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Hazards of human spaceflight.

Löbrich M, Jeggo PA.

Science. 2019 Apr 12;364(6436):127-128. doi: 10.1126/science.aaw7086. No abstract available.


AutoFoci, an automated high-throughput foci detection approach for analyzing low-dose DNA double-strand break repair.

Lengert N, Mirsch J, Weimer RN, Schumann E, Haub P, Drossel B, Löbrich M.

Sci Rep. 2018 Nov 23;8(1):17282. doi: 10.1038/s41598-018-35660-5.


DNA repair synthesis and histone deposition partner during homologous recombination.

Elbakry A, Juhász S, Mathes A, Löbrich M.

Mol Cell Oncol. 2018 Sep 5;5(5):e1511210. doi: 10.1080/23723556.2018.1511210. eCollection 2018.


The pendulum of the Ku-Ku clock.

Shibata A, Jeggo P, Löbrich M.

DNA Repair (Amst). 2018 Nov;71:164-171. doi: 10.1016/j.dnarep.2018.08.020. Epub 2018 Aug 23. Review.


ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination.

Juhász S, Elbakry A, Mathes A, Löbrich M.

Mol Cell. 2018 Jul 5;71(1):11-24.e7. doi: 10.1016/j.molcel.2018.05.014. Epub 2018 Jun 21.


DNA non-homologous end-joining enters the resection arena.

Jeggo PA, Löbrich M.

Oncotarget. 2017 Oct 26;8(55):93317-93318. doi: 10.18632/oncotarget.22075. eCollection 2017 Nov 7. No abstract available.


A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis.

Löbrich M, Jeggo P.

Trends Biochem Sci. 2017 Sep;42(9):690-701. doi: 10.1016/j.tibs.2017.06.011. Epub 2017 Jul 21. Review.


DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.

Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M.

Mol Cell. 2017 Feb 16;65(4):671-684.e5. doi: 10.1016/j.molcel.2016.12.016. Epub 2017 Jan 26.


Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.

Spies J, Waizenegger A, Barton O, Sürder M, Wright WD, Heyer WD, Löbrich M.

Mol Cell. 2016 Jun 16;62(6):903-917. doi: 10.1016/j.molcel.2016.04.032. Epub 2016 Jun 2.


How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability.

Jeggo PA, Löbrich M.

Biochem J. 2015 Oct 1;471(1):1-11. doi: 10.1042/BJ20150582. Review.


Direct measurement of the 3-dimensional DNA lesion distribution induced by energetic charged particles in a mouse model tissue.

Mirsch J, Tommasino F, Frohns A, Conrad S, Durante M, Scholz M, Friedrich T, Löbrich M.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12396-401. doi: 10.1073/pnas.1508702112. Epub 2015 Sep 21.


PTIP associates with Artemis to dictate DNA repair pathway choice.

Wang J, Aroumougame A, Lobrich M, Li Y, Chen D, Chen J, Gong Z.

Genes Dev. 2014 Dec 15;28(24):2693-8. doi: 10.1101/gad.252478.114.


Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M.

J Cell Biol. 2014 Sep 29;206(7):877-94. doi: 10.1083/jcb.201401146.


Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA.

Mol Cell. 2014 Sep 4;55(5):723-32. doi: 10.1016/j.molcel.2014.06.028. Epub 2014 Jul 24.


Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.

Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT.

Mol Cell. 2014 Jun 19;54(6):1022-33. doi: 10.1016/j.molcel.2014.04.011. Epub 2014 May 15.


Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.

Frohns A, Frohns F, Naumann SC, Layer PG, Löbrich M.

Curr Biol. 2014 May 19;24(10):1080-90. doi: 10.1016/j.cub.2014.03.061. Epub 2014 May 1.


Opposing roles for 53BP1 during homologous recombination.

Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA.

Nucleic Acids Res. 2013 Nov;41(21):9719-31. doi: 10.1093/nar/gkt729. Epub 2013 Aug 22.


ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombination.

Geuting V, Reul C, Löbrich M.

PLoS Genet. 2013;9(8):e1003667. doi: 10.1371/journal.pgen.1003667. Epub 2013 Aug 1.


Glioma-amplified sequence KUB3 influences double-strand break repair after ionizing radiation.

Fischer U, Rheinheimer S, Krempler A, Löbrich M, Meese E.

Int J Oncol. 2013 Jul;43(1):50-6. doi: 10.3892/ijo.2013.1937. Epub 2013 May 13.


Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK.

Mol Cell Biol. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14. Erratum in: Mol Cell Biol. 2013 Aug;33(16):3390.


X-ray induced DNA double-strand breaks in coronary CT angiography: comparison of sequential, low-pitch helical and high-pitch helical data acquisition.

Brand M, Sommer M, Achenbach S, Anders K, Lell M, Löbrich M, Uder M, Kuefner MA.

Eur J Radiol. 2012 Mar;81(3):e357-62. doi: 10.1016/j.ejrad.2011.11.027. Epub 2011 Dec 16.


The role of homologous recombination in radiation-induced double-strand break repair.

Jeggo PA, Geuting V, Löbrich M.

Radiother Oncol. 2011 Oct;101(1):7-12. doi: 10.1016/j.radonc.2011.06.019. Epub 2011 Jul 5. Review.


Elevated radiation-induced γH2AX foci in G2 phase heterozygous BRCA2 fibroblasts.

Beucher A, Deckbar D, Schumann E, Krempler A, Frankenberg-Schwager M, Löbrich M.

Radiother Oncol. 2011 Oct;101(1):46-50. doi: 10.1016/j.radonc.2011.05.043. Epub 2011 Jun 12.


Understanding the limitations of radiation-induced cell cycle checkpoints.

Deckbar D, Jeggo PA, Löbrich M.

Crit Rev Biochem Mol Biol. 2011 Aug;46(4):271-83. doi: 10.3109/10409238.2011.575764. Epub 2011 Apr 27. Review.


DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin.

Jakob B, Splinter J, Conrad S, Voss KO, Zink D, Durante M, Löbrich M, Taucher-Scholz G.

Nucleic Acids Res. 2011 Aug;39(15):6489-99. doi: 10.1093/nar/gkr230. Epub 2011 Apr 21.


Factors determining DNA double-strand break repair pathway choice in G2 phase.

Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA.

EMBO J. 2011 Mar 16;30(6):1079-92. doi: 10.1038/emboj.2011.27. Epub 2011 Feb 11.


Sister chromatid exchanges occur in G2-irradiated cells.

Conrad S, Künzel J, Löbrich M.

Cell Cycle. 2011 Jan 15;10(2):222-8. Epub 2011 Jan 15.


CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.

Quennet V, Beucher A, Barton O, Takeda S, Löbrich M.

Nucleic Acids Res. 2011 Mar;39(6):2144-52. doi: 10.1093/nar/gkq1175. Epub 2010 Nov 17.


The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Goodarzi AA, Jeggo P, Lobrich M.

DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30. Review.


Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate.

Nikolova T, Ensminger M, Löbrich M, Kaina B.

DNA Repair (Amst). 2010 Oct 5;9(10):1050-63. doi: 10.1016/j.dnarep.2010.07.005. Epub 2010 Aug 13.


Inducible response required for repair of low-dose radiation damage in human fibroblasts.

Grudzenski S, Raths A, Conrad S, Rübe CE, Löbrich M.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14205-10. doi: 10.1073/pnas.1002213107. Epub 2010 Jul 26.


Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patients undergoing coronary CT angiography.

Kuefner MA, Grudzenski S, Hamann J, Achenbach S, Lell M, Anders K, Schwab SA, Häberle L, Löbrich M, Uder M.

Eur Radiol. 2010 Dec;20(12):2917-24. doi: 10.1007/s00330-010-1873-9. Epub 2010 Jul 13.


The limitations of the G1-S checkpoint.

Deckbar D, Stiff T, Koch B, Reis C, Löbrich M, Jeggo PA.

Cancer Res. 2010 Jun 1;70(11):4412-21. doi: 10.1158/0008-5472.CAN-09-3198. Epub 2010 May 11.


Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.

Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA.

Mol Cell Biol. 2010 Jul;30(13):3371-83. doi: 10.1128/MCB.01644-09. Epub 2010 Apr 26.


Reduction of X-ray induced DNA double-strand breaks in blood lymphocytes during coronary CT angiography using high-pitch spiral data acquisition with prospective ECG-triggering.

Kuefner MA, Hinkmann FM, Alibek S, Azoulay S, Anders K, Kalender WA, Achenbach S, Grudzenski S, Löbrich M, Uder M.

Invest Radiol. 2010 Apr;45(4):182-7. doi: 10.1097/RLI.0b013e3181d3eddf.


gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization.

Löbrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA.

Cell Cycle. 2010 Feb 15;9(4):662-9. Epub 2010 Mar 2.


53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.

Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA.

Nat Cell Biol. 2010 Feb;12(2):177-84. doi: 10.1038/ncb2017. Epub 2010 Jan 17.


Contrast medium-enhanced radiation damage caused by CT examinations.

Grudzenski S, Kuefner MA, Heckmann MB, Uder M, Löbrich M.

Radiology. 2009 Dec;253(3):706-14. doi: 10.1148/radiol.2533090468. Epub 2009 Sep 29.


ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M.

EMBO J. 2009 Nov 4;28(21):3413-27. doi: 10.1038/emboj.2009.276. Epub 2009 Sep 24.


DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures.

Kuefner MA, Grudzenski S, Schwab SA, Wiederseiner M, Heckmann M, Bautz W, Lobrich M, Uder M.

Invest Radiol. 2009 Aug;44(8):440-6. doi: 10.1097/RLI.0b013e3181a654a5.


[X-ray-induced DNA double-strand breaks after angiographic examinations of different anatomic regions].

Kuefner MA, Grudzenski S, Schwab SA, Azoulay S, Heckmann M, Heinrich MC, Lobrich M, Uder M.

Rofo. 2009 Apr;181(4):374-80. doi: 10.1055/s-0028-1109063. Epub 2009 Mar 11. German.


DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing.

Rübe CE, Grudzenski S, Kühne M, Dong X, Rief N, Löbrich M, Rübe C.

Clin Cancer Res. 2008 Oct 15;14(20):6546-55. doi: 10.1158/1078-0432.CCR-07-5147.


ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA.

Mol Cell. 2008 Jul 25;31(2):167-77. doi: 10.1016/j.molcel.2008.05.017.


Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, Lobrich M, Rodemann HP.

Mol Cancer Ther. 2008 Jul;7(7):1772-81. doi: 10.1158/1535-7163.MCT-07-2200.


Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks.

Rothkamm K, Gunasekara K, Warda SA, Krempler A, Löbrich M.

Radiat Res. 2008 Jun;169(6):639-48. doi: 10.1667/RR1185.1.


DNA double-strand breaks: their cellular and clinical impact?

Jeggo PA, Löbrich M.

Oncogene. 2007 Dec 10;26(56):7717-9. Review. No abstract available.


The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

Löbrich M, Jeggo PA.

Nat Rev Cancer. 2007 Nov;7(11):861-9. Review.


X-irradiation of cells on glass slides has a dose doubling impact.

Kegel P, Riballo E, Kühne M, Jeggo PA, Löbrich M.

DNA Repair (Amst). 2007 Nov;6(11):1692-7. Epub 2007 Jul 20.


An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells.

Krempler A, Deckbar D, Jeggo PA, Löbrich M.

Cell Cycle. 2007 Jul 15;6(14):1682-6. Epub 2007 May 21. Review.


The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.

Seifert M, Scherer SJ, Edelmann W, Böhm M, Meineke V, Löbrich M, Tilgen W, Reichrath J.

J Invest Dermatol. 2008 Jan;128(1):203-13. Epub 2007 Jul 5.

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