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Low-Cost Method Generating In Situ Anaerobic Conditions on a 96-Well Plate for Microbial Fermentation in Food Research.

Lam KL, Lin S, Liu C, Wu X, Tang S, Kwan HS, Cheung PC.

J Agric Food Chem. 2018 Nov 7;66(44):11839-11845. doi: 10.1021/acs.jafc.8b04888. Epub 2018 Oct 24.


Community Structure, Dynamics and Interactions of Bacteria, Archaea and Fungi in Subtropical Coastal Wetland Sediments.

Cheung MK, Wong CK, Chu KH, Kwan HS.

Sci Rep. 2018 Sep 26;8(1):14397. doi: 10.1038/s41598-018-32529-5.


Discovery of microRNA-like RNAs during early fruiting body development in the model mushroom Coprinopsis cinerea.

Lau AYT, Cheng X, Cheng CK, Nong W, Cheung MK, Chan RH, Hui JHL, Kwan HS.

PLoS One. 2018 Sep 19;13(9):e0198234. doi: 10.1371/journal.pone.0198234. eCollection 2018.


The diploid genome of the only sclerotia-forming wild-type species in the genus Pleurotus -Pleurotus tuber-regium - provides insights into the mechanism of its biomass conversion from lignocellulose substrates.

Lam KL, Si K, Wu X, Tang S, Sun X, Kwan HS, Cheung PC.

J Biotechnol. 2018 Oct 10;283:22-27. doi: 10.1016/j.jbiotec.2018.07.009. Epub 2018 Jul 9.


Genomic and transcriptomic comparison of Aspergillus oryzae strains: a case study in soy sauce koji fermentation.

Zhong Y, Lu X, Xing L, Ho SWA, Kwan HS.

J Ind Microbiol Biotechnol. 2018 Sep;45(9):839-853. doi: 10.1007/s10295-018-2059-8. Epub 2018 Jul 5.


Detection of Quantitative Trait Loci Underlying Yield-Related Traits in Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes).

Gong WB, Li L, Zhou Y, Bian Y, Kwan HS, Cheung MK, Xiao Y.

Int J Med Mushrooms. 2018;20(5):451-458. doi: 10.1615/IntJMedMushrooms.2018026236.


A Review of Food-Drug Interactions on Oral Drug Absorption.

Deng J, Zhu X, Chen Z, Fan CH, Kwan HS, Wong CH, Shek KY, Zuo Z, Lam TN.

Drugs. 2017 Nov;77(17):1833-1855. doi: 10.1007/s40265-017-0832-z. Review.


Ancestral whole-genome duplication in the marine chelicerate horseshoe crabs.

Kenny NJ, Chan KW, Nong W, Qu Z, Maeso I, Yip HY, Chan TF, Kwan HS, Holland PWH, Chu KH, Hui JHL.

Heredity (Edinb). 2017 Nov;119(5):388. doi: 10.1038/hdy.2017.38. Epub 2017 Aug 9.


Association Mapping Reveals Genetic Loci Associated with Important Agronomic Traits in Lentinula edodes, Shiitake Mushroom.

Li C, Gong W, Zhang L, Yang Z, Nong W, Bian Y, Kwan HS, Cheung MK, Xiao Y.

Front Microbiol. 2017 Feb 17;8:237. doi: 10.3389/fmicb.2017.00237. eCollection 2017.


Mechanistic Study of Utilization of Water-Insoluble Saccharomyces cerevisiae Glucans by Bifidobacterium breve Strain JCM1192.

Keung HY, Li TK, Sham LT, Cheung MK, Cheung PC, Kwan HS.

Appl Environ Microbiol. 2017 Mar 17;83(7). pii: e03442-16. doi: 10.1128/AEM.03442-16. Print 2017 Apr 1.


Diversity of Total Bacterial Communities and Chemoautotrophic Populations in Sulfur-Rich Sediments of Shallow-Water Hydrothermal Vents off Kueishan Island, Taiwan.

Wang L, Cheung MK, Liu R, Wong CK, Kwan HS, Hwang JS.

Microb Ecol. 2017 Apr;73(3):571-582. doi: 10.1007/s00248-016-0898-2. Epub 2016 Dec 1.


Metagenomics of tuberculosis infection in Hong Kong.

Lam WY, Cheung MK, Fung WY, Law PT, Kam KM, Au CH, Nong WY, Hwang D, Chan RC, Kwan HS, Tsui SK.

Hong Kong Med J. 2016 Dec;22 Suppl 7(6):15-17. No abstract available.


Population genomic analysis uncovers environmental stress-driven selection and adaptation of Lentinula edodes population in China.

Xiao Y, Cheng X, Liu J, Li C, Nong W, Bian Y, Cheung MK, Kwan HS.

Sci Rep. 2016 Nov 10;6:36789. doi: 10.1038/srep36789.


Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells.

Kwan SY, Cheng X, Tsang YT, Choi JS, Kwan SY, Izaguirre DI, Kwan HS, Gershenson DM, Wong KK.

Oncotarget. 2016 Aug 30;7(35):56933-56943. doi: 10.18632/oncotarget.10921.


Genetic dissection of fruiting body-related traits using quantitative trait loci mapping in Lentinula edodes.

Gong WB, Li L, Zhou Y, Bian YB, Kwan HS, Cheung MK, Xiao Y.

Appl Microbiol Biotechnol. 2016 Jun;100(12):5437-52. doi: 10.1007/s00253-016-7347-5. Epub 2016 Feb 15.


Ancestral whole-genome duplication in the marine chelicerate horseshoe crabs.

Kenny NJ, Chan KW, Nong W, Qu Z, Maeso I, Yip HY, Chan TF, Kwan HS, Holland PW, Chu KH, Hui JH.

Heredity (Edinb). 2016 Feb;116(2):190-9. doi: 10.1038/hdy.2015.89. Epub 2015 Sep 30. Erratum in: Heredity (Edinb). 2017 Aug 09;:.


Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong.

Cheng CK, Cheung MK, Nong W, Law PT, Qin J, Ling JM, Kam KM, Cheung WM, Kwan HS.

BMC Genomics. 2015 Sep 14;16:688. doi: 10.1186/s12864-015-1900-y.


Rapid Change of Microbiota Diversity in the Gut but Not the Hepatopancreas During Gonadal Development of the New Shrimp Model Neocaridina denticulata.

Cheung MK, Yip HY, Nong W, Law PT, Chu KH, Kwan HS, Hui JH.

Mar Biotechnol (NY). 2015 Dec;17(6):811-9. doi: 10.1007/s10126-015-9662-8. Epub 2015 Aug 30.


Microbial diversity in shallow-water hydrothermal sediments of Kueishan Island, Taiwan as revealed by pyrosequencing.

Wang L, Cheung MK, Kwan HS, Hwang JS, Wong CK.

J Basic Microbiol. 2015 Nov;55(11):1308-18. doi: 10.1002/jobm.201400811. Epub 2015 Jul 1.


A "developmental hourglass" in fungi.

Cheng X, Hui JH, Lee YY, Wan Law PT, Kwan HS.

Mol Biol Evol. 2015 Jun;32(6):1556-66. doi: 10.1093/molbev/msv047. Epub 2015 Feb 27.


Comparative genomic analysis of clinical and environmental strains provides insight into the pathogenicity and evolution of Vibrio parahaemolyticus.

Li L, Wong HC, Nong W, Cheung MK, Law PT, Kam KM, Kwan HS.

BMC Genomics. 2014 Dec 18;15:1135. doi: 10.1186/1471-2164-15-1135.


Human proteins with target sites of multiple post-translational modification types are more prone to be involved in disease.

Huang Q, Chang J, Cheung MK, Nong W, Li L, Lee MT, Kwan HS.

J Proteome Res. 2014 Jun 6;13(6):2735-48. doi: 10.1021/pr401019d. Epub 2014 May 2.


Constructing a new integrated genetic linkage map and mapping quantitative trait loci for vegetative mycelium growth rate in Lentinula edodes.

Gong WB, Liu W, Lu YY, Bian YB, Zhou Y, Kwan HS, Cheung MK, Xiao Y.

Fungal Biol. 2014 Mar;118(3):295-308. doi: 10.1016/j.funbio.2014.01.001. Epub 2014 Jan 21.


The genetic structure of the A mating-type locus of Lentinula edodes.

Au CH, Wong MC, Bao D, Zhang M, Song C, Song W, Law PT, Kües U, Kwan HS.

Gene. 2014 Feb 10;535(2):184-90. doi: 10.1016/j.gene.2013.11.036. Epub 2013 Dec 1.


Genome Sequences of Salmonella enterica Serotype Typhimurium Blood Clinical Isolate ST4848/06 and Stool Isolate ST1489/06.

Cheng CK, Au CH, Li L, Nong W, Law PT, Cheung WM, Ling JM, Kwan HS.

Genome Announc. 2013 Oct 17;1(5). pii: e00823-13. doi: 10.1128/genomeA.00823-13.


Rapid genotyping by low-coverage resequencing to construct genetic linkage maps of fungi: a case study in Lentinula edodes.

Au CH, Cheung MK, Wong MC, Chu AK, Law PT, Kwan HS.

BMC Res Notes. 2013 Aug 2;6:307. doi: 10.1186/1756-0500-6-307.


A novel Lentinula edodes laccase and its comparative enzymology suggest guaiacol-based laccase engineering for bioremediation.

Wong KS, Cheung MK, Au CH, Kwan HS.

PLoS One. 2013 Jun 14;8(6):e66426. doi: 10.1371/journal.pone.0066426. Print 2013.


Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis--a longitudinal study.

Wong VW, Tse CH, Lam TT, Wong GL, Chim AM, Chu WC, Yeung DK, Law PT, Kwan HS, Yu J, Sung JJ, Chan HL.

PLoS One. 2013 Apr 25;8(4):e62885. doi: 10.1371/journal.pone.0062885. Print 2013.


Composition of heterotrophic flagellates in coastal waters of different trophic status.

Cheung MK, Nong W, Kwan HS, Wong CK.

Curr Microbiol. 2013 Sep;67(3):351-5. doi: 10.1007/s00284-013-0374-x. Epub 2013 May 1.


5'-Serial Analysis of Gene Expression studies reveal a transcriptomic switch during fruiting body development in Coprinopsis cinerea.

Cheng CK, Au CH, Wilke SK, Stajich JE, Zolan ME, Pukkila PJ, Kwan HS.

BMC Genomics. 2013 Mar 20;14:195. doi: 10.1186/1471-2164-14-195.


Sputum microbiota in tuberculosis as revealed by 16S rRNA pyrosequencing.

Cheung MK, Lam WY, Fung WY, Law PT, Au CH, Nong W, Kam KM, Kwan HS, Tsui SK.

PLoS One. 2013;8(1):e54574. doi: 10.1371/journal.pone.0054574. Epub 2013 Jan 24.


BSRD: a repository for bacterial small regulatory RNA.

Li L, Huang D, Cheung MK, Nong W, Huang Q, Kwan HS.

Nucleic Acids Res. 2013 Jan;41(Database issue):D233-8. doi: 10.1093/nar/gks1264. Epub 2012 Nov 29.


Draft genome sequence of Salmonella enterica serovar Typhimurium ST1660/06, a multidrug-resistant clinical strain isolated from a diarrheic patient.

Li L, Cheng CK, Cheung MK, Law PT, Ling JM, Kam KM, Cheung WM, Kwan HS.

J Bacteriol. 2012 Nov;194(22):6319-20. doi: 10.1128/JB.01593-12.


Fighting outbreaks with bacterial genomics: case review and workflow proposal.

Cheung MK, Kwan HS.

Public Health Genomics. 2012;15(6):341-51. doi: 10.1159/000342770. Epub 2012 Oct 3. Review.


High-density transcriptional initiation signals underline genomic islands in bacteria.

Huang Q, Cheng X, Cheung MK, Kiselev SS, Ozoline ON, Kwan HS.

PLoS One. 2012;7(3):e33759. doi: 10.1371/journal.pone.0033759. Epub 2012 Mar 20.


A cost-effective and universal strategy for complete prokaryotic genomic sequencing proposed by computer simulation.

Jiang J, Li J, Kwan HS, Au CH, Wan Law PT, Li L, Kam KM, Lun Ling JM, Leung FC.

BMC Res Notes. 2012 Jan 31;5:80. doi: 10.1186/1756-0500-5-80.


2011 German Escherichia coli O104:H4 outbreak: whole-genome phylogeny without alignment.

Cheung MK, Li L, Nong W, Kwan HS.

BMC Res Notes. 2011 Dec 13;4:533. doi: 10.1186/1756-0500-4-533.


Biodegradation of dyes and polyaromatic hydrocarbons by two allelic forms of Lentinula edodes laccase expressed from Pichia pastoris.

Wong KS, Huang Q, Au CH, Wang J, Kwan HS.

Bioresour Technol. 2012 Jan;104:157-64. doi: 10.1016/j.biortech.2011.10.097. Epub 2011 Nov 12.


Cataloging and profiling genes expressed in Lentinula edodes fruiting body by massive cDNA pyrosequencing and LongSAGE.

Chum WW, Kwan HS, Au CH, Kwok IS, Fung YW.

Fungal Genet Biol. 2011 Apr;48(4):359-69. doi: 10.1016/j.fgb.2011.01.009. Epub 2011 Jan 31.


Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).

Stajich JE, Wilke SK, Ahrén D, Au CH, Birren BW, Borodovsky M, Burns C, Canbäck B, Casselton LA, Cheng CK, Deng J, Dietrich FS, Fargo DC, Farman ML, Gathman AC, Goldberg J, Guigó R, Hoegger PJ, Hooker JB, Huggins A, James TY, Kamada T, Kilaru S, Kodira C, Kües U, Kupfer D, Kwan HS, Lomsadze A, Li W, Lilly WW, Ma LJ, Mackey AJ, Manning G, Martin F, Muraguchi H, Natvig DO, Palmerini H, Ramesh MA, Rehmeyer CJ, Roe BA, Shenoy N, Stanke M, Ter-Hovhannisyan V, Tunlid A, Velagapudi R, Vision TJ, Zeng Q, Zolan ME, Pukkila PJ.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11889-94. doi: 10.1073/pnas.1003391107. Epub 2010 Jun 14.


Composition and genetic diversity of picoeukaryotes in subtropical coastal waters as revealed by 454 pyrosequencing.

Cheung MK, Au CH, Chu KH, Kwan HS, Wong CK.

ISME J. 2010 Aug;4(8):1053-9. doi: 10.1038/ismej.2010.26. Epub 2010 Mar 25.


Development of a low-cost polymerase chain reaction-based method for studying differentially expressed genes in developing rice leaves.

Fung YW, Chow HY, Law TW, Dong B, Kwan HS.

J Integr Plant Biol. 2009 Jun;51(6):614-21. doi: 10.1111/j.1744-7909.2008.00801.x.


Molecular evidence for the hybrid origin of Bauhinia blakeana (Caesalpinioideae).

Mak CY, Cheung KS, Yip PY, Kwan HS.

J Integr Plant Biol. 2008 Jan;50(1):111-8. doi: 10.1111/j.1744-7909.2007.00591.x.


Gene expression studies of the dikaryotic mycelium and primordium of Lentinula edodes by serial analysis of gene expression.

Chum WW, Ng KT, Shih RS, Au CH, Kwan HS.

Mycol Res. 2008 Aug;112(Pt 8):950-64. doi: 10.1016/j.mycres.2008.01.028. Epub 2008 Mar 25.


Isolation and transcript analysis of two-component histidine kinase gene Le.nik1 in Shiitake mushroom, Lentinula edodes.

Szeto CY, Wong QW, Leung GS, Kwan HS.

Mycol Res. 2008 Jan;112(Pt 1):108-16. doi: 10.1016/j.mycres.2007.08.024. Epub 2007 Nov 21.


Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia.

Feng HC, Tsao SW, Ngan HY, Xue WC, Kwan HS, Siu MK, Liao XY, Wong E, Cheung AN.

Histopathology. 2008 Jan;52(2):167-74. doi: 10.1111/j.1365-2559.2007.02925.x.


Endocytosis in the shiitake mushroom Lentinula edodes and involvement of GTPase LeRAB7.

Lee MT, Szeto CY, Ng TP, Kwan HS.

Eukaryot Cell. 2007 Dec;6(12):2406-18. Epub 2007 Oct 5.


DNA methods for identification of Chinese medicinal materials.

Yip PY, Chau CF, Mak CY, Kwan HS.

Chin Med. 2007 Sep 5;2:9.


Molecular coordinated regulation of gene expression during ovarian development in the penaeid shrimp.

Lo TS, Cui Z, Mong JL, Wong QW, Chan SM, Kwan HS, Chu KH.

Mar Biotechnol (NY). 2007 Jul-Aug;9(4):459-68. Epub 2007 May 10.


Le.MAPK and its interacting partner, Le.DRMIP, in fruiting body development in Lentinula edodes.

Szeto CY, Leung GS, Kwan HS.

Gene. 2007 May 15;393(1-2):87-93. Epub 2007 Feb 20.


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