lönnberg T.

Chembiochem. 2018 May 18;19(10):1096-1101. doi: 10.1002/cbic.201800112. Epub 2018 Apr 23.

PMID:
29575511
12.

Single-cell RNA-sequencing resolves self-antigen expression during mTEC development.

Miragaia RJ, Zhang X, Gomes T, Svensson V, Ilicic T, Henriksson J, Kar G, Lönnberg T.

Sci Rep. 2018 Jan 12;8(1):685. doi: 10.1038/s41598-017-19100-4.

13.

Oligonucleotides Incorporating Palladacyclic Nucleobase Surrogates.

Maity SK, Lönnberg T.

Chemistry. 2018 Jan 26;24(6):1274-1277. doi: 10.1002/chem.201705797. Epub 2018 Jan 11.

PMID:
29227000
14.

Global and targeted approaches to single-cell transcriptome characterization.

Kolodziejczyk AA, Lönnberg T.

Brief Funct Genomics. 2018 Jul 1;17(4):209-219. doi: 10.1093/bfgp/elx025.

15.

Sulfurization of H-Phosphonate Diesters by Elemental Sulfur under Aqueous Conditions.

Lönnberg T.

ACS Omega. 2017 Aug 29;2(8):5122-5127. doi: 10.1021/acsomega.7b00970. eCollection 2017 Aug 31.

16.

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications.

Haque A, Engel J, Teichmann SA, Lönnberg T.

Genome Med. 2017 Aug 18;9(1):75. doi: 10.1186/s13073-017-0467-4. Review.

17.

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Lönnberg T, Svensson V, James KR, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MS, Fogg LG, Nair AS, Liligeto U, Stubbington MJ, Ly LH, Bagger FO, Zwiessele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegle O, Haque A, Teichmann SA.

Sci Immunol. 2017 Mar 3;2(9). pii: eaal2192. doi: 10.1126/sciimmunol.aal2192. Erratum in: Sci Immunol. 2018 Mar 9;3(21):.

18.

Fluorescent Oligonucleotide Probes for Screening High-Affinity Nucleobase Surrogates.

Aro-Heinilä A, Lönnberg T.

Chemistry. 2017 Jan 23;23(5):1028-1031. doi: 10.1002/chem.201605300. Epub 2016 Dec 20.

PMID:
27911048
19.

Nucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur.

Lönnberg T.

Beilstein J Org Chem. 2016 Apr 11;12:670-3. doi: 10.3762/bjoc.12.67. eCollection 2016.

20.

Erratum to: Single cell analysis of CD4+ T cell differentiation reveals three major cell states and progressive acceleration of proliferation.

Proserpio V, Piccolo A, Haim-Vilmovsky L, Kar G, Lönnberg T, Svensson V, Pramanik J, Natarajan KN, Zhai W, Zhang X, Donati G, Kayikci M, Kotar J, McKenzie AN, Montandon R, James KR, Fernandez-Ruiz D, Heath WR, Haque A, Billker O, Woodhouse S, Cicuta P, Nicodemi M, Teichmann SA.

Genome Biol. 2016 Jun 22;17(1):133. No abstract available.

21.

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation.

Proserpio V, Piccolo A, Haim-Vilmovsky L, Kar G, Lönnberg T, Svensson V, Pramanik J, Natarajan KN, Zhai W, Zhang X, Donati G, Kayikci M, Kotar J, McKenzie AN, Montandon R, Billker O, Woodhouse S, Cicuta P, Nicodemi M, Teichmann SA.

Genome Biol. 2016 May 12;17:103. doi: 10.1186/s13059-016-0957-5. Erratum in: Genome Biol. 2016;17(1):133.

22.

5-Mercuricytosine: An Organometallic Janus Nucleobase.

Ukale D, Shinde VS, Lönnberg T.

Chemistry. 2016 Jun 1;22(23):7917-23. doi: 10.1002/chem.201600851. Epub 2016 Apr 26.

PMID:
27113075
23.

Cutting-edge single-cell genomics and modelling in immunology.

Proserpio V, Lönnberg T.

Immunol Cell Biol. 2016 Mar;94(3):224. doi: 10.1038/icb.2015.117. No abstract available.

PMID:
26975342
24.

T cell fate and clonality inference from single-cell transcriptomes.

Stubbington MJT, Lönnberg T, Proserpio V, Clare S, Speak AO, Dougan G, Teichmann SA.

Nat Methods. 2016 Apr;13(4):329-332. doi: 10.1038/nmeth.3800. Epub 2016 Mar 7.

25.

Single-cell technologies are revolutionizing the approach to rare cells.

Proserpio V, Lönnberg T.

Immunol Cell Biol. 2016 Mar;94(3):225-9. doi: 10.1038/icb.2015.106. Epub 2015 Dec 1. Review.

26.

Pd(2+)-mediated base pairing in oligonucleotides.

Golubev O, Turc G, Lönnberg T.

J Inorg Biochem. 2016 Feb;155:36-43. doi: 10.1016/j.jinorgbio.2015.11.008. Epub 2015 Nov 11.

PMID:
26606291
27.

2,6-Bis(1,4,7,10-tetraazacyclododecan-1-ylmethyl)pyridine and Its Benzene Analog as Nonmetallic Cleaving Agents of RNA Phosphodiester Linkages.

Lain L, Lahdenpohja S, Lönnberg H, Lönnberg T.

Int J Mol Sci. 2015 Aug 3;16(8):17798-811. doi: 10.3390/ijms160817798.

28.

Selective Alkylation of C-Rich Bulge Motifs in Nucleic Acids by Quinone Methide Derivatives.

Lönnberg T, Hutchinson M, Rokita S.

Chemistry. 2015 Sep 7;21(37):13127-36. doi: 10.1002/chem.201502014. Epub 2015 Jul 21.

PMID:
26220692
29.

Participation of an additional 4'-hydroxymethyl group in the cleavage and isomerization of ribonucleoside 3'-phosphodiesters.

Lain L, Lönnberg H, Lönnberg T.

Org Biomol Chem. 2015 Apr 28;13(16):4737-42. doi: 10.1039/c5ob00400d.

PMID:
25805021
30.

Buffer catalyzed cleavage of uridylyl-3',5'-uridine in aqueous DMSO: comparison to its activated analog, 2-hydroxypropyl 4-nitrophenyl phosphate.

Lain L, Lönnberg H, Lönnberg TA.

Org Biomol Chem. 2015 Mar 21;13(11):3484-92. doi: 10.1039/c4ob02682a.

PMID:
25669674
31.

Formation of mixed-ligand complexes of Pd2+ with nucleoside 5'-monophosphates and some metal-ion-binding nucleoside surrogates.

Golubev O, Lönnberg T, Lönnberg H.

Molecules. 2014 Oct 22;19(10):16976-86. doi: 10.3390/molecules191016976.

32.

Metal-ion-mediated base pairing between natural nucleobases and bidentate 3,5-dimethylpyrazolyl-substituted purine ligands.

Taherpour S, Golubev O, Lönnberg T.

J Org Chem. 2014 Oct 3;79(19):8990-9. doi: 10.1021/jo501237r. Epub 2014 Sep 22.

PMID:
25211050
33.

Interaction of Pd(2+) complexes of 2,6-disubstituted pyridines with nucleoside 5'-monophosphates.

Golubev O, Lönnberg T, Lönnberg H.

J Inorg Biochem. 2014 Oct;139:21-9. doi: 10.1016/j.jinorgbio.2014.05.013. Epub 2014 Jun 5.

PMID:
24950386
34.

From a gene-centric to whole-proteome view of differentiation of T helper cell subsets.

Lönnberg T, Chen Z, Lahesmaa R.

Brief Funct Genomics. 2013 Nov;12(6):471-82. doi: 10.1093/bfgp/elt033. Epub 2013 Oct 7.

35.

Intramolecular participation of amino groups in the cleavage and isomerization of ribonucleoside 3'-phosphodiesters: the role in stabilization of the phosphorane intermediate.

Lain L, Lönnberg H, Lönnberg T.

Chemistry. 2013 Sep 9;19(37):12424-34. doi: 10.1002/chem.201301711. Epub 2013 Jul 29.

PMID:
23897743
36.

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.

Hawkins RD, Larjo A, Tripathi SK, Wagner U, Luu Y, Lönnberg T, Raghav SK, Lee LK, Lund R, Ren B, Lähdesmäki H, Lahesmaa R.

Immunity. 2013 Jun 27;38(6):1271-84. doi: 10.1016/j.immuni.2013.05.011. Epub 2013 Jun 20.

37.

Holistic systems biology approaches to molecular mechanisms of human helper T cell differentiation to functionally distinct subsets.

Chen Z, Lönnberg T, Lahesmaa R.

Scand J Immunol. 2013 Aug;78(2):172-80. doi: 10.1111/sji.12071. Review. Erratum in: Scand J Immunol. 2013 Dec;78(6):559.

38.

2,6-Bis(functionalized) purines as metal-ion-binding surrogate nucleobases that enhance hybridization with unmodified 2'-O-methyl oligoribonucleotides.

Taherpour S, Lönnberg H, Lönnberg T.

Org Biomol Chem. 2013 Feb 14;11(6):991-1000. doi: 10.1039/c2ob26885j. Epub 2013 Jan 2.

PMID:
23283364
39.

T-cell activation induces selective changes of cellular lipidome.

Lonnberg T, Yetukuri L, Seppanen-Laakso T, Lahesmaa R, Oresic M.

Front Biosci (Elite Ed). 2013 Jan 1;5:558-73.

PMID:
23277012
40.

Can phosphate-branched RNA persist under physiological conditions?

Lönnberg TA.

Chembiochem. 2012 Dec 21;13(18):2690-700. doi: 10.1002/cbic.201200629. Epub 2012 Nov 26.

PMID:
23255258
41.

An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation.

Aijö T, Edelman SM, Lönnberg T, Larjo A, Kallionpää H, Tuomela S, Engström E, Lahesmaa R, Lähdesmäki H.

BMC Genomics. 2012 Oct 30;13:572. doi: 10.1186/1471-2164-13-572.

42.

Intracomplex general acid/base catalyzed cleavage of RNA phosphodiester bonds: the leaving group effect.

Lönnberg T, Luomala M.

Org Biomol Chem. 2012 Sep 7;10(33):6785-91. doi: 10.1039/c2ob25958c. Epub 2012 Jul 24.

PMID:
22825538
43.
44.

Mimics of small ribozymes utilizing a supramolecular scaffold.

Lönnberg TA, Helkearo M, Jancsó A, Gajda T.

Dalton Trans. 2012 Mar 21;41(11):3328-38. doi: 10.1039/c2dt10193a. Epub 2012 Feb 3.

PMID:
22302100
45.

Impact of steric constraints on the product distribution of phosphate-branched oligonucleotide models of the large ribozymes.

Lönnberg T, Kero KM.

Org Biomol Chem. 2012 Jan 21;10(3):569-74. doi: 10.1039/c1ob06399e. Epub 2011 Nov 23.

PMID:
22113401
46.

The Zn(2+) complex of 1,4,7,10-tetraazacyclododecane as an artificial nucleobase.

Laine M, Aromaa M, Virta P, Lönnberg T, Poijärvi-Virta P, Lönnberg H.

Nucleosides Nucleotides Nucleic Acids. 2011 Jul-Aug;30(7-8):609-18. doi: 10.1080/15257770.2011.583809.

PMID:
21888551
47.

Manipulation of single-stranded DNA by using an artificial site-selective DNA cutter composed of cerium(IV)/EDTA and phosphonate-oligonucleotide conjugates.

Aiba Y, Lönnberg T, Komiyama M.

Chem Asian J. 2011 Sep 5;6(9):2407-11. doi: 10.1002/asia.201100238. Epub 2011 Jul 13.

PMID:
21755600
48.

Understanding catalysis of phosphate-transfer reactions by the large ribozymes.

Lönnberg T.

Chemistry. 2011 Jun 20;17(26):7140-53. doi: 10.1002/chem.201100009. Epub 2011 May 18.

PMID:
21594914
49.

Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation.

Moulder R, Lönnberg T, Elo LL, Filén JJ, Rainio E, Corthals G, Oresic M, Nyman TA, Aittokallio T, Lahesmaa R.

Mol Cell Proteomics. 2010 Sep;9(9):1937-53. doi: 10.1074/mcp.M900483-MCP200. Epub 2010 May 13.

50.

Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group.

Leisvuori A, Aiba Y, Lönnberg T, Poijärvi-Virta P, Blatt L, Beigelman L, Lönnberg H.

Org Biomol Chem. 2010 May 7;8(9):2131-41. doi: 10.1039/b924321f. Epub 2010 Mar 5.

PMID:
20401390

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