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Non-neurologic adverse events after complex adult spinal deformity surgery: results from the prospective, multicenter Scoli-RISK-1 study.

Kwan KYH, Bow C, Samartzis D, Lenke LG, Shaffrey CI, Carreon LY, Dahl BT, Fehlings MG, Ames CP, Boachie-Adjei O, Dekutoski MB, Kebaish KM, Lewis SJ, Matsuyama Y, Mehdian H, Pellisé F, Qiu Y, Schwab FJ, Cheung KMC.

Eur Spine J. 2018 Oct 16. doi: 10.1007/s00586-018-5790-y. [Epub ahead of print]


The prevalence and years lived with disability caused by low back pain in China, 1990 to 2016: findings from the global burden of disease study 2016.

Wu A, Dong W, Liu S, Cheung JPY, Kwan KYH, Zeng X, Zhang K, Sun Z, Wang X, Cheung KMC, Zhou M, Zhao J.

Pain. 2018 Oct 3. doi: 10.1097/j.pain.0000000000001396. [Epub ahead of print]


3D-printing techniques in spine surgery: the future prospects and current challenges.

Wu AM, Lin JL, Kwan KYH, Wang XY, Zhao J.

Expert Rev Med Devices. 2018 Jun;15(6):399-401. doi: 10.1080/17434440.2018.1483234. Epub 2018 Jun 5. Review. No abstract available.


Mechanical and Clinical Evaluation of a Shape Memory Alloy and Conventional Struts in a Flexible Scoliotic Brace.

Chan WY, Yip J, Yick KL, Ng SP, Lu L, Cheung KM, Kwan KY, Cheung JP, Yeung KW, Tse CY.

Ann Biomed Eng. 2018 Aug;46(8):1194-1205. doi: 10.1007/s10439-018-2016-8. Epub 2018 Apr 24.


Prediction of survival in patients with symptomatic spinal metastases: Comparison between the Tokuhashi score and expert oncologists.

Kwan KYH, Lam TC, Choi HCW, Koh HY, Cheung KMC.

Surg Oncol. 2018 Mar;27(1):7-10. doi: 10.1016/j.suronc.2017.11.001. Epub 2017 Nov 3.


Brain transcriptome databases: a user's guide.

Keil JM, Qalieh A, Kwan KY.

J Neurosci. 2018 Feb 7. pii: 1930-17. doi: 10.1523/JNEUROSCI.1930-17.2018. [Epub ahead of print]


Radiologic discrepancies in children with special healthcare needs in a pediatric emergency department.

Festekjian A, Kwan KY, Chang TP, Lai H, Fahit M, Liberman DB.

Am J Emerg Med. 2018 Aug;36(8):1356-1362. doi: 10.1016/j.ajem.2017.12.041. Epub 2017 Dec 21.


Effectiveness of Schroth exercises during bracing in adolescent idiopathic scoliosis: results from a preliminary study-SOSORT Award 2017 Winner.

Kwan KYH, Cheng ACS, Koh HY, Chiu AYY, Cheung KMC.

Scoliosis Spinal Disord. 2017 Oct 16;12:32. doi: 10.1186/s13013-017-0139-6. eCollection 2017.


NEUROG1 Regulates CDK2 to Promote Proliferation in Otic Progenitors.

Song Z, Jadali A, Fritzsch B, Kwan KY.

Stem Cell Reports. 2017 Nov 14;9(5):1516-1529. doi: 10.1016/j.stemcr.2017.09.011. Epub 2017 Oct 12.


Single-Cell Transcriptome Analysis of Developing and Regenerating Spiral Ganglion Neurons.

Kwan KY.

Curr Pharmacol Rep. 2016 Oct;2(5):211-220. doi: 10.1007/s40495-016-0064-z. Epub 2016 Aug 4.


Unplanned Reoperations in Magnetically Controlled Growing Rod Surgery for Early Onset Scoliosis With a Minimum of Two-Year Follow-Up.

Kwan KYH, Alanay A, Yazici M, Demirkiran G, Helenius I, Nnadi C, Ferguson J, Akbarnia BA, Cheung JPY, Cheung KMC.

Spine (Phila Pa 1976). 2017 Dec 15;42(24):E1410-E1414. doi: 10.1097/BRS.0000000000002297.


Ten year follow-up of Jarcho-Levin syndrome with thoracic insufficiency treated by VEPTR and MCGR VEPTR hybrid.

Kwan KYH, Cheung JPY, Yiu KKL, Cheung KMC.

Eur Spine J. 2018 Jul;27(Suppl 3):287-291. doi: 10.1007/s00586-017-5164-x. Epub 2017 Jun 12.


Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival.

Jadali A, Ying YM, Kwan KY.

Front Cell Neurosci. 2017 May 18;11:137. doi: 10.3389/fncel.2017.00137. eCollection 2017.


Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network.

Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review.


Single-Cell Transcriptome Analysis of Neural Stem Cells.

Li Y, Anderson J, Kwan KY, Cai L.

Curr Pharmacol Rep. 2017 Apr;3(2):68-76. doi: 10.1007/s40495-017-0084-3. Epub 2017 Feb 27.


Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits.

Zappia KJ, O'Hara CL, Moehring F, Kwan KY, Stucky CL.

eNeuro. 2017 Mar 13;4(1). pii: ENEURO.0069-16.2017. doi: 10.1523/ENEURO.0069-16.2017. eCollection 2017 Jan-Feb.


Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains.

Akins MR, Berk-Rauch HE, Kwan KY, Mitchell ME, Shepard KA, Korsak LI, Stackpole EE, Warner-Schmidt JL, Sestan N, Cameron HA, Fallon JR.

Hum Mol Genet. 2017 Jan 1;26(1):192-209. doi: 10.1093/hmg/ddw381.


SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes.

Norris A, Tammineni P, Wang S, Gerdes J, Murr A, Kwan KY, Cai Q, Grant BD.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E307-E316. doi: 10.1073/pnas.1612730114. Epub 2017 Jan 4.


Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development.

Li Y, Tzatzalos E, Kwan KY, Grumet M, Cai L.

Sci Rep. 2016 Dec 7;6:38665. doi: 10.1038/srep38665.


TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.

Caubit X, Gubellini P, Andrieux J, Roubertoux PL, Metwaly M, Jacq B, Fatmi A, Had-Aissouni L, Kwan KY, Salin P, Carlier M, Liedén A, Rudd E, Shinawi M, Vincent-Delorme C, Cuisset JM, Lemaitre MP, Abderrehamane F, Duban B, Lemaitre JF, Woolf AS, Bockenhauer D, Severac D, Dubois E, Zhu Y, Sestan N, Garratt AN, Goff LK, Fasano L.

Nat Genet. 2016 Nov;48(11):1359-1369. doi: 10.1038/ng.3681. Epub 2016 Sep 26.


Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.

Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T.

EMBO J. 2016 Dec 1;35(23):2536-2552. Epub 2016 Jul 25.


Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea.

Jadali A, Kwan KY.

Biol Open. 2016 Jun 15;5(6):698-708. doi: 10.1242/bio.016758.


A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.

Iwase S, Brookes E, Agarwal S, Badeaux AI, Ito H, Vallianatos CN, Tomassy GS, Kasza T, Lin G, Thompson A, Gu L, Kwan KY, Chen C, Sartor MA, Egan B, Xu J, Shi Y.

Cell Rep. 2016 Feb 9;14(5):1000-1009. doi: 10.1016/j.celrep.2015.12.091. Epub 2016 Jan 21.


SHIELD: an integrative gene expression database for inner ear research.

Shen J, Scheffer DI, Kwan KY, Corey DP.

Database (Oxford). 2015 Jul 24;2015:bav071. doi: 10.1093/database/bav071. Print 2015.


Introducing Teamwork Challenges in Simulation Using Game Cards.

Chang TP, Kwan KY, Liberman D, Song E, Dao EH, Chung D, Morton I, Festekjian A.

Simul Healthc. 2015 Aug;10(4):223-6. doi: 10.1097/SIH.0000000000000089.


C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells.

Kwan KY, Shen J, Corey DP.

Stem Cell Reports. 2015 Jan 13;4(1):47-60. doi: 10.1016/j.stemcr.2014.11.001. Epub 2014 Dec 11.


Pediatric emergency medicine asynchronous e-learning: a multicenter randomized controlled Solomon four-group study.

Chang TP, Pham PK, Sobolewski B, Doughty CB, Jamal N, Kwan KY, Little K, Brenkert TE, Mathison DJ.

Acad Emerg Med. 2014 Aug;21(8):912-9. doi: 10.1111/acem.12434. Epub 2014 Aug 24.


Dysregulated nitric oxide signaling as a candidate mechanism of fragile X syndrome and other neuropsychiatric disorders.

Colvin SM, Kwan KY.

Front Genet. 2014 Jul 22;5:239. doi: 10.3389/fgene.2014.00239. eCollection 2014. Review.


Nitric oxide signaling in the development and evolution of language and cognitive circuits.

Funk OH, Kwan KY.

Neurosci Res. 2014 Sep;86:77-87. doi: 10.1016/j.neures.2014.06.001. Epub 2014 Jun 13. Review.


EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding.

Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Dravis C, Kwan KY, Šestan N, Greenberg ME, Henkemeyer M, Cowan CW.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2188-93. doi: 10.1073/pnas.1324215111. Epub 2014 Jan 22.


Transcriptional dysregulation of neocortical circuit assembly in ASD.

Kwan KY.

Int Rev Neurobiol. 2013;113:167-205. doi: 10.1016/B978-0-12-418700-9.00006-X. Review.


Cis-regulatory control of corticospinal system development and evolution.

Shim S, Kwan KY, Li M, Lefebvre V, Sestan N.

Nature. 2012 May 30;486(7401):74-9. doi: 10.1038/nature11094.


Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.

Kwan KY, Lam MM, Johnson MB, Dube U, Shim S, Rašin MR, Sousa AM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostović I, Judaš M, Sestan N.

Cell. 2012 May 11;149(4):899-911. doi: 10.1016/j.cell.2012.02.060.


Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex.

Kwan KY, Sestan N, Anton ES.

Development. 2012 May;139(9):1535-46. doi: 10.1242/dev.069963. Review.


TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS.

Nat Neurosci. 2011 Dec 11;15(1):70-80. doi: 10.1038/nn.3000.


Recessive LAMC3 mutations cause malformations of occipital cortical development.

Barak T, Kwan KY, Louvi A, Demirbilek V, Saygı S, Tüysüz B, Choi M, Boyacı H, Doerschner K, Zhu Y, Kaymakçalan H, Yılmaz S, Bakırcıoğlu M, Cağlayan AO, Oztürk AK, Yasuno K, Brunken WJ, Atalar E, Yalçınkaya C, Dinçer A, Bronen RA, Mane S, Ozçelik T, Lifton RP, Sestan N, Bilgüvar K, Günel M.

Nat Genet. 2011 Jun;43(6):590-4. doi: 10.1038/ng.836. Epub 2011 May 15.


TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract.

Han W, Kwan KY, Shim S, Lam MM, Shin Y, Xu X, Zhu Y, Li M, Sestan N.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3041-6. doi: 10.1073/pnas.1016723108. Epub 2011 Feb 1.


Diagnosing pediatric appendicitis: usefulness of laboratory markers.

Kwan KY, Nager AL.

Am J Emerg Med. 2010 Nov;28(9):1009-15. doi: 10.1016/j.ajem.2009.06.004. Epub 2010 Mar 9.


Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.

Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioğlu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandaş S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M.

Nature. 2010 Sep 9;467(7312):207-10. doi: 10.1038/nature09327. Epub 2010 Aug 22.


The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.

Brierley SM, Hughes PA, Page AJ, Kwan KY, Martin CM, O'Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LA.

Gastroenterology. 2009 Dec;137(6):2084-2095.e3. doi: 10.1053/j.gastro.2009.07.048. Epub 2009 Jul 24.


TRPA1 modulates mechanotransduction in cutaneous sensory neurons.

Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CL.

J Neurosci. 2009 Apr 15;29(15):4808-19. doi: 10.1523/JNEUROSCI.5380-08.2009.


Burning cold: involvement of TRPA1 in noxious cold sensation.

Kwan KY, Corey DP.

J Gen Physiol. 2009 Mar;133(3):251-6. doi: 10.1085/jgp.200810146. No abstract available.


Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia.

Fertuzinhos S, Krsnik Z, Kawasawa YI, Rasin MR, Kwan KY, Chen JG, Judas M, Hayashi M, Sestan N.

Cereb Cortex. 2009 Sep;19(9):2196-207. doi: 10.1093/cercor/bhp009. Epub 2009 Feb 20.


TRPA1 acts as a cold sensor in vitro and in vivo.

Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan KY, Vennekens R, Nilius B, Voets T.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1273-8. doi: 10.1073/pnas.0808487106. Epub 2009 Jan 14.


Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study.

Limquiaco JL, Wong J, Wong VW, Wong GL, Tse CH, Chan HY, Kwan KY, Lai PB, Chan HL.

J Med Virol. 2009 Feb;81(2):224-9. doi: 10.1002/jmv.21369.


SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons.

Kwan KY, Lam MM, Krsnik Z, Kawasawa YI, Lefebvre V, Sestan N.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16021-6. doi: 10.1073/pnas.0806791105. Epub 2008 Oct 7.


Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.

Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5063-8. doi: 10.1073/pnas.0801235105. Epub 2008 Mar 26.


Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.

Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnár Z, Tarabykin V.

Neuron. 2008 Feb 7;57(3):378-92. doi: 10.1016/j.neuron.2007.12.028.


An ion channel essential for sensing chemical damage.

Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A.

J Neurosci. 2007 Oct 17;27(42):11412-5.


Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.

Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N.

Nat Neurosci. 2007 Jul;10(7):819-27. Epub 2007 Jun 24.


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