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Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.

Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W.

Hepatology. 2019 Jun 12. doi: 10.1002/hep.30807. [Epub ahead of print]


CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling.

Mou H, Ozata DM, Smith JL, Sheel A, Kwan SY, Hough S, Kucukural A, Kennedy Z, Cao Y, Xue W.

Genome Med. 2019 Apr 16;11(1):21. doi: 10.1186/s13073-019-0627-9.


Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM.

Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.


Ictal networks of temporal lobe epilepsy: views from high-frequency oscillations in stereoelectroencephalography.

Peng SJ, Chou CC, Yu HY, Chen C, Yen DJ, Kwan SY, Hsu SPC, Lin CF, Chen HH, Lee CC.

J Neurosurg. 2018 Nov 1:1-9. doi: 10.3171/2018.6.JNS172844. [Epub ahead of print]


Sample Entropy of High Frequency Oscillations for Epileptogenic Zone Localization.

Su YC, Wu SC, Chen C, Chou CW, Hung SC, Lee Swindlehurst A, Kwan SY.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8512380.


Aberrant Sensory Gating of the Primary Somatosensory Cortex Contributes to the Motor Circuit Dysfunction in Paroxysmal Kinesigenic Dyskinesia.

Liu YT, Chen YC, Kwan SY, Chou CC, Yu HY, Yen DJ, Liao KK, Chen WT, Lin YY, Chen RS, Jih KY, Lu SF, Wu YT, Wang PS, Hsiao FJ.

Front Neurol. 2018 Oct 15;9:831. doi: 10.3389/fneur.2018.00831. eCollection 2018.


Electroencephalographic periodic discharges in Metronidazoleinduced encephalopathy: a case report.

Wang HH, Kwan SY.

Acta Neurol Taiwan. 2017 Dec 15;26(4):184-188. No abstract available.


Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Lu IL, Chen C, Tung CY, Chen HH, Pan JP, Chang CH, Cheng JS, Chen YA, Wang CH, Huang CW, Kang YN, Chang HY, Li LL, Chang KP, Shih YH, Lin CH, Kwan SY, Tsai JW.

Nat Commun. 2018 Jun 27;9(1):2498. doi: 10.1038/s41467-018-04880-8.


Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG.

Nat Chem Biol. 2018 Mar;14(3):311-316. doi: 10.1038/nchembio.2559. Epub 2018 Jan 29.


Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG.

Nat Biotechnol. 2017 Dec;35(12):1179-1187. doi: 10.1038/nbt.4005. Epub 2017 Nov 13.


Prognostic significance of postoperative spikes varied in different surgical procedures for mesial temporal sclerosis.

Yu HY, Hsu SPC, Lin CF, Shih YH, Yen DJ, Kwan SY, Chen C, Chou CC.

Seizure. 2017 Nov;52:71-75. doi: 10.1016/j.seizure.2017.09.018. Epub 2017 Oct 3.


Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition.

Ring KL, Yates MS, Schmandt R, Onstad M, Zhang Q, Celestino J, Kwan SY, Lu KH.

Int J Gynecol Cancer. 2017 Jun;27(5):854-862. doi: 10.1097/IGC.0000000000000960.


Ictus emeticus presenting as an unusual seizure type in chromosome 22q11.2 deletion syndrome.

Hung PL, Huang LT, Kwan SY, Chang KP, Chen HH, Lee YY, Fan HC, Chen C.

Epileptic Disord. 2017 Mar 1;19(1):76-81. doi: 10.1684/epd.2017.0899.


PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects.

Liu YT, Nian FS, Chou WJ, Tai CY, Kwan SY, Chen C, Kuo PW, Lin PH, Chen CY, Huang CW, Lee YC, Soong BW, Tsai JW.

Oncotarget. 2016 Jun 28;7(26):39184-39196. doi: 10.18632/oncotarget.9258.


Review of clinical studies of perampanel in adolescent patients.

Kim HD, Chi CS, Desudchit T, Nikanorova M, Visudtibhan A, Nabangchang C, Chan DW, Fong CY, Chang KP, Kwan SY, Reyes FL, Huang CC, Likasitwattanakul S, Lee WT, Yung A, Dash A.

Brain Behav. 2016 Jun 28;6(9):e00505. eCollection 2016 Sep. Review.


Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells.

Kwan SY, Cheng X, Tsang YT, Choi JS, Kwan SY, Izaguirre DI, Kwan HS, Gershenson DM, Wong KK.

Oncotarget. 2016 Aug 30;7(35):56933-56943. doi: 10.18632/oncotarget.10921.


Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1.

Au Yeung CL, Co NN, Tsuruga T, Yeung TL, Kwan SY, Leung CS, Li Y, Lu ES, Kwan K, Wong KK, Schmandt R, Lu KH, Mok SC.

Nat Commun. 2016 Mar 29;7:11150. doi: 10.1038/ncomms11150.


KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1.

Qiu MT, Fan Q, Zhu Z, Kwan SY, Chen L, Chen JH, Ying ZL, Zhou Y, Gu W, Wang LH, Cheng WW, Zeng J, Wan XP, Mok SC, Wong KK, Bao W.

Oncotarget. 2015 Oct 13;6(31):31702-20. doi: 10.18632/oncotarget.5165.


Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas.

Crane EK, Kwan SY, Izaguirre DI, Tsang YT, Mullany LK, Zu Z, Richards JS, Gershenson DM, Wong KK.

PLoS One. 2015 Aug 6;10(8):e0135101. doi: 10.1371/journal.pone.0135101. eCollection 2015.


Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy.

Kwan SY, Chuang YC, Huang CW, Chen TC, Jou SB, Dash A.

CNS Neurosci Ther. 2015 Sep;21(9):683-91. doi: 10.1111/cns.12418. Epub 2015 Jul 24.


Increased Intrinsic Connectivity of the Default Mode Network in Temporal Lobe Epilepsy: Evidence from Resting-State MEG Recordings.

Hsiao FJ, Yu HY, Chen WT, Kwan SY, Chen C, Yen DJ, Yiu CH, Shih YH, Lin YY.

PLoS One. 2015 Jun 2;10(6):e0128787. doi: 10.1371/journal.pone.0128787. eCollection 2015.


Theory of mind and social functioning in patients with temporal lobe epilepsy.

Wang WH, Shih YH, Yu HY, Yen DJ, Lin YY, Kwan SY, Chen C, Hua MS.

Epilepsia. 2015 Jul;56(7):1117-23. doi: 10.1111/epi.13023. Epub 2015 May 16.


Long-term health-related quality of life in drug-resistant temporal lobe epilepsy after anterior temporal lobectomy.

Chou CC, Shih YH, Yen DJ, Kwan SY, Yu HY.

Epileptic Disord. 2015 Jun;17(2):177-83. doi: 10.1684/epd.2015.0744.


Cognitive and epilepsy outcomes after epilepsy surgery caused by focal cortical dysplasia in children: early intervention maybe better.

Chen HH, Chen C, Hung SC, Liang SY, Lin SC, Hsu TR, Yeh TC, Yu HY, Lin CF, Hsu SP, Liang ML, Yang TF, Chu LS, Lin YY, Chang KP, Kwan SY, Ho DM, Wong TT, Shih YH.

Childs Nerv Syst. 2014 Nov;30(11):1885-95. doi: 10.1007/s00381-014-2463-y. Epub 2014 Oct 9.


Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53.

Co NN, Iglesias D, Celestino J, Kwan SY, Mok SC, Schmandt R, Lu KH.

Cancer. 2014 Nov 15;120(22):3457-68. doi: 10.1002/cncr.28854. Epub 2014 Jul 16.


KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low-grade serous carcinoma.

Tsang YT, Deavers MT, Sun CC, Kwan SY, Kuo E, Malpica A, Mok SC, Gershenson DM, Wong KK.

J Pathol. 2013 Dec;231(4):449-56. doi: 10.1002/path.4252.


Altered inhibitory modulation of somatosensory cortices in paroxysmal kinesigenic dyskinesia.

Hsu WY, Kwan SY, Liao KK, Chen RS, Lin YY.

Mov Disord. 2013 Oct;28(12):1728-31. doi: 10.1002/mds.25656. Epub 2013 Sep 20.


A robust hair segmentation and removal approach for clinical images of skin lesions.

Huang A, Kwan SY, Chang WY, Liu MY, Chi MH, Chen GS.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3315-8. doi: 10.1109/EMBC.2013.6610250.


Poor survival with wild-type TP53 ovarian cancer?

Wong KK, Izaguirre DI, Kwan SY, King ER, Deavers MT, Sood AK, Mok SC, Gershenson DM.

Gynecol Oncol. 2013 Sep;130(3):565-9. doi: 10.1016/j.ygyno.2013.06.016. Epub 2013 Jun 22.


Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia.

Hsu WY, Liao KK, Tseng YJ, Kwan SY, Chen RS, Lin YY.

Neurology. 2013 Jul 23;81(4):353-60. doi: 10.1212/WNL.0b013e31829c5e61. Epub 2013 Jun 21.


The Social and Occupational Functioning Scale for Epilepsy (SOFSE): a brief measure of functional status in a Taiwanese sample with epilepsy.

Wang WH, Yu HY, Yen DJ, Lin YY, Kwan SY, Chen C, Hua MS.

Epilepsia. 2013 May;54(5):888-97. doi: 10.1111/epi.12141. Epub 2013 Mar 18.


PAX2 Expression in Ovarian Cancer.

Song H, Kwan SY, Izaguirre DI, Zu Z, Tsang YT, Tung CS, King ER, Mok SC, Gershenson DM, Wong KK.

Int J Mol Sci. 2013 Mar 15;14(3):6090-105. doi: 10.3390/ijms14036090.


Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer.

Zaid TM, Yeung TL, Thompson MS, Leung CS, Harding T, Co NN, Schmandt RS, Kwan SY, Rodriguez-Aguay C, Lopez-Berestein G, Sood AK, Wong KK, Birrer MJ, Mok SC.

Clin Cancer Res. 2013 Feb 15;19(4):809-20. doi: 10.1158/1078-0432.CCR-12-2736. Epub 2013 Jan 23.


Abdominal auras in patients with mesial temporal sclerosis.

Kuan YC, Shih YH, Chen C, Yu HY, Yiu CH, Lin YY, Kwan SY, Yen DJ.

Epilepsy Behav. 2012 Nov;25(3):386-90. doi: 10.1016/j.yebeh.2012.07.034. Epub 2012 Oct 24.


Short-term results of vagus nerve stimulation in pediatric patients with refractory epilepsy.

Chen CY, Lee HT, Chen CC, Kwan SY, Chen SJ, Hsieh LP, Tsai JD; Taiwan Child Neurology Society VNS Study Group.

Pediatr Neonatol. 2012 Jun;53(3):184-7. doi: 10.1016/j.pedneo.2012.04.005. Epub 2012 Jun 5.


Stimulus-induced rhythmic, periodic, or ictal discharges--a case report.

Lin JH, Chen C, Shyu HY, Kwan SY, Yiu CH.

Clin Neurol Neurosurg. 2012 Nov;114(9):1283-6. doi: 10.1016/j.clineuro.2012.03.006. Epub 2012 Mar 23. No abstract available.


Sleep in patients with epilepsy.

Kwan SY.

Acta Neurol Taiwan. 2011 Dec;20(4):229-31. No abstract available.


Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex.

Wu J, Lee SW, Zhang X, Han F, Kwan SY, Yuan X, Yang WL, Jeong YS, Rezaeian AH, Gao Y, Zeng YX, Lin HK.

Oncogene. 2013 Jan 3;32(1):78-85. doi: 10.1038/onc.2012.26. Epub 2012 Feb 6.


Post-section recruitment of epileptiform discharges in electrocorticography during callosotomy in 48 patients with Lennox-Gastaut syndrome.

Lin JH, Kwan SY.

J Clin Neurosci. 2012 Mar;19(3):388-93. doi: 10.1016/j.jocn.2011.04.044. Epub 2012 Jan 26.


Preferential accumulation within tumors and in vivo imaging by functionalized luminescent dendrimer lanthanide complexes.

Alcala MA, Shade CM, Uh H, Kwan SY, Bischof M, Thompson ZP, Gogick KA, Meier AR, Strein TG, Bartlett DL, Modzelewski RA, Lee YJ, Petoud S, Brown CK.

Biomaterials. 2011 Dec;32(35):9343-52. doi: 10.1016/j.biomaterials.2011.07.076. Epub 2011 Sep 16.


An atypical case of Lennox-Gastaut syndrome not associated with mental retardation: a nosological issue.

Shyu HY, Lin JH, Chen C, Kwan SY, Yiu CH.

Seizure. 2011 Dec;20(10):820-3. doi: 10.1016/j.seizure.2011.08.001. Epub 2011 Aug 21.


Treatment-seeking behavior of people with epilepsy in Taiwan: a preliminary study.

Kuan YC, Yen DJ, Yiu CH, Lin YY, Kwan SY, Chen C, Chou CC, Yu HY.

Epilepsy Behav. 2011 Oct;22(2):308-12. doi: 10.1016/j.yebeh.2011.06.034. Epub 2011 Aug 2.


Reflex absence epilepsy induced by gait.

Lin JH, Shyu HY, Chen C, Kwan SY, Wong TT, Chang KP, Yiu CH.

Epilepsy Behav. 2011 Oct;22(2):395-7. doi: 10.1016/j.yebeh.2011.06.030. Epub 2011 Aug 3.


Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model.

Alcala MA, Kwan SY, Shade CM, Lang M, Uh H, Wang M, Weber SG, Bartlett DL, Petoud S, Lee YJ.

Nanomedicine. 2011 Jun;7(3):249-58. doi: 10.1016/j.nano.2010.09.002. Epub 2010 Oct 12.


Postoperative interictal epileptiform discharge within 1 month is associated with seizure recurrence after anterior temporal lobectomy.

Yu HY, Yen DJ, Yiu CH, Lin YY, Kwan SY, Chen C, Hsu SP, Shih YH.

Epilepsy Behav. 2010 Nov;19(3):436-40. doi: 10.1016/j.yebeh.2010.08.013. Epub 2010 Sep 17.


The role of intravenous valproate in convulsive status epilepticus in the future.

Kwan SY.

Acta Neurol Taiwan. 2010 Jun;19(2):78-81. No abstract available.


The Wada memory test and prediction of outcome after anterior temporal lobectomy.

Yu HY, Shih YH, Su TP, Shan IK, Yiu CH, Lin YY, Kwan SY, Chen C, Yen DJ.

J Clin Neurosci. 2010 Jul;17(7):857-61. doi: 10.1016/j.jocn.2009.11.027. Epub 2010 May 14.


Electrocorticogram changes during corpus callosotomy for uncontrolled symptomatic generalized epilepsy.

Shyu HY, Lin JH, Kwan SY, Chang KP, Yiu CH, Wong TT.

J Clin Neurosci. 2010 Jan;17(1):132-4. doi: 10.1016/j.jocn.2009.02.022. Epub 2009 Oct 27.


Preoperative IQ predicts seizure outcomes after anterior temporal lobectomy.

Yu HY, Shih YH, Su TP, Lin KN, Yiu CH, Lin YY, Kwan SY, Chen C, Yen DJ.

Seizure. 2009 Nov;18(9):639-43. doi: 10.1016/j.seizure.2009.07.009. Epub 2009 Aug 25.


Finding on brain MRI mimicking focal cortical dysplasia in early Rasmussen's encephalitis: a case report and review.

Chiang KL, Wong TT, Kwan SY, Hsu TR, Wang CH, Chang KP.

Childs Nerv Syst. 2009 Nov;25(11):1501-6. doi: 10.1007/s00381-009-0905-8. Epub 2009 Jun 11. Review.


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