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Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness.

Eppensteiner J, Kwun J, Scheuermann U, Barbas A, Limkakeng AT, Kuchibhatla M, Elster EA, Kirk AD, Lee J.

JCI Insight. 2019 Aug 22;4(16). pii: 127925. doi: 10.1172/jci.insight.127925.


Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.

Kwun J, Matignon M, Manook M, Guendouz S, Audard V, Kheav D, Poullot E, Gautreau C, Ezekian B, Bodez D, Damy T, Faivre L, Menouch D, Yoon J, Park J, Belhadj K, Chen D, Bilewski AM, Yi JS, Collins B, Stegall M, Farris AB, Knechtle S, Grimbert P.

J Am Soc Nephrol. 2019 Jul;30(7):1206-1219. doi: 10.1681/ASN.2018121254. Epub 2019 Jun 21.


The past, present, and future of costimulation blockade in organ transplantation.

Schroder PM, Fitch ZW, Schmitz R, Choi AY, Kwun J, Knechtle SJ.

Curr Opin Organ Transplant. 2019 Aug;24(4):391-401. doi: 10.1097/MOT.0000000000000656.


Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.

Fitch Z, Schmitz R, Kwun J, Hering B, Madsen J, Knechtle SJ.

Transplant Rev (Orlando). 2019 Jul;33(3):115-129. doi: 10.1016/j.trre.2019.03.002. Epub 2019 Apr 5. Review.


Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.

Scheuermann U, Zhu M, Song M, Yerxa J, Gao Q, Davis RP, Zhang M, Parker W, Hartwig MG, Kwun J, Brennan TV, Lee J, Barbas AS.

Liver Transpl. 2019 Apr;25(4):610-626. doi: 10.1002/lt.25429. Epub 2019 Mar 15.


Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.

Gu Y, Chen C, Wang Z, Huang PH, Fu H, Wang L, Wu M, Chen Y, Gao T, Gong J, Kwun J, Arepally GM, Huang TJ.

Lab Chip. 2019 Jan 29;19(3):394-402. doi: 10.1039/c8lc00527c.


IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.

Kwun J, Park J, Yi JS, Farris AB, Kirk AD, Knechtle SJ.

Front Immunol. 2018 Oct 15;9:2323. doi: 10.3389/fimmu.2018.02323. eCollection 2018.


Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients.

Burghuber CK, Manook M, Ezekian B, Gibby AC, Leopardi FV, Song M, Jenks J, Saccoccio F, Permar S, Farris AB, Iwakoshi NN, Kwun J, Knechtle SJ.

Am J Transplant. 2019 Mar;19(3):724-736. doi: 10.1111/ajt.15067. Epub 2018 Sep 17.


Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.

Manook M, Kwun J, Sacks S, Dorling A, Mamode N, Knechtle S.

Transplant Rev (Orlando). 2018 Jul;32(3):119-126. doi: 10.1016/j.trre.2018.01.001. Epub 2018 Feb 10. Review.


Contemporary Strategies and Barriers to Transplantation Tolerance.

Ezekian B, Schroder PM, Freischlag K, Yoon J, Kwun J, Knechtle SJ.

Transplantation. 2018 Aug;102(8):1213-1222. doi: 10.1097/TP.0000000000002242. Review.


Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults.

Eppensteiner J, Davis RP, Barbas AS, Kwun J, Lee J.

Front Immunol. 2018 Feb 8;9:190. doi: 10.3389/fimmu.2018.00190. eCollection 2018. Review.


Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.

Kwun J, Burghuber C, Manook M, Ezekian B, Park J, Yoon J, Yi JS, Iwakoshi N, Gibby A, Hong JJ, Farris AB, Kirk AD, Knechtle SJ.

Blood Adv. 2017 Oct 26;1(24):2115-2119. doi: 10.1182/bloodadvances.2017010991. eCollection 2017 Nov 14. Erratum in: Blood Adv. 2018 Jan 23;2(2):89.


Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.

Schroder PM, Ezekian B, Ford M, Knechtle SJ, Kwun J.

Front Immunol. 2017 Nov 23;8:1615. doi: 10.3389/fimmu.2017.01615. eCollection 2017. No abstract available.


Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients.

Kwun J, Burghuber C, Manook M, Iwakoshi N, Gibby A, Hong JJ, Knechtle S.

J Am Soc Nephrol. 2017 Jul;28(7):1991-1996. doi: 10.1681/ASN.2016070727. Epub 2017 Feb 23.


Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

Manook M, Kwun J, Burghuber C, Samy K, Mulvihill M, Yoon J, Xu H, MacDonald AL, Freischlag K, Curfman V, Branum E, Howell D, Farris AB, Smith RA, Sacks S, Dorling A, Mamode N, Knechtle SJ.

Am J Transplant. 2017 Aug;17(8):2055-2064. doi: 10.1111/ajt.14234. Epub 2017 Mar 23. Erratum in: Am J Transplant. 2017 Nov;17 (11):2993.


Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.

Lee J, Jackman JG, Kwun J, Manook M, Moreno A, Elster EA, Kirk AD, Leong KW, Sullenger BA.

Biomaterials. 2017 Mar;120:94-102. doi: 10.1016/j.biomaterials.2016.12.024. Epub 2016 Dec 23.


Crosstalk Between T and B Cells in the Germinal Center After Transplantation.

Kwun J, Manook M, Page E, Burghuber C, Hong J, Knechtle SJ.

Transplantation. 2017 Apr;101(4):704-712. doi: 10.1097/TP.0000000000001588. Review.


Open wedge high tibial osteotomy using three-dimensional printed models: Experimental analysis using porcine bone.

Kwun JD, Kim HJ, Park J, Park IH, Kyung HS.

Knee. 2017 Jan;24(1):16-22. doi: 10.1016/j.knee.2016.09.026. Epub 2016 Nov 19.


Premature T Cell Senescence in Pediatric CKD.

George RP, Mehta AK, Perez SD, Winterberg P, Cheeseman J, Johnson B, Kwun J, Monday S, Stempora L, Warshaw B, Kirk AD.

J Am Soc Nephrol. 2017 Jan;28(1):359-367. doi: 10.1681/ASN.2016010053. Epub 2016 Jul 13.


Observation of phase-retention behavior of the HC(NH2)2PbI3 black perovskite polymorph upon mesoporous TiO2 scaffolds.

Zhou Y, Kwun J, Garces HF, Pang S, Padture NP.

Chem Commun (Camb). 2016 Jun 7;52(45):7273-5. doi: 10.1039/c6cc02086k. Epub 2016 May 16.


Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.

Oh B, Yoon J, Farris A 3rd, Kirk A, Knechtle S, Kwun J.

Am J Transplant. 2016 Sep;16(9):2612-23. doi: 10.1111/ajt.13789. Epub 2016 Apr 8.


Manipulating Crystallization of Organolead Mixed-Halide Thin Films in Antisolvent Baths for Wide-Bandgap Perovskite Solar Cells.

Zhou Y, Yang M, Game OS, Wu W, Kwun J, Strauss MA, Yan Y, Huang J, Zhu K, Padture NP.

ACS Appl Mater Interfaces. 2016 Jan 27;8(3):2232-7. doi: 10.1021/acsami.5b10987. Epub 2016 Jan 13.


Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.

Burghuber CK, Kwun J, Page EJ, Manook M, Gibby AC, Leopardi FV, Song M, Farris AB 3rd, Hong JJ, Villinger F, Adams AB, Iwakoshi NN, Knechtle SJ.

Am J Transplant. 2016 Jun;16(6):1726-38. doi: 10.1111/ajt.13688. Epub 2016 Mar 25.


Intercalation crystallization of phase-pure α-HC(NH₂)₂PbI₃ upon microstructurally engineered PbI₂ thin films for planar perovskite solar cells.

Zhou Y, Yang M, Kwun J, Game OS, Zhao Y, Pang S, Padture NP, Zhu K.

Nanoscale. 2016 Mar 28;8(12):6265-70. doi: 10.1039/c5nr06189j.


Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.

Kwun J, Farris AB, Song H, Mahle WT, Burlingham WJ, Knechtle SJ.

Transplantation. 2015 Dec;99(12):2485-93. doi: 10.1097/TP.0000000000000805.


Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Kwun J, Page E, Hong JJ, Gibby A, Yoon J, Farris AB, Villinger F, Knechtle S.

Am J Transplant. 2015 Mar;15(3):815-22. doi: 10.1111/ajt.13045. Epub 2015 Feb 12.


Development of 1,1'-oxalyldiimidazole chemiluminescent biosensor using the combination of graphene oxide and hairpin aptamer and its application.

Kwun J, Yun S, Park L, Lee JH.

Talanta. 2014 Feb;119:262-7. doi: 10.1016/j.talanta.2013.10.067. Epub 2013 Nov 11.


Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.

Kim EJ, Kwun J, Gibby AC, Hong JJ, Farris AB 3rd, Iwakoshi NN, Villinger F, Kirk AD, Knechtle SJ.

Am J Transplant. 2014 Jan;14(1):59-69. doi: 10.1111/ajt.12526.


Lymphodepletional strategies in transplantation.

Page E, Kwun J, Oh B, Knechtle S.

Cold Spring Harb Perspect Med. 2013 Jul 1;3(7). pii: a015511. doi: 10.1101/cshperspect.a015511. Review.


Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.

Page EK, Page AJ, Kwun J, Gibby AC, Leopardi F, Jenkins JB, Strobert EA, Song M, Hennigar RA, Iwakoshi N, Knechtle SJ.

Am J Transplant. 2012 Sep;12(9):2395-405. doi: 10.1111/j.1600-6143.2012.04074.x. Epub 2012 Jul 9.


Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.

Kwun J, Oh BC, Gibby AC, Ruhil R, Lu VT, Kim DW, Page EK, Bulut OP, Song MQ, Farris AB, Kirk AD, Knechtle SJ, Iwakoshi NN.

Am J Transplant. 2012 Oct;12(10):2641-51. doi: 10.1111/j.1600-6143.2012.04181.x. Epub 2012 Jul 3.


The role of B cells in solid organ transplantation.

Kwun J, Bulut P, Kim E, Dar W, Oh B, Ruhil R, Iwakoshi N, Knechtle SJ.

Semin Immunol. 2012 Apr;24(2):96-108. doi: 10.1016/j.smim.2011.08.022. Epub 2011 Dec 1. Review.


Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.

Kwun J, Malarkannan S, Burlingham WJ, Knechtle SJ.

J Immunol. 2011 Oct 15;187(8):3997-4006. doi: 10.4049/jimmunol.1003918. Epub 2011 Sep 7.


Prevention trumps treatment of antibody-mediated transplant rejection.

Knechtle SJ, Kwun J, Iwakoshi N.

J Clin Invest. 2010 Apr;120(4):1036-9. doi: 10.1172/JCI42532. Epub 2010 Mar 24.


Interleukin-15 receptor blockade in non-human primate kidney transplantation.

Haustein S, Kwun J, Fechner J, Kayaoglu A, Faure JP, Roenneburg D, Torrealba J, Knechtle SJ.

Transplantation. 2010 Apr 27;89(8):937-44. doi: 10.1097/TP.0b013e3181d05a58.


Overcoming Chronic Rejection-Can it B?

Kwun J, Knechtle SJ.

Transplantation. 2009 Oct 27;88(8):955-61. doi: 10.1097/TP.0b013e3181b96646. Review.


Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine.

Hu H, Kwun J, Aizenstein BD, Knechtle SJ.

Transplantation. 2009 Jun 27;87(12):1814-20. doi: 10.1097/TP.0b013e3181a66b3e.


BAFF is increased in renal transplant patients following treatment with alemtuzumab.

Bloom D, Chang Z, Pauly K, Kwun J, Fechner J, Hayes C, Samaniego M, Knechtle S.

Am J Transplant. 2009 Aug;9(8):1835-45. doi: 10.1111/j.1600-6143.2009.02710.x. Epub 2009 Jun 12.


Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring.

Knechtle SJ, Pascual J, Bloom DD, Torrealba JR, Jankowska-Gan E, Burlingham WJ, Kwun J, Colvin RB, Seyfert-Margolis V, Bourcier K, Sollinger HW.

Am J Transplant. 2009 May;9(5):1087-98. doi: 10.1111/j.1600-6143.2009.02581.x. Epub 2009 Mar 16.


Unique aspects of rejection and tolerance in liver transplantation.

Knechtle SJ, Kwun J.

Semin Liver Dis. 2009 Feb;29(1):91-101. doi: 10.1055/s-0029-1192058. Epub 2009 Feb 23. Review.


Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients.

Kwun J, Hazinedaroglu SM, Schadde E, Kayaoglu HA, Fechner J, Hu HZ, Roenneburg D, Torrealba J, Shiao L, Hong X, Peng R, Szewczyk JW, Sullivan KA, DeMartino J, Knechtle SJ.

Am J Transplant. 2008 Aug;8(8):1593-603. doi: 10.1111/j.1600-6143.2008.02250.x. Epub 2008 May 12.


Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.

Molitor-Dart ML, Andrassy J, Kwun J, Kayaoglu HA, Roenneburg DA, Haynes LD, Torrealba JR, Bobadilla JL, Sollinger HW, Knechtle SJ, Burlingham WJ.

J Immunol. 2007 Nov 15;179(10):6749-61.


Arthroscopic synovectomy in wrists with advanced rheumatoid arthritis.

Kim SJ, Jung KA, Kim JM, Kwun JD, Kang HJ.

Clin Orthop Relat Res. 2006 Aug;449:262-6.


Arthroscopic synovectomy of the knee joint in rheumatoid arthritis: surgical steps for complete synovectomy.

Kim SJ, Jung KA, Kwun JD, Kim JM.

Arthroscopy. 2006 Apr;22(4):461.e1-4.


Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.

Kwun J, Knechtle SJ, Hu H.

Transplantation. 2006 Feb 27;81(4):590-8.


Arthroscopic excision of the symptomatic discoid medial meniscus in one piece: a surgical technique.

Kim SJ, Kwun JD, Jung KA, Kim JM.

Arthroscopy. 2005 Dec;21(12):1515.


Arthroscopic all-inside repair of tears of the anterior horn of the lateral meniscus.

Kim SJ, Jung KA, Kim JM, Kwun JD, Baek SH, Han JN.

Arthroscopy. 2005 Nov;21(11):1399.


Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine.

Kanmaz T, Feng P, Torrealba J, Kwun J, Fechner JH, Schultz JM, Dong Y, Kim HT, Dar W, Hamawy MM, Knechtle SJ, Hu H.

Transplantation. 2004 Oct 15;78(7):1002-7.


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