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Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Lin W, Yip YL, Jia L, Deng W, Zheng H, Dai W, Ko JMY, Lo KW, Chung GTY, Yip KY, Lee SD, Kwan JS, Zhang J, Liu T, Chan JY, Kwong DL, Lee VH, Nicholls JM, Busson P, Liu X, Chiang AKS, Hui KF, Kwok H, Cheung ST, Cheung YC, Chan CK, Li B, Cheung AL, Hau PM, Zhou Y, Tsang CM, Middeldorp J, Chen H, Lung ML, Tsao SW.

Nat Commun. 2018 Nov 7;9(1):4663. doi: 10.1038/s41467-018-06889-5.


Wavelength-Flattened Directional Coupler Based Mid-Infrared Chemical Sensor Using Bragg Wavelength in Subwavelength Grating Structure.

Dong B, Hu T, Luo X, Chang Y, Guo X, Wang H, Kwong DL, Lo GQ, Lee C.

Nanomaterials (Basel). 2018 Nov 1;8(11). pii: E893. doi: 10.3390/nano8110893.


A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY.

Cell Stem Cell. 2018 Oct 13. pii: S1934-5909(18)30480-6. doi: 10.1016/j.stem.2018.09.016. [Epub ahead of print]


Camrelizumab for nasopharyngeal carcinoma: a new hope?

Kwong DLW.

Lancet Oncol. 2018 Oct;19(10):1266-1267. doi: 10.1016/S1470-2045(18)30579-5. Epub 2018 Sep 10. No abstract available.


The addition of pretreatment plasma Epstein-Barr virus DNA into the 8th edition of nasopharyngeal cancer TNM stage classification.

Lee VH, Kwong DL, Leung TW, Choi CW, O'Sullivan B, Lam KO, Lai V, Khong PL, Chan SK, Ng CY, Tong CC, Ho PP, Chan WL, Wong LS, Leung DK, Chan SY, So TH, Luk MY, Lee AW.

Int J Cancer. 2018 Sep 7. doi: 10.1002/ijc.31856. [Epub ahead of print]


0.2 λ0 Thick Adaptive Retroreflector Made of Spin-Locked Metasurface.

Yan L, Zhu W, Karim MF, Cai H, Gu AY, Shen Z, Chong PHJ, Kwong DL, Qiu CW, Liu AQ.

Adv Mater. 2018 Sep;30(39):e1802721. doi: 10.1002/adma.201802721. Epub 2018 Aug 20.


Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma.

Jiang C, Chen J, Xie S, Zhang L, Xiang Y, Lung M, Kam NW, Kwong DL, Cao S, Guan XY.

Int J Cancer. 2018 Jul 4. doi: 10.1002/ijc.31642. [Epub ahead of print]


Gate-tunable frequency combs in graphene-nitride microresonators.

Yao B, Huang SW, Liu Y, Vinod AK, Choi C, Hoff M, Li Y, Yu M, Feng Z, Kwong DL, Huang Y, Rao Y, Duan X, Wong CW.

Nature. 2018 Jun;558(7710):410-414. doi: 10.1038/s41586-018-0216-x. Epub 2018 Jun 11.


Leukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese.

Ko JM, Tsang KH, Dai W, Choi SSA, Leong MM, Ngan RK, Kwong DL, Cheng A, Lee AW, Ng WT, Tung S, Lee VH, Lam KO, Chan CK, Lung ML.

Int J Cancer. 2018 Nov 1;143(9):2289-2298. doi: 10.1002/ijc.31617. Epub 2018 Aug 7.


Test-retest reliability of a computer-assisted self-administered questionnaire on early life exposure in a nasopharyngeal carcinoma case-control study.

Mai ZM, Lin JH, Chiang SC, Ngan RK, Kwong DL, Ng WT, Ng AW, Yuen KT, Ip KM, Chan YH, Lee AW, Ho SY, Lung ML, Lam TH.

Sci Rep. 2018 May 4;8(1):7052. doi: 10.1038/s41598-018-25046-y.


Target Therapy for Esophageal Adenocarcinoma.

Lam KO, Kwong DLW.

Methods Mol Biol. 2018;1756:51-65. doi: 10.1007/978-1-4939-7734-5_5.


Chemotherapy for Esophageal Adenocarcinoma.

Lam KO, Kwong DLW.

Methods Mol Biol. 2018;1756:19-34. doi: 10.1007/978-1-4939-7734-5_3.


Radiotherapy for Esophageal Adenocarcinoma.

Kwong DLW, Lam KO.

Methods Mol Biol. 2018;1756:7-17. doi: 10.1007/978-1-4939-7734-5_2.


Prospective, Multicenter, Phase 2 Trial of Induction Chemotherapy Followed by Bio-Chemoradiotherapy for Locally Advanced Recurrent Nasopharyngeal Carcinoma.

Ng WT, Ngan RKC, Kwong DLW, Tung SY, Yuen KT, Kam MKM, Sze HCK, Yiu HHY, Chan LLK, Lung ML, Lee AWM.

Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):630-638. doi: 10.1016/j.ijrobp.2017.11.038. Epub 2017 Dec 1.


Treatment outcomes of nasopharyngeal carcinoma in modern era after intensity modulated radiotherapy (IMRT) in Hong Kong: A report of 3328 patients (HKNPCSG 1301 study).

Au KH, Ngan RKC, Ng AWY, Poon DMC, Ng WT, Yuen KT, Lee VHF, Tung SY, Chan ATC, Sze HCK, Cheng ACK, Lee AWM, Kwong DLW, Tam AHP.

Oral Oncol. 2018 Feb;77:16-21. doi: 10.1016/j.oraloncology.2017.12.004. Epub 2017 Dec 12.


International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma.

Lee AW, Ng WT, Pan JJ, Poh SS, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Soong YL, Tao Y, Yom SS, Wee JT.

Radiother Oncol. 2018 Jan;126(1):25-36. doi: 10.1016/j.radonc.2017.10.032. Epub 2017 Nov 15.


Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Regional Nodal Metastasis in Nasopharyngeal Carcinoma: Correlation with Nodal Staging.

Huang B, Kwong DL, Lai V, Chan Q, Whitcher B, Khong PL.

Contrast Media Mol Imaging. 2017 May 29;2017:4519653. doi: 10.1155/2017/4519653. eCollection 2017.


A study on the post-radiotherapy changes of temporomandibular joint in nasopharyngeal carcinoma patients.

Wu VW, Ying MT, Kwong DL.

Br J Radiol. 2017 Dec;90(1080):20170375. doi: 10.1259/bjr.20170375. Epub 2017 Oct 27.


MicroRNA profiling study reveals miR-150 in association with metastasis in nasopharyngeal carcinoma.

Yue PY, Ha WY, Lau CC, Cheung FM, Lee AW, Ng WT, Ngan RK, Yau CC, Kwong DL, Lung HL, Mak NK, Lung ML, Wong RN.

Sci Rep. 2017 Sep 20;7(1):12012. doi: 10.1038/s41598-017-10695-2.


Cervical nodal volume for prognostication and risk stratification of patients with nasopharyngeal carcinoma, and implications on the TNM-staging system.

Yuan H, Ai QY, Kwong DL, Fong DY, King AD, Vardhanabhuti V, Lee VH, Khong PL.

Sci Rep. 2017 Sep 4;7(1):10387. doi: 10.1038/s41598-017-10423-w.


Third-line systemic treatment versus best supportive care for advanced/metastatic gastric cancer: A systematic review and meta-analysis.

Chan WL, Yuen KK, Siu SW, Lam KO, Kwong DL.

Crit Rev Oncol Hematol. 2017 Aug;116:68-81. doi: 10.1016/j.critrevonc.2017.05.002. Epub 2017 May 24. Review.


A low-frequency chip-scale optomechanical oscillator with 58 kHz mechanical stiffening and more than 100th-order stable harmonics.

Huang Y, Flores JGF, Cai Z, Yu M, Kwong DL, Wen G, Churchill L, Wong CW.

Sci Rep. 2017 Jun 29;7(1):4383. doi: 10.1038/s41598-017-04882-4.


Real-time dynamics and cross-correlation gating spectroscopy of free-carrier Drude slow-light solitons.

Zhou H, Huang SW, Li X, McMillan JF, Zhang C, Wong KK, Yu M, Lo GQ, Kwong DL, Qiu K, Wong CW.

Light Sci Appl. 2017 Jun 30;6(6):e17008. doi: 10.1038/lsa.2017.8. eCollection 2017 Jun.


Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.

Jiang L, Yan Q, Fang S, Liu M, Li Y, Yuan YF, Li Y, Zhu Y, Qi J, Yang X, Kwong DLW, Guan XY.

Hepatology. 2017 Nov;66(5):1529-1545. doi: 10.1002/hep.29312. Epub 2017 Sep 29.


Mesoscopic chaos mediated by Drude electron-hole plasma in silicon optomechanical oscillators.

Wu J, Huang SW, Huang Y, Zhou H, Yang J, Liu JM, Yu M, Lo G, Kwong DL, Duan S, Wei Wong C.

Nat Commun. 2017 Jun 9;8:15570. doi: 10.1038/ncomms15570.


Quasi-phase-matched multispectral Kerr frequency comb.

Huang SW, Vinod AK, Yang J, Yu M, Kwong DL, Wong CW.

Opt Lett. 2017 Jun 1;42(11):2110-2113. doi: 10.1364/OL.42.002110.


Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma.

Lee VH, Kwong DL, Lam KO, Lai YC, Li Y, Tong CC, Ho PP, Chan WL, Wong LS, Leung DK, Chan SY, Chan FT, Leung TW, Lee AW.

Medicine (Baltimore). 2017 Apr;96(15):e6518. doi: 10.1097/MD.0000000000006518.


Impact of intravenous contrast used in computed tomography on radiation dose to carotid arteries and thyroid in intensity-modulated radiation therapy planning for nasopharyngeal carcinoma.

Lee VHF, Ng SCY, Kwong DLW, Lam KO, Leung TW.

Med Dosim. 2017 Summer;42(2):137-144. doi: 10.1016/j.meddos.2017.02.005. Epub 2017 Apr 6.


Controllable optomechanical coupling and Drude self-pulsation plasma locking in chip-scale optomechanical cavities.

Huang Y, Flores JG, Cai Z, Wu J, Yu M, Kwong DL, Wen G, Churchill L, Wong CW.

Opt Express. 2017 Mar 20;25(6):6851-6859. doi: 10.1364/OE.25.006851.


Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma.

Lee VH, Kwong DL, Leung TW, Choi CW, Lai V, Ng L, Lam KO, Ng SC, Sze CK, Tong CC, Ho PP, Chan WL, Wong LS, Leung DK, Chan SY, Khong PL.

Oncotarget. 2017 Jan 17;8(3):5292-5308. doi: 10.18632/oncotarget.14137.


Surrogate End Points for Overall Survival in Loco-Regionally Advanced Nasopharyngeal Carcinoma: An Individual Patient Data Meta-analysis.

Rotolo F, Pignon JP, Bourhis J, Marguet S, Leclercq J, Tong Ng W, Ma J, Chan AT, Huang PY, Zhu G, Chua DT, Chen Y, Mai HQ, Kwong DL, Soong YL, Moon J, Tung Y, Chi KH, Fountzilas G, Zhang L, Hui EP, Lee AW, Blanchard P, Michiels S; MAC-NPC Collaborative Group.

J Natl Cancer Inst. 2017 Apr;109(4). pii: djw239.


What Is the Best Treatment of Locally Advanced Nasopharyngeal Carcinoma? An Individual Patient Data Network Meta-Analysis.

Ribassin-Majed L, Marguet S, Lee AWM, Ng WT, Ma J, Chan ATC, Huang PY, Zhu G, Chua DTT, Chen Y, Mai HQ, Kwong DLW, Cheah SL, Moon J, Tung Y, Chi KH, Fountzilas G, Bourhis J, Pignon JP, Blanchard P.

J Clin Oncol. 2017 Feb 10;35(5):498-505. doi: 10.1200/JCO.2016.67.4119. Epub 2016 Dec 5.


Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma.

Chai AW, Cheung AK, Dai W, Ko JM, Ip JC, Chan KW, Kwong DL, Ng WT, Lee AW, Ngan RK, Yau CC, Tung SY, Lee VH, Lam AK, Pillai S, Law S, Lung ML.

Oncotarget. 2016 Nov 29;7(48):78859-78871. doi: 10.18632/oncotarget.12889.


Hyperfractionation compared to standard fractionation in intensity-modulated radiation therapy for patients with locally advanced recurrent nasopharyngeal carcinoma.

Lee VH, Kwong DL, Leung TW, Ng SC, Lam KO, Tong CC, Sze CK.

Eur Arch Otorhinolaryngol. 2017 Feb;274(2):1067-1078. doi: 10.1007/s00405-016-4339-0. Epub 2016 Oct 13.


Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.

Zheng H, Dai W, Cheung AK, Ko JM, Kan R, Wong BW, Leong MM, Deng M, Kwok TC, Chan JY, Kwong DL, Lee AW, Ng WT, Ngan RK, Yau CC, Tung S, Lee VH, Lam KO, Kwan CK, Li WS, Yau S, Chan KW, Lung ML.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11283-11288. Epub 2016 Sep 19.


Treatment Regret in Long-term Survivors of Nasopharyngeal Carcinoma Treated with Radical Radiotherapy.

Ho S, Ip W, Chu S, Chan S, Lee B, Chan B, Lee J, Flynn B, Ho W, Sin J, Kwong DL, Leung TW, Lam KO.

Clin Oncol (R Coll Radiol). 2017 Jan;29(1):e47. doi: 10.1016/j.clon.2016.08.006. Epub 2016 Aug 25. No abstract available.


Stabilized chip-scale Kerr frequency comb via a high-Q reference photonic microresonator.

Lim J, Huang SW, Vinod AK, Mortazavian P, Yu M, Kwong DL, Savchenkov AA, Matsko AB, Maleki L, Wong CW.

Opt Lett. 2016 Aug 15;41(16):3706-9. doi: 10.1364/OL.41.003706.


Correlation of PD-L1 Expression of Tumor Cells with Survival Outcomes after Radical Intensity-Modulated Radiation Therapy for Non-Metastatic Nasopharyngeal Carcinoma.

Lee VH, Lo AW, Leung CY, Shek WH, Kwong DL, Lam KO, Tong CC, Sze CK, Leung TW.

PLoS One. 2016 Jun 24;11(6):e0157969. doi: 10.1371/journal.pone.0157969. eCollection 2016.


Smooth and flat phase-locked Kerr frequency comb generation by higher order mode suppression.

Huang SW, Liu H, Yang J, Yu M, Kwong DL, Wong CW.

Sci Rep. 2016 May 16;6:26255. doi: 10.1038/srep26255.


A broadband chip-scale optical frequency synthesizer at 2.7 × 10(-16) relative uncertainty.

Huang SW, Yang J, Yu M, McGuyer BH, Kwong DL, Zelevinsky T, Wong CW.

Sci Adv. 2016 Apr 22;2(4):e1501489. doi: 10.1126/sciadv.1501489. eCollection 2016 Apr.


Salivary Anionic Changes after Radiotherapy for Nasopharyngeal Carcinoma: A 1-Year Prospective Study.

Pow EH, Chen Z, Kwong DL, Lam OL.

PLoS One. 2016 Mar 31;11(3):e0152817. doi: 10.1371/journal.pone.0152817. eCollection 2016.


Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.

Dai W, Zheng H, Cheung AK, Tang CS, Ko JM, Wong BW, Leong MM, Sham PC, Cheung F, Kwong DL, Ngan RK, Ng WT, Yau CC, Pan J, Peng X, Tung S, Zhang Z, Ji M, Chiang AK, Lee AW, Lee VH, Lam KO, Au KH, Cheng HC, Yiu HH, Lung ML.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3317-22. doi: 10.1073/pnas.1523436113. Epub 2016 Mar 7.


Yttrium-90 radioembolization for advanced inoperable hepatocellular carcinoma.

Lee VH, Leung DK, Luk MY, Tong CC, Law MW, Ng SC, Wong KK, Poon RT, Kwong DL, Leung TW.

Onco Targets Ther. 2015 Nov 20;8:3457-64. doi: 10.2147/OTT.S92473. eCollection 2015.


Evaluation and optimization of the parameters used in multiple-atlas-based segmentation of prostate cancers in radiation therapy.

Wong WK, Leung LH, Kwong DL.

Br J Radiol. 2016;89(1057):20140732. doi: 10.1259/bjr.20140732. Epub 2015 Nov 5.


Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma.

Lee VH, Kwong DL, Leung TW, Choi CW, Lam KO, Sze CK, Ho P, Chan WL, Wong LS, Leung D.

Clin Oncol (R Coll Radiol). 2016 Jan;28(1):42-9. doi: 10.1016/j.clon.2015.09.009. Epub 2015 Oct 21.


A low-phase-noise 18 GHz Kerr frequency microcomb phase-locked over 65 THz.

Huang SW, Yang J, Lim J, Zhou H, Yu M, Kwong DL, Wong CW.

Sci Rep. 2015 Aug 27;5:13355. doi: 10.1038/srep13355.


Effect of Fluoride-Modified Titanium Surface on Early Adhesion of Irradiated Osteoblasts.

Li JY, Zheng LW, Ma L, Kwong DL, Cheung LK, Pow EH.

Biomed Res Int. 2015;2015:219752. doi: 10.1155/2015/219752. Epub 2015 Jul 22.


HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma.

Jiang L, Kwong DL, Li Y, Liu M, Yuan YF, Li Y, Fu L, Guan XY.

Carcinogenesis. 2015 Oct;36(10):1111-20. doi: 10.1093/carcin/bgv116. Epub 2015 Aug 5.


A flat lens with tunable phase gradient by using random access reconfigurable metamaterial.

Zhu W, Song Q, Yan L, Zhang W, Wu PC, Chin LK, Cai H, Tsai DP, Shen ZX, Deng TW, Ting SK, Gu Y, Lo GQ, Kwong DL, Yang ZC, Huang R, Liu AQ, Zheludev N.

Adv Mater. 2015 Aug 26;27(32):4739-43. doi: 10.1002/adma.201501943. Epub 2015 Jul 16.


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