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Items: 1 to 50 of 83

1.

In the beginning, there was protein phosphorylation.

Kyriakis JM.

J Biol Chem. 2014 Apr 4;289(14):9460-2. doi: 10.1074/jbc.R114.557926. Epub 2014 Feb 19.

2.

Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice.

Zhang Y, Welzig CM, Picard KL, Du C, Wang B, Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, Galper JB.

Diabetes. 2014 Jun;63(6):2097-113. doi: 10.2337/db12-1459. Epub 2014 Jan 23.

3.

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.

Kyriakis JM, Avruch J.

Physiol Rev. 2012 Apr;92(2):689-737. doi: 10.1152/physrev.00028.2011. Review.

4.

Retraction for Zhong et al. GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.

Gavrilescu LC, Molnár Á, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134. doi: 10.1073/pnas.1203089109. Epub 2012 Mar 12. No abstract available.

5.

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.

Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1046-56. doi: 10.1152/ajpcell.00211.2011. Epub 2011 Jul 20.

6.

Activation of SAPK/JNKs in vitro.

Chadee DN, Kyriakis JM.

Methods Mol Biol. 2010;661:59-73. doi: 10.1007/978-1-60761-795-2_3.

PMID:
20811976
7.

Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function.

Kong DK, Georgescu SP, Kyriakis JM, Goruppi S.

Autophagy. 2010 Jul 1;6(5):652-654. doi: 10.4161/auto.6.5.12067.

PMID:
28157434
9.

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.

Mol Biol Cell. 2010 Apr 15;21(8):1335-49. doi: 10.1091/mbc.E09-09-0818. Epub 2010 Feb 24.

10.

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.

Zhong J, Gavrilescu LC, Molnár A, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4372-7. doi: 10.1073/pnas.0812642106. Epub 2009 Feb 25. Retraction in: Gavrilescu LC, Molnár Á, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134.

11.

Thinking outside the box about Ras.

Kyriakis JM.

J Biol Chem. 2009 Apr 24;284(17):10993-4. doi: 10.1074/jbc.R800085200. Epub 2008 Dec 17. Review. No abstract available.

12.
13.

The integration of signaling by multiprotein complexes containing Raf kinases.

Kyriakis JM.

Biochim Biophys Acta. 2007 Aug;1773(8):1238-47. Epub 2006 Nov 7. Review.

14.
16.

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4463-8. Epub 2006 Mar 13.

17.
18.

A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.

Chadee DN, Kyriakis JM.

Cell Cycle. 2004 Oct;3(10):1227-9. Epub 2004 Oct 19.

PMID:
15467451
20.

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.

Chadee DN, Kyriakis JM.

Nat Cell Biol. 2004 Aug;6(8):770-6. Epub 2004 Jul 18.

PMID:
15258589
21.

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM.

Circulation. 2004 Mar 16;109(10):1196-205. Review.

23.

Activation of SAPKs/JNKs and p38s in vitro.

Kyriakis JM, Liu H, Chadee DN.

Methods Mol Biol. 2004;250:61-88. No abstract available.

PMID:
14755080
24.

Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.

Bruna A, Nicolàs M, Muñoz A, Kyriakis JM, Caelles C.

EMBO J. 2003 Nov 17;22(22):6035-44.

26.
27.

Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.

Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY.

Am J Physiol Cell Physiol. 2003 Oct;285(4):C823-30. Epub 2003 Jun 11.

28.

Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy.

Goruppi S, Bonventre JV, Kyriakis JM.

EMBO J. 2002 Oct 15;21(20):5427-36.

29.

Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain.

Hirsch E, Barberis L, Brancaccio M, Azzolino O, Xu D, Kyriakis JM, Silengo L, Giancotti FG, Tarone G, Fässler R, Altruda F.

J Cell Biol. 2002 Apr 29;157(3):481-92. Epub 2002 Apr 29.

31.

MAP kinases and the regulation of nuclear receptors.

Kyriakis JM.

Sci STKE. 2000 Sep 5;2000(48):pe1. Review.

PMID:
11752606
32.

Life-or-death decisions.

Kyriakis JM.

Nature. 2001 Nov 15;414(6861):265-6. No abstract available.

PMID:
11713514
33.

Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform.

Hietakangas V, Elo I, Rosenström H, Coffey ET, Kyriakis JM, Eriksson JE, Sistonen L.

FEBS Lett. 2001 Sep 7;505(1):168-72.

34.

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.

Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I.

J Neurosci. 2001 Sep 1;21(17):6597-607.

35.
36.

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF.

Recent Prog Horm Res. 2001;56:127-55. Review.

PMID:
11237210
39.
41.

Signaling by the germinal center kinase family of protein kinases.

Kyriakis JM.

J Biol Chem. 1999 Feb 26;274(9):5259-62. Review. No abstract available.

42.

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.

Choukroun G, Hajjar R, Kyriakis JM, Bonventre JV, Rosenzweig A, Force T.

J Clin Invest. 1998 Oct 1;102(7):1311-20.

45.

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

Teng DH, Perry WL 3rd, Hogan JK, Baumgard M, Bell R, Berry S, Davis T, Frank D, Frye C, Hattier T, Hu R, Jammulapati S, Janecki T, Leavitt A, Mitchell JT, Pero R, Sexton D, Schroeder M, Su PH, Swedlund B, Kyriakis JM, Avruch J, Bartel P, Wong AK, Tavtigian SV, et al.

Cancer Res. 1997 Oct 1;57(19):4177-82.

46.
47.

Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK.

Molnár A, Theodoras AM, Zon LI, Kyriakis JM.

J Biol Chem. 1997 May 16;272(20):13229-35.

48.

Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.

Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J.

J Biol Chem. 1997 Jan 31;272(5):2620-8.

49.

Sounding the alarm: protein kinase cascades activated by stress and inflammation.

Kyriakis JM, Avruch J.

J Biol Chem. 1996 Oct 4;271(40):24313-6. Review. No abstract available.

50.

The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM, Avruch J.

J Biol Chem. 1996 Aug 9;271(32):19025-8.

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