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Items: 1 to 50 of 133

1.

Thermospermine Synthase (ACL5) and Diamine Oxidase (DAO) Expression Is Needed for Zygotic Embryogenesis and Vascular Development in Scots Pine.

Vuosku J, Muilu-Mäkelä R, Avia K, Suokas M, Kestilä J, Läärä E, Häggman H, Savolainen O, Sarjala T.

Front Plant Sci. 2019 Dec 20;10:1600. doi: 10.3389/fpls.2019.01600. eCollection 2019.

2.

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Couto Alves A, De Silva NMG, Karhunen V, Sovio U, Das S, Taal HR, Warrington NM, Lewin AM, Kaakinen M, Cousminer DL, Thiering E, Timpson NJ, Bond TA, Lowry E, Brown CD, Estivill X, Lindi V, Bradfield JP, Geller F, Speed D, Coin LJM, Loh M, Barton SJ, Beilin LJ, Bisgaard H, Bønnelykke K, Alili R, Hatoum IJ, Schramm K, Cartwright R, Charles MA, Salerno V, Clément K, Claringbould AAJ; BIOS Consortium, van Duijn CM, Moltchanova E, Eriksson JG, Elks C, Feenstra B, Flexeder C, Franks S, Frayling TM, Freathy RM, Elliott P, Widén E, Hakonarson H, Hattersley AT, Rodriguez A, Banterle M, Heinrich J, Heude B, Holloway JW, Hofman A, Hyppönen E, Inskip H, Kaplan LM, Hedman AK, Läärä E, Prokisch H, Grallert H, Lakka TA, Lawlor DA, Melbye M, Ahluwalia TS, Marinelli M, Millwood IY, Palmer LJ, Pennell CE, Perry JR, Ring SM, Savolainen MJ, Rivadeneira F, Standl M, Sunyer J, Tiesler CMT, Uitterlinden AG, Schierding W, O'Sullivan JM, Prokopenko I, Herzig KH, Smith GD, O'Reilly P, Felix JF, Buxton JL, Blakemore AIF, Ong KK, Jaddoe VWV, Grant SFA, Sebert S, McCarthy MI, Järvelin MR; Early Growth Genetics (EGG) Consortium.

Sci Adv. 2019 Sep 4;5(9):eaaw3095. doi: 10.1126/sciadv.aaw3095. eCollection 2019 Sep.

3.

Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes.

Hosio M, Urpilainen E, Marttila M, Hautakoski A, Arffman M, Sund R, Puistola U, Läärä E, Jukkola A, Karihtala P.

Breast Cancer Res Treat. 2019 Jun;175(3):741-748. doi: 10.1007/s10549-019-05185-0. Epub 2019 Mar 20.

4.

Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years.

Pyrhönen K, Kulmala P, Näyhä S, Läärä E.

Ann Allergy Asthma Immunol. 2019 May;122(5):522-531.e3. doi: 10.1016/j.anai.2019.02.027. Epub 2019 Mar 8.

PMID:
30853358
5.

Estimating multilevel regional variation in excess mortality of cancer patients using integrated nested Laplace approximation.

Seppä K, Rue H, Hakulinen T, Läärä E, Sillanpää MJ, Pitkäniemi J.

Stat Med. 2019 Feb 28;38(5):778-791. doi: 10.1002/sim.8010. Epub 2018 Oct 17.

PMID:
30334278
6.

Prognosis of ovarian cancer in women with type 2 diabetes using metformin and other forms of antidiabetic medication or statins: a retrospective cohort study.

Urpilainen E, Marttila M, Hautakoski A, Arffman M, Sund R, Ilanne-Parikka P, Arima R, Kangaskokko J, Puistola U, Hinkula M, Läärä E.

BMC Cancer. 2018 Jul 28;18(1):767. doi: 10.1186/s12885-018-4676-z.

7.

Antidiabetic Medication, Statins and the Risk and Prognosis of Non-endometrioid Endometrial Cancer in Women with Type 2 Diabetes.

Arima R, Marttila M, Hautakoski A, Arffman M, Sund R, Ilanne-Parikka P, Kangaskokko J, Urpilainen E, Läärä E, Hinkula M, Puistola U.

Anticancer Res. 2018 Jul;38(7):4169-4178. doi: 10.21873/anticanres.12710.

PMID:
29970546
8.

Cause-specific mortality in patients with head and neck cancer: Long-term follow-up of a population-based cohort from 1986 to 2012 accounting for competing risks.

Väisänen JA, Alho OP, Koivunen PT, Läärä E.

Oral Oncol. 2018 Apr;79:20-26. doi: 10.1016/j.oraloncology.2018.02.008. Epub 2018 Feb 22.

PMID:
29598946
9.

Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis".

Almangush A, Heikkinen I, Mäkitie AA, Coletta RD, Läärä E, Leivo I, Salo T.

Br J Cancer. 2018 Mar 6;118(5):e12. doi: 10.1038/bjc.2017.491. Epub 2018 Feb 15. No abstract available.

10.

The role of metformin and statins in the incidence of epithelial ovarian cancer in type 2 diabetes: a cohort and nested case-control study.

Urpilainen E, Marttila M, Hautakoski A, Arffman M, Sund R, Ilanne-Parikka P, Arima R, Kangaskokko J, Puistola U, Läärä E, Hinkula M.

BJOG. 2018 Jul;125(8):1001-1008. doi: 10.1111/1471-0528.15151. Epub 2018 Mar 12.

11.

Cause-specific mortality in endometrioid endometrial cancer patients with type 2 diabetes using metformin or other types of antidiabetic medication.

Arima R, Hautakoski A, Marttila M, Arffman M, Sund R, Ilanne-Parikka P, Kangaskokko J, Hinkula M, Puistola U, Läärä E.

Gynecol Oncol. 2017 Dec;147(3):678-683. doi: 10.1016/j.ygyno.2017.10.014. Epub 2017 Oct 18.

PMID:
29054569
12.

Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis.

Almangush A, Heikkinen I, Mäkitie AA, Coletta RD, Läärä E, Leivo I, Salo T.

Br J Cancer. 2017 Sep 5;117(6):856-866. doi: 10.1038/bjc.2017.244. Epub 2017 Jul 27. Review.

13.

Antidiabetic medication, statins and the risk of endometrioid endometrial cancer in patients with type 2 diabetes.

Arima R, Marttila M, Hautakoski A, Arffman M, Sund R, Ilanne-Parikka P, Kangaskokko J, Läärä E, Puistola U, Hinkula M.

Gynecol Oncol. 2017 Sep;146(3):636-641. doi: 10.1016/j.ygyno.2017.06.011. Epub 2017 Jun 20.

PMID:
28645427
14.

Competing risks analysis of cause-specific mortality in patients with oral squamous cell carcinoma.

Läärä E, Korpi JT, Pitkänen H, Alho OP, Kantola S.

Head Neck. 2017 Jan;39(1):56-62. doi: 10.1002/hed.24536. Epub 2016 Jul 20.

PMID:
27437667
15.

Dual targeted poplar ferredoxin NADP(+) oxidoreductase interacts with hemoglobin 1.

Jokipii-Lukkari S, Kastaniotis AJ, Parkash V, Sundström R, Leiva-Eriksson N, Nymalm Y, Blokhina O, Kukkola E, Fagerstedt KV, Salminen TA, Läärä E, Bülow L, Ohlmeier S, Hiltunen JK, Kallio PT, Häggman H.

Plant Sci. 2016 Jun;247:138-49. doi: 10.1016/j.plantsci.2016.03.013. Epub 2016 Mar 26.

PMID:
27095407
16.

Comparing net survival estimators of cancer patients.

Seppä K, Hakulinen T, Läärä E, Pitkäniemi J.

Stat Med. 2016 May 20;35(11):1866-79. doi: 10.1002/sim.6833. Epub 2015 Dec 28.

PMID:
26707551
17.

For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality.

Almangush A, Bello IO, Coletta RD, Mäkitie AA, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Soini Y, Kosma VM, Koivunen P, Kelner N, Kowalski LP, Grénman R, Leivo I, Läärä E, Salo T.

Virchows Arch. 2015 Jul;467(1):39-46. doi: 10.1007/s00428-015-1758-z. Epub 2015 Apr 3.

PMID:
25838076
18.

Dog and cat exposure and respective pet allergy in early childhood.

Pyrhönen K, Näyhä S, Läärä E.

Pediatr Allergy Immunol. 2015 May;26(3):247-255. doi: 10.1111/pai.12369.

PMID:
25735463
19.

Water availability influences morphology, mycorrhizal associations, PSII efficiency and polyamine metabolism at early growth phase of Scots pine seedlings.

Muilu-Mäkelä R, Vuosku J, Läärä E, Saarinen M, Heiskanen J, Häggman H, Sarjala T.

Plant Physiol Biochem. 2015 Mar;88:70-81. doi: 10.1016/j.plaphy.2015.01.009. Epub 2015 Jan 28.

PMID:
25666263
20.

HIV research productivity and structural factors associated with HIV research output in European Union countries: a bibliometric analysis.

Uusküla A, Toompere K, Laisaar KT, Rosenthal M, Pürjer ML, Knellwolf A, Läärä E, Des Jarlais DC.

BMJ Open. 2015 Feb 3;5(2):e006591. doi: 10.1136/bmjopen-2014-006591.

21.

Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure.

Kaakinen M, Sovio U, Hartikainen AL, Pouta A, Savolainen MJ, Herzig KH, Elliott P, De Stavola B, Läärä E, Järvelin MR.

J Epidemiol Community Health. 2014 Dec;68(12):1161-7. doi: 10.1136/jech-2013-203661. Epub 2014 Aug 8.

PMID:
25108017
22.

Predictive factors for quality of life after tonsillectomy among adults with recurrent pharyngitis: a prospective cohort study.

Koskenkorva T, Koivunen P, Läärä E, Alho OP.

Clin Otolaryngol. 2014 Aug;39(4):216-23. doi: 10.1111/coa.12263.

PMID:
24863677
23.

Impact of prior specifications in a shrinkage-inducing Bayesian model for quantitative trait mapping and genomic prediction.

Knürr T, Läärä E, Sillanpää MJ.

Genet Sel Evol. 2013 Jul 8;45:24. doi: 10.1186/1297-9686-45-24.

24.

Caesarean section and allergic manifestations: insufficient evidence of association found in population-based study of children aged 1 to 4 years.

Pyrhönen K, Näyhä S, Hiltunen L, Läärä E.

Acta Paediatr. 2013 Oct;102(10):982-9. doi: 10.1111/apa.12342. Epub 2013 Aug 3.

PMID:
23826787
25.

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.

Fall T, Hägg S, Mägi R, Ploner A, Fischer K, Horikoshi M, Sarin AP, Thorleifsson G, Ladenvall C, Kals M, Kuningas M, Draisma HH, Ried JS, van Zuydam NR, Huikari V, Mangino M, Sonestedt E, Benyamin B, Nelson CP, Rivera NV, Kristiansson K, Shen HY, Havulinna AS, Dehghan A, Donnelly LA, Kaakinen M, Nuotio ML, Robertson N, de Bruijn RF, Ikram MA, Amin N, Balmforth AJ, Braund PS, Doney AS, Döring A, Elliott P, Esko T, Franco OH, Gretarsdottir S, Hartikainen AL, Heikkilä K, Herzig KH, Holm H, Hottenga JJ, Hyppönen E, Illig T, Isaacs A, Isomaa B, Karssen LC, Kettunen J, Koenig W, Kuulasmaa K, Laatikainen T, Laitinen J, Lindgren C, Lyssenko V, Läärä E, Rayner NW, Männistö S, Pouta A, Rathmann W, Rivadeneira F, Ruokonen A, Savolainen MJ, Sijbrands EJ, Small KS, Smit JH, Steinthorsdottir V, Syvänen AC, Taanila A, Tobin MD, Uitterlinden AG, Willems SM, Willemsen G, Witteman J, Perola M, Evans A, Ferrières J, Virtamo J, Kee F, Tregouet DA, Arveiler D, Amouyel P, Ferrario MM, Brambilla P, Hall AS, Heath AC, Madden PA, Martin NG, Montgomery GW, Whitfield JB, Jula A, Knekt P, Oostra B, van Duijn CM, Penninx BW, Smith GD, Kaprio J, Samani NJ, Gieger C, Peters A, Wichmann HE, Boomsma DI, de Geus EJ, Tuomi T, Power C, Hammond CJ, Spector TD, Lind L, Orho-Melander M, Palmer CN, Morris AD, Groop L, Järvelin MR, Salomaa V, Vartiainen E, Hofman A, Ripatti S, Metspalu A, Thorsteinsdottir U, Stefansson K, Pedersen NL, McCarthy MI, Ingelsson E, Prokopenko I; European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium.

PLoS Med. 2013;10(6):e1001474. doi: 10.1371/journal.pmed.1001474. Epub 2013 Jun 25.

26.

Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966.

Kaakinen M, Ducci F, Sillanpää MJ, Läärä E, Järvelin MR.

PLoS One. 2012;7(9):e46557. doi: 10.1371/journal.pone.0046557. Epub 2012 Sep 27.

27.

Avoidable deaths and random variation in patients' survival.

Seppä K, Hakulinen T, Läärä E.

Br J Cancer. 2012 May 22;106(11):1846-9. doi: 10.1038/bjc.2012.169. Epub 2012 Apr 24.

28.

Genetic analysis of complex traits via Bayesian variable selection: the utility of a mixture of uniform priors.

Knürr T, Läärä E, Sillanpää MJ.

Genet Res (Camb). 2011 Aug;93(4):303-18. doi: 10.1017/S0016672311000164. Epub 2011 Jul 18.

PMID:
21767461
29.

Ten-year natural course of habitual snoring and restless legs syndrome in a population aged 61-63 years at the baseline.

Juuti AK, Hiltunen L, Rajala U, Laakso M, Härkönen P, Keinänen-Kiukaanniemi S, Läärä E.

Sleep Breath. 2012 Sep;16(3):639-48. doi: 10.1007/s11325-011-0551-8. Epub 2011 Jul 3.

PMID:
21725862
30.

Real-life epidemiology of food allergy testing in Finnish children.

Pyrhönen K, Hiltunen L, Näyhä S, Läärä E, Kaila M.

Pediatr Allergy Immunol. 2011 Jun;22(4):361-8. doi: 10.1111/j.1399-3038.2011.01140.x. Epub 2011 Feb 1.

PMID:
21284748
31.

SKARP--A population-based cohort study of childhood food-associated symptoms perceived by parents and food allergies diagnosed by physicians: design, methods and participation.

Pyrhönen K, Läärä E, Kaila M, Hiltunen L, Näyhä S.

Scand J Public Health. 2011 Mar;39(2):194-202. doi: 10.1177/1403494810394907. Epub 2011 Jan 21.

PMID:
21257644
32.

Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer.

Bello IO, Vered M, Dayan D, Dobriyan A, Yahalom R, Alanen K, Nieminen P, Kantola S, Läärä E, Salo T.

Oral Oncol. 2011 Jan;47(1):33-8. doi: 10.1016/j.oraloncology.2010.10.013. Epub 2010 Nov 26.

PMID:
21112238
33.

Heredity of food allergies in an unselected child population: an epidemiological survey from Finland.

Pyrhönen K, Hiltunen L, Kaila M, Näyhä S, Läärä E.

Pediatr Allergy Immunol. 2011 Feb;22(1 Pt 2):e124-32. doi: 10.1111/j.1399-3038.2010.01095.x. Epub 2010 Oct 20.

PMID:
20961338
34.

Season of the first trimester of pregnancy predicts sensitisation to food allergens in childhood: a population-based cohort study from Finland.

Pyrhönen K, Läärä E, Hiltunen L, Kaila M, Hugg T, Näyhä S.

J Epidemiol Community Health. 2012 Jan;66(1):49-56. doi: 10.1136/jech.2009.105411. Epub 2010 Oct 19.

PMID:
20959386
35.

Study designs for biobank-based epidemiologic research on chronic diseases.

Läärä E.

Methods Mol Biol. 2011;675:165-78. doi: 10.1007/978-1-59745-423-0_6.

PMID:
20949387
36.

Cure fraction model with random effects for regional variation in cancer survival.

Seppä K, Hakulinen T, Kim HJ, Läärä E.

Stat Med. 2010 Nov 30;29(27):2781-93. doi: 10.1002/sim.4046.

PMID:
20862662
37.

Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling.

Kaakinen M, Läärä E, Pouta A, Hartikainen AL, Laitinen J, Tammelin TH, Herzig KH, Sovio U, Bennett AJ, Peltonen L, McCarthy MI, Elliott P, De Stavola B, Järvelin MR.

Am J Epidemiol. 2010 Sep 15;172(6):653-65. doi: 10.1093/aje/kwq178. Epub 2010 Aug 11.

38.

Association of oral lichen planus with thyroid disease in a Finnish population: a retrospective case-control study.

Siponen M, Huuskonen L, Läärä E, Salo T.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Sep;110(3):319-24. doi: 10.1016/j.tripleo.2010.04.001. Epub 2010 Jul 24.

PMID:
20656530
39.

Population fraction of cervical neoplasia attributable to high-risk human papillomaviruses.

Laukkanen P, Läärä E, Koskela P, Pukkala E, Virkkunen H, Lehtinen M.

Future Oncol. 2010 May;6(5):709-16. doi: 10.2217/fon.10.38.

PMID:
20465386
40.

Prevalence and associated factors of restless legs in a 57-year-old urban population in northern Finland.

Juuti AK, Läärä E, Rajala U, Laakso M, Härkönen P, Keinänen-Kiukaanniemi S, Hiltunen L.

Acta Neurol Scand. 2010 Jul;122(1):63-9. doi: 10.1111/j.1600-0404.2009.01262.x. Epub 2009 Nov 26.

PMID:
19951275
41.

Occurrence of parent-reported food hypersensitivities and food allergies among children aged 1-4 yr.

Pyrhönen K, Näyhä S, Kaila M, Hiltunen L, Läärä E.

Pediatr Allergy Immunol. 2009 Jun;20(4):328-38. doi: 10.1111/j.1399-3038.2008.00792.x.

PMID:
19538354
42.

One tissue, two fates: different roles of megagametophyte cells during Scots pine embryogenesis.

Vuosku J, Sarjala T, Jokela A, Sutela S, Sääskilahti M, Suorsa M, Läärä E, Häggman H.

J Exp Bot. 2009;60(4):1375-86. doi: 10.1093/jxb/erp020. Epub 2009 Feb 26.

43.

Nested case-control data utilized for multiple outcomes: a likelihood approach and alternatives.

Saarela O, Kulathinal S, Arjas E, Läärä E.

Stat Med. 2008 Dec 10;27(28):5991-6008. doi: 10.1002/sim.3416.

PMID:
18792086
44.

Non-participation in a field survey with respect to psychiatric disorders.

Haapea M, Miettunen J, Läärä E, Joukamaa MI, Järvelin MR, Isohanni MK, Veijola JM.

Scand J Public Health. 2008 Sep;36(7):728-36. doi: 10.1177/1403494808092250. Epub 2008 Jul 22.

PMID:
18647788
45.

Association of abnormal glucose tolerance with self-reported sleep apnea among a 57-year-old urban population in Northern Finland.

Juuti AK, Hiltunen L, Rajala U, Laakso M, Härkönen P, Hedberg P, Ruokonen A, Keinänen-Kiukaanniemi S, Läärä E.

Diabetes Res Clin Pract. 2008 Jun;80(3):477-82. doi: 10.1016/j.diabres.2008.02.002. Epub 2008 Mar 18.

PMID:
18353486
46.

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.

Korpi JT, Kervinen V, Mäklin H, Väänänen A, Lahtinen M, Läärä E, Ristimäki A, Thomas G, Ylipalosaari M, Aström P, Lopez-Otin C, Sorsa T, Kantola S, Pirilä E, Salo T.

Br J Cancer. 2008 Feb 26;98(4):766-75. doi: 10.1038/sj.bjc.6604239. Epub 2008 Feb 5.

47.

Coffee consumption and mortality in a 14-year follow-up of an elderly northern Finnish population.

Happonen P, Läärä E, Hiltunen L, Luukinen H.

Br J Nutr. 2008 Jun;99(6):1354-61. Epub 2007 Dec 6.

PMID:
18062826
48.

The enamel matrix derivative (Emdogain) enhances human tongue carcinoma cells gelatinase production, migration and metastasis formation.

Laaksonen M, Suojanen J, Nurmenniemi S, Läärä E, Sorsa T, Salo T.

Oral Oncol. 2008 Aug;44(8):733-42. Epub 2007 Dec 3.

PMID:
18061521
49.

Temporary parental separation at birth and substance use disorder in adulthood. A long-term follow-up of the Finnish Christmas Seal Home Children.

Veijola J, Läärä E, Joukamaa M, Isohanni M, Hakko H, Haapea M, Pirkola S, Mäki P.

Soc Psychiatry Psychiatr Epidemiol. 2008 Jan;43(1):11-7. Epub 2007 Oct 24.

PMID:
17960319
50.

An occupational health intervention programme for workers at high risk for sickness absence. Cost effectiveness analysis based on a randomised controlled trial.

Taimela S, Justén S, Aronen P, Sintonen H, Läärä E, Malmivaara A, Tiekso J, Aro T.

Occup Environ Med. 2008 Apr;65(4):242-8. Epub 2007 Oct 12.

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