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Items: 12


Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors.

López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E.

Toxins (Basel). 2019 Jun 17;11(6). pii: E348. doi: 10.3390/toxins11060348.


Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K.

FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28.


Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements.

Ramírez-Vargas G, López-Ureña D, Badilla A, Orozco-Aguilar J, Murillo T, Rojas P, Riedel T, Overmann J, González G, Chaves-Olarte E, Quesada-Gómez C, Rodríguez C.

Sci Rep. 2018 Sep 17;8(1):13951. doi: 10.1038/s41598-018-32390-6.


Transforming Growth Factor β1/SMAD Signaling Pathway Activation Protects the Intestinal Epithelium from Clostridium difficile Toxin A-Induced Damage.

Tinoco-Veras CM, Santos AAQA, Stipursky J, Meloni M, Araujo APB, Foschetti DA, López-Ureña D, Quesada-Gómez C, Leitão RFC, Gomes FCA, Brito GAC.

Infect Immun. 2017 Sep 20;85(10). pii: e00430-17. doi: 10.1128/IAI.00430-17. Print 2017 Oct.


A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.

Ramírez-Vargas G, Quesada-Gómez C, Acuña-Amador L, López-Ureña D, Murillo T, Del Mar Gamboa-Coronado M, Chaves-Olarte E, Thomson N, Rodríguez-Cavallini E, Rodríguez C.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02054-16. doi: 10.1128/AAC.02054-16. Print 2017 Apr.


A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption.

Costa CL, López-Ureña D, de Oliveira Assis T, Ribeiro RA, Silva RO, Rupnik M, Wilcox MH, de Carvalho AF, do Carmo AO, Dias AA, de Carvalho CB, Chaves-Olarte E, Rodríguez C, Quesada-Gómez C, de Castro Brito GA.

Anaerobe. 2016 Aug;40:76-84. doi: 10.1016/j.anaerobe.2016.06.005. Epub 2016 Jun 14.


Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks.

López-Ureña D, Quesada-Gómez C, Montoya-Ramírez M, del Mar Gamboa-Coronado M, Somogyi T, Rodríguez C, Rodríguez-Cavallini E.

Emerg Microbes Infect. 2016 May 11;5:e42. doi: 10.1038/emi.2016.38.


Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.

Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E.

Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15.


Identification and antimicrobial susceptibility of obligate anaerobic bacteria from clinical samples of animal origin.

Mayorga M, Rodríguez-Cavallini E, López-Ureña D, Barquero-Calvo E, Quesada-Gómez C.

Anaerobe. 2015 Dec;36:19-24. doi: 10.1016/j.anaerobe.2015.09.003. Epub 2015 Sep 15.


Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.

Quesada-Gómez C, López-Ureña D, Acuña-Amador L, Villalobos-Zúñiga M, Du T, Freire R, Guzmán-Verri C, del Mar Gamboa-Coronado M, Lawley TD, Moreno E, Mulvey MR, de Castro Brito GA, Rodríguez-Cavallini E, Rodríguez C, Chaves-Olarte E.

J Clin Microbiol. 2015 Apr;53(4):1216-26. doi: 10.1128/JCM.03058-14. Epub 2015 Feb 4.


Spread of epidemic Clostridium difficile NAP1/027 in Latin America: case reports in Panama.

López-Ureña D, Quesada-Gómez C, Miranda E, Fonseca M, Rodríguez-Cavallini E.

J Med Microbiol. 2014 Feb;63(Pt 2):322-4. doi: 10.1099/jmm.0.066399-0. Epub 2013 Nov 28.


Community-acquired Clostridium difficile NAP1/027-associated diarrhea in an eighteen month old child.

Quesada-Gómez C, Vargas P, López-Ureña D, Gamboa-Coronado Mdel M, Rodríguez-Cavallini E.

Anaerobe. 2012 Dec;18(6):581-3. doi: 10.1016/j.anaerobe.2012.10.002. Epub 2012 Oct 29.


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