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Items: 1 to 50 of 77

1.

Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

Crnkovic S, Egemnazarov B, Damico R, Marsh LM, Nagy BM, Douschan P, Atsina K, Kolb TM, Mathai SC, Hooper JE, Ghanim B, Klepetko W, Fruhwald F, Lassner D, Olschewski A, Olschewski H, Hassoun PM, Kwapiszewska G.

Am J Respir Crit Care Med. 2018 Dec 17. doi: 10.1164/rccm.201809-1737OC. [Epub ahead of print]

PMID:
30557518
2.

Long non-coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1-AS1.

Jandl K, Thekkekara Puthenparampil H, Marsh LM, Hoffmann J, Wilhelm J, Veith C, Sinn K, Klepetko W, Olschewski H, Olschewski A, Brock M, Kwapiszewska G.

J Pathol. 2018 Nov 18. doi: 10.1002/path.5195. [Epub ahead of print]

PMID:
30450722
3.

Lessons from Transcriptomics in Hypoxia Induced Pulmonary Hypertension: Does the Mouse Strain Matter?

Marsh LM, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2018 Oct 18. doi: 10.1165/rcmb.2018-0307ED. [Epub ahead of print] No abstract available.

PMID:
30335513
4.

Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Sep 20. pii: S0167-5273(18)35661-4. doi: 10.1016/j.ijcard.2018.09.070. [Epub ahead of print]

PMID:
30314839
5.

Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.

Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G.

Thromb Haemost. 2018 Oct;118(10):1790-1802. doi: 10.1055/s-0038-1670657. Epub 2018 Sep 20.

PMID:
30235485
6.

Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner.

Gungl A, Biasin V, Wilhelm J, Olschewski A, Kwapiszewska G, Marsh LM.

Front Immunol. 2018 Sep 5;9:2018. doi: 10.3389/fimmu.2018.02018. eCollection 2018.

7.

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.

Eur Respir J. 2018 Nov 22;52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.

PMID:
30166321
8.

Biomarkers for Pulmonary Vascular Remodeling in Systemic Sclerosis: A Pathophysiological Approach.

Odler B, Foris V, Gungl A, Müller V, Hassoun PM, Kwapiszewska G, Olschewski H, Kovacs G.

Front Physiol. 2018 Jun 19;9:587. doi: 10.3389/fphys.2018.00587. eCollection 2018. Review.

9.

Translationally Controlled Tumor Protein in Extracellular Vehicles: Dangerous Cargo?

Jandl K, Gregory CD, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):407-409. doi: 10.1165/rcmb.2018-0160ED. No abstract available.

PMID:
29924940
10.

A Twist on Pulmonary Vascular Remodeling: Endothelial to Mesenchymal Transition?

Kwapiszewska G, Crnkovic S, Stenmark KR.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):140-141. doi: 10.1165/rcmb.2017-0314ED. No abstract available.

PMID:
29388836
11.

The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension.

Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Eur Respir J. 2018 Jan 25;51(1). pii: 1701214. doi: 10.1183/13993003.01214-2017. Print 2018 Jan.

12.

Resident cell lineages are preserved in pulmonary vascular remodeling.

Crnkovic S, Marsh LM, El Agha E, Voswinckel R, Ghanim B, Klepetko W, Stacher-Priehse E, Olschewski H, Bloch W, Bellusci S, Olschewski A, Kwapiszewska G.

J Pathol. 2018 Apr;244(4):485-498. doi: 10.1002/path.5044. Epub 2018 Mar 9.

13.

Right ventricular fibrosis and dysfunction: Actual concepts and common misconceptions.

Egemnazarov B, Crnkovic S, Nagy BM, Olschewski H, Kwapiszewska G.

Matrix Biol. 2018 Aug;68-69:507-521. doi: 10.1016/j.matbio.2018.01.010. Epub 2018 Jan 16. Review.

PMID:
29343458
14.

TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.

Olschewski A, Veale EL, Nagy BM, Nagaraj C, Kwapiszewska G, Antigny F, Lambert M, Humbert M, Czirják G, Enyedi P, Mathie A.

Eur Respir J. 2017 Nov 9;50(5). pii: 1700754. doi: 10.1183/13993003.00754-2017. Print 2017 Nov. Review.

PMID:
29122916
15.

Laser Capture Microdissection of Tissue Sections for High-Throughput RNA Analysis.

Hoffmann J, Wilhelm J, Kwapiszewska G.

Methods Mol Biol. 2017;1627:325-340. doi: 10.1007/978-1-4939-7113-8_21.

PMID:
28836211
16.

Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.

Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H.

Eur Respir J. 2017 Jul 20;50(1). pii: 1601651. doi: 10.1183/13993003.01651-2016. Print 2017 Jul.

PMID:
28729471
17.

Importance of kynurenine in pulmonary hypertension.

Nagy BM, Nagaraj C, Meinitzer A, Sharma N, Papp R, Foris V, Ghanim B, Kwapiszewska G, Kovacs G, Klepetko W, Pieber TR, Mangge H, Olschewski H, Olschewski A.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L741-L751. doi: 10.1152/ajplung.00517.2016. Epub 2017 Jul 13.

18.

Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction.

Thangaratnarajah C, Dinger K, Vohlen C, Klaudt C, Nawabi J, Lopez Garcia E, Kwapiszewska G, Dobner J, Nüsken KD, van Koningsbruggen-Rietschel S, von Hörsten S, Dötsch J, Alejandre Alcázar MA.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L491-L506. doi: 10.1152/ajplung.00432.2016. Epub 2017 Jun 1.

19.

Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension.

Schuoler C, Haider TJ, Leuenberger C, Vogel J, Ostergaard L, Kwapiszewska G, Kohler M, Gassmann M, Huber LC, Brock M.

Basic Res Cardiol. 2017 May;112(3):30. doi: 10.1007/s00395-017-0620-7. Epub 2017 Apr 13.

PMID:
28409279
20.

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Braun T, Morty RE, Günther A, Seeger W, Bellusci S.

Cell Stem Cell. 2017 Apr 6;20(4):571. doi: 10.1016/j.stem.2017.03.011. No abstract available.

21.

Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia.

Nagy BM, Nagaraj C, Egemnazarov B, Kwapiszewska G, Stauber RE, Avian A, Olschewski H, Olschewski A.

Front Physiol. 2017 Feb 21;8:98. doi: 10.3389/fphys.2017.00098. eCollection 2017.

22.

Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.

Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M.

FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1.

PMID:
28148565
23.

Meprin β contributes to collagen deposition in lung fibrosis.

Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G.

Sci Rep. 2017 Jan 6;7:39969. doi: 10.1038/srep39969.

24.

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC.

PMID:
28005404
25.

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C.

FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21.

PMID:
28003343
26.

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Braun T, Morty RE, Günther A, Seeger W, Bellusci S.

Cell Stem Cell. 2017 Feb 2;20(2):261-273.e3. doi: 10.1016/j.stem.2016.10.004. Epub 2016 Nov 17. Erratum in: Cell Stem Cell. 2017 Apr 6;20(4):571.

27.

[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. Epub 2016 Oct 19. German.

PMID:
27760444
28.

Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Nagaraj C, Tang B, Nagy BM, Papp R, Jain PP, Marsh LM, Meredith AL, Ghanim B, Klepetko W, Kwapiszewska G, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2016 Oct;48(4):1127-1136. doi: 10.1183/13993003.01814-2015. Epub 2016 Aug 18.

29.

[Research in Austria - the Ludwig Boltzmann Institute for Lung Vascular Research].

Kovacs G, Kleinschek D, Kwapiszewska G, Bálint Z, Olschewski H, Olschewski A.

Pneumologie. 2016 May;70(5):331-5. doi: 10.1055/s-0042-104767. Epub 2016 May 11. Review. German.

PMID:
27168041
30.

Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension.

Crnkovic S, Schmidt A, Egemnazarov B, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Olschewski A, Olschewski H, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L59-73. doi: 10.1152/ajplung.00381.2015. Epub 2016 Apr 22.

31.

Microarray analysis in pulmonary hypertension.

Hoffmann J, Wilhelm J, Olschewski A, Kwapiszewska G.

Eur Respir J. 2016 Jul;48(1):229-41. doi: 10.1183/13993003.02030-2015. Epub 2016 Apr 13. Review.

32.

[Pulmonary (Arterial) Hypertension].

Kwapiszewska G, Hoffmann J, Kovacs G, Stacher E, Olschewski A, Olschewski H.

Pneumologie. 2016 Oct;70(10):630-637. Epub 2016 Apr 6. Review. German.

PMID:
27050448
33.

Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: An in vitro study.

Wolff M, Czorlich P, Nagaraj C, Schnöbel-Ehehalt R, Li Y, Kwapiszewska G, Olschewski H, Heschl S, Olschewski A.

Neurosci Res. 2016 Aug;109:16-27. doi: 10.1016/j.neures.2016.02.006. Epub 2016 Mar 2.

PMID:
26945616
34.

Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema.

Reimann S, Fink L, Wilhelm J, Hoffmann J, Bednorz M, Seimetz M, Dessureault I, Troesser R, Ghanim B, Klepetko W, Seeger W, Weissmann N, Kwapiszewska G.

Respir Res. 2015 Oct 20;16:127. doi: 10.1186/s12931-015-0284-5.

35.

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Hoffmann J, Marsh LM, Pieper M, Stacher E, Ghanim B, Kovacs G, König P, Wilkens H, Haitchi HM, Hoefler G, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1002-13. doi: 10.1152/ajplung.00383.2014. Epub 2015 Apr 3.

36.

Pressure Overload Creates Right Ventricular Diastolic Dysfunction in a Mouse Model: Assessment by Echocardiography.

Egemnazarov B, Schmidt A, Crnkovic S, Sydykov A, Nagy BM, Kovacs G, Weissmann N, Olschewski H, Olschewski A, Kwapiszewska G, Marsh LM.

J Am Soc Echocardiogr. 2015 Jul;28(7):828-43. doi: 10.1016/j.echo.2015.02.014. Epub 2015 Apr 1.

PMID:
25840639
37.

High-mobility group box-1 induces vascular remodelling processes via c-Jun activation.

Zabini D, Crnkovic S, Xu H, Tscherner M, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G, Marsh LM.

J Cell Mol Med. 2015 May;19(5):1151-61. doi: 10.1111/jcmm.12519. Epub 2015 Feb 28.

38.

[Pulmonary arterial hypertension--a disease of the immune system?].

Riemekasten G, Kuebler WM, Schermuly R, Seyfarth HJ, Behr J, Grohe C, Hoeper MM, Olschewski A, Kwapiszewska G, Ulrich S, Voswinckel R, Weissmann N, Worth H, Viales RR, Pullamsetti SS, Grunig G.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S116-20. doi: 10.1055/s-0034-1387452. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489680
39.

[Epigenetics and genetics of pulmonary arterial hypertension--new insights from the last years].

Kwapiszewska G, Viales RR, Ehlken N, Eichstaedt CA, Riemekasten G, Grünig G, Mäder I, Schröder T, Klose H, Hinderhofer K, Fischer C, Ulrich S, Grünig E, Olschewski A.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S111-5. doi: 10.1055/s-0034-1387454. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489679
40.

Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.

Veith C, Zakrzewicz D, Dahal BK, Bálint Z, Murmann K, Wygrecka M, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Thromb Haemost. 2014 Dec;112(6):1288-303. doi: 10.1160/TH13-12-1031. Epub 2014 Sep 18.

PMID:
25231004
41.

Comprehensive analysis of inflammatory markers in chronic thromboembolic pulmonary hypertension patients.

Zabini D, Heinemann A, Foris V, Nagaraj C, Nierlich P, Bálint Z, Kwapiszewska G, Lang IM, Klepetko W, Olschewski H, Olschewski A.

Eur Respir J. 2014 Oct;44(4):951-62. doi: 10.1183/09031936.00145013. Epub 2014 Jul 17.

42.

Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.

Biasin V, Chwalek K, Wilhelm J, Best J, Marsh LM, Ghanim B, Klepetko W, Fink L, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Int J Biochem Cell Biol. 2014 Sep;54:137-48. doi: 10.1016/j.biocel.2014.06.020. Epub 2014 Jul 10.

PMID:
25016214
43.

Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature.

Grunig G, Marsh LM, Esmaeil N, Jackson K, Gordon T, Reibman J, Kwapiszewska G, Park SH.

Pulm Circ. 2014 Mar;4(1):25-35. doi: 10.1086/674902. Review.

44.

Distinct differences in gene expression patterns in pulmonary arteries of patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis with pulmonary hypertension.

Hoffmann J, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Kovacs G, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Respir Crit Care Med. 2014 Jul 1;190(1):98-111. doi: 10.1164/rccm.201401-0037OC.

PMID:
24918967
45.

NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension.

Crnkovic S, Egemnazarov B, Jain P, Seay U, Gattinger N, Marsh LM, Bálint Z, Kovacs G, Ghanim B, Klepetko W, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Br J Pharmacol. 2014 Aug;171(16):3895-907. doi: 10.1111/bph.12751.

46.

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.

Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Circulation. 2014 Apr 8;129(14):1510-23. doi: 10.1161/CIRCULATIONAHA.113.006402. Epub 2014 Jan 27.

PMID:
24470481
47.

Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension.

Biasin V, Marsh LM, Egemnazarov B, Wilhelm J, Ghanim B, Klepetko W, Wygrecka M, Olschewski H, Eferl R, Olschewski A, Kwapiszewska G.

J Pathol. 2014 May;233(1):7-17. doi: 10.1002/path.4303. Epub 2014 Jan 31.

PMID:
24258247
48.

Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis.

Wygrecka M, Didiasova M, Berscheid S, Piskulak K, Taborski B, Zakrzewicz D, Kwapiszewska G, Preissner KT, Markart P.

Thromb Haemost. 2013 Aug;110(2):295-307. doi: 10.1160/TH12-11-0854. Epub 2013 Jun 6.

PMID:
23739922
49.

Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension.

Veith C, Schmitt S, Veit F, Dahal BK, Wilhelm J, Klepetko W, Marta G, Seeger W, Schermuly RT, Grimminger F, Ghofrani HA, Fink L, Weissmann N, Kwapiszewska G.

Proteomics. 2013 Jan;13(1):75-88. doi: 10.1002/pmic.201200206.

PMID:
23161571
50.

BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.

Kwapiszewska G, Chwalek K, Marsh LM, Wygrecka M, Wilhelm J, Best J, Egemnazarov B, Weisel FC, Osswald SL, Schermuly RT, Olschewski A, Seeger W, Weissmann N, Eickelberg O, Fink L.

Am J Pathol. 2012 Dec;181(6):2018-29. doi: 10.1016/j.ajpath.2012.08.028. Epub 2012 Oct 8.

PMID:
23058367

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