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Items: 37


Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Green JP, Yu S, Martín-Sánchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, Brough D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9371-E9380. doi: 10.1073/pnas.1812744115. Epub 2018 Sep 19.


USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.

Palazón-Riquelme P, Worboys JD, Green J, Valera A, Martín-Sánchez F, Pellegrini C, Brough D, López-Castejón G.

EMBO Rep. 2018 Oct;19(10). pii: e44766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11.


The inflammasomes, immune guardians at defence barriers.

Palazon-Riquelme P, Lopez-Castejon G.

Immunology. 2018 Nov;155(3):320-330. doi: 10.1111/imm.12989. Epub 2018 Sep 6. Review.


Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

Cocco M, Pellegrini C, Martínez-Banaclocha H, Giorgis M, Marini E, Costale A, Miglio G, Fornai M, Antonioli L, López-Castejón G, Tapia-Abellán A, Angosto D, Hafner-Bratkovič I, Regazzoni L, Blandizzi C, Pelegrín P, Bertinaria M.

J Med Chem. 2017 May 11;60(9):3656-3671. doi: 10.1021/acs.jmedchem.6b01624. Epub 2017 Apr 24.


Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation.

Pellegrini C, Antonioli L, Lopez-Castejon G, Blandizzi C, Fornai M.

Front Immunol. 2017 Jan 25;8:36. doi: 10.3389/fimmu.2017.00036. eCollection 2017. Review.


Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

Lopez-Castejon G, Edelmann MJ.

Mediators Inflamm. 2016;2016:3481371. doi: 10.1155/2016/3481371. Epub 2016 Aug 14. Review.


P2X7 receptor-dependent tuning of gut epithelial responses to infection.

Huang SW, Walker C, Pennock J, Else K, Muller W, Daniels MJ, Pellegrini C, Brough D, Lopez-Castejon G, Cruickshank SM.

Immunol Cell Biol. 2017 Feb;95(2):178-188. doi: 10.1038/icb.2016.75. Epub 2016 Aug 25.


Method to Measure Ubiquitination of NLRs.

Palazón-Riquelme P, López-Castejón G.

Methods Mol Biol. 2016;1417:223-9. doi: 10.1007/978-1-4939-3566-6_16.


Functional Reconstruction of NLRs in HEK293 Cells.

Compan V, López-Castejón G.

Methods Mol Biol. 2016;1417:217-21. doi: 10.1007/978-1-4939-3566-6_15.


Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.

Compan V, Martín-Sánchez F, Baroja-Mazo A, López-Castejón G, Gomez AI, Verkhratsky A, Brough D, Pelegrín P.

J Immunol. 2015 Feb 1;194(3):1261-73. doi: 10.4049/jimmunol.1301676. Epub 2014 Dec 31.


Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.

Ainscough JS, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman RJ.

J Biol Chem. 2014 Dec 19;289(51):35582-92. doi: 10.1074/jbc.M114.595686. Epub 2014 Nov 4.


Zinc depletion regulates the processing and secretion of IL-1β.

Summersgill H, England H, Lopez-Castejon G, Lawrence CB, Luheshi NM, Pahle J, Mendes P, Brough D.

Cell Death Dis. 2014 Jan 30;5:e1040. doi: 10.1038/cddis.2013.547.


Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway.

Edye ME, Lopez-Castejon G, Allan SM, Brough D.

J Biol Chem. 2013 Oct 18;288(42):30485-94. doi: 10.1074/jbc.M113.478941. Epub 2013 Sep 10.


Response to Boyle et al.

Angosto D, López-Castejón G, Mulero V, Pelegrín P.

Immunity. 2013 Mar 21;38(3):400-1. doi: 10.1016/j.immuni.2013.02.019. No abstract available.


Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

Girard S, Brough D, Lopez-Castejon G, Giles J, Rothwell NJ, Allan SM.

Glia. 2013 May;61(5):813-24. doi: 10.1002/glia.22478. Epub 2013 Feb 13.


Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome.

Lopez-Castejon G, Luheshi NM, Compan V, High S, Whitehead RC, Flitsch S, Kirov A, Prudovsky I, Swanton E, Brough D.

J Biol Chem. 2013 Jan 25;288(4):2721-33. doi: 10.1074/jbc.M112.422238. Epub 2012 Dec 3.


Cell volume regulation modulates NLRP3 inflammasome activation.

Compan V, Baroja-Mazo A, López-Castejón G, Gomez AI, Martínez CM, Angosto D, Montero MT, Herranz AS, Bazán E, Reimers D, Mulero V, Pelegrín P.

Immunity. 2012 Sep 21;37(3):487-500. doi: 10.1016/j.immuni.2012.06.013. Epub 2012 Sep 13.


Caspase-1: is IL-1 just the tip of the ICEberg?

Denes A, Lopez-Castejon G, Brough D.

Cell Death Dis. 2012 Jul 5;3:e338. doi: 10.1038/cddis.2012.86. Review.


Current status of inflammasome blockers as anti-inflammatory drugs.

López-Castejón G, Pelegrín P.

Expert Opin Investig Drugs. 2012 Jul;21(7):995-1007. doi: 10.1517/13543784.2012.690032. Epub 2012 May 22. Review.


Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes.

Lopez-Castejon G, Corbett D, Goldrick M, Roberts IS, Brough D.

PLoS One. 2012;7(4):e35936. doi: 10.1371/journal.pone.0035936. Epub 2012 Apr 26.


Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β.

Angosto D, López-Castejón G, López-Muñoz A, Sepulcre MP, Arizcun M, Meseguer J, Mulero V.

Innate Immun. 2012 Dec;18(6):815-24. doi: 10.1177/1753425912441956. Epub 2012 Mar 28.


Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues.

Luheshi NM, Kovács KJ, Lopez-Castejon G, Brough D, Denes A.

J Neuroinflammation. 2011 Dec 29;8:186. doi: 10.1186/1742-2094-8-186.


Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

Luheshi NM, Giles JA, Lopez-Castejon G, Brough D.

Eur J Immunol. 2012 Mar;42(3):716-25. doi: 10.1002/eji.201142079. Epub 2011 Dec 27.


Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.

Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Westwood M, Aplin JD, Ingham E, Papageorgiou I, Berry M, Liu J, Dick AD, Garland RJ, Williams N, Singh R, Simon AK, Lewis M, Ham J, Roger L, Baird DM, Crompton LA, Caldwell MA, Swalwell H, Birch-Machin M, Lopez-Castejon G, Randall A, Lin H, Suleiman MS, Evans WH, Newson R, Case CP.

Nat Nanotechnol. 2011 Nov 6;6(12):824-33. doi: 10.1038/nnano.2011.188.


Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo.

Corbett D, Wang J, Schuler S, Lopez-Castejon G, Glenn S, Brough D, Andrew PW, Cavet JS, Roberts IS.

Infect Immun. 2012 Jan;80(1):14-21. doi: 10.1128/IAI.05904-11. Epub 2011 Oct 24.


Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.

Small BG, McColl BW, Allmendinger R, Pahle J, López-Castejón G, Rothwell NJ, Knowles J, Mendes P, Brough D, Kell DB.

Nat Chem Biol. 2011 Oct 23;7(12):902-8. doi: 10.1038/nchembio.689.


Understanding the mechanism of IL-1β secretion.

Lopez-Castejon G, Brough D.

Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95. doi: 10.1016/j.cytogfr.2011.10.001. Epub 2011 Oct 22. Review.


Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules.

Lopez-Castejón G, Baroja-Mazo A, Pelegrín P.

Cell Mol Life Sci. 2011 Sep;68(18):3095-107. doi: 10.1007/s00018-010-0609-y. Epub 2010 Dec 28.


P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.

Lopez-Castejon G, Theaker J, Pelegrin P, Clifton AD, Braddock M, Surprenant A.

J Immunol. 2010 Aug 15;185(4):2611-9. doi: 10.4049/jimmunol.1000436. Epub 2010 Jul 16.


Nanoparticles can cause DNA damage across a cellular barrier.

Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP.

Nat Nanotechnol. 2009 Dec;4(12):876-83. doi: 10.1038/nnano.2009.313.


Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish.

López-Castejón G, Sepulcre MP, Mulero I, Pelegrín P, Meseguer J, Mulero V.

Mol Immunol. 2008 Jan;45(1):49-57. Epub 2007 Jul 3.


The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels.

López-Castejón G, Sepulcre MP, Roca FJ, Castellana B, Planas JV, Meseguer J, Mulero V.

Mol Immunol. 2007 Apr;44(10):2772-80. Epub 2007 Jan 17.


The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish.

Sepulcre MP, López-Castejón G, Meseguer J, Mulero V.

Mol Immunol. 2007 Mar;44(8):2009-16. Epub 2006 Nov 7.


Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta.

López-Castejón G, Young MT, Meseguer J, Surprenant A, Mulero V.

Mol Immunol. 2007 Feb;44(6):1286-99. Epub 2006 Jul 11.


Turbot TNFalpha gene: molecular characterization and biological activity of the recombinant protein.

Ordás MC, Costa MM, Roca FJ, López-Castejón G, Mulero V, Meseguer J, Figueras A, Novoa B.

Mol Immunol. 2007 Jan;44(4):389-400. Epub 2006 Apr 17.


The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream.

Roca FJ, Sepulcre MA, López-Castejón G, Meseguer J, Mulero V.

Mol Immunol. 2006 Mar;43(9):1418-23. Epub 2005 Aug 30.


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