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Items: 33


Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Chafe SC, McDonald PC, Saberi S, Nemirovsky O, Venkateswaran G, Burugu S, Gao D, Delaidelli A, Kyle AH, Baker JHE, Gillespie JA, Bashashati A, Minchinton AI, Zhou Y, Shah SP, Dedhar S.

Cancer Immunol Res. 2019 Jul;7(7):1064-1078. doi: 10.1158/2326-6066.CIR-18-0657. Epub 2019 May 14.


Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.

Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, Karsan A.

Cell Rep. 2019 May 7;27(6):1769-1780.e4. doi: 10.1016/j.celrep.2019.04.039.


Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment.

Baker JHE, Kyle AH, Reinsberg SA, Moosvi F, Patrick HM, Cran J, Saatchi K, Häfeli U, Minchinton AI.

Clin Exp Metastasis. 2018 Oct;35(7):691-705. doi: 10.1007/s10585-018-9929-3. Epub 2018 Sep 8.


The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth.

Yapp DT, Wong MQ, Kyle AH, Valdez SM, Tso J, Yung A, Kozlowski P, Owen DA, Buczkowski AK, Chung SW, Scudamore CH, Minchinton AI, Ng SS.

Angiogenesis. 2016 Apr;19(2):229-44. doi: 10.1007/s10456-016-9503-z. Epub 2016 Mar 9.


Tissue Discs: A 3D Model for Assessing Modulation of Tissue Oxygenation.

Gandolfo MJ, Kyle AH, Minchinton AI.

Adv Exp Med Biol. 2016;876:169-175. doi: 10.1007/978-1-4939-3023-4_21.


Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.

El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH.

Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003.


The Prognostic Impact of CD163-Positive Macrophages in Follicular Lymphoma: A Study from the BC Cancer Agency and the Lymphoma Study Association.

Kridel R, Xerri L, Gelas-Dore B, Tan K, Feugier P, Vawda A, Canioni D, Farinha P, Boussetta S, Moccia AA, Brice P, Chavez EA, Kyle AH, Scott DW, Sanders AD, Fabiani B, Slack GW, Minchinton AI, Haioun C, Connors JM, Sehn LH, Steidl C, Gascoyne RD, Salles G.

Clin Cancer Res. 2015 Aug 1;21(15):3428-35. doi: 10.1158/1078-0432.CCR-14-3253. Epub 2015 Apr 13.


Effect of radiation on cell proliferation and tumor hypoxia in HPV-positive head and neck cancer in vivo models.

Sørensen BS, Busk M, Horsman MR, Alsner J, Overgaard J, Kyle AH, Minchinton AI.

Anticancer Res. 2014 Nov;34(11):6297-304.


Tissue penetration and activity of camptothecins in solid tumor xenografts.

Kyle AH, Baker JH, Gandolfo MJ, Reinsberg SA, Minchinton AI.

Mol Cancer Ther. 2014 Nov;13(11):2727-37. doi: 10.1158/1535-7163.MCT-14-0475. Epub 2014 Aug 20.


Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism.

Patenaude A, Fuller M, Chang L, Wong F, Paliouras G, Shaw R, Kyle AH, Umlandt P, Baker JH, Diaz E, Tong J, Minchinton AI, Karsan A.

Cancer Res. 2014 May 1;74(9):2402-11. doi: 10.1158/0008-5472.CAN-12-4038. Epub 2014 Mar 5.


Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.

Baker JH, Kyle AH, Bartels KL, Methot SP, Flanagan EJ, Balbirnie A, Cran JD, Minchinton AI.

PLoS One. 2013 Oct 28;8(10):e76832. doi: 10.1371/journal.pone.0076832. eCollection 2013.


Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells.

Pahlevaninezhad H, Cecic I, Lee AM, Kyle AH, Lam S, MacAulay C, Lane PM.

J Biomed Opt. 2013 Oct;18(10):106007. doi: 10.1117/1.JBO.18.10.106007.


Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.

Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD, Thurston G.

Cancer Res. 2013 Jan 1;73(1):108-18. doi: 10.1158/0008-5472.CAN-12-2064. Epub 2012 Nov 13.


Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.

Chang L, Noseda M, Higginson M, Ly M, Patenaude A, Fuller M, Kyle AH, Minchinton AI, Puri MC, Dumont DJ, Karsan A.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6993-8. doi: 10.1073/pnas.1118512109. Epub 2012 Apr 16.


Targeting quiescent tumor cells via oxygen and IGF-I supplementation.

Kyle AH, Baker JH, Minchinton AI.

Cancer Res. 2012 Feb 1;72(3):801-9. doi: 10.1158/0008-5472.CAN-11-3059. Epub 2011 Dec 12.


Vascularization predicts overall survival and risk of transformation in follicular lymphoma.

Farinha P, Kyle AH, Minchinton AI, Connors JM, Karsan A, Gascoyne RD.

Haematologica. 2010 Dec;95(12):2157-60. doi: 10.3324/haematol.2009.021766. Epub 2010 Aug 16.


Detecting vascular-targeting effects of the hypoxic cytotoxin tirapazamine in tumor xenografts using magnetic resonance imaging.

Bains LJ, Baker JH, Kyle AH, Minchinton AI, Reinsberg SA.

Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):957-65. doi: 10.1016/j.ijrobp.2008.11.068.


Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin.

Baker JH, Lam J, Kyle AH, Sy J, Oliver T, Co SJ, Dragowska WH, Ramsay E, Anantha M, Ruth TJ, Adam MJ, Yung A, Kozlowski P, Minchinton AI, Ng SS, Bally MB, Yapp DT.

Clin Cancer Res. 2008 Nov 15;14(22):7260-71. doi: 10.1158/1078-0432.CCR-08-0736.


Direct visualization of heterogeneous extravascular distribution of trastuzumab in human epidermal growth factor receptor type 2 overexpressing xenografts.

Baker JH, Lindquist KE, Huxham LA, Kyle AH, Sy JT, Minchinton AI.

Clin Cancer Res. 2008 Apr 1;14(7):2171-9. doi: 10.1158/1078-0432.CCR-07-4465. Erratum in: Clin Cancer Res. 2008 May 1;14(9):2893.


Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels.

Tucker CA, Kapanen AI, Chikh G, Hoffman BG, Kyle AH, Wilson IM, Masin D, Gascoyne RD, Bally M, Klasa RJ.

Mol Cancer Ther. 2008 Apr;7(4):749-58. doi: 10.1158/1535-7163.MCT-07-0302. Epub 2008 Mar 28.


Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK).

Edwards LA, Woo J, Huxham LA, Verreault M, Dragowska WH, Chiu G, Rajput A, Kyle AH, Kalra J, Yapp D, Yan H, Minchinton AI, Huntsman D, Daynard T, Waterhouse DN, Thiessen B, Dedhar S, Bally MB.

Mol Cancer Ther. 2008 Jan;7(1):59-70. doi: 10.1158/1535-7163.MCT-07-0329.


Exploring vascular dysfunction caused by tirapazamine.

Huxham LA, Kyle AH, Baker JH, McNicol KL, Minchinton AI.

Microvasc Res. 2008 Mar;75(2):247-55. Epub 2007 Oct 11.


Limited tissue penetration of taxanes: a mechanism for resistance in solid tumors.

Kyle AH, Huxham LA, Yeoman DM, Minchinton AI.

Clin Cancer Res. 2007 May 1;13(9):2804-10.


Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay.

Baker JH, Huxham LA, Kyle AH, Lam KK, Minchinton AI.

Microvasc Res. 2006 Mar;71(2):69-75. Epub 2006 Mar 20.


Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts.

Huxham LA, Kyle AH, Baker JH, McNicol KL, Minchinton AI.

Radiother Oncol. 2006 Feb;78(2):138-45. Epub 2006 Feb 7.


HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization.

Dragowska WH, Warburton C, Yapp DT, Minchinton AI, Hu Y, Waterhouse DN, Gelmon K, Skov K, Woo J, Masin D, Huxham LA, Kyle AH, Bally MB.

Mol Cancer Res. 2004 Nov;2(11):606-19.


Microregional effects of gemcitabine in HCT-116 xenografts.

Huxham LA, Kyle AH, Baker JH, Nykilchuk LK, Minchinton AI.

Cancer Res. 2004 Sep 15;64(18):6537-41.


Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture.

Kyle AH, Huxham LA, Chiam AS, Sim DH, Minchinton AI.

Cancer Res. 2004 Sep 1;64(17):6304-9.


Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent.

Kyle AH, Huxham LA, Baker JH, Burston HE, Minchinton AI.

Cancer Res. 2003 Sep 15;63(18):5707-11.


Carbogen breathing after irradiation enhances the effectiveness of tirapazamine in SiHa tumors but not SCCVII tumors in mice.

Minchinton AI, Tonn DA, Sutherland DP, Kyle AH.

Radiat Res. 2002 Jul;158(1):94-100.


Serum free thyroxine levels in cats maintained on diets relatively high or low in iodine.

Kyle AH, Tarttelin MF, Cooke RR, Ford HC.

N Z Vet J. 1994 Jun;42(3):101-3.


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