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Items: 20

1.

CDK4 regulates lysosomal function and mTORC1 activation to promote cancer cell survival.

Martínez-Carreres L, Puyal J, Leal-Esteban LC, Orpinell M, Castillo-Armengol J, Giralt A, Dergai O, Moret C, Barquissau V, Nasrallah A, Pabois A, Zhang L, Romero P, Lopez-Mejia IC, Fajas L.

Cancer Res. 2019 Aug 8. pii: canres.0708.2019. doi: 10.1158/0008-5472.CAN-19-0708. [Epub ahead of print]

PMID:
31395606
2.

CDK4, a new metabolic sensor that antagonizes AMPK.

Fajas L, Lopez-Mejia IC.

Mol Cell Oncol. 2018 May 16;5(5):e1409862. doi: 10.1080/23723556.2017.1409862. eCollection 2018.

3.

Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.

Trompette A, Gollwitzer ES, Pattaroni C, Lopez-Mejia IC, Riva E, Pernot J, Ubags N, Fajas L, Nicod LP, Marsland BJ.

Immunity. 2018 May 15;48(5):992-1005.e8. doi: 10.1016/j.immuni.2018.04.022.

4.

E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.

Giralt A, Denechaud PD, Lopez-Mejia IC, Delacuisine B, Blanchet E, Bonner C, Pattou F, Annicotte JS, Fajas L.

Mol Metab. 2018 May;11:104-112. doi: 10.1016/j.molmet.2018.02.011. Epub 2018 Feb 26.

5.

Cdkn2a deficiency promotes adipose tissue browning.

Rabhi N, Hannou SA, Gromada X, Salas E, Yao X, Oger F, Carney C, Lopez-Mejia IC, Durand E, Rabearivelo I, Bonnefond A, Caron E, Fajas L, Dani C, Froguel P, Annicotte JS.

Mol Metab. 2018 Feb;8:65-76. doi: 10.1016/j.molmet.2017.11.012. Epub 2017 Dec 1.

6.

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L.

Mol Cell. 2017 Oct 19;68(2):336-349.e6. doi: 10.1016/j.molcel.2017.09.034.

7.

Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.

Lopez-Mejia IC, Castillo-Armengol J, Lagarrigue S, Fajas L.

Cell Mol Life Sci. 2018 Mar;75(6):975-987. doi: 10.1007/s00018-017-2668-9. Epub 2017 Oct 7. Review.

PMID:
28988292
8.

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway.

Khan AUH, Allende-Vega N, Gitenay D, Gerbal-Chaloin S, Gondeau C, Vo DN, Belkahla S, Orecchioni S, Talarico G, Bertolini F, Bozic M, Valdivielso JM, Bejjani F, Jariel I, Lopez-Mejia IC, Fajas L, Lecellier CH, Hernandez J, Daujat M, Villalba M.

Sci Rep. 2017 Sep 6;7(1):10654. doi: 10.1038/s41598-017-10339-5.

9.

Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

Santo J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.

Int J Obes (Lond). 2017 Mar;41(3):390-401. doi: 10.1038/ijo.2016.220. Epub 2016 Dec 5.

PMID:
27916986
10.

[Cell cycle regulators CDK4 and E2F1 control glucose and lipid homeostasis].

Denechaud PD, Lopez-Mejia IC, Fajas L.

Med Sci (Paris). 2016 Oct;32(10):815-818. Epub 2016 Oct 19. French. No abstract available.

11.

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.

Scholz G, Jandus C, Zhang L, Grandclément C, Lopez-Mejia IC, Soneson C, Delorenzi M, Fajas L, Held W, Dormond O, Romero P.

EBioMedicine. 2016 Jan 16;4:50-61. doi: 10.1016/j.ebiom.2016.01.019. eCollection 2016 Feb.

12.

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.

Zhang L, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, Rüegg MA, Hall MN, Fajas L, Zehn D, Mach JP, Donda A, Romero P.

Cell Rep. 2016 Feb 9;14(5):1206-1217. doi: 10.1016/j.celrep.2015.12.095. Epub 2016 Jan 21.

13.

CDK4 is an essential insulin effector in adipocytes.

Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, Abella A, Tinahones FJ, Vendrell J, Dubus P, Bosch F, Kahn CR, Fajas L.

J Clin Invest. 2016 Jan;126(1):335-48. doi: 10.1172/JCI81480. Epub 2015 Dec 14.

14.

E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.

Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, Annicotte JS, Fajas L.

J Clin Invest. 2016 Jan;126(1):137-50. doi: 10.1172/JCI81542. Epub 2015 Nov 30.

15.

Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells.

Petrov PD, Ribot J, López-Mejía IC, Fajas L, Palou A, Bonet ML.

J Cell Physiol. 2016 Mar;231(3):708-18. doi: 10.1002/jcp.25121.

PMID:
26241807
16.

Cell cycle regulation of mitochondrial function.

Lopez-Mejia IC, Fajas L.

Curr Opin Cell Biol. 2015 Apr;33:19-25. doi: 10.1016/j.ceb.2014.10.006. Epub 2014 Nov 12. Review.

PMID:
25463842
17.

Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

Lopez-Mejia IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C, Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

EMBO Rep. 2014 May;15(5):529-39. doi: 10.1002/embr.201338126. Epub 2014 Mar 17.

18.

Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion.

Lopez-Mejia IC, De Toledo M, Della Seta F, Fafet P, Rebouissou C, Deleuze V, Blanchard JM, Jorgensen C, Tazi J, Vignais ML.

Mol Biol Cell. 2013 Oct;24(20):3164-76. doi: 10.1091/mbc.E13-03-0142. Epub 2013 Aug 21.

19.

Splicing-directed therapy in a new mouse model of human accelerated aging.

Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C.

Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847.

20.

A conserved splicing mechanism of the LMNA gene controls premature aging.

Lopez-Mejia IC, Vautrot V, De Toledo M, Behm-Ansmant I, Bourgeois CF, Navarro CL, Osorio FG, Freije JM, Stévenin J, De Sandre-Giovannoli A, Lopez-Otin C, Lévy N, Branlant C, Tazi J.

Hum Mol Genet. 2011 Dec 1;20(23):4540-55. doi: 10.1093/hmg/ddr385. Epub 2011 Aug 29.

PMID:
21875900

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