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Items: 1 to 50 of 91

1.

Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators.

Woloszynska M, Le Gall S, Neyt P, Boccardi TM, Grasser M, Längst G, Aesaert S, Coussens G, Dhondt S, Van De Slijke E, Bruno L, Fung-Uceda J, Mas P, Van Montagu M, Inzé D, Himanen K, De Jaeger G, Grasser KD, Van Lijsebettens M.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8060-8069. doi: 10.1073/pnas.1806541116. Epub 2019 Mar 28.

2.

The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity.

Azuara-Medina PM, Sandoval-Duarte AM, Morales-Lázaro SL, Modragón-González R, Vélez-Aguilera G, Gómez-López JD, Jiménez-Gutiérrez GE, Tiburcio-Félix R, Martínez-Vieyra I, Suárez-Sánchez R, Längst G, Magaña JJ, Winder SJ, Ortega A, Ramos Perlingeiro RC, Jacobs LA, Cisneros B.

Cell Death Dis. 2019 Feb 27;10(3):196. doi: 10.1038/s41419-019-1454-z.

3.

Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids.

Killian T, Buntz A, Herlet T, Seul H, Mundigl O, Längst G, Brinkmann U.

Nucleic Acids Res. 2019 Jun 4;47(10):e55. doi: 10.1093/nar/gkz137.

4.

Nucleosomes Stabilize ssRNA-dsDNA Triple Helices in Human Cells.

Maldonado R, Schwartz U, Silberhorn E, Längst G.

Mol Cell. 2019 Mar 21;73(6):1243-1254.e6. doi: 10.1016/j.molcel.2019.01.007. Epub 2019 Feb 12.

PMID:
30770238
5.

The UAP56-Interacting Export Factors UIEF1 and UIEF2 Function in mRNA Export.

Ehrnsberger HF, Pfaff C, Hachani I, Flores-Tornero M, Sørensen BB, Längst G, Sprunck S, Grasser M, Grasser KD.

Plant Physiol. 2019 Apr;179(4):1525-1536. doi: 10.1104/pp.18.01476. Epub 2019 Jan 30.

6.

Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1.

Hoffmeister H, Fuchs A, Strobl L, Sprenger F, Gröbner-Ferreira R, Michaelis S, Hoffmann P, Nazet J, Merkl R, Längst G.

J Biol Chem. 2019 Mar 1;294(9):3294-3310. doi: 10.1074/jbc.RA118.005685. Epub 2019 Jan 15.

PMID:
30647132
7.

Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.

Schwartz U, Németh A, Diermeier S, Exler JH, Hansch S, Maldonado R, Heizinger L, Merkl R, Längst G.

Nucleic Acids Res. 2019 Feb 20;47(3):1239-1254. doi: 10.1093/nar/gky1203.

8.

The Arabidopsis Histone Chaperone FACT: Role of the HMG-Box Domain of SSRP1.

Pfab A, Grønlund JT, Holzinger P, Längst G, Grasser KD.

J Mol Biol. 2018 Aug 17;430(17):2747-2759. doi: 10.1016/j.jmb.2018.06.046. Epub 2018 Jun 30.

PMID:
29966609
9.

Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner.

Kovač K, Sauer A, Mačinković I, Awe S, Finkernagel F, Hoffmeister H, Fuchs A, Müller R, Rathke C, Längst G, Brehm A.

Nat Commun. 2018 May 29;9(1):2112. doi: 10.1038/s41467-018-04503-2.

10.

ALY RNA-Binding Proteins Are Required for Nucleocytosolic mRNA Transport and Modulate Plant Growth and Development.

Pfaff C, Ehrnsberger HF, Flores-Tornero M, Sørensen BB, Schubert T, Längst G, Griesenbeck J, Sprunck S, Grasser M, Grasser KD.

Plant Physiol. 2018 May;177(1):226-240. doi: 10.1104/pp.18.00173. Epub 2018 Mar 14.

11.

Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma.

Beck A, Trippel F, Wagner A, Joppien S, Felle M, Vokuhl C, Schwarzmayr T, Strom TM, von Schweinitz D, Längst G, Kappler R.

Clin Epigenetics. 2018 Mar 2;10:27. doi: 10.1186/s13148-018-0462-7. eCollection 2018.

12.

Purine- and pyrimidine-triple-helix-forming oligonucleotides recognize qualitatively different target sites at the ribosomal DNA locus.

Maldonado R, Filarsky M, Grummt I, Längst G.

RNA. 2018 Mar;24(3):371-380. doi: 10.1261/rna.063800.117. Epub 2017 Dec 8.

13.

MicroScale Thermophoresis: A Rapid and Precise Method to Quantify Protein-Nucleic Acid Interactions in Solution.

Mueller AM, Breitsprecher D, Duhr S, Baaske P, Schubert T, Längst G.

Methods Mol Biol. 2017;1654:151-164. doi: 10.1007/978-1-4939-7231-9_10.

PMID:
28986788
14.

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

Hoffmeister H, Fuchs A, Erdel F, Pinz S, Gröbner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer AS, Rippe K, Längst G.

Nucleic Acids Res. 2017 Oct 13;45(18):10534-10554. doi: 10.1093/nar/gkx711.

15.

The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences.

König F, Schubert T, Längst G.

PLoS One. 2017 Jun 8;12(6):e0178875. doi: 10.1371/journal.pone.0178875. eCollection 2017.

16.

The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors.

Antosz W, Pfab A, Ehrnsberger HF, Holzinger P, Köllen K, Mortensen SA, Bruckmann A, Schubert T, Längst G, Griesenbeck J, Schubert V, Grasser M, Grasser KD.

Plant Cell. 2017 Apr;29(4):854-870. doi: 10.1105/tpc.16.00735. Epub 2017 Mar 28.

17.

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning.

Silberhorn E, Schwartz U, Löffler P, Schmitz S, Symelka A, de Koning-Ward T, Merkl R, Längst G.

PLoS Pathog. 2016 Dec 29;12(12):e1006080. doi: 10.1371/journal.ppat.1006080. eCollection 2016 Dec.

18.

The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events.

Sørensen BB, Ehrnsberger HF, Esposito S, Pfab A, Bruckmann A, Hauptmann J, Meister G, Merkl R, Schubert T, Längst G, Melzer M, Grasser M, Grasser KD.

Plant Mol Biol. 2017 Feb;93(3):283-298. doi: 10.1007/s11103-016-0561-9. Epub 2016 Dec 21.

PMID:
28004241
19.

Bioinformatic Analysis of ChIP-seq Data on the Repetitive Ribosomal RNA Gene.

Schwartz U, Längst G.

Methods Mol Biol. 2016;1455:225-30. doi: 10.1007/978-1-4939-3792-9_17.

PMID:
27576722
20.

Preparation of Chromatin Templates to Study RNA Polymerase I Transcription In Vitro.

Längst G.

Methods Mol Biol. 2016;1455:109-19. doi: 10.1007/978-1-4939-3792-9_9.

PMID:
27576714
21.

Differential enrichment of TTF-I and Tip5 in the T-like promoter structures of the rDNA contribute to the epigenetic response of Cyprinus carpio during environmental adaptation.

Nardocci G, Simonet NG, Navarro C, Längst G, Alvarez M.

Biochem Cell Biol. 2016 Aug;94(4):315-21. doi: 10.1139/bcb-2016-0015. Epub 2016 Apr 13.

PMID:
27458840
22.

Cross-sectoral cancer care: views from patients and health care professionals regarding a personal electronic health record.

Baudendistel I, Winkler EC, Kamradt M, Brophy S, Längst G, Eckrich F, Heinze O, Bergh B, Szecsenyi J, Ose D.

Eur J Cancer Care (Engl). 2017 Mar;26(2). doi: 10.1111/ecc.12429. Epub 2016 Feb 3.

PMID:
26840784
23.

Factors associated with medication information in diabetes care: differences in perceptions between patients and health care professionals.

Längst G, Seidling HM, Stützle M, Ose D, Baudendistel I, Szecsenyi J, Wensing M, Mahler C.

Patient Prefer Adherence. 2015 Oct 14;9:1431-41. doi: 10.2147/PPA.S88357. eCollection 2015.

24.

Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays.

Schrader A, Gross T, Thalhammer V, Längst G.

PLoS One. 2015 Oct 23;10(10):e0140076. doi: 10.1371/journal.pone.0140076. eCollection 2015.

25.

Collaboration and communication in colorectal cancer care: a qualitative study of the challenges experienced by patients and health care professionals.

Kamradt M, Baudendistel I, Längst G, Kiel M, Eckrich F, Winkler E, Szecsenyi J, Ose D.

Fam Pract. 2015 Dec;32(6):686-93. doi: 10.1093/fampra/cmv069. Epub 2015 Aug 26.

26.

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.

Friedrich U, Datta S, Schubert T, Plössl K, Schneider M, Grassmann F, Fuchshofer R, Tiefenbach KJ, Längst G, Weber BH.

Hum Mol Genet. 2015 Nov 15;24(22):6361-73. doi: 10.1093/hmg/ddv346. Epub 2015 Aug 26.

PMID:
26310622
27.

The extended AT-hook is a novel RNA binding motif.

Filarsky M, Zillner K, Araya I, Villar-Garea A, Merkl R, Längst G, Németh A.

RNA Biol. 2015;12(8):864-76. doi: 10.1080/15476286.2015.1060394.

28.

Chromatin Remodelers: From Function to Dysfunction.

Längst G, Manelyte L.

Genes (Basel). 2015 Jun 12;6(2):299-324. doi: 10.3390/genes6020299. Review.

29.

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.

Josling GA, Petter M, Oehring SC, Gupta AP, Dietz O, Wilson DW, Schubert T, Längst G, Gilson PR, Crabb BS, Moes S, Jenoe P, Lim SW, Brown GV, Bozdech Z, Voss TS, Duffy MF.

Cell Host Microbe. 2015 Jun 10;17(6):741-51. doi: 10.1016/j.chom.2015.05.009.

30.

Personal electronic health records: understanding user requirements and needs in chronic cancer care.

Baudendistel I, Winkler E, Kamradt M, Längst G, Eckrich F, Heinze O, Bergh B, Szecsenyi J, Ose D.

J Med Internet Res. 2015 May 21;17(5):e121. doi: 10.2196/jmir.3884.

31.

Splicing of many human genes involves sites embedded within introns.

Kelly S, Georgomanolis T, Zirkel A, Diermeier S, O'Reilly D, Murphy S, Längst G, Cook PR, Papantonis A.

Nucleic Acids Res. 2015 May 19;43(9):4721-32. doi: 10.1093/nar/gkv386. Epub 2015 Apr 20.

32.

The patients' active role in managing a personal electronic health record: a qualitative analysis.

Baudendistel I, Winkler E, Kamradt M, Brophy S, Längst G, Eckrich F, Heinze O, Bergh B, Szecsenyi J, Ose D.

Support Care Cancer. 2015 Sep;23(9):2613-21. doi: 10.1007/s00520-015-2620-1. Epub 2015 Feb 5.

PMID:
25652149
33.

TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.

Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Knoch TA, Merkl R, Cook PR, Längst G, Papantonis A.

Genome Biol. 2014 Dec 3;15(12):536. doi: 10.1186/s13059-014-0536-6.

34.

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.

Loedige I, Stotz M, Qamar S, Kramer K, Hennig J, Schubert T, Löffler P, Längst G, Merkl R, Urlaub H, Meister G.

Genes Dev. 2014 Apr 1;28(7):749-64. doi: 10.1101/gad.236513.113.

35.

Chromatin targeting signals, nucleosome positioning mechanism and non-coding RNA-mediated regulation of the chromatin remodeling complex NoRC.

Manelyte L, Strohner R, Gross T, Längst G.

PLoS Genet. 2014 Mar 20;10(3):e1004157. doi: 10.1371/journal.pgen.1004157. eCollection 2014 Mar.

36.

CpG domains downstream of TSSs promote high levels of gene expression.

Krinner S, Heitzer AP, Diermeier SD, Obermeier I, Längst G, Wagner R.

Nucleic Acids Res. 2014 Apr;42(6):3551-64. doi: 10.1093/nar/gkt1358. Epub 2014 Jan 9.

37.

Deep sequencing of small chromatin-associated RNA: bioinformatic analysis.

Diermeier SD, Längst G.

Methods Mol Biol. 2014;1094:355-9. doi: 10.1007/978-1-62703-706-8_28.

PMID:
24163002
38.

Deep sequencing of small chromatin-associated RNA: isolation and library preparation.

Diermeier SD, Schubert T, Längst G.

Methods Mol Biol. 2014;1094:343-53. doi: 10.1007/978-1-62703-706-8_27.

PMID:
24163001
39.

Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites.

Diermeier SD, Németh A, Rehli M, Grummt I, Längst G.

PLoS Genet. 2013;9(9):e1003786. doi: 10.1371/journal.pgen.1003786. Epub 2013 Sep 12.

40.

Health-related quality of life and risk factor control: the importance of educational level in prevention of cardiovascular diseases.

Ose D, Rochon J, Campbell SM, Wensing M, Freund T, van Lieshout J, Längst G, Szecsenyi J, Ludt S.

Eur J Public Health. 2014 Aug;24(4):679-84. doi: 10.1093/eurpub/ckt139. Epub 2013 Sep 24.

PMID:
24068548
41.

Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1.

Pham TH, Minderjahn J, Schmidl C, Hoffmeister H, Schmidhofer S, Chen W, Längst G, Benner C, Rehli M.

Nucleic Acids Res. 2013 Jul;41(13):6391-402. doi: 10.1093/nar/gkt355. Epub 2013 May 8.

42.

Large-scale organization of ribosomal DNA chromatin is regulated by Tip5.

Zillner K, Filarsky M, Rachow K, Weinberger M, Längst G, Németh A.

Nucleic Acids Res. 2013 May 1;41(10):5251-62. doi: 10.1093/nar/gkt218. Epub 2013 Apr 10.

43.

Arabidopsis DEAD-box RNA helicase UAP56 interacts with both RNA and DNA as well as with mRNA export factors.

Kammel C, Thomaier M, Sørensen BB, Schubert T, Längst G, Grasser M, Grasser KD.

PLoS One. 2013;8(3):e60644. doi: 10.1371/journal.pone.0060644. Epub 2013 Mar 26.

44.

Changes in higher order structures of chromatin by RNP complexes.

Schubert T, Längst G.

RNA Biol. 2013 Feb;10(2):175-9. doi: 10.4161/rna.23175. Epub 2013 Jan 25.

45.

Epigenetic control of RNA polymerase I transcription in mammalian cells.

Grummt I, Längst G.

Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):393-404. doi: 10.1016/j.bbagrm.2012.10.004. Epub 2012 Oct 12. Review.

PMID:
23063748
46.

Df31 protein and snoRNAs maintain accessible higher-order structures of chromatin.

Schubert T, Pusch MC, Diermeier S, Benes V, Kremmer E, Imhof A, Längst G.

Mol Cell. 2012 Nov 9;48(3):434-44. doi: 10.1016/j.molcel.2012.08.021. Epub 2012 Sep 27.

47.

Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.

Hochstatter J, Hölzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Längst G, Németh A.

J Biol Chem. 2012 Jul 13;287(29):24365-77. doi: 10.1074/jbc.M111.303719. Epub 2012 May 29.

48.

Microscale thermophoresis as a sensitive method to quantify protein: nucleic acid interactions in solution.

Zillner K, Jerabek-Willemsen M, Duhr S, Braun D, Längst G, Baaske P.

Methods Mol Biol. 2012;815:241-52. doi: 10.1007/978-1-61779-424-7_18.

PMID:
22130996
49.

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

Felle M, Joppien S, Németh A, Diermeier S, Thalhammer V, Dobner T, Kremmer E, Kappler R, Längst G.

Nucleic Acids Res. 2011 Oct;39(19):8355-65. doi: 10.1093/nar/gkr528. Epub 2011 Jul 10.

50.

Targeting chromatin remodelers: signals and search mechanisms.

Erdel F, Krug J, Längst G, Rippe K.

Biochim Biophys Acta. 2011 Sep;1809(9):497-508. doi: 10.1016/j.bbagrm.2011.06.005. Epub 2011 Jun 16. Review.

PMID:
21704204

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