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Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne H, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T.

Cancer Discov. 2019 Dec;9(12):1736-1753. doi: 10.1158/2159-8290.CD-18-1463. Epub 2019 Oct 29.


Multimodal imaging for tumour characterization from micro- to macroscopic level using a newly developed dorsal chamber designed for long-term follow-up.

Rouffiac V, Roux KS, Salomé-Desnoulez S, Leguerney I, Ginefri JC, Sébrié C, Jourdain L, Lécluse Y, Laplace-Builhé C.

J Biophotonics. 2020 Jan;13(1):e201900217. doi: 10.1002/jbio.201900217. Epub 2019 Oct 23.


Acquired Resistance Mutations to ALK Inhibitors Identified by Single Circulating Tumor Cell Sequencing in ALK-Rearranged Non-Small-Cell Lung Cancer.

Pailler E, Faugeroux V, Oulhen M, Mezquita L, Laporte M, Honoré A, Lecluse Y, Queffelec P, NgoCamus M, Nicotra C, Remon J, Lacroix L, Planchard D, Friboulet L, Besse B, Farace F.

Clin Cancer Res. 2019 Nov 15;25(22):6671-6682. doi: 10.1158/1078-0432.CCR-19-1176. Epub 2019 Aug 22.


Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN.

Piel C, Pouchieu C, Carles C, Béziat B, Boulanger M, Bureau M, Busson A, Grüber A, Lecluse Y, Migault L, Renier M, Rondeau V, Schwall X, Tual S; AGRICAN group, Pierre L, Baldi I.

Environ Int. 2019 Sep;130:104876. doi: 10.1016/j.envint.2019.05.070. Epub 2019 Jul 22.


Increased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN.

Piel C, Pouchieu C, Migault L, Béziat B, Boulanger M, Bureau M, Carles C, Grüber A, Lecluse Y, Rondeau V, Schwall X, Tual S, Lebailly P, Baldi I; AGRICAN group.

Int J Epidemiol. 2019 Apr 1;48(2):512-526. doi: 10.1093/ije/dyy246.


Towards a new standardized method for circulating miRNAs profiling in clinical studies: Interest of the exogenous normalization to improve miRNA signature accuracy.

Vigneron N, Meryet-Figuière M, Guttin A, Issartel JP, Lambert B, Briand M, Louis MH, Vernon M, Lebailly P, Lecluse Y, Joly F, Krieger S, Lheureux S, Clarisse B, Leconte A, Gauduchon P, Poulain L, Denoyelle C.

Mol Oncol. 2016 Aug;10(7):981-92. doi: 10.1016/j.molonc.2016.03.005. Epub 2016 Apr 2.


Prevalence of monoclonal gammopathy of undetermined significance (MGUS) among farmers involved in open field farming and/or cattle breading in France.

Lecluse Y, Comby E, Mariotte D, Tual S, Le Mauff B, Lebailly P, Gauduchon P.

Leuk Lymphoma. 2016 Jul;57(7):1727-30. doi: 10.3109/10428194.2015.1113277. Epub 2015 Dec 21. No abstract available.


DNA damage in B and T lymphocytes of farmers during one pesticide spraying season.

Lebailly P, Mirey G, Herin F, Lecluse Y, Salles B, Boutet-Robinet E.

Int Arch Occup Environ Health. 2015 Oct;88(7):963-72. doi: 10.1007/s00420-015-1024-3. Epub 2015 Feb 3.


The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons.

Pan J, Lordier L, Meyran D, Rameau P, Lecluse Y, Kitchen-Goosen S, Badirou I, Mokrani H, Narumiya S, Alberts AS, Vainchenker W, Chang Y.

Blood. 2014 Dec 18;124(26):3967-77. doi: 10.1182/blood-2013-12-544924. Epub 2014 Oct 8.


JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.

Besancenot R, Roos-Weil D, Tonetti C, Abdelouahab H, Lacout C, Pasquier F, Willekens C, Rameau P, Lecluse Y, Micol JB, Constantinescu SN, Vainchenker W, Solary E, Giraudier S.

Blood. 2014 Sep 25;124(13):2104-15. doi: 10.1182/blood-2014-03-559815. Epub 2014 Aug 20.


The NF-κB pathway is rarely spontaneously activated in mantle cell lymphoma (MCL) cell lines and patient's samples.

Camara-Clayette V, Lecluse Y, Schrader C, Klapper W, Vainchenker W, Hermine O, Ribrag V.

Eur J Cancer. 2014 Jan;50(1):159-69. doi: 10.1016/j.ejca.2013.09.010. Epub 2013 Oct 14.


Assessment of the genotoxic and carcinogenic potentials of 3-aminothiophene derivatives using in vitro and in silico methodologies.

Lepailleur A, Bureau R, Halm-Lemeille MP, Bouquet M, Pecquet R, Paris-Soubayrol C, Goff JL, André V, Lecluse Y, Lebailly P, Maire MA, Vasseur P.

J Appl Toxicol. 2014 Jul;34(7):775-86. doi: 10.1002/jat.2938. Epub 2013 Oct 11.


Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

Ali A, Bluteau O, Messaoudi K, Palazzo A, Boukour S, Lordier L, Lecluse Y, Rameau P, Kraus-Berthier L, Jacquet-Bescond A, Lelièvre H, Depil S, Dessen P, Solary E, Raslova H, Vainchenker W, Plo I, Debili N.

Cell Death Dis. 2013 Jul 25;4:e738. doi: 10.1038/cddis.2013.260.


Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.

Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Guégan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, Bornhauser B, Gautheret D, Lecluse Y, Landman-Parker J, Radford I, Vainchenker W, Dastugue N, de Botton S, Dessen P, Bourquin JP, Crispino JD, Ballerini P, Bernard OA, Pflumio F, Mercher T.

J Exp Med. 2012 Oct 22;209(11):2017-31. doi: 10.1084/jem.20121343. Epub 2012 Oct 8.


Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

Moniz H, Gastou M, Leblanc T, Hurtaud C, Crétien A, Lécluse Y, Raslova H, Larghero J, Croisille L, Faubladier M, Bluteau O, Lordier L, Tchernia G, Vainchenker W, Mohandas N, Da Costa L; DBA Group of Société d'Hématologie et d'Immunologie Pédiatrique-SHIP.

Cell Death Dis. 2012 Jul 26;3:e356. doi: 10.1038/cddis.2012.88.


Red cells exchanges in sickle cells disease lead to a selective reduction of erythrocytes-derived blood microparticles.

Mahfoudhi E, Lecluse Y, Driss F, Abbes S, Flaujac C, Garçon L.

Br J Haematol. 2012 Feb;156(4):545-7. doi: 10.1111/j.1365-2141.2011.08897.x. Epub 2011 Oct 11. No abstract available.


Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.

Tabbekh M, Franciszkiewicz K, Haouas H, Lécluse Y, Benihoud K, Raman C, Mami-Chouaib F.

J Immunol. 2011 Jul 1;187(1):102-9. doi: 10.4049/jimmunol.1004145. Epub 2011 May 27.


LYL-1 deficiency induces a stress erythropoiesis.

Capron C, Lacout C, Lécluse Y, Wagner-Ballon O, Kaushik AL, Cramer-Bordé E, Sablitzky F, Duménil D, Vainchenker W.

Exp Hematol. 2011 Jun;39(6):629-42. doi: 10.1016/j.exphem.2011.02.014. Epub 2011 Mar 21.


A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation.

Besancenot R, Chaligné R, Tonetti C, Pasquier F, Marty C, Lécluse Y, Vainchenker W, Constantinescu SN, Giraudier S.

PLoS Biol. 2010 Sep 7;8(9). pii: e1000476. doi: 10.1371/journal.pbio.1000476.


Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.

Lordier L, Chang Y, Jalil A, Aurade F, Garçon L, Lécluse Y, Larbret F, Kawashima T, Kitamura T, Larghero J, Debili N, Vainchenker W.

Blood. 2010 Sep 30;116(13):2345-55. doi: 10.1182/blood-2010-01-265785. Epub 2010 Jun 14.


A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors.

Capron C, Lacout C, Lécluse Y, Jalbert V, Chagraoui H, Charrier S, Galy A, Bennaceur-Griscelli A, Cramer-Bordé E, Vainchenker W.

Blood. 2010 Aug 26;116(8):1244-53. doi: 10.1182/blood-2009-05-221093. Epub 2010 May 20.


Determinants of urinary deoxynivalenol and de-epoxy deoxynivalenol in male farmers from Normandy, France.

Turner PC, Hopton RP, Lecluse Y, White KL, Fisher J, Lebailly P.

J Agric Food Chem. 2010 Apr 28;58(8):5206-12. doi: 10.1021/jf100892v.


Agricultural pesticide exposure and the molecular connection to lymphomagenesis.

Agopian J, Navarro JM, Gac AC, Lecluse Y, Briand M, Grenot P, Gauduchon P, Ruminy P, Lebailly P, Nadel B, Roulland S.

J Exp Med. 2009 Jul 6;206(7):1473-83. doi: 10.1084/jem.20082842. Epub 2009 Jun 8.


A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.

Klimchenko O, Mori M, Distefano A, Langlois T, Larbret F, Lecluse Y, Feraud O, Vainchenker W, Norol F, Debili N.

Blood. 2009 Aug 20;114(8):1506-17. doi: 10.1182/blood-2008-09-178863. Epub 2009 May 28.


Mutation in TET2 in myeloid cancers.

Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Massé A, Kosmider O, Le Couedic JP, Robert F, Alberdi A, Lécluse Y, Plo I, Dreyfus FJ, Marzac C, Casadevall N, Lacombe C, Romana SP, Dessen P, Soulier J, Viguié F, Fontenay M, Vainchenker W, Bernard OA.

N Engl J Med. 2009 May 28;360(22):2289-301. doi: 10.1056/NEJMoa0810069.


The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

Noman MZ, Buart S, Van Pelt J, Richon C, Hasmim M, Leleu N, Suchorska WM, Jalil A, Lecluse Y, El Hage F, Giuliani M, Pichon C, Azzarone B, Mazure N, Romero P, Mami-Chouaib F, Chouaib S.

J Immunol. 2009 Mar 15;182(6):3510-21. doi: 10.4049/jimmunol.0800854.


t(11;14)-positive clones can persist over a long period of time in the peripheral blood of healthy individuals.

Lecluse Y, Lebailly P, Roulland S, Gac AC, Nadel B, Gauduchon P.

Leukemia. 2009 Jun;23(6):1190-3. doi: 10.1038/leu.2009.31. Epub 2009 Feb 26. No abstract available.


ICAM-1 has a critical role in the regulation of metastatic melanoma tumor susceptibility to CTL lysis by interfering with PI3K/AKT pathway.

Hamaï A, Meslin F, Benlalam H, Jalil A, Mehrpour M, Faure F, Lecluse Y, Vielh P, Avril MF, Robert C, Chouaib S.

Cancer Res. 2008 Dec 1;68(23):9854-64. doi: 10.1158/0008-5472.CAN-08-0719.


Exposure to pesticides in open-field farming in France.

Lebailly P, Bouchart V, Baldi I, Lecluse Y, Heutte N, Gislard A, Malas JP.

Ann Occup Hyg. 2009 Jan;53(1):69-81. doi: 10.1093/annhyg/men072. Epub 2008 Nov 20.


Quantification of circulating mature endothelial cells using a whole blood four-color flow cytometric assay.

Jacques N, Vimond N, Conforti R, Griscelli F, Lecluse Y, Laplanche A, Malka D, Vielh P, Farace F.

J Immunol Methods. 2008 Sep 15;337(2):132-43. doi: 10.1016/j.jim.2008.07.006. Epub 2008 Jul 26.


EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts.

Geoerger B, Gaspar N, Opolon P, Morizet J, Devanz P, Lecluse Y, Valent A, Lacroix L, Grill J, Vassal G.

Int J Cancer. 2008 Jul 1;123(1):209-16. doi: 10.1002/ijc.23488.


A new generation of pPRIG-based retroviral vectors.

Albagli-Curiel O, Lécluse Y, Pognonec P, Boulukos KE, Martin P.

BMC Biotechnol. 2007 Nov 30;7:85.


Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells.

Tao Y, Zhang P, Frascogna V, Lecluse Y, Auperin A, Bourhis J, Deutsch E.

Br J Cancer. 2007 Dec 17;97(12):1664-72. Epub 2007 Nov 20.


Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle.

Haond C, Farace F, Guillier M, Lécluse Y, Mazurier F, Vainchenker W, Turhan AG.

Cell Res. 2007 Sep;17(9):783-91.


Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.

Chaligné R, James C, Tonetti C, Besancenot R, Le Couédic JP, Fava F, Mazurier F, Godin I, Maloum K, Larbret F, Lécluse Y, Vainchenker W, Giraudier S.

Blood. 2007 Nov 15;110(10):3735-43. Epub 2007 Aug 20.


Expression of erythropoietin and its receptor in neuroblastomas.

Sartelet H, Fabre M, Castaing M, Bosq J, Racu I, Lagonotte E, Scott V, Lecluse Y, Barette S, Michiels S, Vassal G.

Cancer. 2007 Sep 1;110(5):1096-106.


Human CD5 protects circulating tumor antigen-specific CTL from tumor-mediated activation-induced cell death.

Friedlein G, El Hage F, Vergnon I, Richon C, Saulnier P, Lécluse Y, Caignard A, Boumsell L, Bismuth G, Chouaib S, Mami-Chouaib F.

J Immunol. 2007 Jun 1;178(11):6821-7.


The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera.

Dupont S, Massé A, James C, Teyssandier I, Lécluse Y, Larbret F, Ugo V, Saulnier P, Koscielny S, Le Couédic JP, Casadevall N, Vainchenker W, Delhommeau F.

Blood. 2007 Aug 1;110(3):1013-21. Epub 2007 Mar 27.


Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: Relationship to Bcl-2 family and caspase activation.

Hamaï A, Richon C, Meslin F, Faure F, Kauffmann A, Lecluse Y, Jalil A, Larue L, Avril MF, Chouaib S, Mehrpour M.

Oncogene. 2006 Dec 7;25(58):7618-34. Epub 2006 Sep 18. Erratum in: Oncogene. 2007 Feb 22;26(8):1256.


Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells.

Garçon L, Rivat C, James C, Lacout C, Camara-Clayette V, Ugo V, Lecluse Y, Bennaceur-Griscelli A, Vainchenker W.

Blood. 2006 Sep 1;108(5):1551-4. Epub 2006 May 9.


The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation.

Capron C, Lécluse Y, Kaushik AL, Foudi A, Lacout C, Sekkai D, Godin I, Albagli O, Poullion I, Svinartchouk F, Schanze E, Vainchenker W, Sablitzky F, Bennaceur-Griscelli A, Duménil D.

Blood. 2006 Jun 15;107(12):4678-86. Epub 2006 Mar 2.


A novel dendritic cell subset involved in tumor immunosurveillance.

Taieb J, Chaput N, Ménard C, Apetoh L, Ullrich E, Bonmort M, Péquignot M, Casares N, Terme M, Flament C, Opolon P, Lecluse Y, Métivier D, Tomasello E, Vivier E, Ghiringhelli F, Martin F, Klatzmann D, Poynard T, Tursz T, Raposo G, Yagita H, Ryffel B, Kroemer G, Zitvogel L.

Nat Med. 2006 Feb;12(2):214-9. Epub 2006 Jan 29.


Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individuals.

Roulland S, Lebailly P, Lecluse Y, Heutte N, Nadel B, Gauduchon P.

Leukemia. 2006 Jan;20(1):158-62. No abstract available.


Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.

Foudi A, Jarrier P, Zhang Y, Wittner M, Geay JF, Lecluse Y, Nagasawa T, Vainchenker W, Louache F.

Blood. 2006 Mar 15;107(6):2243-51. Epub 2005 Nov 15.


NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors.

Le Maux Chansac B, Moretta A, Vergnon I, Opolon P, Lécluse Y, Grunenwald D, Kubin M, Soria JC, Chouaib S, Mami-Chouaib F.

J Immunol. 2005 Nov 1;175(9):5790-8.


Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.

Boissan M, Beurel E, Wendum D, Rey C, Lécluse Y, Housset C, Lacombe ML, Desbois-Mouthon C.

Am J Pathol. 2005 Sep;167(3):869-77.


Screening of TP53 mutations by DHPLC and sequencing in brain tumours from patients with an occupational exposure to pesticides or organic solvents.

Loyant V, Jaffré A, Breton J, Baldi I, Vital A, Chapon F, Dutoit S, Lecluse Y, Loiseau H, Lebailly P, Gauduchon P.

Mutagenesis. 2005 Sep;20(5):365-73. Epub 2005 Aug 16.


In situ sensory adaptation of tumor-infiltrating T lymphocytes to peptide-MHC levels elicits strong antitumor reactivity.

Dorothée G, Vergnon I, El Hage F, Le Maux Chansac B, Ferrand V, Lécluse Y, Opolon P, Chouaib S, Bismuth G, Mami-Chouaib F.

J Immunol. 2005 Jun 1;174(11):6888-97.


Expression of p53, or targeting towards EGFR, enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma.

Geoerger B, van Beusechem VW, Opolon P, Morizet J, Laudani L, Lecluse Y, Barrois M, Idema S, Grill J, Gerritsen WR, Vassal G.

J Gene Med. 2005 May;7(5):584-94.


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