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Science. 2005 Feb 25;307(5713):1321-4. Epub 2005 Jan 13.

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

Author information

1
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. bjloftus@tigr.org

Abstract

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.

PMID:
15653466
PMCID:
PMC3520129
DOI:
10.1126/science.1103773
[Indexed for MEDLINE]
Free PMC Article

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