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Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial.

Nichols AC, Lang P, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Fung K, de Almeida JR, Bayley A, Goldstein DP, Eskander A, Husain Z, Bahig H, Christopoulous A, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Mendez A, Winquist E, Read N, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Corsten M, Rajaraman M, Johnson-Obaseki S, Eapen L, Odell M, Chandarana S, Banerjee R, Dort J, Matthews TW, Hart R, Kerr P, Dowthwaite S, Gupta M, Zhang H, Wright J, Parker C, Wehrli B, Kwan K, Theurer J, Palma DA.

BMC Cancer. 2020 Feb 14;20(1):125. doi: 10.1186/s12885-020-6607-z.


Optic cup morphogenesis requires neural crest-mediated basement membrane assembly.

Bryan CD, Casey MA, Pfeiffer RL, Jones BW, Kwan KM.

Development. 2020 Jan 27. pii: dev.181420. doi: 10.1242/dev.181420. [Epub ahead of print]


Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways.

Yu AX, Xu ML, Yao P, Kwan KK, Liu YX, Duan R, Dong TT, Ko RK, Tsim KW.

FASEB J. 2020 Jan 21. doi: 10.1096/fj.201902319RRR. [Epub ahead of print]


Minimally Invasive Navigated Foraminal Discectomy via Contralateral Approach Using a 3-Dimensional 4K High-Definition Exoscope: 2-Dimensional Operative Video.

Oren J, Kwan K, Schneider J, Levine M, Langer D.

Oper Neurosurg (Hagerstown). 2019 Dec 24. pii: opz392. doi: 10.1093/ons/opz392. [Epub ahead of print]


Identification and characterization of occult human-specific LINE-1 insertions using long-read sequencing technology.

Zhou W, Emery SB, Flasch DA, Wang Y, Kwan KY, Kidd JM, Moran JV, Mills RE.

Nucleic Acids Res. 2020 Feb 20;48(3):1146-1163. doi: 10.1093/nar/gkz1173.


Developments in Bio-Inspired Nanomaterials for Therapeutic Delivery to Treat Hearing Loss.

Rathnam C, Chueng SD, Ying YM, Lee KB, Kwan K.

Front Cell Neurosci. 2019 Nov 6;13:493. doi: 10.3389/fncel.2019.00493. eCollection 2019. Review.


A rare case of retroperitoneal and mesenteric lymphangiomatosis.

Chan WYS, Kwan KEL, Teo LT.

Radiol Case Rep. 2019 Nov 8;15(1):11-14. doi: 10.1016/j.radcr.2019.09.039. eCollection 2020 Jan.


Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents.

Huang Y, Kwan KKL, Leung KW, Yao P, Wang H, Dong TT, Tsim KWK.

J Ginseng Res. 2019 Oct;43(4):517-526. doi: 10.1016/j.jgr.2018.02.002. Epub 2018 Feb 12.


Possible Abscopal Effect Observed in Frontal Meningioma After Localized IMRT on Posterior Meningioma Resection Cavity Without Adjuvant Immunotherapy.

Golub D, Kwan K, Knisely JPS, Schulder M.

Front Oncol. 2019 Oct 18;9:1109. doi: 10.3389/fonc.2019.01109. eCollection 2019.


Children's Appraisals of Gender Nonconformity: Developmental Pattern and Intervention.

Kwan KMW, Shi SY, Nabbijohn AN, MacMullin LN, VanderLaan DP, Wong WI.

Child Dev. 2019 Oct 24. doi: 10.1111/cdev.13316. [Epub ahead of print]


Youth Kicker's Knee: Lateral Distal Femoral Hemiphyseal Arrest Secondary to Chronic Repetitive Microtrauma.

Dempewolf M, Kwan K, Sherman B, Schlechter JA.

J Am Acad Orthop Surg Glob Res Rev. 2019 Aug 6;3(8):e079. doi: 10.5435/JAAOSGlobal-D-19-00079. eCollection 2019 Aug.


LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation.

Carney KR, Bryan CD, Gordon HB, Kwan KM.

Dev Biol. 2020 Feb 1;458(1):1-11. doi: 10.1016/j.ydbio.2019.09.016. Epub 2019 Oct 5.


Cerebrospinal fluid macrophage migration inhibitory factor: a potential predictor of cerebral vasospasm and clinical outcome after aneurysmal subarachnoid hemorrhage.

Kwan K, Arapi O, Wagner KE, Schneider J, Sy HL, Ward MF, Sison CP, Li C, Eisenberg MB, Chalif D, Narayan RK, Miller EJ, Ledoux D.

J Neurosurg. 2019 Oct 4:1-6. doi: 10.3171/2019.6.JNS19613. [Epub ahead of print]


The Crooked Rod Sign: A New Radiological Sign to Detect Deformed Threads in the Distraction Mechanism of Magnetically Controlled Growing Rods and a Mode of Distraction Failure.

Cheung JPY, Zhang T, Bow C, Kwan K, Sze KY, Cheung KMC.

Spine (Phila Pa 1976). 2019 Sep 30. doi: 10.1097/BRS.0000000000003268. [Epub ahead of print]


Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations.

Kwan K, Schneider J, Ullman JS.

Front Neurol. 2019 Sep 6;10:876. doi: 10.3389/fneur.2019.00876. eCollection 2019. Review.


Unilateral Venous Approach to Contralateral or Bilateral Carotid Cavernous Shunts.

Nossek E, Lombardo K, Schneider JR, Kwan K, Chalif DJ, Setton A.

World Neurosurg. 2020 Jan;133:e479-e486. doi: 10.1016/j.wneu.2019.09.054. Epub 2019 Sep 18.


Resection of a Posterior Fossa Endodermal Cyst With Exoscopic Assistance: 2-Dimensional Operative Video.

Kleshchova O, White TG, Kwan K, Chiluwal A, Anderson TA, Langer DJ.

Oper Neurosurg (Hagerstown). 2019 Aug 27. pii: opz238. doi: 10.1093/ons/opz238. [Epub ahead of print]


Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial.

Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Eapen L, Odell M, Parker C, Wehrli B, Kwan K, Palma DA.

Lancet Oncol. 2019 Oct;20(10):1349-1359. doi: 10.1016/S1470-2045(19)30410-3. Epub 2019 Aug 12. Erratum in: Lancet Oncol. 2019 Dec;20(12):e663.


Selection of Lowest Instrumented Vertebra Using Fulcrum Bending Radiographs Achieved Shorter Fusion Safely Compared With the Last "Substantially" Touching Vertebra in Lenke Type 1A and 2A Curves.

Kwan KYH, Wong CP, Koh HY, Cheung KMC.

Spine (Phila Pa 1976). 2019 Dec 15;44(24):E1419-E1427. doi: 10.1097/BRS.0000000000003182.


Impact of Thoracic Cage Dimension and Geometry on Cardiopulmonary Function in Patients With Congenital Scoliosis: A Prospective Study.

Lin Y, Tan H, Rong T, Chen C, Shen J, Liu S, Yuan W, Cong H, Chen L, Luo J, Kwan KYH.

Spine (Phila Pa 1976). 2019 Oct 15;44(20):1441-1448. doi: 10.1097/BRS.0000000000003178.


Founder Mutation c.1516A>C in KLHL40 Is a Frequent Cause of Nemaline Myopathy With Hyponatremia in Ethnic Chinese.

Lee HH, Wong S, Leung FY, Ho LC, Chan ST, Fung TS, Kwan KF, Yau KE, Li KW, Yau WN, Leung HC, Chen SP, Mak CM.

J Neuropathol Exp Neurol. 2019 Sep 1;78(9):854-864. doi: 10.1093/jnen/nlz056.


Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Modulates Mitochondrial Bioenergetics in Cultured Cardiomyoblasts.

Kwan KKL, Huang Y, Leung KW, Dong TTX, Tsim KWK.

Front Pharmacol. 2019 Jun 21;10:614. doi: 10.3389/fphar.2019.00614. eCollection 2019.


Missing Naïve T Cells in the Setting of Glioblastoma Are Found to Be Sequestered in the Bone Marrow.

Schneider JR, Kwan K, Boockvar JA.

Neurosurgery. 2019 Aug 1;85(2):E194-E195. doi: 10.1093/neuros/nyz167. No abstract available.


Repeat Assault Injury Among Adolescents Utilizing Emergency Care: A Statewide Longitudinal Study.

Kwan K, Wiebe D, Cerdá M, Goldman-Mellor S.

J Emerg Med. 2019 Aug;57(2):254-262. doi: 10.1016/j.jemermed.2019.05.030. Epub 2019 Jun 29.


Cardiopulmonary Function in Patients with Congenital Scoliosis: An Observational Study.

Lin Y, Shen J, Chen L, Yuan W, Cong H, Luo J, Kwan KYH.

J Bone Joint Surg Am. 2019 Jun 19;101(12):1109-1118. doi: 10.2106/JBJS.18.00935.


Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion.

Shi L, Qalieh A, Lam MM, Keil JM, Kwan KY.

Nat Commun. 2019 Jun 13;10(1):2588. doi: 10.1038/s41467-019-10411-w.


Single-Cell Fluorescence Analysis of Pseudotemporal Ordered Cells Provides Protein Expression Dynamics for Neuronal Differentiation.

Song Z, Laureano AS, Patel K, Yip S, Jadali A, Kwan KY.

Front Cell Dev Biol. 2019 May 29;7:87. doi: 10.3389/fcell.2019.00087. eCollection 2019.


An electro-osmotic microfluidic system to characterize cancer cell migration under confinement.

Hui TH, Cho WC, Fong HW, Yu M, Kwan KW, Ngan KC, Wong KH, Tan Y, Yao S, Jiang H, Gu Z, Lin Y.

J R Soc Interface. 2019 Jun 28;16(155):20190062. doi: 10.1098/rsif.2019.0062. Epub 2019 Jun 5.


Author Correction: Draft genomic and transcriptome resources for marine chelicerate Tachypleus tridentatus.

Liao YY, Xu PW, Kwan KY, Ma ZY, Fang HY, Xu JY, Wang PL, Yang SY, Xie SB, Xu SQ, Dan Qian, Li WF, Bai LR, Zhou DJ, Zhang YQ, Lei J, Liu K, Li F, Li J, Zhu P, Wang YJ, Wu HP, Xu YH, Huang H, Zhang C, Liu JX, Han JF.

Sci Data. 2019 Mar 26;6(1):11. doi: 10.1038/s41597-019-0025-6.


Minimum 2-Year Experience with Magnetically Controlled Growing Rods for the Treatment of Early-Onset Scoliosis: A Systematic Review.

Wu AM, Cheung JPY, Cheung KMC, Lin JL, Jin HM, Chen D, Wang XY, Zhao J, Kwan KYH.

Asian Spine J. 2019 Mar 26;13(4):682-693. doi: 10.31616/asj.2018.0272. Print 2019 Aug.


Draft genomic and transcriptome resources for marine chelicerate Tachypleus tridentatus.

Liao YY, Xu PW, Kwan KY, Ma ZY, Fang HY, Xu JY, Wang PL, Yang SY, Xie SB, Xu SQ, Qian D, Li WF, Bai LR, Zhou DJ, Zhang YQ, Lei J, Liu K, Li F, Li J, Zhu P, Wang YJ, Wu HP, Xu YH, Huang H, Zhang C, Liu JX, Han JF.

Sci Data. 2019 Feb 26;6:190029. doi: 10.1038/sdata.2019.29. Erratum in: Sci Data. 2019 Mar 26;6(1):11.


Measuring the Integration of Stereotactic Ablative Radiotherapy Plus Surgery for Early-Stage Non-Small Cell Lung Cancer: A Phase 2 Clinical Trial.

Palma DA, Nguyen TK, Louie AV, Malthaner R, Fortin D, Rodrigues GB, Yaremko B, Laba J, Kwan K, Gaede S, Lee T, Ward A, Warner A, Inculet R.

JAMA Oncol. 2019 May 1;5(5):681-688. doi: 10.1001/jamaoncol.2018.6993.


Cellular crowding influences extrusion and proliferation to facilitate epithelial tissue repair.

Franco JJ, Atieh Y, Bryan CD, Kwan KM, Eisenhoffer GT.

Mol Biol Cell. 2019 Jul 22;30(16):1890-1899. doi: 10.1091/mbc.E18-05-0295. Epub 2019 Feb 20.


Phenotypic Transformation of Astrocytes Into Tumor-Supportive Cells: Glioblastoma Cell Vesicle Release.

Patel NV, Schneider JR, Kwan K, Boockvar JA.

Neurosurgery. 2019 Mar 1;84(3):E144-E145. doi: 10.1093/neuros/nyy624. No abstract available.


Early Epidural Blood Patch to Treat Intracranial Hypotension after Iatrogenic Cerebrospinal Fluid Leakage from Lumbar Tubular Microdiscectomy.

Faltings L, Kulason KO, Du V, Schneider JR, Chakraborty S, Kwan K, Pramanik B, Boockvar J.

Cureus. 2018 Nov 26;10(11):e3633. doi: 10.7759/cureus.3633.


Persistent vasomotor symptoms and breast cancer in the Women's Health Initiative.

Chlebowski RT, Mortimer JE, Crandall CJ, Pan K, Manson JE, Nelson R, Johnson KC, Vitolin MZ, Lane D, Wactawski-Wende J, Kwan K, Stefanick ML.

Menopause. 2018 Dec 28;26(6):578-587. doi: 10.1097/GME.0000000000001283.


Supracerebellar Transtentorial Approach for Occipital Meningioma to Maximize Visual Preservation: Technical Note.

Golub D, Mehan ND, Kwan K, Salas SJ, Schulder M.

Oper Neurosurg (Hagerstown). 2019 Oct 1;17(4):E177-E183. doi: 10.1093/ons/opy380.


Predictors of self-harm emergency department visits in adolescents: A statewide longitudinal study.

Goldman-Mellor S, Kwan K, Boyajian J, Gruenewald P, Brown P, Wiebe D, Cerdá M.

Gen Hosp Psychiatry. 2019 Jan - Feb;56:28-35. doi: 10.1016/j.genhosppsych.2018.12.004. Epub 2018 Dec 8.


Tracing the Origin of Glioblastoma: Subventricular Zone Neural Stem Cells.

Kwan K, Schneider JR, Patel NV, Boockvar JA.

Neurosurgery. 2019 Jan 1;84(1):E15-E16. doi: 10.1093/neuros/nyy512. No abstract available.


Vertebral Growth Around Distal Instrumented Vertebra in Patients With Early-Onset Scoliosis Who Underwent Traditional Dual Growing Rod Treatment.

Rong T, Shen J, Kwan K, Zhang J, Wang Y, Li S, Li Z, Chen C, Lin Y, Tan H.

Spine (Phila Pa 1976). 2019 Jun 15;44(12):855-865. doi: 10.1097/BRS.0000000000002957.


Technical Aspects and Operative Nuances Using a High-Definition 3-Dimensional Exoscope for Cerebral Bypass Surgery.

Nossek E, Schneider JR, Kwan K, Kulason KO, Du V, Chakraborty S, Rahme R, Faltings L, Ellis J, Ortiz R, Boockvar JA, Langer DJ.

Oper Neurosurg (Hagerstown). 2019 Aug 1;17(2):157-163. doi: 10.1093/ons/opy342.


Commentary: Endoscopic Endonasal Resection of Orbital Apex Cavernous Hemangioma: 2-Dimensional Operative Video.

Patel NV, Schneider JR, Kwan K, Boockvar JA.

Oper Neurosurg (Hagerstown). 2019 May 1;16(5):E146-E147. doi: 10.1093/ons/opy248. No abstract available.


Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration.

Yang M, Zhang Q, Wang Q, Sørensen KK, Boesen JT, Ma SY, Jensen KJ, Kwan KM, Ngo JCK, Chan HYE, Zuo Z.

Mol Pharm. 2018 Dec 3;15(12):5781-5792. doi: 10.1021/acs.molpharmaceut.8b00938. Epub 2018 Nov 12.


Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration.

Wang Q, Peng S, Hu Y, Wong CH, Kwan KM, Chan HYE, Zuo Z.

Eur J Pharm Sci. 2019 Jan 15;127:240-251. doi: 10.1016/j.ejps.2018.10.025. Epub 2018 Nov 1.


Do different sitting postures affect spinal biomechanics of asymptomatic individuals?

Wong AYL, Chan TPM, Chau AWM, Tung Cheung H, Kwan KCK, Lam AKH, Wong PYC, De Carvalho D.

Gait Posture. 2019 Jan;67:230-235. doi: 10.1016/j.gaitpost.2018.10.028. Epub 2018 Oct 21.


Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis.

Gordon HB, Lusk S, Carney KR, Wirick EO, Murray BF, Kwan KM.

Development. 2018 Nov 19;145(22). pii: dev165068. doi: 10.1242/dev.165068.


Non-neurologic adverse events after complex adult spinal deformity surgery: results from the prospective, multicenter Scoli-RISK-1 study.

Kwan KYH, Bow C, Samartzis D, Lenke LG, Shaffrey CI, Carreon LY, Dahl BT, Fehlings MG, Ames CP, Boachie-Adjei O, Dekutoski MB, Kebaish KM, Lewis SJ, Matsuyama Y, Mehdian H, Pellisé F, Qiu Y, Schwab FJ, Cheung KMC.

Eur Spine J. 2019 Jan;28(1):170-179. doi: 10.1007/s00586-018-5790-y. Epub 2018 Oct 16.


Recurrent Glioblastoma Treated With Recombinant Poliovirus.

Schneider JR, Patel NV, Kwan K, Boockvar JA.

Neurosurgery. 2018 Nov 1;83(5):E200. doi: 10.1093/neuros/nyy400. No abstract available.


The prevalence and years lived with disability caused by low back pain in China, 1990 to 2016: findings from the global burden of disease study 2016.

Wu A, Dong W, Liu S, Cheung JPY, Kwan KYH, Zeng X, Zhang K, Sun Z, Wang X, Cheung KMC, Zhou M, Zhao J.

Pain. 2019 Jan;160(1):237-245. doi: 10.1097/j.pain.0000000000001396.


Understanding the hepatitis B core positive liver donor.

Kwan KWC, Lim TR, Kumar R, Krishnamoorthy TL.

Singapore Med J. 2019 Oct;60(10):545-549. doi: 10.11622/smedj.2018104. Epub 2018 Sep 5.

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