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Items: 1 to 50 of 72

1.

Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function.

Ramratnam M, Kenny B, Kyle JW, Wiedmeyer B, Hacker TA, Barefield DY, McNally EM, Makielski JC.

Heliyon. 2018 Jul 4;4(7):e00677. doi: 10.1016/j.heliyon.2018.e00677. eCollection 2018 Jul.

2.

An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population.

Cheng J, Kyle JW, Lang D, Wiedmeyer B, Guo J, Yin K, Huang L, Vaidyanathan R, Su T, Makielski JC.

J Am Heart Assoc. 2017 Apr 3;6(4). pii: e005330. doi: 10.1161/JAHA.116.005330.

3.

Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current.

Cheng J, Kyle JW, Wiedmeyer B, Lang D, Vaidyanathan R, Makielski JC.

Sci Rep. 2017 Feb 20;7:42953. doi: 10.1038/srep42953.

4.

Does Sudden Unexplained Nocturnal Death Syndrome Remain the Autopsy-Negative Disorder: A Gross, Microscopic, and Molecular Autopsy Investigation in Southern China.

Zhang L, Tester DJ, Lang D, Chen Y, Zheng J, Gao R, Corliss RF, Tang S, Kyle JW, Liu C, Ackerman MJ, Makielski JC, Cheng J.

Mayo Clin Proc. 2016 Nov;91(11):1503-1514. doi: 10.1016/j.mayocp.2016.06.031. Epub 2016 Oct 1.

5.

Late I(Na) in the Heart: Physiology, Pathology, and Pathways.

Makielski JC, Kyle JW.

Circulation. 2015 Aug 18;132(7):553-5. doi: 10.1161/CIRCULATIONAHA.115.017980. Epub 2015 Jul 17. No abstract available.

6.

Mechanisms of sudden cardiac death: oxidants and metabolism.

Yang KC, Kyle JW, Makielski JC, Dudley SC Jr.

Circ Res. 2015 Jun 5;116(12):1937-55. doi: 10.1161/CIRCRESAHA.116.304691. Review.

7.

Mouse ERG K(+) channel clones reveal differences in protein trafficking and function.

Lin EC, Moungey BM, Lim E, Concannon SP, Anderson CL, Kyle JW, Makielski JC, Balijepalli SY, January CT.

J Am Heart Assoc. 2014 Dec 11;3(6):e001491. doi: 10.1161/JAHA.114.001491.

8.

Diseases caused by mutations in Nav1.5 interacting proteins.

Kyle JW, Makielski JC.

Card Electrophysiol Clin. 2014 Dec 1;6(4):797-809.

9.

Channelopathies from mutations in the cardiac sodium channel protein complex.

Adsit GS, Vaidyanathan R, Galler CM, Kyle JW, Makielski JC.

J Mol Cell Cardiol. 2013 Aug;61:34-43. doi: 10.1016/j.yjmcc.2013.03.017. Epub 2013 Apr 1. Review.

10.

An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract.

Senthil Kumar G, Kyle JW, Minogue PJ, Dinesh Kumar K, Vasantha K, Berthoud VM, Beyer EC, Santhiya ST.

Exp Eye Res. 2013 May;110:136-41. doi: 10.1016/j.exer.2012.10.010. Epub 2012 Oct 29.

11.

Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure.

Beyer EC, Lipkind GM, Kyle JW, Berthoud VM.

Biochim Biophys Acta. 2012 Aug;1818(8):1823-30. doi: 10.1016/j.bbamem.2011.10.011. Epub 2011 Oct 20. Review.

12.

The N terminus of connexin37 contains an alpha-helix that is required for channel function.

Kyle JW, Berthoud VM, Kurutz J, Minogue PJ, Greenspan M, Hanck DA, Beyer EC.

J Biol Chem. 2009 Jul 24;284(30):20418-27. doi: 10.1074/jbc.M109.016907. Epub 2009 May 28.

13.

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.

Maltsev VA, Kyle JW, Undrovinas A.

J Physiol Sci. 2009 May;59(3):217-25. doi: 10.1007/s12576-009-0029-7. Epub 2009 Mar 3.

14.

An intact connexin N-terminus is required for function but not gap junction formation.

Kyle JW, Minogue PJ, Thomas BC, Domowicz DA, Berthoud VM, Hanck DA, Beyer EC.

J Cell Sci. 2008 Aug 15;121(Pt 16):2744-50. doi: 10.1242/jcs.032482. Epub 2008 Jul 29.

15.

Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition.

Maltsev VA, Kyle JW, Mishra S, Undrovinas A.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H667-76. doi: 10.1152/ajpheart.00111.2008. Epub 2008 Jun 13.

16.

Economic evaluation of the US Environmental Protection Agency's SunWise program: sun protection education for young children.

Kyle JW, Hammitt JK, Lim HW, Geller AC, Hall-Jordan LH, Maibach EW, De Fabo EC, Wagner MC.

Pediatrics. 2008 May;121(5):e1074-84. doi: 10.1542/peds.2007-1400.

PMID:
18450850
17.

Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.

Jost MC, Hillis DM, Lu Y, Kyle JW, Fozzard HA, Zakon HH.

Mol Biol Evol. 2008 Jun;25(6):1016-24. doi: 10.1093/molbev/msn025. Epub 2008 Feb 6.

18.

An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.

McNulty MM, Kyle JW, Lipkind GM, Hanck DA.

Mol Pharmacol. 2006 Nov;70(5):1514-23. Epub 2006 Aug 2.

PMID:
16885209
19.

Isoform-dependent interaction of voltage-gated sodium channels with protons.

Khan A, Kyle JW, Hanck DA, Lipkind GM, Fozzard HA.

J Physiol. 2006 Oct 15;576(Pt 2):493-501. Epub 2006 Jul 27.

20.

A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies.

Zhong X, Liu JR, Kyle JW, Hanck DA, Agnew WS.

Hum Mol Genet. 2006 May 1;15(9):1497-512. Epub 2006 Mar 24.

PMID:
16565161
21.

Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.

Zhu Y, Kyle JW, Lee PJ.

Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H29-37. Epub 2006 Feb 24.

22.

Gating of the late Na+ channel in normal and failing human myocardium.

Undrovinas AI, Maltsev VA, Kyle JW, Silverman N, Sabbah HN.

J Mol Cell Cardiol. 2002 Nov;34(11):1477-89.

PMID:
12431447
23.

Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias?

Fozzard HA, Kyle JW.

Sci STKE. 2002 Apr 30;2002(130):pe19. Review.

PMID:
11983936
24.

The selectivity filter of the voltage-gated sodium channel is involved in channel activation.

Hilber K, Sandtner W, Kudlacek O, Glaaser IW, Weisz E, Kyle JW, French RJ, Fozzard HA, Dudley SC, Todt H.

J Biol Chem. 2001 Jul 27;276(30):27831-9. Epub 2001 May 29.

25.

Voltage-dependent inhibition of brain Na(+) channels by American ginseng.

Liu D, Li B, Liu Y, Attele AS, Kyle JW, Yuan CS.

Eur J Pharmacol. 2001 Feb 9;413(1):47-54.

PMID:
11173062
26.

Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.

Camoretti-Mercado B, Liu HW, Halayko AJ, Forsythe SM, Kyle JW, Li B, Fu Y, McConville J, Kogut P, Vieira JE, Patel NM, Hershenson MB, Fuchs E, Sinha S, Miano JM, Parmacek MS, Burkhardt JK, Solway J.

J Biol Chem. 2000 Sep 29;275(39):30387-93.

27.

The role of the putative inactivation lid in sodium channel gating current immobilization.

Sheets MF, Kyle JW, Hanck DA.

J Gen Physiol. 2000 May;115(5):609-20.

28.
29.
30.

Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule.

Todt H, Dudley SC Jr, Kyle JW, French RJ, Fozzard HA.

Biophys J. 1999 Mar;76(3):1335-45.

31.

Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels.

Nagatomo T, Fan Z, Ye B, Tonkovich GS, January CT, Kyle JW, Makielski JC.

Am J Physiol. 1998 Dec;275(6):H2016-24. doi: 10.1152/ajpheart.1998.275.6.H2016.

PMID:
9843800
32.

A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.

Benzinger GR, Kyle JW, Blumenthal KM, Hanck DA.

J Biol Chem. 1998 Jan 2;273(1):80-4.

33.
34.

Optimization of a mammalian expression system for the measurement of sodium channel gating currents.

Sheets MF, Kyle JW, Krueger S, Hanck DA.

Am J Physiol. 1996 Sep;271(3 Pt 1):C1001-6.

PMID:
8843731
35.

Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.

Zeng D, Kyle JW, Martin RL, Ambler KS, Hanck DA.

Am J Physiol. 1996 May;270(5 Pt 1):C1522-31.

PMID:
8967455
36.

Coexpression of beta 1 with cardiac sodium channel alpha subunits in oocytes decreases lidocaine block.

Makielski JC, Limberis JT, Chang SY, Fan Z, Kyle JW.

Mol Pharmacol. 1996 Jan;49(1):30-9.

PMID:
8569709
37.
38.

High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector.

Wolfe JH, Kyle JW, Sands MS, Sly WS, Markowitz DG, Parente MK.

Gene Ther. 1995 Jan;2(1):70-8.

PMID:
7712336
39.

The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field.

Satin J, Limberis JT, Kyle JW, Rogart RB, Fozzard HA.

Biophys J. 1994 Sep;67(3):1007-14.

40.

Enzyme replacement therapy for murine mucopolysaccharidosis type VII.

Sands MS, Vogler C, Kyle JW, Grubb JH, Levy B, Galvin N, Sly WS, Birkenmeier EH.

J Clin Invest. 1994 Jun;93(6):2324-31.

41.

Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids.

Satin J, Kyle JW, Fan Z, Rogart R, Fozzard HA, Makielski JC.

Biophys J. 1994 May;66(5):1353-63.

42.

Mucopolysaccharidosis VII: postmortem biochemical and pathological findings in a young adult with beta-glucuronidase deficiency.

Vogler C, Levy B, Kyle JW, Sly WS, Williamson J, Whyte MP.

Mod Pathol. 1994 Jan;7(1):132-7.

PMID:
8159643
43.
44.
45.

The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels.

Satin J, Kyle JW, Chen M, Rogart RB, Fozzard HA.

J Membr Biol. 1992 Oct;130(1):11-22.

PMID:
1335083
46.

A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties.

Satin J, Kyle JW, Chen M, Bell P, Cribbs LL, Fozzard HA, Rogart RB.

Science. 1992 May 22;256(5060):1202-5.

PMID:
1375397
47.

Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation.

Birkenmeier EH, Barker JE, Vogler CA, Kyle JW, Sly WS, Gwynn B, Levy B, Pegors C.

Blood. 1991 Dec 1;78(11):3081-92.

PMID:
1954394
48.

Analysis of the 5' flanking region of the human beta-glucuronidase gene.

Shipley JM, Miller RD, Wu BM, Grubb JH, Christensen SG, Kyle JW, Sly WS.

Genomics. 1991 Aug;10(4):1009-18.

PMID:
1916806
49.

Cloning and characterization of the human beta-glucuronidase gene.

Miller RD, Hoffmann JW, Powell PP, Kyle JW, Shipley JM, Bachinsky DR, Sly WS.

Genomics. 1990 Jun;7(2):280-3.

PMID:
2347593
50.

Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene.

Kyle JW, Birkenmeier EH, Gwynn B, Vogler C, Hoppe PC, Hoffmann JW, Sly WS.

Proc Natl Acad Sci U S A. 1990 May;87(10):3914-8.

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