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Items: 1 to 50 of 92


Elevated Thrombospondin-2 Contributes to Delayed Wound Healing in Diabetes.

Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR.

Diabetes. 2019 Aug 7. pii: db181001. doi: 10.2337/db18-1001. [Epub ahead of print]


Extracellular matrix-derived biomaterials in engineering cell function.

Xing H, Lee H, Luo L, Kyriakides TR.

Biotechnol Adv. 2019 Aug 2:107421. doi: 10.1016/j.biotechadv.2019.107421. [Epub ahead of print] Review.


The impact of modulating the blood-brain barrier on the electrophysiological and histological outcomes of intracortical electrodes.

Falcone JD, Sohal HS, Kyriakides TR, Bellamkonda RV.

J Neural Eng. 2019 Aug;16(4):046005. doi: 10.1088/1741-2552/ab1ef9. Epub 2019 May 2.


Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.

Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR.

Matrix Biol. 2019 Sep;82:71-85. doi: 10.1016/j.matbio.2019.03.002. Epub 2019 Mar 13.


Tunable Hydrogels Derived from Genetically Engineered Extracellular Matrix Accelerate Diabetic Wound Healing.

Morris AH, Lee H, Xing H, Stamer DK, Tan M, Kyriakides TR.

ACS Appl Mater Interfaces. 2018 Dec 12;10(49):41892-41901. doi: 10.1021/acsami.8b08920. Epub 2018 Nov 28.


Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass.

Loye AM, Kinser ER, Bensouda S, Shayan M, Davis R, Wang R, Chen Z, Schwarz UD, Schroers J, Kyriakides TR.

Sci Rep. 2018 Jun 8;8(1):8758. doi: 10.1038/s41598-018-27098-6.


Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization.

Shayan M, Padmanabhan J, Morris AH, Cheung B, Smith R, Schroers J, Kyriakides TR.

Acta Biomater. 2018 Jul 15;75:427-438. doi: 10.1016/j.actbio.2018.05.051. Epub 2018 Jun 1.


Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds.

Morris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR.

Biomaterials. 2018 Jul;169:61-71. doi: 10.1016/j.biomaterials.2018.03.049. Epub 2018 Mar 29.


Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.

Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):870-879. doi: 10.1161/ATVBAHA.118.310748. Epub 2018 Feb 15.


Nanopatterned Bulk Metallic Glass Biosensors.

Kinser ER, Padmanabhan J, Yu R, Corona SL, Li J, Vaddiraju S, Legassey A, Loye A, Balestrini J, Solly DA, Schroers J, Taylor AD, Papadimitrakopoulos F, Herzog RI, Kyriakides TR.

ACS Sens. 2017 Dec 22;2(12):1779-1787. doi: 10.1021/acssensors.7b00455. Epub 2017 Nov 22.


HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.

MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR.

Matrix Biol. 2018 Jan;65:45-58. doi: 10.1016/j.matbio.2017.07.002. Epub 2017 Aug 5.


Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition.

Kunkemoeller B, Kyriakides TR.

Antioxid Redox Signal. 2017 Oct 20;27(12):823-838. doi: 10.1089/ars.2017.7263. Epub 2017 Aug 10. Review.


Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.

Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR.

Biomaterials. 2017 Oct;141:63-73. doi: 10.1016/j.biomaterials.2017.06.025. Epub 2017 Jun 22.


Exploring a wider range of Mg-Ca-Zn metallic glass as biocompatible alloys using combinatorial sputtering.

Li J, Gittleson FS, Liu Y, Liu J, Loye AM, McMillon-Brown L, Kyriakides TR, Schroers J, Taylor AD.

Chem Commun (Camb). 2017 Jul 20;53(59):8288-8291. doi: 10.1039/c7cc02733h.


Multicompartment Drug Release System for Dynamic Modulation of Tissue Responses.

Morris AH, Mahal RS, Udell J, Wu M, Kyriakides TR.

Adv Healthc Mater. 2017 Oct;6(19). doi: 10.1002/adhm.201700370. Epub 2017 Jun 21.


A hidden structural vulnerability in the thrombospondin-2 deficient aorta increases the propensity to intramural delamination.

Bellini C, Kristofik NJ, Bersi MR, Kyriakides TR, Humphrey JD.

J Mech Behav Biomed Mater. 2017 Jul;71:397-406. doi: 10.1016/j.jmbbm.2017.01.045. Epub 2017 Mar 9.


The host response to naturally-derived extracellular matrix biomaterials.

Morris AH, Stamer DK, Kyriakides TR.

Semin Immunol. 2017 Feb;29:72-91. doi: 10.1016/j.smim.2017.01.002. Epub 2017 Mar 6. Review.


Regulation of cell-cell fusion by nanotopography.

Padmanabhan J, Augelli MJ, Cheung B, Kinser ER, Cleary B, Kumar P, Wang R, Sawyer AJ, Li R, Schwarz UD, Schroers J, Kyriakides TR.

Sci Rep. 2016 Sep 12;6:33277. doi: 10.1038/srep33277.


Inadequate Processing of Decellularized Dermal Matrix Reduces Cell Viability In Vitro and Increases Apoptosis and Acute Inflammation In Vivo.

Morris AH, Chang J, Kyriakides TR.

Biores Open Access. 2016 Jul 1;5(1):177-87. doi: 10.1089/biores.2016.0021. eCollection 2016.


Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.

Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR.

Blood. 2016 Sep 22;128(12):1642-50. doi: 10.1182/blood-2016-03-702845. Epub 2016 Jul 28.


New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx.

Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1847-53. doi: 10.1161/ATVBAHA.116.308023. Epub 2016 Jul 7.


Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses.

Liu Y, Padmanabhan J, Cheung B, Liu J, Chen Z, Scanley BE, Wesolowski D, Pressley M, Broadbridge CC, Altman S, Schwarz UD, Kyriakides TR, Schroers J.

Sci Rep. 2016 May 27;6:26950. doi: 10.1038/srep26950.


Nanoparticle delivery of miR-223 to attenuate macrophage fusion.

Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR.

Biomaterials. 2016 May;89:127-35. doi: 10.1016/j.biomaterials.2016.02.036. Epub 2016 Feb 26.


Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.

Sawyer AJ, Kyriakides TR.

Adv Drug Deliv Rev. 2016 Feb 1;97:56-68. doi: 10.1016/j.addr.2015.12.016. Epub 2016 Jan 4. Review.


Molecular Characterization of Macrophage-Biomaterial Interactions.

Moore LB, Kyriakides TR.

Adv Exp Med Biol. 2015;865:109-22. doi: 10.1007/978-3-319-18603-0_7. Review.


Angiogenesis and Vasculogenesis in Health and Disease.

D'Alessio A, Moccia F, Li JH, Micera A, Kyriakides TR.

Biomed Res Int. 2015;2015:126582. doi: 10.1155/2015/126582. Epub 2015 Jun 10. No abstract available.


Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sites.

Papanna R, Mann LK, Tseng SC, Stewart RJ, Kaur SS, Swindle MM, Kyriakides TR, Tatevian N, Moise KJ Jr.

Placenta. 2015 Aug;36(8):888-94. doi: 10.1016/j.placenta.2015.05.015. Epub 2015 May 30.


Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels.

Swartzlander MD, Blakney AK, Amer LD, Hankenson KD, Kyriakides TR, Bryant SJ.

Biomaterials. 2015 Feb;41:79-88. doi: 10.1016/j.biomaterials.2014.11.020. Epub 2014 Dec 5.


Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics.

Swartzlander MD, Barnes CA, Blakney AK, Kaar JL, Kyriakides TR, Bryant SJ.

Biomaterials. 2015 Feb;41:26-36. doi: 10.1016/j.biomaterials.2014.11.026. Epub 2014 Dec 2.


Click-coated, heparinized, decellularized vascular grafts.

Dimitrievska S, Cai C, Weyers A, Balestrini JL, Lin T, Sundaram S, Hatachi G, Spiegel DA, Kyriakides TR, Miao J, Li G, Niklason LE, Linhardt RJ.

Acta Biomater. 2015 Feb;13:177-87. doi: 10.1016/j.actbio.2014.11.015. Epub 2014 Nov 20.


Nanomaterials, inflammation, and tissue engineering.

Padmanabhan J, Kyriakides TR.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 May-Jun;7(3):355-70. doi: 10.1002/wnan.1320. Epub 2014 Nov 25. Review.


Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR.

J Biol Chem. 2015 Jan 2;290(1):409-22. doi: 10.1074/jbc.M114.618421. Epub 2014 Nov 11.


Loss of monocyte chemoattractant protein-1 alters macrophage polarization and reduces NFκB activation in the foreign body response.

Moore LB, Sawyer AJ, Charokopos A, Skokos EA, Kyriakides TR.

Acta Biomater. 2015 Jan;11:37-47. doi: 10.1016/j.actbio.2014.09.022. Epub 2014 Sep 19.


Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12865-70. doi: 10.1073/pnas.1408472111. Epub 2014 Aug 18.


The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation.

Sawyer AJ, Tian W, Saucier-Sawyer JK, Rizk PJ, Saltzman WM, Bellamkonda RV, Kyriakides TR.

Biomaterials. 2014 Aug;35(25):6698-706. doi: 10.1016/j.biomaterials.2014.05.008. Epub 2014 May 29.


Engineering cellular response using nanopatterned bulk metallic glass.

Padmanabhan J, Kinser ER, Stalter MA, Duncan-Lewis C, Balestrini JL, Sawyer AJ, Schroers J, Kyriakides TR.

ACS Nano. 2014 May 27;8(5):4366-75. doi: 10.1021/nn501874q. Epub 2014 Apr 17.


Matricellular proteins and biomaterials.

Morris AH, Kyriakides TR.

Matrix Biol. 2014 Jul;37:183-91. doi: 10.1016/j.matbio.2014.03.002. Epub 2014 Mar 20. Review.


Thrombospondin-2 and extracellular matrix assembly.

Calabro NE, Kristofik NJ, Kyriakides TR.

Biochim Biophys Acta. 2014 Aug;1840(8):2396-402. doi: 10.1016/j.bbagen.2014.01.013. Epub 2014 Jan 15. Review.


A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model.

Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR.

Int J Pharm. 2013 Sep 10;453(2):651-5. doi: 10.1016/j.ijpharm.2013.05.041. Epub 2013 May 29.


An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds.

Kobsa S, Kristofik NJ, Sawyer AJ, Bothwell AL, Kyriakides TR, Saltzman WM.

Biomaterials. 2013 May;34(15):3891-901. doi: 10.1016/j.biomaterials.2013.02.016. Epub 2013 Feb 27.


Nanoparticle-based evaluation of blood-brain barrier leakage during the foreign body response.

Sawyer AJ, Kyriakides TR.

J Neural Eng. 2013 Feb;10(1):016013. doi: 10.1088/1741-2560/10/1/016013. Epub 2013 Jan 21.


Understanding the host response to cell-laden poly(ethylene glycol)-based hydrogels.

Swartzlander MD, Lynn AD, Blakney AK, Kyriakides TR, Bryant SJ.

Biomaterials. 2013 Jan;34(4):952-64. doi: 10.1016/j.biomaterials.2012.10.037. Epub 2012 Nov 10.


Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.

Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20095-100. doi: 10.1073/pnas.1105152108. Epub 2011 Nov 22.


Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.

MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1137-45. doi: 10.1073/pnas.1104357108. Epub 2011 Sep 26.


Astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier.

Tian W, Sawyer A, Kocaoglu FB, Kyriakides TR.

Am J Pathol. 2011 Aug;179(2):860-8. doi: 10.1016/j.ajpath.2011.05.002. Epub 2011 Jun 23.


Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters.

Liu J, Jiang Z, Zhang S, Liu C, Gross RA, Kyriakides TR, Saltzman WM.

Biomaterials. 2011 Sep;32(27):6646-54. doi: 10.1016/j.biomaterials.2011.05.046.


Lack of TNF-α-induced MMP-9 production and abnormal E-cadherin redistribution associated with compromised fusion in MCP-1-null macrophages.

Skokos EA, Charokopos A, Khan K, Wanjala J, Kyriakides TR.

Am J Pathol. 2011 May;178(5):2311-21. doi: 10.1016/j.ajpath.2011.01.045.


Temporal progression of the host response to implanted poly(ethylene glycol)-based hydrogels.

Lynn AD, Blakney AK, Kyriakides TR, Bryant SJ.

J Biomed Mater Res A. 2011 Mar 15;96(4):621-31. doi: 10.1002/jbm.a.33015. Epub 2011 Jan 25.


CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.

Zhou J, Tang PC, Qin L, Gayed PM, Li W, Skokos EA, Kyriakides TR, Pober JS, Tellides G.

J Exp Med. 2010 Aug 30;207(9):1951-66. doi: 10.1084/jem.20100098. Epub 2010 Aug 23.


Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling.

Roh JD, Sawh-Martinez R, Brennan MP, Jay SM, Devine L, Rao DA, Yi T, Mirensky TL, Nalbandian A, Udelsman B, Hibino N, Shinoka T, Saltzman WM, Snyder E, Kyriakides TR, Pober JS, Breuer CK.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4669-74. doi: 10.1073/pnas.0911465107. Epub 2010 Mar 5.

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