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Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome. Implications for HLA-B*27-negative Ankylosing Spondylitis.

Lorente E, Redondo-Antón J, Martín-Esteban A, Guasp P, Barnea E, Lauzurica P, Admon A, López de Castro JA.

Mol Cell Proteomics. 2019 Sep 17. pii: mcp.RA119.001710. doi: 10.1074/mcp.RA119.001710. [Epub ahead of print]


Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome.

Guasp P, Lorente E, Martín-Esteban A, Barnea E, Romania P, Fruci D, Kuiper JJW, Admon A, López de Castro JA.

Mol Cell Proteomics. 2019 Aug;18(8):1491-1510. doi: 10.1074/mcp.RA119.001515. Epub 2019 May 15.


How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins.

López de Castro JA.

Front Immunol. 2018 Oct 30;9:2463. doi: 10.3389/fimmu.2018.02463. eCollection 2018. Review.


Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy.

Sanz-Bravo A, Martín-Esteban A, Kuiper JJW, García-Peydró M, Barnea E, Admon A, López de Castro JA.

Mol Cell Proteomics. 2018 Aug;17(8):1564-1577. doi: 10.1074/mcp.RA118.000778. Epub 2018 May 16.


Ranking the Contribution of Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphisms to Shaping the HLA-B*27 Peptidome.

Sanz-Bravo A, Alvarez-Navarro C, Martín-Esteban A, Barnea E, Admon A, López de Castro JA.

Mol Cell Proteomics. 2018 Jul;17(7):1308-1323. doi: 10.1074/mcp.RA117.000565. Epub 2018 Apr 9.


The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing.

Guasp P, Barnea E, González-Escribano MF, Jiménez-Reinoso A, Regueiro JR, Admon A, López de Castro JA.

J Biol Chem. 2017 Jun 9;292(23):9680-9689. doi: 10.1074/jbc.M117.789180. Epub 2017 Apr 26.


Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.

Martín-Esteban A, Sanz-Bravo A, Guasp P, Barnea E, Admon A, López de Castro JA.

J Autoimmun. 2017 May;79:28-38. doi: 10.1016/j.jaut.2016.12.008. Epub 2017 Jan 4.


Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view.

López de Castro JA, Alvarez-Navarro C, Brito A, Guasp P, Martín-Esteban A, Sanz-Bravo A.

Mol Immunol. 2016 Sep;77:193-204. doi: 10.1016/j.molimm.2016.08.005. Epub 2016 Aug 11. Review.


Functional Interaction of the Ankylosing Spondylitis-Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA-B*27 Peptidome in Human Cells.

Martín-Esteban A, Guasp P, Barnea E, Admon A, López de Castro JA.

Arthritis Rheumatol. 2016 Oct;68(10):2466-75. doi: 10.1002/art.39734.


The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1.

Guasp P, Alvarez-Navarro C, Gomez-Molina P, Martín-Esteban A, Marcilla M, Barnea E, Admon A, López de Castro JA.

Arthritis Rheumatol. 2016 Feb;68(2):505-15. doi: 10.1002/art.39430. Erratum in: Arthritis Rheumatol. 2017 Mar;69(3):686.


Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.

Alvarez-Navarro C, Martín-Esteban A, Barnea E, Admon A, López de Castro JA.

Mol Cell Proteomics. 2015 Jul;14(7):1770-80. doi: 10.1074/mcp.M115.048959. Epub 2015 Apr 19.


Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues.

Sanz-Bravo A, Campos J, Mazariegos MS, López de Castro JA.

Arthritis Rheumatol. 2015 Mar;67(3):692-701. doi: 10.1002/art.38980.


Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands.

Martín-Esteban A, Gómez-Molina P, Sanz-Bravo A, López de Castro JA.

J Biol Chem. 2014 Feb 14;289(7):3978-90. doi: 10.1074/jbc.M113.529610. Epub 2013 Dec 18.


ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.

Alvarez-Navarro C, López de Castro JA.

Mol Immunol. 2014 Jan;57(1):12-21. doi: 10.1016/j.molimm.2013.06.012. Epub 2013 Jul 31. Review.


Novel HLA-B27-restricted epitopes from Chlamydia trachomatis generated upon endogenous processing of bacterial proteins suggest a role of molecular mimicry in reactive arthritis.

Alvarez-Navarro C, Cragnolini JJ, Dos Santos HG, Barnea E, Admon A, Morreale A, López de Castro JA.

J Biol Chem. 2013 Sep 6;288(36):25810-25. doi: 10.1074/jbc.M113.493247. Epub 2013 Jul 18.


ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role.

Alvarez-Navarro C, López de Castro JA.

Curr Opin Rheumatol. 2013 Jul;25(4):419-25. doi: 10.1097/BOR.0b013e328362042f. Review.


The origin of proteasome-inhibitor resistant HLA class I peptidomes: a study with HLA-A*68:01.

García-Medel N, Sanz-Bravo A, Barnea E, Admon A, López de Castro JA.

Mol Cell Proteomics. 2012 Jan;11(1):M111.011486. doi: 10.1074/mcp.M111.011486. Epub 2011 Oct 3.


Mutational analysis reveals a complex interplay of peptide binding and multiple biological features of HLA-B27.

Galocha B, López de Castro JA.

J Biol Chem. 2010 Dec 10;285(50):39180-90. doi: 10.1074/jbc.M110.149906. Epub 2010 Oct 2.


The HLA-B27 peptidome: building on the cornerstone.

López de Castro JA.

Arthritis Rheum. 2010 Feb;62(2):316-9. doi: 10.1002/art.27188. No abstract available.


Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens.

Kumar P, Vahedi-Faridi A, Saenger W, Merino E, López de Castro JA, Uchanska-Ziegler B, Ziegler A.

J Biol Chem. 2009 Oct 23;284(43):29784-97. doi: 10.1074/jbc.M109.038497. Epub 2009 Jul 18.


Presentation of cytosolically stable peptides by HLA-B27 is not dependent on the canonic interactions of N-terminal basic residues in the A pocket.

Gómez P, Mavian C, Galocha B, García-Medel N, López de Castro JA.

J Immunol. 2009 Jan 1;182(1):446-55.


Disparate folding and stability of the ankylosing spondylitis-associated HLA-B*1403 and B*2705 proteins.

Merino E, Galocha B, Vázquez MN, López de Castro JA.

Arthritis Rheum. 2008 Dec;58(12):3693-704. doi: 10.1002/art.24045.


Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis.

Marcilla M, López de Castro JA.

Tissue Antigens. 2008 Jun;71(6):495-506. doi: 10.1111/j.1399-0039.2008.01051.x. Review.


Expression, purification and preliminary X-ray crystallographic analysis of the human major histocompatibility antigen HLA-B*1402 in complex with a viral peptide and with a self-peptide.

Kumar P, Vahedi-Faridi A, Merino E, López de Castro JA, Volz A, Ziegler A, Saenger W, Uchanska-Ziegler B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jul 1;63(Pt 7):631-4. Epub 2007 Jun 29.


HLA-B27 y patogenia de las espondiloartropatías.

López de Castro JA.

Reumatol Clin. 2007 Jul;3 Suppl 2:S24-8. doi: 10.1016/S1699-258X(07)73636-7. Epub 2008 Dec 29. Spanish. No abstract available.


Proteasome-independent HLA-B27 ligands arise mainly from small basic proteins.

Marcilla M, Cragnolini JJ, López de Castro JA.

Mol Cell Proteomics. 2007 May;6(5):923-38. Epub 2007 Feb 16.


HLA-B27 and the pathogenesis of spondyloarthropathies.

López de Castro JA.

Immunol Lett. 2007 Jan 15;108(1):27-33. Epub 2006 Nov 16. Review.


Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor.

Sesma L, Galocha B, Vázquez M, Purcell AW, Marcilla M, McCluskey J, López de Castro JA.

J Immunol. 2005 Jun 15;174(12):7833-44.


HLA-B27: portraying immunodominant viral epitopes.

López de Castro JA.

Eur J Immunol. 2005 Feb;35(2):336-40.


HLA-B27: a registry of constitutive peptide ligands.

Lopez de Castro JA, Alvarez I, Marcilla M, Paradela A, Ramos M, Sesma L, Vázquez M.

Tissue Antigens. 2004 May;63(5):424-45.


Species-specific differences in proteasomal processing and tapasin-mediated loading influence peptide presentation by HLA-B27 in murine cells.

Sesma L, Alvarez I, Marcilla M, Paradela A, López de Castro JA.

J Biol Chem. 2003 Nov 21;278(47):46461-72. Epub 2003 Sep 8.


Peptide rearrangement during quadrupole ion trap fragmentation: added complexity to MS/MS spectra.

Yagüe J, Paradela A, Ramos M, Ogueta S, Marina A, Barahona F, López de Castro JA, Vázquez J.

Anal Chem. 2003 Mar 15;75(6):1524-35.


Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.

May E, Dulphy N, Frauendorf E, Duchmann R, Bowness P, Lopez de Castro JA, Toubert A, Märker-Hermann E.

Tissue Antigens. 2002 Oct;60(4):299-308.


HLA-B27 and the pathogenesis of spondyloarthritis.

Ramos M, López de Castro JA.

Tissue Antigens. 2002 Sep;60(3):191-205. Review.


Molecular mimicry of an HLA-B27-derived ligand of arthritis-linked subtypes with chlamydial proteins.

Ramos M, Alvarez I, Sesma L, Logean A, Rognan D, López de Castro JA.

J Biol Chem. 2002 Oct 4;277(40):37573-81. Epub 2002 Jul 16.


Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability.

Ramos M, Paradela A, Vazquez M, Marina A, Vazquez J, Lopez de Castro JA.

J Biol Chem. 2002 Aug 9;277(32):28749-56. Epub 2002 May 31.


Large sharing of T-cell epitopes and natural ligands between HLA-B27 subtypes (B*2702 and B*2705) associated with spondyloarthritis.

Martí M, Alvarez I, Montserrat V, López de Castro JA.

Tissue Antigens. 2001 Dec;58(6):351-62.


The peptide repertoires of HLA-B27 subtypes differentially associated to spondyloarthropathy (B*2704 and B*2706) differ by specific changes at three anchor positions.

Sesma L, Montserrat V, Lamas JR, Marina A, Vázquez J, López de Castro JA.

J Biol Chem. 2002 May 10;277(19):16744-9. Epub 2002 Mar 1.


The Cys-67 residue of HLA-B27 influences cell surface stability, peptide specificity, and T-cell antigen presentation.

Alvarez I, Martí M, Vázquez J, Camafeita E, Ogueta S, López de Castro JA.

J Biol Chem. 2001 Dec 28;276(52):48740-7. Epub 2001 Oct 22.


Major histocompatibility complex class I molecules bind natural peptide ligands lacking the amino-terminal binding residue in vivo.

Yague J, Marina A, Vazquez J, Lopez De Castro JA.

J Biol Chem. 2001 Nov 23;276(47):43699-707. Epub 2001 Sep 13.


Minimal alterations in the HLA-B27-bound peptide repertoire induced upon infection of lymphoid cells with Salmonella typhimurium.

Ramos M, Alvarez I, García-del-Portillo F, López de Castro JA.

Arthritis Rheum. 2001 Jul;44(7):1677-88.


Quantitative and qualitative influences of tapasin on the class I peptide repertoire.

Purcell AW, Gorman JJ, Garcia-Peydró M, Paradela A, Burrows SR, Talbo GH, Laham N, Peh CA, Reynolds EC, López De Castro JA, McCluskey J.

J Immunol. 2001 Jan 15;166(2):1016-27.


Peptide specificity of the Amerindian B*3905 allotype: molecular insight into selection mechanisms driving HLA class I evolution in indigenous populations of the Americas.

Yagüe J, Ramos M, Ogueta S, Vázquez J, López de Castro JA.

Tissue Antigens. 2000 Nov;56(5):385-91. Erratum in: Tissue Antigens 2001 Mar;57(3):285.


A molecular insight on the association of HLA-B27 with spondyloarthropathies.

Martí M, Alvarez I, López de Castro JA.

Curr Rheumatol Rep. 1999 Oct;1(1):78-85. Review.


HLA-B27 and immunogenetics of spondyloarthropathies.

Alvarez I, López de Castro JA.

Curr Opin Rheumatol. 2000 Jul;12(4):248-53. Review.


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