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Items: 1 to 50 of 85

1.

Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases.

Birnhuber A, Biasin V, Schnoegl D, Marsh LM, Kwapiszewska G.

Cell Signal. 2019 Aug 29;64:109408. doi: 10.1016/j.cellsig.2019.109408. [Epub ahead of print] Review.

2.

IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis.

Birnhuber A, Crnkovic S, Biasin V, Marsh LM, Odler B, Sahu-Osen A, Stacher-Priehse E, Brcic L, Schneider F, Cikes N, Ghanim B, Klepetko W, Graninger W, Allanore Y, Eferl R, Olschewski A, Olschewski H, Kwapiszewska G.

Eur Respir J. 2019 Sep 29;54(3). pii: 1900154. doi: 10.1183/13993003.00154-2019. Print 2019 Sep.

PMID:
31320452
3.

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.

Kheirollahi V, Wasnick RM, Biasin V, Vazquez-Armendariz AI, Chu X, Moiseenko A, Weiss A, Wilhelm J, Zhang JS, Kwapiszewska G, Herold S, Schermuly RT, Mari B, Li X, Seeger W, Günther A, Bellusci S, El Agha E.

Nat Commun. 2019 Jul 5;10(1):2987. doi: 10.1038/s41467-019-10839-0.

4.

Role of the Aryl Hydrocarbon Receptor/ARNT/Cytochrome P450 System in Pulmonary Vascular Diseases.

Kwapiszewska G, Johansen AKZ, Gomez-Arroyo J, Voelkel NF.

Circ Res. 2019 Jul 19;125(3):356-366. doi: 10.1161/CIRCRESAHA.119.315054. Epub 2019 Jun 26.

PMID:
31242807
5.

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse.

Egemnazarov B, Kwapiszewska G, Marsh LM.

J Vis Exp. 2019 Apr 27;(146). doi: 10.3791/58021.

PMID:
31081820
6.

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension.

Papp R, Nagaraj C, Zabini D, Nagy BM, Lengyel M, Skofic Maurer D, Sharma N, Egemnazarov B, Kovacs G, Kwapiszewska G, Marsh LM, Hrzenjak A, Höfler G, Didiasova M, Wygrecka M, Sievers LK, Szucs P, Enyedi P, Ghanim B, Klepetko W, Olschewski H, Olschewski A.

Eur Respir J. 2019 Jun 5;53(6). pii: 1800965. doi: 10.1183/13993003.00965-2018. Print 2019 Jun.

PMID:
31023847
7.

LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension.

Zucker MM, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1604-1616. doi: 10.1016/j.bbadis.2019.03.012. Epub 2019 Mar 22.

PMID:
30910704
8.

Editorial: Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction.

Karmouty-Quintana H, Guignabert C, Kwapiszewska G, Ormiston ML.

Front Physiol. 2018 Dec 10;9:1777. doi: 10.3389/fphys.2018.01777. eCollection 2018. No abstract available.

9.

Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

Crnkovic S, Egemnazarov B, Damico R, Marsh LM, Nagy BM, Douschan P, Atsina K, Kolb TM, Mathai SC, Hooper JE, Ghanim B, Klepetko W, Fruhwald F, Lassner D, Olschewski A, Olschewski H, Hassoun PM, Kwapiszewska G.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1550-1560. doi: 10.1164/rccm.201809-1737OC.

PMID:
30557518
10.

Long non-coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1-AS1.

Jandl K, Thekkekara Puthenparampil H, Marsh LM, Hoffmann J, Wilhelm J, Veith C, Sinn K, Klepetko W, Olschewski H, Olschewski A, Brock M, Kwapiszewska G.

J Pathol. 2019 Mar;247(3):357-370. doi: 10.1002/path.5195. Epub 2019 Jan 16.

PMID:
30450722
11.

Lessons from Transcriptomics in Hypoxia-induced Pulmonary Hypertension: Does the Mouse Strain Matter?

Marsh LM, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):13-15. doi: 10.1165/rcmb.2018-0307ED. No abstract available.

PMID:
30335513
12.

Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.

PMID:
30314839
13.

Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.

Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G.

Thromb Haemost. 2018 Oct;118(10):1790-1802. doi: 10.1055/s-0038-1670657. Epub 2018 Sep 20.

PMID:
30235485
14.

Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner.

Gungl A, Biasin V, Wilhelm J, Olschewski A, Kwapiszewska G, Marsh LM.

Front Immunol. 2018 Sep 5;9:2018. doi: 10.3389/fimmu.2018.02018. eCollection 2018.

15.

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.

Eur Respir J. 2018 Nov 22;52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.

16.

Biomarkers for Pulmonary Vascular Remodeling in Systemic Sclerosis: A Pathophysiological Approach.

Odler B, Foris V, Gungl A, Müller V, Hassoun PM, Kwapiszewska G, Olschewski H, Kovacs G.

Front Physiol. 2018 Jun 19;9:587. doi: 10.3389/fphys.2018.00587. eCollection 2018. Review.

17.

Translationally Controlled Tumor Protein in Extracellular Vehicles: Dangerous Cargo?

Jandl K, Gregory CD, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):407-409. doi: 10.1165/rcmb.2018-0160ED. No abstract available.

PMID:
29924940
18.

A Twist on Pulmonary Vascular Remodeling: Endothelial to Mesenchymal Transition?

Kwapiszewska G, Crnkovic S, Stenmark KR.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):140-141. doi: 10.1165/rcmb.2017-0314ED. No abstract available.

PMID:
29388836
19.

The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension.

Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Eur Respir J. 2018 Jan 25;51(1). pii: 1701214. doi: 10.1183/13993003.01214-2017. Print 2018 Jan.

20.

Resident cell lineages are preserved in pulmonary vascular remodeling.

Crnkovic S, Marsh LM, El Agha E, Voswinckel R, Ghanim B, Klepetko W, Stacher-Priehse E, Olschewski H, Bloch W, Bellusci S, Olschewski A, Kwapiszewska G.

J Pathol. 2018 Apr;244(4):485-498. doi: 10.1002/path.5044. Epub 2018 Mar 9.

21.

Right ventricular fibrosis and dysfunction: Actual concepts and common misconceptions.

Egemnazarov B, Crnkovic S, Nagy BM, Olschewski H, Kwapiszewska G.

Matrix Biol. 2018 Aug;68-69:507-521. doi: 10.1016/j.matbio.2018.01.010. Epub 2018 Jan 16. Review.

PMID:
29343458
22.

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.

Olschewski A, Veale EL, Nagy BM, Nagaraj C, Kwapiszewska G, Antigny F, Lambert M, Humbert M, Czirják G, Enyedi P, Mathie A.

Eur Respir J. 2017 Nov 9;50(5). pii: 1700754. doi: 10.1183/13993003.00754-2017. Print 2017 Nov. Review.

23.

Laser Capture Microdissection of Tissue Sections for High-Throughput RNA Analysis.

Hoffmann J, Wilhelm J, Kwapiszewska G.

Methods Mol Biol. 2017;1627:325-340. doi: 10.1007/978-1-4939-7113-8_21.

PMID:
28836211
24.

Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.

Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H.

Eur Respir J. 2017 Jul 20;50(1). pii: 1601651. doi: 10.1183/13993003.01651-2016. Print 2017 Jul.

25.

Importance of kynurenine in pulmonary hypertension.

Nagy BM, Nagaraj C, Meinitzer A, Sharma N, Papp R, Foris V, Ghanim B, Kwapiszewska G, Kovacs G, Klepetko W, Pieber TR, Mangge H, Olschewski H, Olschewski A.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L741-L751. doi: 10.1152/ajplung.00517.2016. Epub 2017 Jul 13.

26.

Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction.

Thangaratnarajah C, Dinger K, Vohlen C, Klaudt C, Nawabi J, Lopez Garcia E, Kwapiszewska G, Dobner J, Nüsken KD, van Koningsbruggen-Rietschel S, von Hörsten S, Dötsch J, Alejandre Alcázar MA.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L491-L506. doi: 10.1152/ajplung.00432.2016. Epub 2017 Jun 1.

27.

Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension.

Schuoler C, Haider TJ, Leuenberger C, Vogel J, Ostergaard L, Kwapiszewska G, Kohler M, Gassmann M, Huber LC, Brock M.

Basic Res Cardiol. 2017 May;112(3):30. doi: 10.1007/s00395-017-0620-7. Epub 2017 Apr 13.

PMID:
28409279
28.

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Braun T, Morty RE, Günther A, Seeger W, Bellusci S.

Cell Stem Cell. 2017 Apr 6;20(4):571. doi: 10.1016/j.stem.2017.03.011. No abstract available.

29.

Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia.

Nagy BM, Nagaraj C, Egemnazarov B, Kwapiszewska G, Stauber RE, Avian A, Olschewski H, Olschewski A.

Front Physiol. 2017 Feb 21;8:98. doi: 10.3389/fphys.2017.00098. eCollection 2017.

30.

Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.

Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M.

FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1.

PMID:
28148565
31.

Meprin β contributes to collagen deposition in lung fibrosis.

Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G.

Sci Rep. 2017 Jan 6;7:39969. doi: 10.1038/srep39969.

32.

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC.

PMID:
28005404
33.

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C.

FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21.

PMID:
28003343
34.

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Braun T, Morty RE, Günther A, Seeger W, Bellusci S.

Cell Stem Cell. 2017 Feb 2;20(2):261-273.e3. doi: 10.1016/j.stem.2016.10.004. Epub 2016 Nov 17. Erratum in: Cell Stem Cell. 2017 Apr 6;20(4):571.

35.

[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. Epub 2016 Oct 19. German.

PMID:
27760444
36.

Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Nagaraj C, Tang B, Nagy BM, Papp R, Jain PP, Marsh LM, Meredith AL, Ghanim B, Klepetko W, Kwapiszewska G, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2016 Oct;48(4):1127-1136. doi: 10.1183/13993003.01814-2015. Epub 2016 Aug 18.

37.

[Research in Austria - the Ludwig Boltzmann Institute for Lung Vascular Research].

Kovacs G, Kleinschek D, Kwapiszewska G, Bálint Z, Olschewski H, Olschewski A.

Pneumologie. 2016 May;70(5):331-5. doi: 10.1055/s-0042-104767. Epub 2016 May 11. Review. German.

PMID:
27168041
38.

Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension.

Crnkovic S, Schmidt A, Egemnazarov B, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Olschewski A, Olschewski H, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L59-73. doi: 10.1152/ajplung.00381.2015. Epub 2016 Apr 22.

39.

Microarray analysis in pulmonary hypertension.

Hoffmann J, Wilhelm J, Olschewski A, Kwapiszewska G.

Eur Respir J. 2016 Jul;48(1):229-41. doi: 10.1183/13993003.02030-2015. Epub 2016 Apr 13. Review.

40.

[Pulmonary (Arterial) Hypertension].

Kwapiszewska G, Hoffmann J, Kovacs G, Stacher E, Olschewski A, Olschewski H.

Pneumologie. 2016 Oct;70(10):630-637. Epub 2016 Apr 6. Review. German.

PMID:
27050448
41.

Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: An in vitro study.

Wolff M, Czorlich P, Nagaraj C, Schnöbel-Ehehalt R, Li Y, Kwapiszewska G, Olschewski H, Heschl S, Olschewski A.

Neurosci Res. 2016 Aug;109:16-27. doi: 10.1016/j.neures.2016.02.006. Epub 2016 Mar 2.

PMID:
26945616
42.

Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema.

Reimann S, Fink L, Wilhelm J, Hoffmann J, Bednorz M, Seimetz M, Dessureault I, Troesser R, Ghanim B, Klepetko W, Seeger W, Weissmann N, Kwapiszewska G.

Respir Res. 2015 Oct 20;16:127. doi: 10.1186/s12931-015-0284-5.

43.

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Hoffmann J, Marsh LM, Pieper M, Stacher E, Ghanim B, Kovacs G, König P, Wilkens H, Haitchi HM, Hoefler G, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1002-13. doi: 10.1152/ajplung.00383.2014. Epub 2015 Apr 3.

44.

Pressure Overload Creates Right Ventricular Diastolic Dysfunction in a Mouse Model: Assessment by Echocardiography.

Egemnazarov B, Schmidt A, Crnkovic S, Sydykov A, Nagy BM, Kovacs G, Weissmann N, Olschewski H, Olschewski A, Kwapiszewska G, Marsh LM.

J Am Soc Echocardiogr. 2015 Jul;28(7):828-43. doi: 10.1016/j.echo.2015.02.014. Epub 2015 Apr 1.

PMID:
25840639
45.

High-mobility group box-1 induces vascular remodelling processes via c-Jun activation.

Zabini D, Crnkovic S, Xu H, Tscherner M, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G, Marsh LM.

J Cell Mol Med. 2015 May;19(5):1151-61. doi: 10.1111/jcmm.12519. Epub 2015 Feb 28.

46.

[Pulmonary arterial hypertension--a disease of the immune system?].

Riemekasten G, Kuebler WM, Schermuly R, Seyfarth HJ, Behr J, Grohe C, Hoeper MM, Olschewski A, Kwapiszewska G, Ulrich S, Voswinckel R, Weissmann N, Worth H, Viales RR, Pullamsetti SS, Grunig G.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S116-20. doi: 10.1055/s-0034-1387452. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489680
47.

[Epigenetics and genetics of pulmonary arterial hypertension--new insights from the last years].

Kwapiszewska G, Viales RR, Ehlken N, Eichstaedt CA, Riemekasten G, Grünig G, Mäder I, Schröder T, Klose H, Hinderhofer K, Fischer C, Ulrich S, Grünig E, Olschewski A.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S111-5. doi: 10.1055/s-0034-1387454. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489679
48.

Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.

Veith C, Zakrzewicz D, Dahal BK, Bálint Z, Murmann K, Wygrecka M, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Thromb Haemost. 2014 Dec;112(6):1288-303. doi: 10.1160/TH13-12-1031. Epub 2014 Sep 18.

PMID:
25231004
49.

Comprehensive analysis of inflammatory markers in chronic thromboembolic pulmonary hypertension patients.

Zabini D, Heinemann A, Foris V, Nagaraj C, Nierlich P, Bálint Z, Kwapiszewska G, Lang IM, Klepetko W, Olschewski H, Olschewski A.

Eur Respir J. 2014 Oct;44(4):951-62. doi: 10.1183/09031936.00145013. Epub 2014 Jul 17.

50.

Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.

Biasin V, Chwalek K, Wilhelm J, Best J, Marsh LM, Ghanim B, Klepetko W, Fink L, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Int J Biochem Cell Biol. 2014 Sep;54:137-48. doi: 10.1016/j.biocel.2014.06.020. Epub 2014 Jul 10.

PMID:
25016214

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