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Items: 31


Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.

Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, Bessho T, Kwok BH, Peng A.

Elife. 2020 Jan 17;9. pii: e53402. doi: 10.7554/eLife.53402.


Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.

Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly J.

Hum Mol Genet. 2020 Mar 27;29(5):766-784. doi: 10.1093/hmg/ddz316.


Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.

Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok BH, Borden KLB.

Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24056-24065. doi: 10.1073/pnas.1904752116. Epub 2019 Nov 11.


Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.

Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Gregory-Evans CY, Shan X, Filges I, Allingham JS, Kwok BH, Saunier S, Giles RH, Benmerah A.

Hum Mol Genet. 2019 Mar 1;28(5):778-795. doi: 10.1093/hmg/ddy381.


The influence of dissolved oxygen on partial nitritation/anammox performance and microbial community of the 200,000 m3/d activated sludge process at the Changi water reclamation plant (2011 to 2016).

Cao Y, Kwok BH, van Loosdrecht MCM, Daigger G, Png HY, Long WY, Eng OK.

Water Sci Technol. 2018 Sep;78(3-4):634-643. doi: 10.2166/wst.2018.333.


Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.

Trofimova D, Paydar M, Zara A, Talje L, Kwok BH, Allingham JS.

Nat Commun. 2018 Jul 6;9(1):2628. doi: 10.1038/s41467-018-05025-7.


DHTP is an allosteric inhibitor of the kinesin-13 family of microtubule depolymerases.

Talje L, El Kadhi KB, Atchia K, Tremblay-Boudreault T, Carreno S, Kwok BH.

FEBS Lett. 2017 Sep;591(18):2952. doi: 10.1002/1873-3468.12793. Epub 2017 Aug 30. No abstract available.


The occurrence of enhanced biological phosphorus removal in a 200,000 m3/day partial nitration and Anammox activated sludge process at the Changi water reclamation plant, Singapore.

Cao Y, Kwok BH, van Loosdrecht MC, Daigger GT, Png HY, Long WY, Chye CS, Ghani YA.

Water Sci Technol. 2017 Feb;75(3-4):741-751. doi: 10.2166/wst.2016.565.


Multimodal and Polymorphic Interactions between Anillin and Actin: Their Implications for Cytokinesis.

Jananji S, Risi C, Lindamulage IKS, Picard LP, Van Sciver R, Laflamme G, Albaghjati A, Hickson GRX, Kwok BH, Galkin VE.

J Mol Biol. 2017 Mar 10;429(5):715-731. doi: 10.1016/j.jmb.2017.01.020. Epub 2017 Jan 29.


Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.

Orr B, Talje L, Liu Z, Kwok BH, Compton DA.

Cell Rep. 2016 Nov 8;17(7):1755-1763. doi: 10.1016/j.celrep.2016.10.030.


High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.

J Clin Invest. 2016 Dec 1;126(12):4569-4584. doi: 10.1172/JCI86489. Epub 2016 Oct 31.


Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.

Kachaner D, Pinson X, El Kadhi KB, Normandin K, Talje L, Lavoie H, Lépine G, Carréno S, Kwok BH, Hickson GR, Archambault V.

J Cell Biol. 2014 Oct 27;207(2):201-11. doi: 10.1083/jcb.201408081. Epub 2014 Oct 20.


Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity.

Laflamme G, Tremblay-Boudreault T, Roy MA, Andersen P, Bonneil É, Atchia K, Thibault P, D'Amours D, Kwok BH.

J Biol Chem. 2014 Oct 3;289(40):27418-31. doi: 10.1074/jbc.M114.569608. Epub 2014 Aug 18.


KIF14 binds tightly to microtubules and adopts a rigor-like conformation.

Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS, Kwok BH.

J Mol Biol. 2014 Aug 26;426(17):2997-3015. doi: 10.1016/j.jmb.2014.05.030. Epub 2014 Jun 17.


DHTP is an allosteric inhibitor of the kinesin-13 family of microtubule depolymerases.

Talje L, Ben El Kadhi K, Atchia K, Tremblay-Boudreault T, Carreno S, Kwok BH.

FEBS Lett. 2014 Jun 27;588(14):2315-20. doi: 10.1016/j.febslet.2014.05.024. Epub 2014 May 22. Erratum in: FEBS Lett. 2017 Sep;591(18):2952.


The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex.

Solinet S, Mahmud K, Stewman SF, Ben El Kadhi K, Decelle B, Talje L, Ma A, Kwok BH, Carreno S.

J Cell Biol. 2013 Jul 22;202(2):251-60. doi: 10.1083/jcb.201304052. Epub 2013 Jul 15.


Microtubule cross-linking triggers the directional motility of kinesin-5.

Kapitein LC, Kwok BH, Weinger JS, Schmidt CF, Kapoor TM, Peterman EJ.

J Cell Biol. 2008 Aug 11;182(3):421-8. doi: 10.1083/jcb.200801145. Epub 2008 Aug 4.


Efficient identification of phosphorylation by mass spectrometric phosphopeptide fingerprinting.

Woo EM, Fenyo D, Kwok BH, Funabiki H, Chait BT.

Anal Chem. 2008 Apr 1;80(7):2419-25. doi: 10.1021/ac702059p. Epub 2008 Mar 6.


Microtubule flux: drivers wanted.

Kwok BH, Kapoor TM.

Curr Opin Cell Biol. 2007 Feb;19(1):36-42. Epub 2006 Dec 15. Review.


Probing cell-division phenotype space and Polo-like kinase function using small molecules.

Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM.

Nat Chem Biol. 2006 Nov;2(11):618-26. Epub 2006 Oct 8.


Allosteric inhibition of kinesin-5 modulates its processive directional motility.

Kwok BH, Kapitein LC, Kim JH, Peterman EJ, Schmidt CF, Kapoor TM.

Nat Chem Biol. 2006 Sep;2(9):480-5. Epub 2006 Aug 6.


The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.

Kapitein LC, Peterman EJ, Kwok BH, Kim JH, Kapoor TM, Schmidt CF.

Nature. 2005 May 5;435(7038):114-8.


Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR.

Lin S, Yang ZQ, Kwok BH, Koldobskiy M, Crews CM, Danishefsky SJ.

J Am Chem Soc. 2004 May 26;126(20):6347-55.


Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity.

Yang ZQ, Kwok BH, Lin S, Koldobskiy MA, Crews CM, Danishefsky SJ.

Chembiochem. 2003 Jun 6;4(6):508-13.


Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13.

Ndubuisil MI, Kwok BH, Vervoort J, Koh BD, Elofsson M, Crews CM.

Biochemistry. 2002 Jun 18;41(24):7841-8.


Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity.

Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10403-8.


Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology.

Sin N, Kim KB, Elofsson M, Meng L, Auth H, Kwok BH, Crews CM.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2283-8.


Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

Meng L, Kwok BH, Sin N, Crews CM.

Cancer Res. 1999 Jun 15;59(12):2798-801.

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