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Items: 42

1.

The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase.

Lambertos A, Ramos-Molina B, Cerezo D, López-Contreras AJ, Peñafiel R.

Biochim Biophys Acta. 2018 Mar;1862(3):365-376. doi: 10.1016/j.bbagen.2017.11.007. Epub 2017 Nov 4.

PMID:
29108956
2.

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress.

Munk S, Sigurðsson JO, Xiao Z, Batth TS, Franciosa G, von Stechow L, Lopez-Contreras AJ, Vertegaal ACO, Olsen JV.

Cell Rep. 2017 Oct 10;21(2):546-558. doi: 10.1016/j.celrep.2017.09.059.

3.

A simple DNA recombination screening method by RT-PCR as an alternative to Southern blot.

Albers E, Sbroggiò M, Martin-Gonzalez J, Avram A, Munk S, Lopez-Contreras AJ.

Transgenic Res. 2017 Jun;26(3):429-434. doi: 10.1007/s11248-017-0008-3. Epub 2017 Jan 19.

PMID:
28105543
4.

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A.

Cell. 2016 Nov 17;167(5):1264-1280.e18. doi: 10.1016/j.cell.2016.09.054. Epub 2016 Oct 27.

5.

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O.

Oncotarget. 2016 Sep 13;7(37):58759-58767. doi: 10.18632/oncotarget.11643.

6.

USP7 is a SUMO deubiquitinase essential for DNA replication.

Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7.

7.

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J.

Nat Commun. 2015 Oct 12;6:8548. doi: 10.1038/ncomms9548.

8.

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.

Ruiz S, Lopez-Contreras AJ, Gabut M, Marion RM, Gutierrez-Martinez P, Bua S, Ramirez O, Olalde I, Rodrigo-Perez S, Li H, Marques-Bonet T, Serrano M, Blasco MA, Batada NN, Fernandez-Capetillo O.

Nat Commun. 2015 Aug 21;6:8036. doi: 10.1038/ncomms9036.

9.

A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

Specks J, Lecona E, Lopez-Contreras AJ, Fernandez-Capetillo O.

Mol Cell Biol. 2015 Sep 1;35(17):2910-7. doi: 10.1128/MCB.00475-15. Epub 2015 Jun 15.

10.

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.

Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O.

Genes Dev. 2015 Apr 1;29(7):690-5. doi: 10.1101/gad.256958.114.

11.

Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells.

Ramos-Molina B, López-Contreras AJ, Lambertos A, Dardonville C, Cremades A, Peñafiel R.

Amino Acids. 2015 May;47(5):1025-34. doi: 10.1007/s00726-015-1931-3. Epub 2015 Feb 6.

PMID:
25655388
12.

Modeling the study of DNA damage responses in mice.

Specks J, Nieto-Soler M, Lopez-Contreras AJ, Fernandez-Capetillo O.

Methods Mol Biol. 2015;1267:413-37. doi: 10.1007/978-1-4939-2297-0_21. Review.

13.

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

Farrés J, Llacuna L, Martin-Caballero J, Martínez C, Lozano JJ, Ampurdanés C, López-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yélamos J.

Cell Death Differ. 2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12.

14.

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2.

Ramos-Molina B, Lambertos A, Lopez-Contreras AJ, Kasprzak JM, Czerwoniec A, Bujnicki JM, Cremades A, Peñafiel R.

FEBS Open Bio. 2014 Jun 2;4:510-21. doi: 10.1016/j.fob.2014.05.004. eCollection 2014.

15.

Fos-dependent induction of Chk1 protects osteoblasts from replication stress.

Schulze J, Lopez-Contreras AJ, Uluçkan Ö, Graña-Castro O, Fernandez-Capetillo O, Wagner EF.

Cell Cycle. 2014;13(12):1980-6. doi: 10.4161/cc.28923. Epub 2014 Apr 24.

16.

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.

Eguren M, Álvarez-Fernández M, García F, López-Contreras AJ, Fujimitsu K, Yaguchi H, Luque-García JL, Fernández-Capetillo O, Muñoz J, Yamano H, Malumbres M.

Cell Rep. 2014 Feb 27;6(4):670-83. doi: 10.1016/j.celrep.2014.01.017. Epub 2014 Feb 6.

17.

Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes.

López-Garcia C, Ramos-Molina B, Lambertos A, López-Contreras AJ, Cremades A, Peñafiel R.

PLoS One. 2013 Jul 12;8(7):e69188. doi: 10.1371/journal.pone.0069188. Print 2013.

18.

Mutational analysis of the antizyme-binding element reveals critical residues for the function of ornithine decarboxylase.

Ramos-Molina B, Lambertos A, López-Contreras AJ, Peñafiel R.

Biochim Biophys Acta. 2013 Nov;1830(11):5157-65. doi: 10.1016/j.bbagen.2013.07.003. Epub 2013 Jul 19.

PMID:
23872168
19.

INK4a/ARF limits the expansion of cells suffering from replication stress.

Monasor A, Murga M, Lopez-Contreras AJ, Navas C, Gomez G, Pisano DG, Fernandez-Capetillo O.

Cell Cycle. 2013 Jun 15;12(12):1948-54. doi: 10.4161/cc.25017. Epub 2013 May 15.

20.

A proteomic characterization of factors enriched at nascent DNA molecules.

Lopez-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodriguez-Acebes S, Remeseiro S, Rodrigo-Perez S, Rojas AM, Mendez J, Muñoz J, Fernandez-Capetillo O.

Cell Rep. 2013 Apr 25;3(4):1105-16. doi: 10.1016/j.celrep.2013.03.009. Epub 2013 Mar 28.

21.

The induction of cardiac ornithine decarboxylase by β2 -adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2.

López-Contreras AJ, de la Morena ME, Ramos-Molina B, Lambertos A, Cremades A, Peñafiel R.

J Cell Biochem. 2013 Sep;114(9):1978-86. doi: 10.1002/jcb.24540.

PMID:
23519605
22.

Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression.

Marqués-Torrejón MÁ, Porlan E, Banito A, Gómez-Ibarlucea E, Lopez-Contreras AJ, Fernández-Capetillo O, Vidal A, Gil J, Torres J, Fariñas I.

Cell Stem Cell. 2013 Jan 3;12(1):88-100. doi: 10.1016/j.stem.2012.12.001. Epub 2012 Dec 20.

23.

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A.

Mol Cell. 2012 Apr 27;46(2):125-35. doi: 10.1016/j.molcel.2012.02.015. Epub 2012 Mar 22.

24.

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.

López-Contreras AJ, Gutierrez-Martinez P, Specks J, Rodrigo-Perez S, Fernandez-Capetillo O.

J Exp Med. 2012 Mar 12;209(3):455-61. doi: 10.1084/jem.20112147. Epub 2012 Feb 27.

25.

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.

Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335. doi: 10.1038/nsmb.2189.

26.

Differential expression of ornithine decarboxylase antizyme inhibitors and antizymes in rodent tissues and human cell lines.

Ramos-Molina B, López-Contreras AJ, Cremades A, Peñafiel R.

Amino Acids. 2012 Feb;42(2-3):539-47. doi: 10.1007/s00726-011-1031-y. Epub 2011 Aug 4.

PMID:
21814789
27.

Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding.

Vogler C, Huber C, Waldmann T, Ettig R, Braun L, Izzo A, Daujat S, Chassignet I, Lopez-Contreras AJ, Fernandez-Capetillo O, Dundr M, Rippe K, Längst G, Schneider R.

PLoS Genet. 2010 Dec 9;6(12):e1001234. doi: 10.1371/journal.pgen.1001234.

28.

The ATR barrier to replication-born DNA damage.

López-Contreras AJ, Fernandez-Capetillo O.

DNA Repair (Amst). 2010 Dec 10;9(12):1249-55. doi: 10.1016/j.dnarep.2010.09.012. Epub 2010 Oct 30. Review.

29.

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.

Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.

J Exp Med. 2010 May 10;207(5):973-81. doi: 10.1084/jem.20092308. Epub 2010 Apr 12.

30.

Antizyme inhibitor 2: molecular, cellular and physiological aspects.

López-Contreras AJ, Ramos-Molina B, Cremades A, Peñafiel R.

Amino Acids. 2010 Feb;38(2):603-11. doi: 10.1007/s00726-009-0419-4. Epub 2009 Dec 3. Review.

PMID:
19956990
31.

Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes.

López-Contreras AJ, Sánchez-Laorden BL, Ramos-Molina B, de la Morena ME, Cremades A, Peñafiel R.

J Cell Biochem. 2009 Jul 1;107(4):732-40. doi: 10.1002/jcb.22168.

PMID:
19449338
32.

Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level.

Bruce AW, López-Contreras AJ, Flicek P, Down TA, Dhami P, Dillon SC, Koch CM, Langford CF, Dunham I, Andrews RM, Vetrie D.

Genome Res. 2009 Jun;19(6):994-1005. doi: 10.1101/gr.089086.108. Epub 2009 Apr 28.

33.

Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy.

Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Peñafiel R.

Placenta. 2009 Mar;30(3):241-9. doi: 10.1016/j.placenta.2008.12.004. Epub 2009 Jan 7.

PMID:
19131104
34.

Expression of antizyme inhibitor 2 in male haploid germinal cells suggests a role in spermiogenesis.

López-Contreras AJ, Ramos-Molina B, Martínez-de-la-Torre M, Peñafiel-Verdú C, Puelles L, Cremades A, Peñafiel R.

Int J Biochem Cell Biol. 2009 May;41(5):1070-8. doi: 10.1016/j.biocel.2008.09.029. Epub 2008 Oct 14.

PMID:
18973822
35.

Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.

López-García C, López-Contreras AJ, Cremades A, Castells MT, Marín F, Schreiber F, Peñafiel R.

Endocrinology. 2008 Oct;149(10):5012-23. doi: 10.1210/en.2008-0084. Epub 2008 Jun 26.

PMID:
18583422
36.

Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells.

López-Contreras AJ, Ramos-Molina B, Cremades A, Peñafiel R.

J Biol Chem. 2008 Jul 25;283(30):20761-9. doi: 10.1074/jbc.M801024200. Epub 2008 May 28.

37.

Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice.

López-Contreras AJ, Galindo JD, López-García C, Castells MT, Cremades A, Peñafiel R.

J Endocrinol. 2008 Mar;196(3):615-24. doi: 10.1677/JOE-07-0564.

38.

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels.

Bastida CM, Cremades A, Castells MT, López-Contreras AJ, López-García C, Sánchez-Mas J, Peñafiel R.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1010-7. Epub 2006 Dec 5.

39.

Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.

López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R.

J Biol Chem. 2006 Oct 13;281(41):30896-906. Epub 2006 Aug 17.

40.

Protecting or promoting effects of spermine on DNA strand breakage induced by iron or copper ions as a function of metal concentration.

Pedreño E, López-Contreras AJ, Cremades A, Peñafiel R.

J Inorg Biochem. 2005 Oct;99(10):2074-80.

PMID:
16146650
41.

Influence of dietary arginine on the anabolic effects of androgens.

Cremades A, Ruzafa C, Monserrat F, López-Contreras AJ, Peñafiel R.

J Endocrinol. 2004 Nov;183(2):343-51.

42.

Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization.

Bastida CM, Cremades A, Castells MT, López-Contreras AJ, López-García C, Tejada F, Peñafiel R.

Endocrinology. 2005 Feb;146(2):666-74. Epub 2004 Oct 28.

PMID:
15514084

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