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LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation.

Carney KR, Bryan CD, Gordon HB, Kwan KM.

Dev Biol. 2019 Oct 5. pii: S0012-1606(19)30414-2. doi: 10.1016/j.ydbio.2019.09.016. [Epub ahead of print]


Cellular crowding influences extrusion and proliferation to facilitate epithelial tissue repair.

Franco JJ, Atieh Y, Bryan CD, Kwan KM, Eisenhoffer GT.

Mol Biol Cell. 2019 Jul 22;30(16):1890-1899. doi: 10.1091/mbc.E18-05-0295. Epub 2019 Feb 20.


Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration.

Yang M, Zhang Q, Wang Q, Sørensen KK, Boesen JT, Ma SY, Jensen KJ, Kwan KM, Ngo JCK, Chan HYE, Zuo Z.

Mol Pharm. 2018 Dec 3;15(12):5781-5792. doi: 10.1021/acs.molpharmaceut.8b00938. Epub 2018 Nov 12.


Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration.

Wang Q, Peng S, Hu Y, Wong CH, Kwan KM, Chan HYE, Zuo Z.

Eur J Pharm Sci. 2019 Jan 15;127:240-251. doi: 10.1016/j.ejps.2018.10.025. Epub 2018 Nov 1.


Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis.

Gordon HB, Lusk S, Carney KR, Wirick EO, Murray BF, Kwan KM.

Development. 2018 Nov 19;145(22). pii: dev165068. doi: 10.1242/dev.165068.


Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.

Chen ZS, Li L, Peng S, Chen FM, Zhang Q, An Y, Lin X, Li W, Koon AC, Chan TF, Lau KF, Ngo JCK, Wong WT, Kwan KM, Chan HYE.

EMBO Rep. 2018 Sep;19(9). pii: e45409. doi: 10.15252/embr.201745409. Epub 2018 Jul 19.


School accreditation scheme reduces childhood obesity in Hong Kong.

Fu YCA, To KC, Tao WY, Kwan KMA, Lee YH, Fung YKA, Ching CTR, Chung WHT.

Glob Health Promot. 2018 May 29:1757975918764318. doi: 10.1177/1757975918764318. [Epub ahead of print]


Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.

Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM.

Nat Commun. 2017 May 18;8:15079. doi: 10.1038/ncomms15079.


Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow.

Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y.

Nature. 2016 Dec 22;540(7634):579-582. doi: 10.1038/nature20602. Epub 2016 Dec 7.


Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis.

Bryan CD, Chien CB, Kwan KM.

Dev Biol. 2016 Aug 15;416(2):324-37. doi: 10.1016/j.ydbio.2016.06.025. Epub 2016 Jun 20.


Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT.

Zhu J, Kwan KM, Mackem S.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3820-5. doi: 10.1073/pnas.1601252113. Epub 2016 Mar 22.


Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity.

Lam YF, Tong KK, Kwan KM, Tsuneyama K, Shu SA, Leung PS, Chu KH.

Int Arch Allergy Immunol. 2015;167(1):29-40. doi: 10.1159/000431228. Epub 2015 Jun 25.


Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.

Fossat N, Ip CK, Jones VJ, Studdert JB, Khoo PL, Lewis SL, Power M, Tourle K, Loebel DA, Kwan KM, Behringer RR, Tam PP.

Development. 2015 Jun 1;142(11):2069-79. doi: 10.1242/dev.120907. Epub 2015 May 14.


Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum.

Vong KI, Leung CK, Behringer RR, Kwan KM.

Mol Brain. 2015 Apr 12;8:25. doi: 10.1186/s13041-015-0115-0.


BMP/Smad signaling and embryonic cerebellum development: stem cell specification and heterogeneity of anterior rhombic lip.

Tong KK, Ma TC, Kwan KM.

Dev Growth Differ. 2015 Feb;57(2):121-34. doi: 10.1111/dgd.12198. Epub 2015 Feb 23. Review.


High-resolution analysis of central nervous system expression patterns in zebrafish Gal4 enhancer-trap lines.

Otsuna H, Hutcheson DA, Duncan RN, McPherson AD, Scoresby AN, Gaynes BF, Tong Z, Fujimoto E, Kwan KM, Chien CB, Dorsky RI.

Dev Dyn. 2015 Jun;244(6):785-96. doi: 10.1002/dvdy.24260. Epub 2015 Apr 23.


Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal transmembrane protein.

Tam WY, Jiang L, Kwan KM.

Protoplasma. 2015 Jul;252(4):977-83. doi: 10.1007/s00709-014-0733-x. Epub 2014 Nov 25.


Coming into focus: the role of extracellular matrix in vertebrate optic cup morphogenesis.

Kwan KM.

Dev Dyn. 2014 Oct;243(10):1242-8. doi: 10.1002/dvdy.24162. Epub 2014 Jul 19. Review.


Lhx1 is required in Müllerian duct epithelium for uterine development.

Huang CC, Orvis GD, Kwan KM, Behringer RR.

Dev Biol. 2014 May 15;389(2):124-36. doi: 10.1016/j.ydbio.2014.01.025. Epub 2014 Feb 21.


Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.

Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo J, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X, Huang Y.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):152-9. doi: 10.1161/ATVBAHA.113.302696. Epub 2013 Nov 7.


Management plan to reduce risks in perioperative care of patients with obstructive sleep apnoea averts the need for presurgical polysomnography.

Chong CT, Tey J, Leow SL, Low W, Kwan KM, Wong YL, Lew TW.

Ann Acad Med Singapore. 2013 Mar;42(3):110-9.


Dietary calcium decreases plasma cholesterol level only in female but not in male hamster fed a high cholesterol diet.

Ma KY, Liang YT, Chen JN, Jiang Y, Kwan KM, Peng C, Jiao R, Zuo YY, Huang Y, Chen ZY.

Biomed Environ Sci. 2012 Aug;25(4):392-8. doi: 10.3967/0895-3988.2012.04.003.


Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.

Wong YL, Behringer RR, Kwan KM.

Dev Biol. 2012 Mar 1;363(1):247-57. doi: 10.1016/j.ydbio.2011.12.037. Epub 2012 Jan 3.


Blueberry extract prolongs lifespan of Drosophila melanogaster.

Peng C, Zuo Y, Kwan KM, Liang Y, Ma KY, Chan HY, Huang Y, Yu H, Chen ZY.

Exp Gerontol. 2012 Feb;47(2):170-8. doi: 10.1016/j.exger.2011.12.001. Epub 2011 Dec 17.


A complex choreography of cell movements shapes the vertebrate eye.

Kwan KM, Otsuna H, Kidokoro H, Carney KR, Saijoh Y, Chien CB.

Development. 2012 Jan;139(2):359-72. doi: 10.1242/dev.071407.


Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway.

Tian XY, Yung LH, Wong WT, Liu J, Leung FP, Liu L, Chen Y, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X, Huang Y.

J Mol Cell Cardiol. 2012 Jan;52(1):237-44. doi: 10.1016/j.yjmcc.2011.10.013. Epub 2011 Oct 25.


Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum.

Tam WY, Leung CK, Tong KK, Kwan KM.

Neuroscience. 2011 Jan 13;172:562-71. doi: 10.1016/j.neuroscience.2010.10.023. Epub 2010 Oct 15.


Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse.

Tanaka SS, Yamaguchi YL, Steiner KA, Nakano T, Nishinakamura R, Kwan KM, Behringer RR, Tam PP.

Dev Dyn. 2010 Nov;239(11):2851-9. doi: 10.1002/dvdy.22417.


Cthrc1 is a positive regulator of osteoblastic bone formation.

Kimura H, Kwan KM, Zhang Z, Deng JM, Darnay BG, Behringer RR, Nakamura T, de Crombrugghe B, Akiyama H.

PLoS One. 2008 Sep 9;3(9):e3174. doi: 10.1371/journal.pone.0003174.


Somal positioning and dendritic growth of horizontal cells are regulated by interactions with homotypic neighbors.

Poché RA, Raven MA, Kwan KM, Furuta Y, Behringer RR, Reese BE.

Eur J Neurosci. 2008 Apr;27(7):1607-14. doi: 10.1111/j.1460-9568.2008.06132.x.


Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.

Orvis GD, Jamin SP, Kwan KM, Mishina Y, Kaartinen VM, Huang S, Roberts AB, Umans L, Huylebroeck D, Zwijsen A, Wang D, Martin JF, Behringer RR.

Biol Reprod. 2008 Jun;78(6):994-1001. doi: 10.1095/biolreprod.107.066605. Epub 2008 Mar 5.


Lim1 is essential for the correct laminar positioning of retinal horizontal cells.

Poché RA, Kwan KM, Raven MA, Furuta Y, Reese BE, Behringer RR.

J Neurosci. 2007 Dec 19;27(51):14099-107.


The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs.

Kwan KM, Fujimoto E, Grabher C, Mangum BD, Hardy ME, Campbell DS, Parant JM, Yost HJ, Kanki JP, Chien CB.

Dev Dyn. 2007 Nov;236(11):3088-99.


LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.

Zhao Y, Kwan KM, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR, Westphal H.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13182-6. Epub 2007 Jul 30.


Laser capture-microarray analysis of Lim1 mutant kidney development.

Potter SS, Hartman HA, Kwan KM, Behringer RR, Patterson LT.

Genesis. 2007 Jul;45(7):432-9.


Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function.

Tsang KY, Chan D, Cheslett D, Chan WC, So CL, Melhado IG, Chan TW, Kwan KM, Hunziker EB, Yamada Y, Bateman JF, Cheung KM, Cheah KS.

PLoS Biol. 2007 Mar;5(3):e44.


Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice.

Chen YT, Kobayashi A, Kwan KM, Johnson RL, Behringer RR.

BMC Nephrol. 2006 Feb 7;7:1.


A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis.

Kwan KM, Kirschner MW.

Development. 2005 Oct;132(20):4599-610. Epub 2005 Sep 21.


Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development.

Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR.

Development. 2005 Jun;132(12):2809-23.


The Drosophila MOS ortholog is not essential for meiosis.

Ivanovska I, Lee E, Kwan KM, Fenger DD, Orr-Weaver TL.

Curr Biol. 2004 Jan 6;14(1):75-80.


Notch signaling controls multiple steps of pancreatic differentiation.

Murtaugh LC, Stanger BZ, Kwan KM, Melton DA.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14920-5. Epub 2003 Dec 1.


Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome.

Lew TW, Kwek TK, Tai D, Earnest A, Loo S, Singh K, Kwan KM, Chan Y, Yim CF, Bek SL, Kor AC, Yap WS, Chelliah YR, Lai YC, Goh SK.

JAMA. 2003 Jul 16;290(3):374-80.


A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice.

Purandare SM, Ware SM, Kwan KM, Gebbia M, Bassi MT, Deng JM, Vogel H, Behringer RR, Belmont JW, Casey B.

Development. 2002 May;129(9):2293-302.


Conditional inactivation of Lim1 function.

Kwan KM, Behringer RR.

Genesis. 2002 Feb;32(2):118-20. No abstract available.


Conditional alleles in mice: practical considerations for tissue-specific knockouts.

Kwan KM.

Genesis. 2002 Feb;32(2):49-62. Review. No abstract available.


A case report of a fractured healthytooth during use of Guedel oropharyngeal airway.

Kok PH, Kwan KM, Koay CK.

Singapore Med J. 2001 Jul;42(7):322-4.


Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo.

Tsang TE, Shawlot W, Kinder SJ, Kobayashi A, Kwan KM, Schughart K, Kania A, Jessell TM, Behringer RR, Tam PP.

Dev Biol. 2000 Jul 1;223(1):77-90.


Requirement of LIM domains for LIM1 function in mouse head development.

Cheah SS, Kwan KM, Behringer RR.

Genesis. 2000 May;27(1):12-21.


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