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Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy.

Fernandez-Gil BI, Guerra-Librero A, Shen YQ, Florido J, Martínez-Ruiz L, García-López S, Adan C, Rodríguez-Santana C, Acuña-Castroviejo D, Quiñones-Hinojosa A, Fernández-Martínez J, Abdel Moneim AE, López LC, Rodríguez Ferrer JM, Escames G.

Oxid Med Cell Longev. 2019 Feb 28;2019:7187128. doi: 10.1155/2019/7187128. eCollection 2019.


Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease.

Barriocanal-Casado E, Hidalgo-Gutiérrez A, Raimundo N, González-García P, Acuña-Castroviejo D, Escames G, López LC.

EBioMedicine. 2019 Apr;42:511-523. doi: 10.1016/j.ebiom.2019.03.025. Epub 2019 Mar 18.


Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin.

Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Aranda-Martínez P, Fernández-Martínez J, Guerra-Librero A, Escames G, López LC, Alsaadawy RM, Acuña-Castroviejo D.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz079. doi: 10.1093/gerona/glz079. [Epub ahead of print]


Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats.

Casuso RA, Al-Fazazi S, Hidalgo-Gutierrez A, López LC, Plaza-Díaz J, Rueda-Robles A, Huertas JR.

Free Radic Biol Med. 2019 Jan 24;134:304-310. doi: 10.1016/j.freeradbiomed.2019.01.027. [Epub ahead of print]


β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.

Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2019 Jan;11(1). pii: e9466. doi: 10.15252/emmm.201809466.


CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway.

Kleiner G, Barca E, Ziosi M, Emmanuele V, Xu Y, Hidalgo-Gutierrez A, Qiao C, Tadesse S, Area-Gomez E, Lopez LC, Quinzii CM.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3708-3722. doi: 10.1016/j.bbadis.2018.09.002. Epub 2018 Sep 6.


Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC.

Sci Rep. 2018 Sep 18;8(1):14013. doi: 10.1038/s41598-018-32190-y.


Characterization and effect of metal ions on the formation of the Thermus thermophilus Sco mixed disulfide intermediate.

Lopez LC, Mukhitov N, Handley LD, Hamme CS, Hofman CR, Euers L, McKinney JR, Piers AD, Wadler E, Hunsicker-Wang LM.

Protein Sci. 2018 Nov;27(11):1942-1954. doi: 10.1002/pro.3502. Epub 2018 Oct 3.


The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.

Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Rusanova I, Rahim I, Escames G, López LC, Mokhtar DM, Acuña-Castroviejo D.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1330-1338. doi: 10.1093/gerona/gly059.


Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.

Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, García-López S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acuña-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, López LC, Escames G.

J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12461. Epub 2018 Jan 9.


Bypassing human CoQ10 deficiency.

Herebian D, López LC, Distelmaier F.

Mol Genet Metab. 2018 Mar;123(3):289-291. doi: 10.1016/j.ymgme.2017.12.008. Epub 2017 Dec 9.


In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

Díaz-Casado ME, Rusanova I, Aranda P, Fernández-Ortiz M, Sayed RKA, Fernández-Gil BI, Hidalgo-Gutiérrez A, Escames G, López LC, Acuña-Castroviejo D.

Zebrafish. 2018 Feb;15(1):15-26. doi: 10.1089/zeb.2017.1479. Epub 2017 Nov 29.


Allometric trends reveal distinct evolutionary trajectories for avian communication.

Torres IMD, Lopez LCS, de Araújo CB.

J Acoust Soc Am. 2017 Oct;142(4):1879. doi: 10.1121/1.5005495.


Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López LC, Acuña-Castroviejo D.

PLoS One. 2017 Aug 11;12(8):e0183090. doi: 10.1371/journal.pone.0183090. eCollection 2017.


The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency.

Quinzii CM, Luna-Sanchez M, Ziosi M, Hidalgo-Gutierrez A, Kleiner G, Lopez LC.

Front Physiol. 2017 Jul 25;8:525. doi: 10.3389/fphys.2017.00525. eCollection 2017. Review.


Melatonin, clock genes and mitochondria in sepsis.

Acuña-Castroviejo D, Rahim I, Acuña-Fernández C, Fernández-Ortiz M, Solera-Marín J, Sayed RKA, Díaz-Casado ME, Rusanova I, López LC, Escames G.

Cell Mol Life Sci. 2017 Nov;74(21):3965-3987. doi: 10.1007/s00018-017-2610-1. Epub 2017 Aug 7. Review.


Antioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly.

Huertas JR, Al Fazazi S, Hidalgo-Gutierrez A, López LC, Casuso RA.

Redox Biol. 2017 Oct;13:477-481. doi: 10.1016/j.redox.2017.07.009. Epub 2017 Jul 11.


Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Herebian D, Seibt A, Smits SHJ, Bünning G, Freyer C, Prokisch H, Karall D, Wredenberg A, Wedell A, López LC, Mayatepek E, Distelmaier F.

Mol Genet Metab. 2017 Jul;121(3):216-223. doi: 10.1016/j.ymgme.2017.05.012. Epub 2017 May 20.


Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

Mendivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, Acuña-Castroviejo D, López LC, Velez-Pardo C, Jimenez-Del-Rio M, Ferrer JM, Escames G.

J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12415. Epub 2017 May 18.


Melatonin protects rats from radiotherapy-induced small intestine toxicity.

Fernández-Gil B, Moneim AE, Ortiz F, Shen YQ, Soto-Mercado V, Mendivil-Perez M, Guerra-Librero A, Acuña-Castroviejo D, Molina-Navarro MM, García-Verdugo JM, Sayed RK, Florido J, Luna JD, López LC, Escames G.

PLoS One. 2017 Apr 12;12(4):e0174474. doi: 10.1371/journal.pone.0174474. eCollection 2017.


Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

Rahim I, Djerdjouri B, Sayed RK, Fernández-Ortiz M, Fernández-Gil B, Hidalgo-Gutiérrez A, López LC, Escames G, Reiter RJ, Acuña-Castroviejo D.

J Pineal Res. 2017 Aug;63(1). doi: 10.1111/jpi.12410. Epub 2017 Apr 29.


Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis.

Fernández-Mosquera L, Diogo CV, Yambire KF, Santos GL, Luna Sánchez M, Bénit P, Rustin P, Lopez LC, Milosevic I, Raimundo N.

Sci Rep. 2017 Mar 27;7:45076. doi: 10.1038/srep45076.


CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2017 Jan;9(1):78-95. doi: 10.15252/emmm.201606345.


Self-Criticism: A Measure of Uncompassionate Behaviors Toward the Self, Based on the Negative Components of the Self-Compassion Scale.

Montero-Marín J, Gaete J, Demarzo M, Rodero B, Lopez LC, García-Campayo J.

Front Psychol. 2016 Aug 30;7:1281. doi: 10.3389/fpsyg.2016.01281. eCollection 2016.


Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

Sayed RK, de Leonardis EC, Guerrero-Martínez JA, Rahim I, Mokhtar DM, Saleh AM, Abdalla KE, Pozo MJ, Escames G, López LC, Acuña-Castroviejo D.

Exp Gerontol. 2016 Oct;83:22-30. doi: 10.1016/j.exger.2016.07.007. Epub 2016 Jul 18.


Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice.

Barriocanal-Casado E, Cueto-Ureña C, Benabdellah K, Gutiérrez-Guerrero A, Cobo M, Hidalgo-Gutiérrez A, Rodríguez-Sevilla JJ, Martín F, López LC.

PLoS One. 2016 Jun 24;11(6):e0158344. doi: 10.1371/journal.pone.0158344. eCollection 2016.


Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation.

López LC, Varea O, Navarro S, Carrodeguas JA, Sanchez de Groot N, Ventura S, Sancho J.

Int J Mol Sci. 2016 Jun 18;17(6). pii: E964. doi: 10.3390/ijms17060964.


The role of local versus biogeographical processes in influencing diversity and body-size variation in mammal assemblages.

Lopez LC, Figueiredo MS, Fracasso MP, Mesquita DO, Anjos UU, Grelle CE.

Ecol Evol. 2016 Feb 3;6(5):1447-56. doi: 10.1002/ece3.1978. eCollection 2016 Mar.


Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network.

Díaz-Casado ME, Lima E, García JA, Doerrier C, Aranda P, Sayed RK, Guerra-Librero A, Escames G, López LC, Acuña-Castroviejo D.

J Pineal Res. 2016 Aug;61(1):96-107. doi: 10.1111/jpi.12332. Epub 2016 Apr 30.


Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network.

Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D.

Mitochondrion. 2016 Mar;27:56-63. doi: 10.1016/j.mito.2015.12.010. Epub 2015 Dec 31.


Erratum to: Assessing human-bat interactions around a protected area in northeastern Brazil.

Rego KM, Zeppelini CG, Lopez LC, Alves RR.

J Ethnobiol Ethnomed. 2015 Dec 29;11:87. doi: 10.1186/s13002-015-0069-4. No abstract available.


Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D.

J Pineal Res. 2016 Mar;60(2):193-205. doi: 10.1111/jpi.12303. Epub 2016 Jan 13.


Effortless Attention as a Biomarker for Experienced Mindfulness Practitioners.

Tanaka GK, Maslahati T, Gongora M, Bittencourt J, Lopez LC, Demarzo MM, Budde H, Teixeira S, Basile LF, Campayo JG, Cagy M, Ribeiro P, Velasques B.

PLoS One. 2015 Oct 12;10(10):e0138561. doi: 10.1371/journal.pone.0138561. eCollection 2015.


Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice.

García JA, Volt H, Venegas C, Doerrier C, Escames G, López LC, Acuña-Castroviejo D.

FASEB J. 2015 Sep;29(9):3863-75. doi: 10.1096/fj.15-273656. Epub 2015 Jun 4.


Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway.

Garcia-Diaz B, Barca E, Balreira A, Lopez LC, Tadesse S, Krishna S, Naini A, Mariotti C, Castellotti B, Quinzii CM.

Hum Mol Genet. 2015 Aug 15;24(16):4516-29. doi: 10.1093/hmg/ddv183. Epub 2015 May 14.


The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

Luna-Sánchez M, Díaz-Casado E, Barca E, Tejada MÁ, Montilla-García Á, Cobos EJ, Escames G, Acuña-Castroviejo D, Quinzii CM, López LC.

EMBO Mol Med. 2015 May;7(5):670-87. doi: 10.15252/emmm.201404632.


Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats.

Abdel Moneim AE, Ortiz F, Leonardo-Mendonça RC, Vergano-Villodres R, Guerrero-Martínez JA, López LC, Acuña-Castroviejo D, Escames G.

Acta Trop. 2015 Mar;143:58-65. doi: 10.1016/j.actatropica.2014.12.007. Epub 2014 Dec 24.


Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

Doerrier C, García JA, Volt H, Díaz-Casado ME, Lima-Cabello E, Ortiz F, Luna-Sánchez M, Escames G, López LC, Acuña-Castroviejo D.

Life Sci. 2015 Jan 15;121:158-65. doi: 10.1016/j.lfs.2014.11.031. Epub 2014 Dec 10.


Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

Escames G, Díaz-Casado ME, Doerrier C, Luna-Sánchez M, López LC, Acuña-Castroviejo D.

Horm Mol Biol Clin Investig. 2013 Dec;16(2):91-100. doi: 10.1515/hmbci-2013-0026.


Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis.

Ortiz F, Acuña-Castroviejo D, Doerrier C, Dayoub JC, López LC, Venegas C, García JA, López A, Volt H, Luna-Sánchez M, Escames G.

J Pineal Res. 2015 Jan;58(1):34-49. doi: 10.1111/jpi.12191. Epub 2014 Dec 4.


Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.

Lohman DC, Forouhar F, Beebe ET, Stefely MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-Sánchez M, Jochem A, Lew S, Seetharaman J, Xiao R, Wang H, Westphall MS, Wrobel RL, Everett JK, Mitchell JC, López LC, Coon JJ, Tong L, Pagliarini DJ.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4697-705. doi: 10.1073/pnas.1413128111. Epub 2014 Oct 22.


Patterns and inferred processes associated with sea turtle strandings in Paraíba State, Northeast Brazil.

Poli C, Lopez LC, Mesquita DO, Saska C, Mascarenhas R.

Braz J Biol. 2014 May;74(2):283-9.


Pathomechanisms in coenzyme q10-deficient human fibroblasts.

López LC, Luna-Sánchez M, García-Corzo L, Quinzii CM, Hirano M.

Mol Syndromol. 2014 Jul;5(3-4):163-9. doi: 10.1159/000360494.


Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.

Garone C, Garcia-Diaz B, Emmanuele V, Lopez LC, Tadesse S, Akman HO, Tanji K, Quinzii CM, Hirano M.

EMBO Mol Med. 2014 Aug;6(8):1016-27. doi: 10.15252/emmm.201404092.


A review of the melatonin functions in zebrafish physiology.

Lima-Cabello E, Díaz-Casado ME, Guerrero JA, Otalora BB, Escames G, López LC, Reiter RJ, Acuña-Castroviejo D.

J Pineal Res. 2014 Aug;57(1):1-9. doi: 10.1111/jpi.12149. Epub 2014 Jul 3.


Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency.

García-Corzo L, Luna-Sánchez M, Doerrier C, Ortiz F, Escames G, Acuña-Castroviejo D, López LC.

Biochim Biophys Acta. 2014 Jul;1842(7):893-901. doi: 10.1016/j.bbadis.2014.02.008. Epub 2014 Feb 24.


Extrapineal melatonin: sources, regulation, and potential functions.

Acuña-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, López LC, Rosales-Corral S, Tan DX, Reiter RJ.

Cell Mol Life Sci. 2014 Aug;71(16):2997-3025. doi: 10.1007/s00018-014-1579-2. Epub 2014 Feb 20. Review.


The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

Ortiz F, García JA, Acuña-Castroviejo D, Doerrier C, López A, Venegas C, Volt H, Luna-Sánchez M, López LC, Escames G.

J Pineal Res. 2014 Jan;56(1):71-81. doi: 10.1111/jpi.12099. Epub 2013 Oct 21.


Argan oil-contained antioxidants for human mitochondria.

López LC, Cabrera-Vique C, Venegas C, García-Corzo L, Luna-Sánchez M, Acuña-Castroviejo D, Escames G.

Nat Prod Commun. 2013 Jan;8(1):47-50. Review.


Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function.

Romero-Moya D, Bueno C, Montes R, Navarro-Montero O, Iborra FJ, López LC, Martin M, Menendez P.

Haematologica. 2013 Jul;98(7):1022-9. doi: 10.3324/haematol.2012.079244. Epub 2013 Jan 24.

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