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Items: 18

1.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.

Shu M, Loebach JL, Parker KA, Mills SG, Chapman KT, Shen DM, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Salvo JD, Lyons K, Pivnichny JV, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):947-52.

PMID:
15012999
2.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.

Shen DM, Shu M, Willoughby CA, Shah S, Lynch CL, Hale JJ, Mills SG, Chapman KT, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Lyons K, Pivnichny JV, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):941-5.

PMID:
15012998
3.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.

Shen DM, Shu M, Mills SG, Chapman KT, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):935-9.

PMID:
15012997
4.

Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.

Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA.

J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71.

PMID:
12604693
5.

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

Tang W, Stearns RA, Miller RR, Ngui JS, Mathvink RJ, Weber AE, Kwei GY, Strauss JR, Keohane CA, Doss GA, Chiu SH, Baillie TA.

Drug Metab Dispos. 2002 Jul;30(7):778-87.

PMID:
12065436
6.

The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability.

Stearns RA, Miller RR, Tang W, Kwei GY, Tang FS, Mathvink RJ, Naylor EM, Chitty D, Colandrea VJ, Weber AE, Colletti AE, Strauss JR, Keohane CA, Feeney WP, Iliff SA, Chiu SH.

Drug Metab Dispos. 2002 Jul;30(7):771-7.

PMID:
12065435
7.

Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism.

Tang W, Stearns RA, Kwei GY, Iliff SA, Miller RR, Egan MA, Yu NX, Dean DC, Kumar S, Shou M, Lin JH, Baillie TA.

J Pharmacol Exp Ther. 1999 Dec;291(3):1068-74.

PMID:
10565826
8.

Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein.

Kwei GY, Alvaro RF, Chen Q, Jenkins HJ, Hop CE, Keohane CA, Ly VT, Strauss JR, Wang RW, Wang Z, Pippert TR, Umbenhauer DR.

Drug Metab Dispos. 1999 May;27(5):581-7.

PMID:
10220486
9.

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.

Drug Metab Dispos. 1999 Mar;27(3):365-72.

PMID:
10064567
10.

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

Lin JH, Chiba M, Balani SK, Chen IW, Kwei GY, Vastag KJ, Nishime JA.

Drug Metab Dispos. 1996 Oct;24(10):1111-20.

PMID:
8894513
11.

Chronic catheterization of the intestines and portal vein for absorption experimentation in beagle dogs.

Kwei GY, Gehret JR, Novak LB, Drag MD, Goodwin T.

Lab Anim Sci. 1995 Dec;45(6):683-5. No abstract available.

PMID:
8746531
12.

Regiospecific intestinal absorption of the HIV protease inhibitor L-735,524 in beagle dogs.

Kwei GY, Novak LB, Hettrick LA, Reiss ER, Ostovic D, Loper AE, Lui CY, Higgins RJ, Chen IW, Lin JH.

Pharm Res. 1995 Jun;12(6):884-8.

PMID:
7667195
13.

Conjugation of benzo(a)pyrene 7,8-dihydrodiol-9,10-epoxide in infant Swiss-Webster mice.

Kwei GY, Zaleski J, Irwin SE, Thurman RG, Kauffman FC.

Cancer Res. 1992 Mar 15;52(6):1639-42. Erratum in: Cancer Res 1992 Jun 15;52(12):3512.

14.

Mutagenicity of benzo(a)pyrenyl-1-sulfate in the Ames test.

Irwin SE, Kwei GY, Blackburn GR, Thurman R, Kauffman FC.

Environ Mol Mutagen. 1992;19(3):253-8.

PMID:
1572348
15.
16.

The liver plays a central role in the mechanism of chemical carcinogenesis due to polycyclic aromatic hydrocarbons.

Wall KL, Gao WS, te Koppele JM, Kwei GY, Kauffman FC, Thurman RG.

Carcinogenesis. 1991 May;12(5):783-6.

PMID:
2029742
17.
18.

Stimulation of binding of benzo[a]pyrene metabolites to DNA by diet-induced peroxidative stress.

Kwei GY, Bjeldanes LF.

Food Chem Toxicol. 1990 Jul;28(7):491-5.

PMID:
2210521

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