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Items: 1 to 50 of 356

1.

Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.

Perretta-Tejedor N, Muñoz-Félix JM, Düwel A, Quiros-Luis Y, Fernández-Martín JL, Morales AI, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.

Acta Physiol (Oxf). 2019 Jun;226(2):e13247. doi: 10.1111/apha.13247. Epub 2019 Jan 18.

PMID:
30589223
2.

Cardiotrophin-1 Improves Kidney Preservation, Graft Function, and Survival in Transplanted Rats.

García-Cenador B, Blanco-Gozalo V, López-Montañés D, Sanz Giménez-Rico JR, López-Novoa JM, López-Hernández FJ.

Transplantation. 2018 Oct;102(10):e404-e412. doi: 10.1097/TP.0000000000002313.

PMID:
30247450
3.

Corrigendum: Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.

Perretta-Tejedor N, Fernández-Mateos J, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Agudo-Conde C, Rodriguez-Sánchez E, Morales AI, López-Hernández FJ, López-Novoa JM, González-Sarmiento R, Martínez-Salgado C.

Sci Rep. 2018 May 11;8:46977. doi: 10.1038/srep46977.

4.

N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity.

Sancho-Martínez SM, Prieto-García L, Prieto M, Fuentes-Calvo I, López-Novoa JM, Morales AI, Martínez-Salgado C, López-Hernández FJ.

Toxicol Appl Pharmacol. 2018 Jun 15;349:83-93. doi: 10.1016/j.taap.2018.04.010. Epub 2018 Apr 18.

PMID:
29679655
5.

Cardiotrophin-1 attenuates experimental colitis in mice.

Prieto-Vicente V, Sánchez-Garrido AI, Blanco-Gozalo V, Arévalo M, García-Sánchez E, López-Montañés D, Quiros Y, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JM.

Clin Sci (Lond). 2018 May 23;132(9):985-1001. doi: 10.1042/CS20171513. Print 2018 May 23.

PMID:
29572384
6.

Circulating soluble endoglin modifies the inflammatory response in mice.

Ruiz-Remolina L, Ollauri-Ibáñez C, Pérez-Roque L, Núñez-Gómez E, Pérez-Barriocanal F, López-Novoa JM, Pericacho M, Rodríguez-Barbero A.

PLoS One. 2017 Nov 16;12(11):e0188204. doi: 10.1371/journal.pone.0188204. eCollection 2017.

7.

Impaired erythropoietin synthesis in chronic kidney disease is caused by alterations in extracellular matrix composition.

Olmos G, Muñoz-Félix JM, Mora I, Müller AG, Ruiz-Torres MP, López-Novoa JM, Rodríguez-Puyol D.

J Cell Mol Med. 2018 Jan;22(1):302-314. doi: 10.1111/jcmm.13319. Epub 2017 Aug 30.

8.

Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues.

Sánchez-González PD, López-Hernández FJ, Dueñas M, Prieto M, Sánchez-López E, Thomale J, Ruiz-Ortega M, López-Novoa JM, Morales AI.

Food Chem Toxicol. 2017 Sep;107(Pt A):226-236. doi: 10.1016/j.fct.2017.06.047. Epub 2017 Jun 30.

PMID:
28669851
9.

Endoglin-based biological therapy in the treatment of angiogenesis-dependent pathologies.

Ollauri-Ibáñez C, López-Novoa JM, Pericacho M.

Expert Opin Biol Ther. 2017 Sep;17(9):1053-1063. doi: 10.1080/14712598.2017.1346607. Epub 2017 Jul 10. Review.

PMID:
28656781
10.

Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.

Perretta-Tejedor N, Fernández-Mateos J, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Agudo-Conde C, Rodriguez-Sánchez E, Morales AI, López-Hernández FJ, López-Novoa JM, González-Sarmiento R, Martínez-Salgado C.

Sci Rep. 2017 Feb 3;7:41875. doi: 10.1038/srep41875. Erratum in: Sci Rep. 2018 May 11;8:46977.

11.

The role of endoglin in post-ischemic revascularization.

Núñez-Gómez E, Pericacho M, Ollauri-Ibáñez C, Bernabéu C, López-Novoa JM.

Angiogenesis. 2017 Feb;20(1):1-24. doi: 10.1007/s10456-016-9535-4. Epub 2016 Dec 9. Review.

PMID:
27943030
12.

Tyrosine hydroxylase haploinsufficiency prevents age-associated arterial pressure elevation and increases half-life in mice.

Gamella-Pozuelo L, Grande MT, Clemente-Lorenzo M, Murillo-Gómez C, De Pablo F, López-Novoa JM, Hernández-Sánchez C.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):113-120. doi: 10.1016/j.bbadis.2016.10.014. Epub 2016 Oct 19.

13.

High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet.

Jezkova K, Rathouska J, Nemeckova I, Fikrova P, Dolezelova E, Varejckova M, Vitverova B, Tysonova K, Serwadczak A, Buczek E, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P.

J Vasc Res. 2016;53(3-4):149-162. Epub 2016 Oct 8.

PMID:
27721318
14.

Mechanisms of triple whammy acute kidney injury.

Prieto-García L, Pericacho M, Sancho-Martínez SM, Sánchez Á, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.

Pharmacol Ther. 2016 Nov;167:132-145. doi: 10.1016/j.pharmthera.2016.07.011. Epub 2016 Aug 1.

PMID:
27490717
15.

Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction.

Muñoz-Félix JM, Pérez-Roque L, Núñez-Gómez E, Oujo B, Arévalo M, Ruiz-Remolina L, Cuesta C, Langa C, Pérez-Barriocanal F, Bernabeu C, Lopez-Novoa JM.

Biochim Biophys Acta. 2016 Sep;1862(9):1801-14. doi: 10.1016/j.bbadis.2016.06.010. Epub 2016 Jun 15.

16.

Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro.

Muñoz-Félix JM, Cuesta C, Perretta-Tejedor N, Subileau M, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.

Cell Signal. 2016 Sep;28(9):1252-61. doi: 10.1016/j.cellsig.2016.05.015. Epub 2016 May 18.

PMID:
27208502
17.

Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats.

Quirós Y, Blanco-Gozalo V, Sanchez-Gallego JI, López-Hernandez FJ, Ruiz J, Perez de Obanos MP, López-Novoa JM.

Pharmacol Res. 2016 May;107:137-146. doi: 10.1016/j.phrs.2016.02.025. Epub 2016 Mar 17.

PMID:
26996880
18.

Absence of K-Ras Reduces Proliferation and Migration But Increases Extracellular Matrix Synthesis in Fibroblasts.

Muñoz-Félix JM, Fuentes-Calvo I, Cuesta C, Eleno N, Crespo P, López-Novoa JM, Martínez-Salgado C.

J Cell Physiol. 2016 Oct;231(10):2224-35. doi: 10.1002/jcp.25340. Epub 2016 Mar 6.

PMID:
26873620
19.

Erratum: Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.

Grande MT, Sánchez-Laorden B, López-Blau C, De Frutos CA, Boutet A, Arévalo M, Rowe RG, Weiss SJ, López-Novoa JM, Nieto MA.

Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217d. No abstract available.

PMID:
26845406
20.

Endoglin regulates mural cell adhesion in the circulatory system.

Rossi E, Smadja DM, Boscolo E, Langa C, Arevalo MA, Pericacho M, Gamella-Pozuelo L, Kauskot A, Botella LM, Gaussem P, Bischoff J, Lopez-Novoa JM, Bernabeu C.

Cell Mol Life Sci. 2016 Apr;73(8):1715-39. doi: 10.1007/s00018-015-2099-4. Epub 2015 Dec 8.

21.

TGF-β/BMP proteins as therapeutic targets in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?

Muñoz-Félix JM, González-Núñez M, Martínez-Salgado C, López-Novoa JM.

Pharmacol Ther. 2015 Dec;156:44-58. doi: 10.1016/j.pharmthera.2015.10.003. Epub 2015 Oct 19. Review.

PMID:
26493350
22.

Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations.

Blázquez-Medela AM, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.

Medicine (Baltimore). 2015 Oct;94(41):e1617. doi: 10.1097/MD.0000000000001617.

23.

Activation of the ALK-5 Pathway is not per se Sufficient for the Antiproliferative Effect of TGF-β1 on Renal Tubule Epithelial Cells.

García-Sánchez O, Sancho-Martínez SM, López-Novoa JM, López-Hernández FJ.

Cell Physiol Biochem. 2015;37(4):1231-9. doi: 10.1159/000430246. Epub 2015 Oct 5.

24.

Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury.

Sancho-Martínez SM, López-Novoa JM, López-Hernández FJ.

Clin Kidney J. 2015 Oct;8(5):548-59. doi: 10.1093/ckj/sfv069. Epub 2015 Aug 25. Review.

25.

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice.

González-Núñez M, Riolobos AS, Castellano O, Fuentes-Calvo I, de los Ángeles Sevilla M, Oujo B, Pericacho M, Cruz-Gonzalez I, Pérez-Barriocanal F, ten Dijke P, López-Novoa JM.

Dis Model Mech. 2015 Nov;8(11):1427-39. doi: 10.1242/dmm.019695. Epub 2015 Sep 17.

26.

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.

Fabbiano S, Menacho-Márquez M, Robles-Valero J, Pericacho M, Matesanz-Marín A, García-Macías C, Sevilla MA, Montero MJ, Alarcón B, López-Novoa JM, Martín P, Bustelo XR.

Mol Cell Biol. 2015 Oct;35(20):3528-46. doi: 10.1128/MCB.00518-15. Epub 2015 Aug 3.

27.

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.

Grande MT, Sánchez-Laorden B, López-Blau C, De Frutos CA, Boutet A, Arévalo M, Rowe RG, Weiss SJ, López-Novoa JM, Nieto MA.

Nat Med. 2015 Sep;21(9):989-97. doi: 10.1038/nm.3901. Epub 2015 Aug 3. Erratum in: Nat Med. 2016 Feb;22(2):217.

PMID:
26236989
28.

Plasma Cardiotrophin-1 as a Marker of Hypertension and Diabetes-Induced Target Organ Damage and Cardiovascular Risk.

Gamella-Pozuelo L, Fuentes-Calvo I, Gómez-Marcos MA, Recio-Rodriguez JI, Agudo-Conde C, Fernández-Martín JL, Cannata-Andía JB, López-Novoa JM, García-Ortiz L, Martínez-Salgado C.

Medicine (Baltimore). 2015 Jul;94(30):e1218. doi: 10.1097/MD.0000000000001218.

29.

Urinary proteomics in renal pathophysiology: Impact of proteinuria.

Sancho-Martínez SM, Prieto-García L, Blanco-Gozalo V, Fontecha-Barriuso M, López-Novoa JM, López-Hernández FJ.

Proteomics Clin Appl. 2015 Jun;9(5-6):636-40. doi: 10.1002/prca.201400183.

PMID:
25921434
30.

Translational value of animal models of kidney failure.

Ortiz A, Sanchez-Niño MD, Izquierdo MC, Martin-Cleary C, Garcia-Bermejo L, Moreno JA, Ruiz-Ortega M, Draibe J, Cruzado JM, Garcia-Gonzalez MA, Lopez-Novoa JM, Soler MJ, Sanz AB; Red de Investigacion Renal (REDINREN) and Consorcio Madrileño para investigación del fracaso renal agudo (CIFRA).

Eur J Pharmacol. 2015 Jul 15;759:205-20. doi: 10.1016/j.ejphar.2015.03.026. Epub 2015 Mar 24. Review.

PMID:
25814248
31.

High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta.

Nemeckova I, Serwadczak A, Oujo B, Jezkova K, Rathouska J, Fikrova P, Varejckova M, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P.

PLoS One. 2015 Mar 13;10(3):e0119665. doi: 10.1371/journal.pone.0119665. eCollection 2015.

32.

Endoglin involvement in integrin-mediated cell adhesion as a putative pathogenic mechanism in hereditary hemorrhagic telangiectasia type 1 (HHT1).

Rossi E, Lopez-Novoa JM, Bernabeu C.

Front Genet. 2015 Jan 7;5:457. doi: 10.3389/fgene.2014.00457. eCollection 2014. Review.

33.

Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.

Vicente-Vicente L, Sánchez-Juanes F, García-Sánchez O, Blanco-Gozalo V, Pescador M, Sevilla MA, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI.

Toxicol Lett. 2015 Apr 16;234(2):99-109. doi: 10.1016/j.toxlet.2014.11.033. Epub 2015 Feb 9.

PMID:
25677510
34.

The role of endoglin in kidney fibrosis.

Muñoz-Felix JM, Oujo B, Lopez-Novoa JM.

Expert Rev Mol Med. 2014 Dec 2;16:e18. doi: 10.1017/erm.2014.20.

PMID:
25439793
35.

L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction.

Oujo B, Muñoz-Félix JM, Arévalo M, Núñez-Gómez E, Pérez-Roque L, Pericacho M, González-Núñez M, Langa C, Martínez-Salgado C, Perez-Barriocanal F, Bernabeu C, Lopez-Novoa JM.

PLoS One. 2014 Oct 14;9(10):e110365. doi: 10.1371/journal.pone.0110365. eCollection 2014.

36.

Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.

Blázquez-Medela AM, García-Sánchez O, Blanco-Gozalo V, Quiros Y, Montero MJ, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.

PLoS One. 2014 Aug 22;9(8):e105988. doi: 10.1371/journal.pone.0105988. eCollection 2014.

37.

Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy.

Rodríguez-Peña AB, Fuentes-Calvo I, Docherty NG, Arévalo M, Grande MT, Eleno N, Pérez-Barriocanal F, López-Novoa JM.

Biomed Res Int. 2014;2014:124902. doi: 10.1155/2014/124902. Epub 2014 Jul 3.

38.

Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals.

Valcheva P, Cardus A, Panizo S, Parisi E, Bozic M, Lopez Novoa JM, Dusso A, Fernández E, Valdivielso JM.

Atherosclerosis. 2014 Aug;235(2):247-55. doi: 10.1016/j.atherosclerosis.2014.05.911. Epub 2014 May 13.

PMID:
24880896
39.

ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts.

Muñoz-Félix JM, Perretta-Tejedor N, Eleno N, López-Novoa JM, Martínez-Salgado C.

Biochim Biophys Acta. 2014 Jun;1843(6):1111-22. doi: 10.1016/j.bbamcr.2014.02.017. Epub 2014 Mar 1.

40.

Interferon-γ Reduces the Proliferation of Primed Human Renal Tubular Cells.

García-Sánchez O, López-Novoa JM, López-Hernández FJ.

Nephron Extra. 2014 Jan 3;4(1):1-7. doi: 10.1159/000353587. eCollection 2014 Jan.

41.

Cardiotrophin-1 administration protects from ischemia-reperfusion renal injury and inflammation.

Garcia-Cenador MB, Lorenzo-Gomez MF, Herrero-Payo JJ, Ruiz J, Perez de Obanos MP, Pascual J, Lopez-Novoa JM, Garcia-Criado FJ.

Transplantation. 2013 Dec 27;96(12):1034-42. doi: 10.1097/TP.0b013e3182a74db4.

PMID:
24092386
42.

ALK1-Smad1/5 signaling pathway in fibrosis development: friend or foe?

Muñoz-Félix JM, González-Núñez M, López-Novoa JM.

Cytokine Growth Factor Rev. 2013 Dec;24(6):523-37. doi: 10.1016/j.cytogfr.2013.08.002. Epub 2013 Sep 13. Review.

PMID:
24055043
43.

Met signaling in cardiomyocytes is required for normal cardiac function in adult mice.

Arechederra M, Carmona R, González-Nuñez M, Gutiérrez-Uzquiza A, Bragado P, Cruz-González I, Cano E, Guerrero C, Sánchez A, López-Novoa JM, Schneider MD, Maina F, Muñoz-Chápuli R, Porras A.

Biochim Biophys Acta. 2013 Dec;1832(12):2204-15. doi: 10.1016/j.bbadis.2013.08.008. Epub 2013 Aug 28.

44.

Concerted action of ANP and dopamine D1-receptor to regulate sodium homeostasis in nephrotic syndrome.

Fernandes-Cerqueira C, Sampaio-Maia B, Quelhas-Santos J, Moreira-Rodrigues M, Simões-Silva L, Blazquez-Medela AM, Martinez-Salgado C, Lopez-Novoa JM, Pestana M.

Biomed Res Int. 2013;2013:397391. doi: 10.1155/2013/397391. Epub 2013 Jul 15.

45.

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.

Muñoz-Félix JM, López-Novoa JM, Martínez-Salgado C.

Kidney Int. 2014 Feb;85(2):319-32. doi: 10.1038/ki.2013.292. Epub 2013 Aug 14.

46.

The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts.

Fuentes-Calvo I, Crespo P, Santos E, López-Novoa JM, Martínez-Salgado C.

Biochim Biophys Acta. 2013 Dec;1833(12):2734-2744. doi: 10.1016/j.bbamcr.2013.07.008. Epub 2013 Jul 18.

47.

Membrane and soluble forms of endoglin in preeclampsia.

Oujo B, Perez-Barriocanal F, Bernabeu C, Lopez-Novoa JM.

Curr Mol Med. 2013 Sep;13(8):1345-57. Review.

48.

Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability.

Pérez-Gómez E, Jerkic M, Prieto M, Del Castillo G, Martín-Villar E, Letarte M, Bernabeu C, Pérez-Barriocanal F, Quintanilla M, López-Novoa JM.

J Invest Dermatol. 2014 Jan;134(1):247-255. doi: 10.1038/jid.2013.263. Epub 2013 Jun 13.

49.

TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast.

Ucero AC, Benito-Martin A, Fuentes-Calvo I, Santamaria B, Blanco J, Lopez-Novoa JM, Ruiz-Ortega M, Egido J, Burkly LC, Martinez-Salgado C, Ortiz A.

Biochim Biophys Acta. 2013 Oct;1832(10):1744-55. doi: 10.1016/j.bbadis.2013.05.032. Epub 2013 Jun 6.

50.

The ALK-1/Smad1 pathway in cardiovascular physiopathology. A new target for therapy?

González-Núñez M, Muñoz-Félix JM, López-Novoa JM.

Biochim Biophys Acta. 2013 Oct;1832(10):1492-510. doi: 10.1016/j.bbadis.2013.05.016. Epub 2013 May 22. Review.

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