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Correction to: Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.

Santiago M, Antunes C, Guedes M, Iacovino M, Kyba M, Reik W, Sousa N, Pinto L, Branco MR, Marques CJ.

Cell Mol Life Sci. 2020 Jan 9. doi: 10.1007/s00018-019-03443-4. [Epub ahead of print]


Tet3 regulates cellular identity and DNA methylation in neural progenitor cells.

Santiago M, Antunes C, Guedes M, Iacovino M, Kyba M, Reik W, Sousa N, Pinto L, Branco MR, Marques CJ.

Cell Mol Life Sci. 2019 Oct 23. doi: 10.1007/s00018-019-03335-7. [Epub ahead of print] Erratum in: Cell Mol Life Sci. 2020 Jan 9;:.


A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.

Bosnakovski D, da Silva MT, Sunny ST, Ener ET, Toso EA, Yuan C, Cui Z, Walters MA, Jadhav A, Kyba M.

Sci Adv. 2019 Sep 11;5(9):eaaw7781. doi: 10.1126/sciadv.aaw7781. eCollection 2019 Sep.


Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies.

Selvaraj S, Kyba M, Perlingeiro RCR.

Trends Mol Med. 2019 Sep;25(9):803-816. doi: 10.1016/j.molmed.2019.07.004. Review.


Estrogen Regulates the Satellite Cell Compartment in Females.

Collins BC, Arpke RW, Larson AA, Baumann CW, Xie N, Cabelka CA, Nash NL, Juppi HK, Laakkonen EK, Sipilä S, Kovanen V, Spangenburg EE, Kyba M, Lowe DA.

Cell Rep. 2019 Jul 9;28(2):368-381.e6. doi: 10.1016/j.celrep.2019.06.025.


Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment.

Incitti T, Magli A, Darabi R, Yuan C, Lin K, Arpke RW, Azzag K, Yamamoto A, Stewart R, Thomson JA, Kyba M, Perlingeiro RCR.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4346-4351. doi: 10.1073/pnas.1808303116. Epub 2019 Feb 13.


Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA.

Lee JK, Bosnakovski D, Toso EA, Dinh T, Banerjee S, Bohl TE, Shi K, Orellana K, Kyba M, Aihara H.

Cell Rep. 2018 Dec 11;25(11):2955-2962.e3. doi: 10.1016/j.celrep.2018.11.060.


Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression.

Bosnakovski D, Gearhart MD, Toso EA, Ener ET, Choi SH, Kyba M.

Sci Rep. 2018 Nov 16;8(1):16957. doi: 10.1038/s41598-018-35150-8.


Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.

Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10615-E10624. doi: 10.1073/pnas.1811624115. Epub 2018 Oct 23.


Comment on structural basis of DUX4/IGH-driven transactivation.

Aihara H, Shi K, Lee JK, Bosnakovski D, Kyba M.

Leukemia. 2018 Sep;32(9):2090-2092. doi: 10.1038/s41375-018-0217-7. Epub 2018 Jul 27. No abstract available.


A moderate oestradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated.

Le G, Novotny SA, Mader TL, Greising SM, Chan SSK, Kyba M, Lowe DA, Warren GL.

J Physiol. 2018 Oct;596(19):4665-4680. doi: 10.1113/JP276432. Epub 2018 Aug 24.


DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells.

Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MA.

Genome Biol. 2018 Jul 12;19(1):88. doi: 10.1186/s13059-018-1464-7.


Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity.

Chan SS, Arpke RW, Filareto A, Xie N, Pappas MP, Penaloza JS, Perlingeiro RCR, Kyba M.

Cell Stem Cell. 2018 Jul 5;23(1):74-85.e6. doi: 10.1016/j.stem.2018.06.010.


A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia.

Stavropoulou V, Almosailleakh M, Royo H, Spetz JF, Juge S, Brault L, Kopp P, Iacovino M, Kyba M, Tzankov A, Stadler MB, Cazzaniga G, Peters AHFM, Schwaller J.

Hemasphere. 2018 Jun 12;2(4):e51. doi: 10.1097/HS9.0000000000000051. eCollection 2018 Aug.


Author Correction: Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.

Bosnakovski D, Chan SSK, Recht OO, Hartweck LM, Gustafson CJ, Athman LL, Lowe DA, Kyba M.

Nat Commun. 2018 Feb 22;9(1):856. doi: 10.1038/s41467-018-03449-9.


ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.

Park JM, Seo M, Jung CH, Grunwald D, Stone M, Otto NM, Toso E, Ahn Y, Kyba M, Griffin TJ, Higgins L, Kim DH.

Autophagy. 2018;14(4):584-597. doi: 10.1080/15548627.2017.1422851. Epub 2018 Feb 21.


Mouse models of two missense mutations in actin-binding domain 1 of dystrophin associated with Duchenne or Becker muscular dystrophy.

McCourt JL, Talsness DM, Lindsay A, Arpke RW, Chatterton PD, Nelson DM, Chamberlain CM, Olthoff JT, Belanto JJ, McCourt PM, Kyba M, Lowe DA, Ervasti JM.

Hum Mol Genet. 2018 Feb 1;27(3):451-462. doi: 10.1093/hmg/ddx414.


Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.

Sanghez V, Luzzi A, Clarke D, Kee D, Beuder S, Rux D, Osawa M, Madrenas J, Chou TF, Kyba M, Iacovino M.

PLoS One. 2017 Oct 26;12(10):e0186818. doi: 10.1371/journal.pone.0186818. eCollection 2017.


The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

Bosnakovski D, Toso EA, Hartweck LM, Magli A, Lee HA, Thompson ER, Dandapat A, Perlingeiro RCR, Kyba M.

J Cell Sci. 2017 Nov 1;130(21):3685-3697. doi: 10.1242/jcs.205427. Epub 2017 Sep 21.


Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.

Bosnakovski D, Chan SSK, Recht OO, Hartweck LM, Gustafson CJ, Athman LL, Lowe DA, Kyba M.

Nat Commun. 2017 Sep 15;8(1):550. doi: 10.1038/s41467-017-00730-1. Erratum in: Nat Commun. 2018 Feb 22;9(1):856.


p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.

Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M.

Dis Model Mech. 2017 Oct 1;10(10):1211-1216. doi: 10.1242/dmm.030064. Epub 2017 Jul 28.


A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.

Jiang Y, Berry DC, Jo A, Tang W, Arpke RW, Kyba M, Graff JM.

Nat Commun. 2017 Jun 26;8:15926. doi: 10.1038/ncomms15926.


Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors.

Kim J, Magli A, Chan SSK, Oliveira VKP, Wu J, Darabi R, Kyba M, Perlingeiro RCR.

Stem Cell Reports. 2017 Jul 11;9(1):12-22. doi: 10.1016/j.stemcr.2017.04.022. Epub 2017 May 18.


Pax7 remodels the chromatin landscape in skeletal muscle stem cells.

Lilja KC, Zhang N, Magli A, Gunduz V, Bowman CJ, Arpke RW, Darabi R, Kyba M, Perlingeiro R, Dynlacht BD.

PLoS One. 2017 Apr 25;12(4):e0176190. doi: 10.1371/journal.pone.0176190. eCollection 2017.


Twist of fate for skeletal muscle mesenchymal cells.

Goloviznina NA, Kyba M.

Nat Cell Biol. 2017 Mar 1;19(3):153-154. doi: 10.1038/ncb3482.


Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.

Berry DC, Jiang Y, Arpke RW, Close EL, Uchida A, Reading D, Berglund ED, Kyba M, Graff JM.

Cell Metab. 2017 Feb 7;25(2):481. doi: 10.1016/j.cmet.2017.01.011. No abstract available.


Modulating the malignancy of Hox proteins.

Kyba M.

Blood. 2017 Jan 19;129(3):269-270. doi: 10.1182/blood-2016-11-751909. No abstract available.


miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.

Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J.

Blood. 2017 Mar 16;129(11):1491-1502. doi: 10.1182/blood-2016-06-721027. Epub 2017 Jan 4.


Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.

Berry DC, Jiang Y, Arpke RW, Close EL, Uchida A, Reading D, Berglund ED, Kyba M, Graff JM.

Cell Metab. 2017 Jan 10;25(1):166-181. doi: 10.1016/j.cmet.2016.10.023. Epub 2016 Nov 23. Erratum in: Cell Metab. 2017 Feb 7;25(2):481.


Mesoderm, Cooked Up Fast and Served to Order.

Kyba M.

Cell Stem Cell. 2016 Aug 4;19(2):146-148. doi: 10.1016/j.stem.2016.07.007.


Flow Cytometry and Transplantation-Based Quantitative Assays for Satellite Cell Self-Renewal and Differentiation.

Arpke RW, Kyba M.

Methods Mol Biol. 2016;1460:163-79. doi: 10.1007/978-1-4939-3810-0_12.


Freeze Injury of the Tibialis Anterior Muscle.

Le G, Lowe DA, Kyba M.

Methods Mol Biol. 2016;1460:33-41. doi: 10.1007/978-1-4939-3810-0_3.


MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome.

Stavropoulou V, Kaspar S, Brault L, Sanders MA, Juge S, Morettini S, Tzankov A, Iacovino M, Lau IJ, Milne TA, Royo H, Kyba M, Valk PJM, Peters AHFM, Schwaller J.

Cancer Cell. 2016 Jul 11;30(1):43-58. doi: 10.1016/j.ccell.2016.05.011. Epub 2016 Jun 23.


Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.

Choi SH, Bosnakovski D, Strasser JM, Toso EA, Walters MA, Kyba M.

J Biomol Screen. 2016 Aug;21(7):680-8. doi: 10.1177/1087057116651868. Epub 2016 May 31.


Heterogeneity of Mesp1+ mesoderm revealed by single-cell RNA-seq.

Chan SS, Chan HHW, Kyba M.

Biochem Biophys Res Commun. 2016 Jun 3;474(3):469-475. doi: 10.1016/j.bbrc.2016.04.139. Epub 2016 Apr 27.


High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice.

Dandapat A, Perrin BJ, Cabelka C, Razzoli M, Ervasti JM, Bartolomucci A, Lowe DA, Kyba M.

PLoS One. 2016 Mar 15;11(3):e0151467. doi: 10.1371/journal.pone.0151467. eCollection 2016.


DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.

Choi SH, Gearhart MD, Cui Z, Bosnakovski D, Kim M, Schennum N, Kyba M.

Nucleic Acids Res. 2016 Jun 20;44(11):5161-73. doi: 10.1093/nar/gkw141. Epub 2016 Mar 6.


Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.

Lalit PA, Salick MR, Nelson DO, Squirrell JM, Shafer CM, Patel NG, Saeed I, Schmuck EG, Markandeya YS, Wong R, Lea MR, Eliceiri KW, Hacker TA, Crone WC, Kyba M, Garry DJ, Stewart R, Thomson JA, Downs KM, Lyons GE, Kamp TJ.

Cell Stem Cell. 2016 Mar 3;18(3):354-67. doi: 10.1016/j.stem.2015.12.001. Epub 2016 Feb 11.


DNA-binding sequence specificity of DUX4.

Zhang Y, Lee JK, Toso EA, Lee JS, Choi SH, Slattery M, Aihara H, Kyba M.

Skelet Muscle. 2016 Jan 28;6:8. doi: 10.1186/s13395-016-0080-z. eCollection 2016.


Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm.

Chan SS, Hagen HR, Swanson SA, Stewart R, Boll KA, Aho J, Thomson JA, Kyba M.

Stem Cell Reports. 2016 Jan 12;6(1):26-34. doi: 10.1016/j.stemcr.2015.12.003.


Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.

Wang H, Wang X, Xu X, Kyba M, Cooney AJ.

J Biol Chem. 2016 Apr 15;291(16):8644-52. doi: 10.1074/jbc.M115.694208. Epub 2016 Jan 14.


Pax3-induced expansion enables the genetic correction of dystrophic satellite cells.

Filareto A, Rinaldi F, Arpke RW, Darabi R, Belanto JJ, Toso EA, Miller AZ, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RC.

Skelet Muscle. 2015 Oct 26;5:36. doi: 10.1186/s13395-015-0061-7. eCollection 2015.


GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.

Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T.

Exp Hematol. 2016 Jan;44(1):68-74.e1-10. doi: 10.1016/j.exphem.2015.09.007. Epub 2015 Oct 23.


Drosophila Cyclin G and epigenetic maintenance of gene expression during development.

Dupont CA, Dardalhon-Cuménal D, Kyba M, Brock HW, Randsholt NB, Peronnet F.

Epigenetics Chromatin. 2015 May 7;8:18. doi: 10.1186/s13072-015-0008-6. eCollection 2015.


Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE Jr, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ.

J Clin Invest. 2015 Jun;125(6):2369-74. doi: 10.1172/JCI77670. Epub 2015 May 11.


Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast.

Zhang L, Guo J, Zhang P, Xiong Q, Wu SC, Xia L, Roy SS, Tolar J, O'Connell TD, Kyba M, Liao K, Zhang J.

Circ Heart Fail. 2015 Jan;8(1):156-66. doi: 10.1161/CIRCHEARTFAILURE.114.001317. Epub 2014 Nov 24.


Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.

Bedada FB, Chan SS, Metzger SK, Zhang L, Zhang J, Garry DJ, Kamp TJ, Kyba M, Metzger JM.

Stem Cell Reports. 2014 Oct 14;3(4):594-605. doi: 10.1016/j.stemcr.2014.07.012. Epub 2014 Sep 4.


OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.

Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, Oh SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae JI, Park C.

Blood. 2014 Nov 6;124(19):2948-52. doi: 10.1182/blood-2014-03-556332. Epub 2014 Sep 29.


Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene.

Dandapat A, Bosnakovski D, Hartweck LM, Arpke RW, Baltgalvis KA, Vang D, Baik J, Darabi R, Perlingeiro RC, Hamra FK, Gupta K, Lowe DA, Kyba M.

Cell Rep. 2014 Sep 11;8(5):1484-96. doi: 10.1016/j.celrep.2014.07.056. Epub 2014 Aug 28.


Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.

Elcheva I, Brok-Volchanskaya V, Kumar A, Liu P, Lee JH, Tong L, Vodyanik M, Swanson S, Stewart R, Kyba M, Yakubov E, Cooke J, Thomson JA, Slukvin I.

Nat Commun. 2014 Jul 14;5:4372. doi: 10.1038/ncomms5372.

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