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Items: 23


Excessive rDNA Transcription Drives the Disruption in Nuclear Homeostasis during Entry into Senescence in Budding Yeast.

Morlot S, Song J, Léger-Silvestre I, Matifas A, Gadal O, Charvin G.

Cell Rep. 2019 Jul 9;28(2):408-422.e4. doi: 10.1016/j.celrep.2019.06.032.


Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I.

Darrière T, Pilsl M, Sarthou MK, Chauvier A, Genty T, Audibert S, Dez C, Léger-Silvestre I, Normand C, Henras AK, Kwapisz M, Calvo O, Fernández-Tornero C, Tschochner H, Gadal O.

PLoS Genet. 2019 May 28;15(5):e1008157. doi: 10.1371/journal.pgen.1008157. eCollection 2019 May.


High resolution microscopy reveals the nuclear shape of budding yeast during cell cycle and in various biological states.

Wang R, Kamgoue A, Normand C, Léger-Silvestre I, Mangeat T, Gadal O.

J Cell Sci. 2016 Dec 15;129(24):4480-4495. Epub 2016 Nov 9.


Correlative Light and Electron Microscopy of Nucleolar Transcription in Saccharomyces cerevisiae.

Normand C, Berthaud M, Gadal O, Léger-Silvestre I.

Methods Mol Biol. 2016;1455:29-40. doi: 10.1007/978-1-4939-3792-9_3.


Decoding the principles underlying the frequency of association with nucleoli for RNA polymerase III-transcribed genes in budding yeast.

Belagal P, Normand C, Shukla A, Wang R, Léger-Silvestre I, Dez C, Bhargava P, Gadal O.

Mol Biol Cell. 2016 Oct 15;27(20):3164-3177. Epub 2016 Aug 24.


A new function for the yeast trehalose-6P synthase (Tps1) protein, as key pro-survival factor during growth, chronological ageing, and apoptotic stress.

Petitjean M, Teste MA, Léger-Silvestre I, François JM, Parrou JL.

Mech Ageing Dev. 2017 Jan;161(Pt B):234-246. doi: 10.1016/j.mad.2016.07.011. Epub 2016 Aug 6.


Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human.

Albert B, Colleran C, Léger-Silvestre I, Berger AB, Dez C, Normand C, Perez-Fernandez J, McStay B, Gadal O.

Nucleic Acids Res. 2013 Dec;41(22):10135-49. doi: 10.1093/nar/gkt770. Epub 2013 Sep 9.


Systematic characterization of the conformation and dynamics of budding yeast chromosome XII.

Albert B, Mathon J, Shukla A, Saad H, Normand C, Léger-Silvestre I, Villa D, Kamgoue A, Mozziconacci J, Wong H, Zimmer C, Bhargava P, Bancaud A, Gadal O.

J Cell Biol. 2013 Jul 22;202(2):201-10. doi: 10.1083/jcb.201208186.


Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae.

Ohmayer U, Gamalinda M, Sauert M, Ossowski J, Pöll G, Linnemann J, Hierlmeier T, Perez-Fernandez J, Kumcuoglu B, Leger-Silvestre I, Faubladier M, Griesenbeck J, Woolford J, Tschochner H, Milkereit P.

PLoS One. 2013 Jul 10;8(7):e68412. doi: 10.1371/journal.pone.0068412. Print 2013.


Regulation of ribosomal RNA production by RNA polymerase I: does elongation come first?

Albert B, Perez-Fernandez J, Léger-Silvestre I, Gadal O.

Genet Res Int. 2012;2012:276948. doi: 10.1155/2012/276948. Epub 2012 Jan 12.


Nuclear organization and chromatin dynamics in yeast: biophysical models or biologically driven interactions?

Albert B, Léger-Silvestre I, Normand C, Gadal O.

Biochim Biophys Acta. 2012 Jun;1819(6):468-81. doi: 10.1016/j.bbagrm.2011.12.010. Epub 2012 Jan 5. Review.


RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle.

Albert B, Léger-Silvestre I, Normand C, Ostermaier MK, Pérez-Fernández J, Panov KI, Zomerdijk JC, Schultz P, Gadal O.

J Cell Biol. 2011 Jan 24;192(2):277-93. doi: 10.1083/jcb.201006040.


TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production.

Philippi A, Steinbauer R, Reiter A, Fath S, Leger-Silvestre I, Milkereit P, Griesenbeck J, Tschochner H.

Nucleic Acids Res. 2010 Sep;38(16):5315-26. doi: 10.1093/nar/gkq264. Epub 2010 Apr 25.


Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis.

Léger-Silvestre I, Caffrey JM, Dawaliby R, Alvarez-Arias DA, Gas N, Bertolone SJ, Gleizes PE, Ellis SR.

J Biol Chem. 2005 Nov 18;280(46):38177-85. Epub 2005 Sep 12.


The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast.

Léger-Silvestre I, Milkereit P, Ferreira-Cerca S, Saveanu C, Rousselle JC, Choesmel V, Guinefoleau C, Gas N, Gleizes PE.

EMBO J. 2004 Jun 16;23(12):2336-47. Epub 2004 May 27.


The carboxy-terminal extension of yeast ribosomal protein S14 is necessary for maturation of 43S preribosomes.

Jakovljevic J, de Mayolo PA, Miles TD, Nguyen TM, Léger-Silvestre I, Gas N, Woolford JL Jr.

Mol Cell. 2004 May 7;14(3):331-42.


Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex.

Gleizes PE, Noaillac-Depeyre J, Léger-Silvestre I, Teulières F, Dauxois JY, Pommet D, Azum-Gelade MC, Gas N.

J Cell Biol. 2001 Dec 10;155(6):923-36. Epub 2001 Dec 10.


Assembly and functional organization of the nucleolus: ultrastructural analysis of Saccharomyces cerevisiae mutants.

Trumtel S, Léger-Silvestre I, Gleizes PE, Teulières F, Gas N.

Mol Biol Cell. 2000 Jun;11(6):2175-89.


Assembly of 5S ribosomal RNA is required at a specific step of the pre-rRNA processing pathway.

Dechampesme AM, Koroleva O, Leger-Silvestre I, Gas N, Camier S.

J Cell Biol. 1999 Jun 28;145(7):1369-80.


Functional compartmentalization of the nucleus in the budding yeast Saccharomyces cerevisiae.

Léger-Silvestre I, Trumtel S, Noaillac-Depeyre J, Gas N.

Chromosoma. 1999 May;108(2):103-13.


Ultrastructural changes in the Schizosaccharomyces pombe nucleolus following the disruption of the gar2+ gene, which encodes a nucleolar protein structurally related to nucleolin.

Léger-Silvestre I, Gulli MP, Noaillac-Depeyre J, Faubladier M, Sicard H, Caizergues-Ferrer M, Gas N.

Chromosoma. 1997 Jun;105(7-8):542-52.


Structural and functional analysis of the nucleolus of the fission yeast Schizosaccharomyces pombe.

Léger-Silvestre I, Noaillac-Depeyre J, Faubladier M, Gas N.

Eur J Cell Biol. 1997 Jan;72(1):13-23.


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