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Items: 1 to 50 of 206

1.

Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity.

Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Vieira SM, Kriegel C, Adeniyi O, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA.

Cell Host Microbe. 2019 Jun 17. pii: S1931-3128(19)30248-3. doi: 10.1016/j.chom.2019.05.003. [Epub ahead of print]

PMID:
31227334
2.

Identification of Human Antigen-Specific CD4+ T-Cells with Peptide-MHC Multimer Technologies.

Kong YY, Kwok WW.

Methods Mol Biol. 2019;1988:375-386. doi: 10.1007/978-1-4939-9450-2_26.

PMID:
31147953
3.

Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy.

Rudulier CD, Tonti E, James E, Kwok WW, Larché M.

Allergy. 2019 May 11. doi: 10.1111/all.13867. [Epub ahead of print]

PMID:
31077596
4.

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S.

Sci Immunol. 2019 Apr 5;4(34). pii: eaav7517. doi: 10.1126/sciimmunol.aav7517.

PMID:
30952805
5.

Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense.

Hung SC, Hou T, Jiang W, Wang N, Qiao SW, Chow IT, Liu X, van der Burg SH, Koelle DM, Kwok WW, Sollid LM, Mellins ED.

J Immunol. 2019 May 1;202(9):2558-2569. doi: 10.4049/jimmunol.1801454. Epub 2019 Mar 29.

PMID:
30926644
6.

A Novel Approach of Identifying Immunodominant Self and Viral Antigen Cross-Reactive T Cells and Defining the Epitopes They Recognize.

Yang J, Jing L, James EA, Gebe JA, Koelle DM, Kwok WW.

Front Immunol. 2018 Dec 3;9:2811. doi: 10.3389/fimmu.2018.02811. eCollection 2018.

7.

Der p 1-specific regulatory T-cell response during house dust mite allergen immunotherapy.

Boonpiyathad T, Sokolowska M, Morita H, Rückert B, Kast JI, Wawrzyniak M, Sangasapaviliya A, Pradubpongsa P, Fuengthong R, Thantiworasit P, Sirivichayakul S, Kwok WW, Ruxrungtham K, Akdis M, Akdis CA.

Allergy. 2019 May;74(5):976-985. doi: 10.1111/all.13684. Epub 2019 Jan 13.

PMID:
30485456
8.

DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes.

James EA, Gillette L, Durinovic-Bello I, Speake C, Bondinas GP, Moustakas AK, Greenbaum CJ, Papadopoulos GK, Kwok WW.

J Immunol. 2018 Dec 15;201(12):3524-3533. doi: 10.4049/jimmunol.1800723. Epub 2018 Nov 19.

PMID:
30455401
9.

Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells.

Blahnik G, Uchtenhagen H, Chow IT, Speake C, Greenbaum C, Kwok WW, James EA.

Cell Immunol. 2019 Jan;335:68-75. doi: 10.1016/j.cellimm.2018.11.004. Epub 2018 Nov 7.

PMID:
30428974
10.

Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.

Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Raddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D.

Lab Chip. 2018 Dec 7;18(23):3703. doi: 10.1039/c8lc90095g. Epub 2018 Nov 13.

PMID:
30420988
11.

Peanut-specific T cell responses in patients with different clinical reactivity.

Birrueta G, Tripple V, Pham J, Manohar M, James EA, Kwok WW, Nadeau KC, Sette A, Peters B, Schulten V.

PLoS One. 2018 Oct 10;13(10):e0204620. doi: 10.1371/journal.pone.0204620. eCollection 2018.

12.

Ratiometric Barcoding for Mass Cytometry.

Wu X, DeGottardi Q, Wu IC, Wu L, Yu J, Kwok WW, Chiu DT.

Anal Chem. 2018 Sep 18;90(18):10688-10694. doi: 10.1021/acs.analchem.8b03201. Epub 2018 Sep 5.

PMID:
30139253
13.

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.

Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Raddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D.

Lab Chip. 2018 Aug 7;18(16):2396-2409. doi: 10.1039/c8lc00518d. Erratum in: Lab Chip. 2018 Nov 13;:.

PMID:
30039125
14.

Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.

Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW.

Front Immunol. 2018 Jun 25;9:1408. doi: 10.3389/fimmu.2018.01408. eCollection 2018.

15.

SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes.

Lacher MD, Bauer G, Fury B, Graeve S, Fledderman EL, Petrie TD, Coleal-Bergum DP, Hackett T, Perotti NH, Kong YY, Kwok WW, Wagner JP, Wiseman CL, Williams WV.

Front Immunol. 2018 May 15;9:776. doi: 10.3389/fimmu.2018.00776. eCollection 2018.

16.

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

Pieper J, Dubnovitsky A, Gerstner C, James EA, Rieck M, Kozhukh G, Tandre K, Pellegrino S, Gebe JA, Rönnblom L, Sandalova T, Kwok WW, Klareskog L, Buckner JH, Achour A, Malmström V.

J Autoimmun. 2018 Aug;92:47-56. doi: 10.1016/j.jaut.2018.04.004. Epub 2018 May 28.

17.

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA.

Diabetes. 2018 Jul;67(7):1356-1368. doi: 10.2337/db17-1166. Epub 2018 Apr 13.

18.

Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.

Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.

Circulation. 2018 Sep 11;138(11):1130-1143. doi: 10.1161/CIRCULATIONAHA.117.031420.

PMID:
29588316
19.

Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.

Veatch JR, Lee SM, Fitzgibbon M, Chow IT, Jesernig B, Schmitt T, Kong YY, Kargl J, Houghton AM, Thompson JA, McIntosh M, Kwok WW, Riddell SR.

J Clin Invest. 2018 Apr 2;128(4):1563-1568. doi: 10.1172/JCI98689. Epub 2018 Mar 12.

20.

Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans.

Muehling LM, Turner RB, Brown KB, Wright PW, Patrie JT, Lahtinen SJ, Lehtinen MJ, Kwok WW, Woodfolk JA.

J Infect Dis. 2018 Jan 17;217(3):381-392. doi: 10.1093/infdis/jix514.

21.

C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):162-167. doi: 10.1073/pnas.1716527115. Epub 2017 Dec 18.

22.

Synchronous immune alterations mirror clinical response during allergen immunotherapy.

Renand A, Shamji MH, Harris KM, Qin T, Wambre E, Scadding GW, Wurtzen PA, Till SJ, Togias A, Nepom GT, Kwok WW, Durham SR.

J Allergy Clin Immunol. 2018 May;141(5):1750-1760.e1. doi: 10.1016/j.jaci.2017.09.041. Epub 2017 Nov 9.

23.

Lanthanide-Coordinated Semiconducting Polymer Dots Used for Flow Cytometry and Mass Cytometry.

Wu X, DeGottardi Q, Wu IC, Yu J, Wu L, Ye F, Kuo CT, Kwok WW, Chiu DT.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14908-14912. doi: 10.1002/anie.201708463. Epub 2017 Oct 12.

24.

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.

Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam9171. doi: 10.1126/scitranslmed.aam9171.

25.

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, DeBerg HA, Dufort MJ, Murray SA, Israelsson E, Speake C, Gersuk VH, Eddy JA, Reijonen H, Greenbaum CJ, Kwok WW, Wambre E, Prlic M, Gottardo R, Nepom GT, Linsley PS.

J Immunol. 2017 Jul 1;199(1):323-335. doi: 10.4049/jimmunol.1700172. Epub 2017 May 31.

26.

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

Yang J, Wen X, Xu H, Torres-Chinn N, Speake C, Greenbaum CJ, Nepom GT, Kwok WW.

J Immunol. 2017 Jul 1;199(1):91-96. doi: 10.4049/jimmunol.1601570. Epub 2017 May 26.

27.

αS1-Casein elucidate major T-cell responses in cow's milk allergy.

Archila LD, Khan FS, Bhatnagar N, Robinson D, Farrington ML, Kwok WW.

J Allergy Clin Immunol. 2017 Sep;140(3):854-857.e6. doi: 10.1016/j.jaci.2017.02.028. Epub 2017 Mar 23. No abstract available.

28.

Tetramer-Guided Epitope Mapping: A Rapid Approach to Identify HLA-Restricted T-Cell Epitopes from Composite Allergens.

Archila LL, Kwok WW.

Methods Mol Biol. 2017;1592:199-209. doi: 10.1007/978-1-4939-6925-8_16.

PMID:
28315222
29.

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.

Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M.

Diabetes. 2017 Mar;66(3):722-734. doi: 10.2337/db16-1025. Epub 2016 Dec 5.

30.

Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.

Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD.

Sci Transl Med. 2016 Oct 5;8(359):359ra132.

31.

Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

Muehling LM, Mai DT, Kwok WW, Heymann PW, Pomés A, Woodfolk JA.

J Immunol. 2016 Oct 15;197(8):3214-3224. Epub 2016 Sep 2.

32.

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining.

Uchtenhagen H, Rims C, Blahnik G, Chow IT, Kwok WW, Buckner JH, James EA.

Nat Commun. 2016 Aug 30;7:12614. doi: 10.1038/ncomms12614.

33.

A Comparative Analysis of the Peptide Repertoires of HLA-DR Molecules Differentially Associated With Rheumatoid Arthritis.

Scholz E, Mestre-Ferrer A, Daura X, García-Medel N, Carrascal M, James EA, Kwok WW, Canals F, Álvarez I.

Arthritis Rheumatol. 2016 Oct;68(10):2412-21. doi: 10.1002/art.39736.

34.

Ana o 1 and Ana o 2 cashew allergens share cross-reactive CD4(+) T cell epitopes with other tree nuts.

Archila LD, Chow IT, McGinty JW, Renand A, Jeong D, Robinson D, Farrington ML, Kwok WW.

Clin Exp Allergy. 2016 Jun;46(6):871-83. doi: 10.1111/cea.12746.

35.

Reply.

Renand A, Robinson D, Kwok WW.

J Allergy Clin Immunol. 2016 May;137(5):1622-3. doi: 10.1016/j.jaci.2015.11.046. Epub 2016 Mar 11. No abstract available.

PMID:
26971693
36.

Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome.

James EA, Gates TJ, LaFond RE, Yamamoto S, Ni C, Mai D, Gersuk VH, O'Brien K, Nguyen QA, Zeitner B, Lanteri MC, Norris PJ, Chaussabel D, Malhotra U, Kwok WW.

PLoS Pathog. 2016 Jan 21;12(1):e1005375. doi: 10.1371/journal.ppat.1005375. eCollection 2016 Jan.

37.

Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity.

Hinz D, Seumois G, Gholami AM, Greenbaum JA, Lane J, White B, Broide DH, Schulten V, Sidney J, Bakhru P, Oseroff C, Wambre E, James EA, Kwok WW, Peters B, Vijayanand P, Sette A.

Clin Exp Allergy. 2016 May;46(5):705-19. doi: 10.1111/cea.12692.

38.

Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.

Renand A, Archila LD, McGinty J, Wambre E, Robinson D, Hales BJ, Thomas WR, Kwok WW.

J Allergy Clin Immunol. 2015 Dec;136(6):1627-1635.e13. doi: 10.1016/j.jaci.2015.07.031. Epub 2015 Sep 11.

39.

Modulation of Peanut-specific humoral and cellular responses pre- and post-oral immunotherapy.

Kwok WW.

Clin Exp Allergy. 2015 Jul;45(7):1146-9. doi: 10.1111/cea.12552. No abstract available.

PMID:
26082305
40.

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA.

Sci Transl Med. 2015 May 13;7(287):287ra74. doi: 10.1126/scitranslmed.aaa8038.

41.

Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

Alvarez I, Collado JA, Colobran R, Carrascal M, Ciudad MT, Canals F, James EA, Kwok WW, Gärtner M, Kyewski B, Pujol-Borrell R, Jaraquemada D.

J Autoimmun. 2015 Jun;60:12-9. doi: 10.1016/j.jaut.2015.03.004. Epub 2015 Apr 21.

PMID:
25911201
42.

Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening.

Nayak K, Jing L, Russell RM, Davies DH, Hermanson G, Molina DM, Liang X, Sherman DR, Kwok WW, Yang J, Kenneth J, Ahamed SF, Chandele A, Murali-Krishna K, Koelle DM.

Tuberculosis (Edinb). 2015 May;95(3):275-87. doi: 10.1016/j.tube.2015.03.001. Epub 2015 Mar 27.

43.

Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy.

Archila LD, Jeong D, Pascal M, Bartra J, Juan M, Robinson D, Farrington ML, Kwok WW.

J Allergy Clin Immunol. 2015 Oct;136(4):983-92.e7. doi: 10.1016/j.jaci.2015.01.029. Epub 2015 Mar 13.

44.

Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development.

Chow IT, Yang J, Gates TJ, James EA, Mai DT, Greenbaum C, Kwok WW.

PLoS One. 2014 Nov 18;9(11):e112882. doi: 10.1371/journal.pone.0112882. eCollection 2014.

45.

Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients.

Wesa AK, Mandic M, Taylor JL, Moschos S, Kirkwood JM, Kwok WW, Finke JH, Storkus WJ.

Front Oncol. 2014 Sep 29;4:266. doi: 10.3389/fonc.2014.00266. eCollection 2014.

46.

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.

Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.

47.

Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells.

Renand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW.

J Allergy Clin Immunol. 2014 Dec;134(6):1456-1459.e7. doi: 10.1016/j.jaci.2014.07.048. Epub 2014 Sep 12. No abstract available.

48.

Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine.

Zaleska A, Eiwegger T, Soyer O, van de Veen W, Rhyner C, Soyka MB, Bekpen C, Demiröz D, Treis A, Söllner S, Palomares O, Kwok WW, Rose H, Senti G, Kündig TM, Ozoren N, Jutel M, Akdis CA, Crameri R, Akdis M.

Allergy. 2014 Sep;69(9):1162-70. doi: 10.1111/all.12461. Epub 2014 Jul 12. Erratum in: Allergy. 2016 Jan;71(1):129.

PMID:
24934402
49.

Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy.

Archila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW.

Clin Exp Allergy. 2014 Jul;44(7):986-98. doi: 10.1111/cea.12324.

50.

Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.

McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW, James EA.

Diabetes. 2014 Sep;63(9):3033-40. doi: 10.2337/db13-1952. Epub 2014 Apr 4.

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