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Elevated Thrombospondin-2 Contributes to Delayed Wound Healing in Diabetes.

Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR.

Diabetes. 2019 Aug 7. pii: db181001. doi: 10.2337/db18-1001. [Epub ahead of print]


Extracellular matrix-derived biomaterials in engineering cell function.

Xing H, Lee H, Luo L, Kyriakides TR.

Biotechnol Adv. 2019 Aug 2:107421. doi: 10.1016/j.biotechadv.2019.107421. [Epub ahead of print] Review.


A retrospective observational study of rituximab treatment in multiple sclerosis patients in Cyprus.

Leonidou E, Pantzaris M, Kleopa KA, Loizidou MA, Kyriakides T, Christou YP.

Postgrad Med. 2019 Jul 30:1-4. doi: 10.1080/00325481.2019.1649975. [Epub ahead of print]


Analysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection.

Ma R, Jung TH, Peduzzi PN, Brown ST, Kyriakides TC.

J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219849101. doi: 10.1177/2325958219849101.


Open versus Endovascular Repair of Abdominal Aortic Aneurysm.

Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, Padberg FT Jr, Matsumura JS, Huo Z, Johnson GR; OVER Veterans Affairs Cooperative Study Group.

N Engl J Med. 2019 May 30;380(22):2126-2135. doi: 10.1056/NEJMoa1715955.


The impact of modulating the blood-brain barrier on the electrophysiological and histological outcomes of intracortical electrodes.

Falcone JD, Sohal HS, Kyriakides TR, Bellamkonda RV.

J Neural Eng. 2019 May 2;16(4):046005. doi: 10.1088/1741-2552/ab1ef9. [Epub ahead of print]


Employment outcomes from VA vocational services involving transitional work for veterans with a diagnosis of posttraumatic stress disorder.

Davis LL, Resnick SG, Maieritsch KP, Weber KC, Erbes CR, Strom TQ, McCall KP, Kyriakides TC.

Psychiatr Rehabil J. 2019 Apr 4. doi: 10.1037/prj0000357. [Epub ahead of print]


Positive impact of IPS supported employment on PTSD-related occupational-psychosocial functional outcomes: Results from a VA randomized-controlled trial.

Mueller L, Wolfe WR, Neylan TC, McCaslin SE, Yehuda R, Flory JD, Kyriakides TC, Toscano R, Davis LL.

Psychiatr Rehabil J. 2019 Apr 1. doi: 10.1037/prj0000345. [Epub ahead of print]


Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.

Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR.

Matrix Biol. 2019 Mar 13. pii: S0945-053X(18)30438-4. doi: 10.1016/j.matbio.2019.03.002. [Epub ahead of print]


Gene variants of adhesion molecules predispose to MS: A case-control study.

Dardiotis E, Panayiotou E, Siokas V, Aloizou AM, Christodoulou K, Hadjisavvas A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T.

Neurol Genet. 2019 Jan 16;5(1):e304. doi: 10.1212/NXG.0000000000000304. eCollection 2019 Feb.


Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis.

Buxbaum JN, Brannagan T 3rd, Buades-Reinés J, Cisneros E, Conceicao I, Kyriakides T, Merlini G, Obici L, Plante-Bordeneuve V, Rousseau A, Sekijima Y, Imai A, Waddington Cruz M, Yamada M.

Amyloid. 2019 Mar;26(1):10-14. doi: 10.1080/13506129.2018.1554563. Epub 2019 Jan 24.


LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis.

Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA.

Circulation. 2019 Jan 29;139(5):679-693. doi: 10.1161/CIRCULATIONAHA.118.034615.


Epidemiology of ATTRV30M neuropathy in Cyprus and the modifier effect of complement C1q on the age of disease onset.

Andreou S, Panayiotou E, Michailidou K, Pirpa P, Hadjisavvas A, El Salloukh A, Barnes D, Antoniou A, Agathangelou P, Papastavrou K, Christodoulou K, Tanteles GA, Kyriakides T.

Amyloid. 2018 Dec;25(4):220-226. doi: 10.1080/13506129.2018.1534731. Epub 2018 Dec 20.


Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin-mediated amyloidosis.

Kristen AV, Ajroud-Driss S, Conceição I, Gorevic P, Kyriakides T, Obici L.

Neurodegener Dis Manag. 2019 Feb;9(1):5-23. doi: 10.2217/nmt-2018-0033. Epub 2018 Nov 27.


Automated safety event monitoring using electronic medical records in a clinical trial setting: Validation study using the VA NEPHRON-D trial.

Huang Y, Fried LF, Kyriakides TC, Johnson GR, Chiu S, Mcdonald L, Zhang JH.

Clin Trials. 2019 Feb;16(1):81-89. doi: 10.1177/1740774518813121. Epub 2018 Nov 16.


Tunable Hydrogels Derived from Genetically Engineered Extracellular Matrix Accelerate Diabetic Wound Healing.

Morris AH, Lee H, Xing H, Stamer DK, Tan M, Kyriakides TR.

ACS Appl Mater Interfaces. 2018 Dec 12;10(49):41892-41901. doi: 10.1021/acsami.8b08920. Epub 2018 Nov 28.


Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study.

Ofori-Atta A, Reynolds NR, Antwi S, Renner L, Nichols JS, Lartey M, Amissah K, Tettey JK, Alhassan A, Ofori IP, Catlin AC, Gan G, Kyriakides TC, Paintsil E; Sankofa Study Team.

AIDS Care. 2019 Mar;31(3):283-292. doi: 10.1080/09540121.2018.1537463. Epub 2018 Oct 25.


High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana.

Nichols JS, Kyriakides TC, Antwi S, Renner L, Lartey M, Seaneke OA, Obeng R, Catlin AC, Gan G, Reynolds NR, Paintsil E; Sankofa Study Team.

AIDS Care. 2019 Jan;31(1):25-34. doi: 10.1080/09540121.2018.1524113. Epub 2018 Sep 20.


Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial.

Edelman EJ, Moore BA, Holt SR, Hansen N, Kyriakides TC, Virata M, Brown ST, Justice AC, Bryant KJ, Fiellin DA, Fiellin LE.

AIDS Behav. 2019 Jan;23(1):211-221. doi: 10.1007/s10461-018-2241-z.


A joint model for recurrent events and a semi-competing risk in the presence of multi-level clustering.

Jung TH, Peduzzi P, Allore H, Kyriakides TC, Esserman D.

Stat Methods Med Res. 2018 Jul 31:962280218790107. doi: 10.1177/0962280218790107. [Epub ahead of print]


In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents.

Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ.

JACC Basic Transl Sci. 2018 May 30;3(3):378-390. doi: 10.1016/j.jacbts.2018.02.003. eCollection 2018 Jun.


Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass.

Loye AM, Kinser ER, Bensouda S, Shayan M, Davis R, Wang R, Chen Z, Schwarz UD, Schroers J, Kyriakides TR.

Sci Rep. 2018 Jun 8;8(1):8758. doi: 10.1038/s41598-018-27098-6.


Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization.

Shayan M, Padmanabhan J, Morris AH, Cheung B, Smith R, Schroers J, Kyriakides TR.

Acta Biomater. 2018 Jul 15;75:427-438. doi: 10.1016/j.actbio.2018.05.051. Epub 2018 Jun 1.


Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds.

Morris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR.

Biomaterials. 2018 Jul;169:61-71. doi: 10.1016/j.biomaterials.2018.03.049. Epub 2018 Mar 29.


Effect of Evidence-Based Supported Employment vs Transitional Work on Achieving Steady Work Among Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial.

Davis LL, Kyriakides TC, Suris AM, Ottomanelli LA, Mueller L, Parker PE, Resnick SG, Toscano R, Scrymgeour AA, Drake RE; VA CSP #589 Veterans Individual Placement and Support Toward Advancing Recovery Investigators.

JAMA Psychiatry. 2018 Apr 1;75(4):316-324. doi: 10.1001/jamapsychiatry.2017.4472.


Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT.

Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn SL, Zonouz TH, Liu YH, Lampert RJ, Sinusas AJ, Carson RE, Liu C.

J Nucl Med. 2018 Oct;59(10):1574-1580. doi: 10.2967/jnumed.117.202143. Epub 2018 Feb 23.


Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.

Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):870-879. doi: 10.1161/ATVBAHA.118.310748. Epub 2018 Feb 15.


A joint frailty model provides for risk stratification of human immunodeficiency virus-infected patients based on unobserved heterogeneity.

Jung TH, Kyriakides T, Holodniy M, Esserman D, Peduzzi P.

J Clin Epidemiol. 2018 Jun;98:16-23. doi: 10.1016/j.jclinepi.2018.02.007. Epub 2018 Feb 9.


Nanopatterned Bulk Metallic Glass Biosensors.

Kinser ER, Padmanabhan J, Yu R, Corona SL, Li J, Vaddiraju S, Legassey A, Loye A, Balestrini J, Solly DA, Schroers J, Taylor AD, Papadimitrakopoulos F, Herzog RI, Kyriakides TR.

ACS Sens. 2017 Dec 22;2(12):1779-1787. doi: 10.1021/acssensors.7b00455. Epub 2017 Nov 22.


Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy.

Panayiotou E, Papacharalambous R, Antoniou A, Christophides G, Papageorgiou L, Fella E, Malas S, Kyriakides T.

Biochem Biophys Rep. 2016 Aug 11;8:48-54. doi: 10.1016/j.bbrep.2016.08.005. eCollection 2016 Dec.


Video Game Intervention for Sexual Risk Reduction in Minority Adolescents: Randomized Controlled Trial.

Fiellin LE, Hieftje KD, Pendergrass TM, Kyriakides TC, Duncan LR, Dziura JD, Sawyer BG, Mayes L, Crusto CA, Forsyth BW, Fiellin DA.

J Med Internet Res. 2017 Sep 18;19(9):e314. doi: 10.2196/jmir.8148.


HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.

MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR.

Matrix Biol. 2018 Jan;65:45-58. doi: 10.1016/j.matbio.2017.07.002. Epub 2017 Aug 5.


Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition.

Kunkemoeller B, Kyriakides TR.

Antioxid Redox Signal. 2017 Oct 20;27(12):823-838. doi: 10.1089/ars.2017.7263. Epub 2017 Aug 10. Review.


Integrated Tuberculosis/Human Immunodeficiency Virus Community-Based Case Finding in Rural South Africa: Implications for Tuberculosis Control Efforts.

Shenoi SV, Moll AP, Brooks RP, Kyriakides T, Andrews L, Kompala T, Upadhya D, Altice FL, Eksteen FJ, Friedland G.

Open Forum Infect Dis. 2017 May 4;4(3):ofx092. doi: 10.1093/ofid/ofx092. eCollection 2017 Summer.


Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.

Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR.

Biomaterials. 2017 Oct;141:63-73. doi: 10.1016/j.biomaterials.2017.06.025. Epub 2017 Jun 22.


Exploring a wider range of Mg-Ca-Zn metallic glass as biocompatible alloys using combinatorial sputtering.

Li J, Gittleson FS, Liu Y, Liu J, Loye AM, McMillon-Brown L, Kyriakides TR, Schroers J, Taylor AD.

Chem Commun (Camb). 2017 Jul 20;53(59):8288-8291. doi: 10.1039/c7cc02733h.


Identification of exosomal muscle-specific miRNAs in serum of myotonic dystrophy patients relating to muscle disease progress.

Koutsoulidou A, Photiades M, Kyriakides TC, Georgiou K, Prokopi M, Kapnisis K, Lusakowska A, Nearchou M, Christou Y, Papadimas GK, Anayiotos A, Kyriakou K, Kararizou E, Zamba Papanicolaou E, Phylactou LA.

Hum Mol Genet. 2017 Sep 1;26(17):3285-3302. doi: 10.1093/hmg/ddx212.


Multicompartment Drug Release System for Dynamic Modulation of Tissue Responses.

Morris AH, Mahal RS, Udell J, Wu M, Kyriakides TR.

Adv Healthc Mater. 2017 Oct;6(19). doi: 10.1002/adhm.201700370. Epub 2017 Jun 21.


Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy.

Fella E, Sokratous K, Papacharalambous R, Kyriacou K, Phillips J, Sanderson S, Panayiotou E, Kyriakides T.

Front Mol Neurosci. 2017 May 10;10:138. doi: 10.3389/fnmol.2017.00138. eCollection 2017.


Epidemiology of Amyotrophic Lateral Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study.

Demetriou CA, Hadjivasiliou PM, Kleopa KA, Christou YP, Leonidou E, Kyriakides T, Zamba-Papanicolaou E.

Neuroepidemiology. 2017;48(1-2):79-85. doi: 10.1159/000477126. Epub 2017 May 20.


The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft.

Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C.

Regen Med. 2017 Apr;12(3):249-261. doi: 10.2217/rme-2016-0141. Epub 2017 May 19.


Variations in the 3'UTR of the CYP21A2 Gene in Heterozygous Females with Hyperandrogenaemia.

Neocleous V, Fanis P, Toumba M, Phedonos AAP, Picolos M, Andreou E, Kyriakides TC, Tanteles GA, Shammas C, Phylactou LA, Skordis N.

Int J Endocrinol. 2017;2017:8984365. doi: 10.1155/2017/8984365. Epub 2017 Apr 12.


Gene variants of adhesion molecules act as modifiers of disease severity in MS.

Dardiotis E, Panayiotou E, Provatas A, Christodoulou K, Hadjisavvas A, Antoniades A, Lourbopoulos A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T.

Neurol Neuroimmunol Neuroinflamm. 2017 Apr 24;4(4):e350. doi: 10.1212/NXI.0000000000000350. eCollection 2017 Jul.


A hidden structural vulnerability in the thrombospondin-2 deficient aorta increases the propensity to intramural delamination.

Bellini C, Kristofik NJ, Bersi MR, Kyriakides TR, Humphrey JD.

J Mech Behav Biomed Mater. 2017 Jul;71:397-406. doi: 10.1016/j.jmbbm.2017.01.045. Epub 2017 Mar 9.


C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy.

Panayiotou E, Fella E, Papacharalambous R, Malas S, Saraiva MJ, Kyriakides T.

PLoS One. 2017 Apr 13;12(4):e0175767. doi: 10.1371/journal.pone.0175767. eCollection 2017.


CDKN2A and MC1R variants found in Cypriot patients diagnosed with cutaneous melanoma.

Koulermou G, Shammas C, Vassiliou A, Kyriakides TC, Costi C, Neocleous V, Phylactou LA, Pantelidou M.

J Genet. 2017 Mar;96(1):155-160.


Veterans individual placement and support towards advancing recovery: Methods and baseline clinical characteristics of a multisite study.

Davis LL, Kyriakides TC, Suris A, Ottomanelli L, Drake RE, Parker PE, Mueller L, Resnick SG, Toscano R, Blansett CM, McCall KP, Huang GD.

Psychiatr Rehabil J. 2018 Mar;41(1):55-66. doi: 10.1037/prj0000250. Epub 2017 Mar 30.


The host response to naturally-derived extracellular matrix biomaterials.

Morris AH, Stamer DK, Kyriakides TR.

Semin Immunol. 2017 Feb;29:72-91. doi: 10.1016/j.smim.2017.01.002. Epub 2017 Mar 6. Review.


Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study.

Helou E, Shenoi S, Kyriakides T, Landry ML, Kozal M, Barakat LA.

J Int Assoc Provid AIDS Care. 2017 May/Jun;16(3):261-266. doi: 10.1177/2325957416680028. Epub 2016 Nov 30.


Long-term Cost-effectiveness in the Veterans Affairs Open vs Endovascular Repair Study of Aortic Abdominal Aneurysm: A Randomized Clinical Trial.

Lederle FA, Stroupe KT, Kyriakides TC, Ge L, Freischlag JA; Open vs Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group.

JAMA Surg. 2016 Dec 1;151(12):1139-1144. doi: 10.1001/jamasurg.2016.2783.


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